IN2012DN03632A - - Google Patents
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- Publication number
- IN2012DN03632A IN2012DN03632A IN3632DEN2012A IN2012DN03632A IN 2012DN03632 A IN2012DN03632 A IN 2012DN03632A IN 3632DEN2012 A IN3632DEN2012 A IN 3632DEN2012A IN 2012DN03632 A IN2012DN03632 A IN 2012DN03632A
- Authority
- IN
- India
- Prior art keywords
- weight
- amount
- fos
- present
- inulin
- Prior art date
Links
- 229920001202 Inulin Polymers 0.000 abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 abstract 2
- 229940029339 inulin Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 235000016709 nutrition Nutrition 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 abstract 1
- 229920000189 Arabinogalactan Polymers 0.000 abstract 1
- 239000001904 Arabinogalactan Substances 0.000 abstract 1
- 229920002907 Guar gum Polymers 0.000 abstract 1
- 235000019312 arabinogalactan Nutrition 0.000 abstract 1
- 239000000665 guar gum Substances 0.000 abstract 1
- 229960002154 guar gum Drugs 0.000 abstract 1
- 235000010417 guar gum Nutrition 0.000 abstract 1
- 244000005709 gut microbiome Species 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/25—Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26049509P | 2009-11-12 | 2009-11-12 | |
| US26443009P | 2009-11-25 | 2009-11-25 | |
| US39480510P | 2010-10-20 | 2010-10-20 | |
| PCT/US2010/056321 WO2011060123A1 (fr) | 2009-11-12 | 2010-11-11 | Composition nutritionnelle permettant de favoriser l'équilibre de microbiotes digestifs et la santé |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN03632A true IN2012DN03632A (fr) | 2015-06-26 |
Family
ID=43567734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3632DEN2012 IN2012DN03632A (fr) | 2009-11-12 | 2010-11-11 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9192179B2 (fr) |
| EP (1) | EP2498626B1 (fr) |
| JP (2) | JP6006117B2 (fr) |
| CN (2) | CN104206946A (fr) |
| AU (1) | AU2010319490B2 (fr) |
| BR (1) | BR112012011294B1 (fr) |
| CA (1) | CA2777941C (fr) |
| DK (1) | DK2498626T3 (fr) |
| ES (1) | ES2545597T3 (fr) |
| HK (1) | HK1172516A1 (fr) |
| IN (1) | IN2012DN03632A (fr) |
| MX (1) | MX336032B (fr) |
| RU (1) | RU2012123959A (fr) |
| WO (1) | WO2011060123A1 (fr) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104206946A (zh) * | 2009-11-12 | 2014-12-17 | 雀巢产品技术援助有限公司 | 用于促进肠微生物群平衡和健康的营养组合物 |
| CN108741083A (zh) * | 2010-12-31 | 2018-11-06 | 雅培制药有限公司 | 促进有益细菌生长的中性人乳寡糖 |
| WO2012177556A2 (fr) | 2011-06-20 | 2012-12-27 | H.J. Heinz Company | Méthodes et compositions probiotiques |
| WO2012175639A1 (fr) * | 2011-06-22 | 2012-12-27 | Universite De Rouen | Protéines arabinogalactanes pour l'utilisation en tant qu'agent antiparasitaire |
| FI126711B (fi) * | 2011-10-12 | 2017-04-13 | Gut Guide Oy | Serotoniinivajeeseen liittyvän terveysriskin arvioiminen |
| PL2768312T3 (pl) | 2011-10-18 | 2016-06-30 | Nestec Sa | Kompozycja do stosowania dla wspomagania zdrowego rozwoju oraz/albo w zapobieganiu oraz/albo w leczeniu chorób kości |
| TW201318566A (zh) * | 2011-11-01 | 2013-05-16 | Jimmy Lu | 膳食補充劑組合物及其用於調控血糖之方法 |
| WO2013130773A2 (fr) | 2012-02-29 | 2013-09-06 | Ethicon Endo-Surgery, Inc. | Compositions de microbiota et leurs procédés associés |
| ITRM20120084A1 (it) | 2012-03-07 | 2013-09-08 | Aboca Spa Societa Agricola | Miscela prebiotica. |
| WO2014007606A1 (fr) | 2012-07-05 | 2014-01-09 | N.V. Nutricia | Produit pour l'utilisation dans le traitement prophylactique ou thérapeutique d'une émotion négative ou d'un comportement introverti |
| AU2013338774B2 (en) * | 2012-11-01 | 2017-03-02 | Academisch Ziekenhuis Groningen | Methods and compositions for stimulating beneficial bacteria in the gastrointestinal tract |
| US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| US20150296851A1 (en) * | 2012-11-27 | 2015-10-22 | Shanghai Jiao Tong University | Compositions for Balancing Gut Microbiota and the Preparation and the Uses thereof |
| NZ711771A (en) | 2013-02-04 | 2016-11-25 | Seres Therapeutics Inc | Compositions for treating or preventing or reducing the severity of clostridium difficile related diseases |
| US10973861B2 (en) | 2013-02-04 | 2021-04-13 | Seres Therapeutics, Inc. | Compositions and methods |
| US10076546B2 (en) | 2013-03-15 | 2018-09-18 | Seres Therapeutics, Inc. | Network-based microbial compositions and methods |
| CA2902248A1 (fr) * | 2013-03-15 | 2014-09-25 | Microbiome Therapeutics, Llc | Fibre de cosse de soja activee |
| GB201312713D0 (en) * | 2013-03-22 | 2013-08-28 | Weaver Connie M | Uses of soluble corn fibre for increasing colonic bacteria populations and increasing mineral absorption |
| GB201305708D0 (en) * | 2013-03-28 | 2013-05-15 | Clasado Inc | Novel use |
| US20160051468A1 (en) * | 2013-04-11 | 2016-02-25 | Bright Drinks Inc. | Compositions for Prevention and/or Treatment of Gastrointestinal Imbalances in Digestive Disorders |
| ITMI20131467A1 (it) * | 2013-09-06 | 2015-03-07 | Sofar Spa | Uso di una composizione comprendente microrganismi per aumentare la produzione intestinale di acido butirrico, di acido folico o di niacina e/o per diminuire la produzione intestinale di acido succinico |
| KR102515850B1 (ko) | 2013-11-25 | 2023-03-30 | 세레스 테라퓨틱스, 인코포레이티드 | 상승적 박테리아 조성물 및 그것의 생산 방법 및 용도 |
| WO2015095241A2 (fr) | 2013-12-16 | 2015-06-25 | Seres Health, Inc. | Compositions bactériennes et leurs méthodes d'utilisation pour traiter des troubles du système immunitaire |
| CN105828641A (zh) * | 2013-12-20 | 2016-08-03 | 雀巢产品技术援助有限公司 | 用于减少肠病原体的营养组合物 |
| MA39710A (fr) | 2014-04-23 | 2015-10-29 | Sofar Spa | Composition topique destinée à être utilisée dans le traitement d'une maladie inflammatoire de l'intestin |
| CN104187624B (zh) * | 2014-08-07 | 2016-06-08 | 逯明福 | 综合营养粉及其制备方法 |
| WO2016029113A1 (fr) * | 2014-08-22 | 2016-02-25 | Abbott Laboratories | Procédés d'augmentation de la production endogène de bêta-hydroxy-bêta-méthylbutyrate |
| MX2017003293A (es) | 2014-09-30 | 2017-06-21 | Kimberly Clark Co | Composicion prebiotica sinergica. |
| WO2016053309A1 (fr) | 2014-09-30 | 2016-04-07 | Kimberly-Clark Worldwide, Inc. | Tissu prébiotique crêpé |
| SG10201903823QA (en) | 2014-10-31 | 2019-05-30 | Whole Biome Inc | Methods and compositions relating to microbial treatment and diagnosis of disorders |
| CN104432069A (zh) * | 2014-12-22 | 2015-03-25 | 威海百合生物技术股份有限公司 | 一种肠胃通畅片 |
| JP6338113B2 (ja) * | 2015-03-31 | 2018-06-06 | 株式会社東洋新薬 | 除脂肪体重の増加剤 |
| EP3397960B1 (fr) * | 2015-12-30 | 2020-01-29 | Société des Produits Nestlé S.A. | Méthode pour définir la masse du corps |
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| EP1175905A1 (fr) * | 2000-07-24 | 2002-01-30 | Societe Des Produits Nestle S.A. | Composition nutritive |
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| EP1243273A1 (fr) | 2001-03-22 | 2002-09-25 | Societe Des Produits Nestle S.A. | Composition contenant un agent prebiotique pour le traitement d'inflammation et d'activation anormal des agents immunitaires non-spécifiques |
| GB0308104D0 (en) * | 2003-04-08 | 2003-05-14 | Novartis Nutrition Ag | Organic compounds |
| ITMI20040956A1 (it) * | 2004-05-12 | 2004-08-12 | Curti Alessandro | Composizioni alimentari |
| EP1597978A1 (fr) | 2004-05-17 | 2005-11-23 | Nutricia N.V. | Synergie de GOS et polyfructose |
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| CN101534656B (zh) * | 2006-11-07 | 2013-05-22 | 宝洁公司 | 包含纤维的组合物及其制备和使用方法 |
| ITMI20071214A1 (it) | 2007-06-15 | 2008-12-16 | S I I T Srl Servizio Internazi | Composizioni a base di componenti prebiotici ed immunogenici per la prevenzione e il trattamento di disturbi gastroenterici da disbiosi e/o alterazioni della normale flora intestinale |
| PL2178385T3 (pl) | 2007-07-18 | 2012-12-31 | Campina Nederland Holding Bv | Termostabilny napój odżywczy i sposób jego wytwarzania |
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| JP5992654B2 (ja) | 2007-12-21 | 2016-09-14 | ニュートリー株式会社 | 整腸及び／又は便通改善のための組成物 |
| CN104206946A (zh) * | 2009-11-12 | 2014-12-17 | 雀巢产品技术援助有限公司 | 用于促进肠微生物群平衡和健康的营养组合物 |
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| DK2498626T3 (en) | 2015-07-13 |
| EP2498626A1 (fr) | 2012-09-19 |
| BR112012011294A2 (pt) | 2015-09-15 |
| US10015978B2 (en) | 2018-07-10 |
| HK1172516A1 (en) | 2013-04-26 |
| CN104206946A (zh) | 2014-12-17 |
| MX336032B (es) | 2016-01-07 |
| RU2012123959A (ru) | 2013-12-20 |
| MX2012004778A (es) | 2012-06-01 |
| BR112012011294B1 (pt) | 2018-03-20 |
| JP6006117B2 (ja) | 2016-10-12 |
| JP6205003B2 (ja) | 2017-09-27 |
| JP2013510865A (ja) | 2013-03-28 |
| WO2011060123A1 (fr) | 2011-05-19 |
| US20160100617A1 (en) | 2016-04-14 |
| US9192179B2 (en) | 2015-11-24 |
| CA2777941A1 (fr) | 2011-05-19 |
| CN102595934A (zh) | 2012-07-18 |
| ES2545597T3 (es) | 2015-09-14 |
| AU2010319490A1 (en) | 2012-05-03 |
| JP2016166176A (ja) | 2016-09-15 |
| EP2498626B1 (fr) | 2015-06-17 |
| AU2010319490B2 (en) | 2015-03-19 |
| US20120269865A1 (en) | 2012-10-25 |
| CA2777941C (fr) | 2018-08-14 |
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