TW201318566A - 膳食補充劑組合物及其用於調控血糖之方法 - Google Patents
膳食補充劑組合物及其用於調控血糖之方法 Download PDFInfo
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- TW201318566A TW201318566A TW101139886A TW101139886A TW201318566A TW 201318566 A TW201318566 A TW 201318566A TW 101139886 A TW101139886 A TW 101139886A TW 101139886 A TW101139886 A TW 101139886A TW 201318566 A TW201318566 A TW 201318566A
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Abstract
本發明提供一種膳食補充劑組合物,其包含L-阿拉伯糖以及至少一種選擇性化合物;可藉由上述之膳食補充劑組合物調控血糖以防止代謝綜合症、抗消化道感染、幫助益生菌生長及控制體重。
Description
本發明係關於一種膳食補充劑組合物,尤指一種包含L-阿拉伯糖及至少一種選擇性化合物之膳食補充劑組合物,可用於補充膳食營養缺乏(dietary deficiency)、阻斷蔗糖吸收來調控血糖以防止代謝綜合症、抗消化道感染、幫助益生菌生長及控制體重;本發明更關於一種調控血糖之方法,其係將前述之膳食補充劑組合物投予人體,其中該膳食補充劑組合物包含有效劑量之L-阿拉伯糖以及至少一種選擇性化合物。
蔗糖酶(sucrase)係由小腸之絨毛(villi)所分泌,其可將蔗糖(sucrose)經水解作用(hydrolysis)成等量的兩種單醣(monosaccharide):果糖(fructose)及葡萄糖(glucose),以被人體吸收利用。由於人體具有較多蔗糖酶,且人體為求可快速利用能量,造成人體過度依賴由蔗糖水解而來之果糖及葡萄糖,而無法有效利用其它主要營養素(macronutrients),此處主要營養素係指除了蔗糖之外之其他碳水化合物、蛋白質及脂肪。
由於加工提取的甘蔗糖及甜菜糖在現代食物中的大量使用,其水解後的葡萄糖迅速進入血液導致血糖升高,而同量的果糖則通過肝臟合成內臟脂肪(visceral fat)導致血脂及三酸甘油酯(triglyceride)升高。
當人體無法有效利用過多的葡萄糖時,人體藉由自身分泌的胰島素形成脂肪儲存。當人體無法有效產生足夠的
胰島素時,過剩的血糖經腎臟再吸收後可能導致罹患糖尿病、肥胖症、心血管疾患、失明、肢體壞死截除、情緒波動(mood swings)甚至癌症等疾病。
鑒於現有經濟及技術之發展使人體過量攝入加工蔗糖造成上述營養結構及人體健康的潛在的危害,故本發明之目的在於提供一種膳食補充劑組合物,該膳食補充劑組合物可藉由抑制蔗糖水解,進而改善人體依賴蔗糖產生能量之缺點,以及控制被阻斷的蔗糖在經過小腸進入大腸被益生菌利用前可能發生的炎症及其它酸性反應,同時達到控制食量的目的。
為達上述目的,本發明提供一種膳食補充劑組合物,其包含L-阿拉伯糖及至少一種選擇性化合物,該至少一種選擇性化合物係分別選自於由根皮酯(phlorizin)、雲芝菌(coriolus versicolor)、桑黄(fomes yucatensis murrill)等靈芝類提取的多糖、蒟蒻(Konjac)、白芸豆(white kidney bean)及武靴藤(gymnema sylvestre)萃取而得之化合物或萃取物所組成的群組,並藉由混合適當劑量之L-阿拉伯糖以及至少一種選擇性化合物,而具有調控血糖、血脂或改善消化道健康效果。
阿拉伯糖係一種單醣(C5H10O5),於哺乳類動物之小腸內可抑制蔗糖分解成果糖及葡萄糖,該阿拉伯糖可被發現於水果及其他植物諸如玉米。L-阿拉伯糖係一種諸如果膠(pectin)及半纖維素(hemicellulose)之生物聚合物(biopolymers),並可來自多種來源諸如玉米梗(corn stalks)
及玉米穗(corn cobs)。
本發明再提供一種膳食補充劑組合物,其包含L-阿拉伯糖及至少一種選擇性化合物,該至少一種選擇性化合物係分別選自由萜類(terpene)、多酚化合物(polyphenolic compound)及皂素(saponin)所組成的群組。
本發明又提供一種膳食補充劑組合物,其包含L-阿拉伯糖及銀杏(ginkgo biloba)。
本發明更提供一種膳食補充劑組合物,其包含L-阿拉伯糖及蛋白質抑制劑(protein inhibitors)。
本發明再提供一種膳食補充劑組合物,其包含L-阿拉伯糖及至少一種植物化合物(phytochemical compounds),該至少一種植物化合物係分別選自由根皮酯、雲芝菌、白芸豆、扶桑(Hibiscus rosa-sinensis L.)、綠茶、咖啡豆及武靴藤或其萃取物所組成的群組。
本發明再提供一種膳食補充劑組合物,其包含L-阿拉伯糖及至少一種選擇性化合物,該至少一種選擇性化合物係選自由酚類化合物(phenolic compounds)、萜類(terpene)[異戊二烯(isoprenoids)]、甜菜紅色素(betalains)、有機硫化物(organsufides)、吲哚(indoles)、葡萄糖苷(glucosinolates)、蛋白質抑制劑(protein inhibitors)及有機酸(organic acids)所組成的群組。
本發明再提供一種調控血糖之方法,其包含將前述之膳食補充劑組合物投予人體,其中該膳食補充劑組合物包含有效劑量之L-阿拉伯糖以及至少一種選擇性化合物,且該至少一種選擇性化合物係分別選自於由根皮酯、雲芝菌
及武靴藤所組成的群組。
依據本發明,「有效劑量」於此所指涉者係指該劑量可降低或減緩蔗糖分解成葡萄糖及果糖之劑量。
較佳的,所述之有效劑量之L-阿拉伯糖與該至少一種選擇性化合物之比例係10:1。
較佳的,所述之有效劑量之L-阿拉伯糖與該至少一種選擇性化合物之比例係1:1。
另一方面,本發明亦提供一種醫藥品,其包含前述之膳食補充劑組合物及其藥學上可接受之載劑(水性載劑或非水性之載劑)。
再另一方面,本發明亦提供一種藉由給予前述之含有有效治療劑量之膳食補充劑組合物以調控血糖及/或改善消化道健康之方法。
本發明之膳食補充劑組合物可由任何藥學上可接受形式之L-阿拉伯糖及至少一種選擇性化合物製備而得,其膳食補充劑組合物更包括至少一黏合劑(binder)、填充劑(filler)、調味劑(flavoring)、緩衝劑(buffer)、凝膠(gel)、賦型劑(excipient)、載劑(carrie)或其他可幫助製備或投藥之化合物。
本發明之膳食補充劑組合物可被製成錠劑(tablets)、粉末(powders)、凝膠(gels)或液狀,其中「錠劑」於此所指涉者係任何型式之固態且可口服劑量,包括,但不限於片劑、膜衣錠(caplets)、膠囊(capsules)及粉粒。
較佳的,所述之膳食補充劑組合物可通過小腸,其中L-阿拉伯糖可抑制蔗糖分解,膳食補充劑組合物之其他成分
可提供如前述之優點。
本發明之實施例中,該膳食補充劑組合物可以每天三次,每次兩顆丸劑(pills)之方式服用,亦可依所需調整劑量及型式;換句話說,劑量可依據個人或個體於24小時內攝取多少量的蔗糖以作調整;平均一餐會攝入20公克(g)之蔗糖。本發明之實施例中,每一丸劑或錠劑[含不低於500毫克(mg)之L-阿拉伯糖]可抑制高達10 g之蔗糖,因此,平均一餐服用兩顆即可足以抑制一餐所累積之高比例蔗糖,且每一劑量之抑制效果可於服用後維持約2小時。
本發明之優點在於改變人體由果糖及葡萄糖快速獲得能量來源之習慣,進而利用其他非蔗糖之主要營養素。藉由消化本發明之組合物,人體明顯吸收較少蔗糖(諸如1份L-阿拉伯糖可抑制高達20份蔗糖),使蔗糖作為消化道益生菌之食物或通過消化系統;且人體每天所需卡路里(calories)為2000卡,進而使人體轉而利用主要營養素,該主要營養素包括碳水化合物、蛋白質及脂肪,且為哺乳類動物大量所需。
較佳的,人體轉換利用非蔗糖主要營養素係有益的,舉例來說,肝臟由血液中回收單糖而合成之肝醣(glycogen)可作為人體能量來源,並進而避免果糖通過肝臟合成內臟脂肪(visceral fat)導致血脂及三酸甘油酯(triglyceride)升高,以達到調控血脂效果;攝食本發明之組合物可降低血糖,並使人體轉而利用脂肪細胞內儲存的脂肪以提供能量,以達到控制體重之效果。
本發明之另一優點在於可改善哺乳動物之消化系統,
由於L-阿拉伯糖可抑制蔗糖水解,使蔗糖仍為完整雙醣並通過消化道,以及作為益菌生提供益生菌食物來源,進而促進益生菌之數量。益生菌係一種對消化道有益之微生物,包括,但不限於雙叉桿菌(bifidobacterium)及酪酸桿菌(clostridium butyricum),該益生菌可藉由乳果(yogurt)等食物進入消化系統,且藉由較多數量之益生菌,可減緩便秘以及軟化糞便以達到幫助消化系統之功效。
本發明之實施例中,本發明提供一種膳食補充劑組合物可抑制蔗糖水解成果糖及葡萄糖,且該膳食補充劑組合物包含L-阿拉伯糖及至少一種選擇性化合物,該至少一種選擇性化合物係分別選自於由根皮酯(phlorizin)、雲芝菌(coriolus versicolor)、桑黄(fomes yucatensis murrill)等靈芝類提取的多糖、蒟蒻(Konjac)、白芸豆(white kidney bean)及武靴藤(gymnema sylvestre)所萃取而得之化合物或萃取物所組成的群組。
在另一較佳實施例中,該至少一種選擇性化合物係分別選自於由萜類(terpene)、多酚化合物(polyphenolic compound)及皂素(saponin)所組成的群組。
在另一較佳實施例中,L-阿拉伯糖與至少一種選擇性化合物之比例係10:1。
在另一較佳實施例中,所述之L-阿拉伯糖與至少一種選擇性化合物之比例係1:1。
在另一較佳實施例中,所述之至少一種選擇性化合物係植物化合物(phytochemicals),其包含多醣
(polysaccharides)。
「植物化合物」於此所指涉者係非動物之生物合成之分子,存在於食物、植物組織之複合有機基質(complex organic matrix)或真菌(fungi)中。
在另一較佳實施例中,該至少一種選擇性化合物係來自植物化合物、植物萃取物及真菌萃取物。
在另一較佳的實施例中,來自植物化合物或萃取物以及真菌萃取物之選擇性化合物具有藥用及草藥之優點,諸如有機或以碳為基礎之植物化合物。此外,L-阿拉伯糖,諸如L-阿拉伯糖萃取物,可與真菌及/或真菌萃取物結合,以達到類似前述L-阿拉伯糖及至少一選擇性化合物之優點。
其中植物化合物包含,但不限於酚類化合物(phenolic compounds)、萜類(terpene)[異戊二烯(isoprenoids)]、甜菜紅色素(betalains)、有機硫化物(organsufides)、吲哚類硫化葡萄糖苷(indoles glucosinolates)、蘿蔔硫素(sulforaphane)、柚苷(naringin)、柑果苷(hesperidin)、芸香柚皮苷(narirutin)、檞黃素(quercrtin)、β-胡蘿蔔素(β-carotene)、葉黃素(lutein)、茄紅素(lycopene)、異黃酮(isoflavones)、蛋白質抑制劑(protein inhibitors)及其他有機酸(organic acid)。
其中酚類化合物包含,但不限於單酚(monophenols)、類黃酮(flavonoids)、酚酸(phenolic acids)、羥桂皮酸(hydroxycinnamic acids)、木脂素(lignans)[植物雌激素(phytoestrogen)]、酪醇酯(tyrosol esters)、類二苯乙烯(stilbenoids)及石榴甙(punicalagins)。
其中萜類包含,但不限於類胡蘿蔔素(carotenoids)[四萜(tetraterpenoids)]、單松烯類(monoterpenes)、皂素、脂質(lipids)及三萜類(triterpenoid);其中甜菜紅色素包含,但不限於甜菜青素(betacyanin)及甜菜黃素(betaxanthin)。
其中有機硫化物包含,但不限於雙硫氫硫(dithiolthiones)及蒜蔥素(thiosulphonates);其中吲哚類硫化葡萄糖苷包含,但不限於吲哚-3-甲醇(indole-3-carbinol)、蘿蔔硫素(sulforaphane)、3,3'-二吲哚甲烷(3,3'-diindolylmethane,DIM)、黑芥素(sinigrin)、蒜素(allicin)、蒜胺酸(alliin)、異硫氰酸烯丙(allyl sothiocyanate)、胡椒鹼(piperine)及顺式-丙硫醛-S-氧化物(syn-propanethial-S-oxide);其中蛋白質抑制劑包含,但不限於蛋白酶抑制劑(protease inhibitor);有機酸包含,但不限於草酸(oxalic acid)、植酸(phytic acid)及酒石酸(tartaric acid)。
在另一較佳的實施例中,該至少一選擇性化合物係來自多酚、類黃酮、菊糖(inulin)、根皮酯、雲芝菌、武靴藤及萜類。
本發明之膳食補充劑組合物包含L-阿拉伯糖及至少一種選擇性化合物,其中該至少一種選擇性化合物諸如多酚、類黃酮、菊糖、根皮酯、雲芝菌、武靴藤及萜類以提供營養補充(nutritional supplement),並抑制蔗糖分解而使得蔗糖進入人體後在血液中不會被吸收或用於形成脂肪。本發明之膳食補充劑組合物中的L-阿拉伯糖係以約20:1之比例抑制蔗糖分解(諸如一份L-阿拉伯糖可使約20份蔗
糖不會被分解成果糖和葡萄糖),且可提供其他健康益處。
舉例來說,植物化合物菊糖作為哺乳類動物消化系統之益菌生(prebiotic),該益菌生係一種食物或營養補充物中不會被消化之成分,菊糖與L-阿拉伯糖結合可幫助消化系統運作,該L-阿拉伯糖無法被哺乳動物之消化系統消化且可抑制蔗糖分解;同樣地,菊糖亦無法被消化,故菊糖與L-阿拉伯糖係不能被消化之碳水化合物(carbohydrates),亦被稱為膳食纖維(dietary fiber)。因此,菊糖與L-阿拉伯糖係直接通過消化系統至結腸(colon),並於結腸中進行自然發酵(natural fermentation),而使結腸具有較多飲食纖維補充或非消化碳水化合物(non-digestible carbohydrates),這些非消化碳水化合物(蔗糖、L-阿拉伯糖及菊糖)係益菌生並可提供食物給原本即存在於結腸之益生菌(probiotic),使益生菌活性提高並可化結腸中的糞便(stool),益生菌亦可幫助結腸之廢物自然排出(natural discharge)。
在另一實施例中,L-阿拉伯糖係與真菌萃取物之雲芝菌[又稱為雲芝(cloud mushroom)]結合。
在另一實施例中,L-阿拉伯糖係與萃取自雲芝(Yun-Zhi)之多醣結合,於其他實施例將L-阿拉伯糖與其他真菌諸如桑黃(fomes yucatensis murrill)或靈芝(ganoderma lucidum)(又稱為reshi mushroom)萃取物結合。靈芝類真菌及其多醣和其它提取、萃取物具有抗炎、抗癌、調節免疫力以及保護及滋養人體臟器等功能。
在另一例子中,本發明之組合物之L-阿拉伯糖係與草藥之武靴藤結合,其中武靴藤係一種生長於印度中南部之
熱帶林之天然草藥,並用於治療糖尿病之天然療法(natural treatment)已有兩千年歷史。武靴藤所具有之生物活性成分(bioactive constituent)係齊燉果烷類型(oleanane-type)三萜皂甙(triterpenoids saponins),又稱武靴葉酸(gymnemic acids),且研究指出,武靴藤萃取物對於人類及哺乳類動物皆具有幫助胰島素分泌之功效。所屬技術領域所知者,可依據本發明之不同實施例結合L-阿拉伯糖及不同類型之武靴葉酸。
在另一例子中,本發明之組合物之L-阿拉伯糖係與根皮酯結合,其中根皮酯係一種類黃酮,亦為一種萃取源自果樹諸如蘋果樹或櫻桃樹之樹皮之植物化合物,並可作為提供哺乳類動物之糖的二次阻斷劑(a secondary block of sugar)。哺乳類動物之血液係藉由腎臟過濾,其中存在腎元(nephrons)之近曲管(proximal tube)的鈉依賴型葡萄糖轉運蛋白-2(sodium-dependent glucose transporters-2,SGLT-2)可將糖類由血液中再吸收(reabsorption),若無鈉依賴型葡萄糖轉運蛋白-2以及存在於小腸之鈉依賴型葡萄糖轉運蛋白-1,血中的糖份會藉由腎移除並經由膀胱排出。根皮酯係用於抑制鈉依賴型葡萄糖轉運蛋白-1以減少糖分循環,藉此可降低血糖並排除糖分作為能量來源。所屬技術領域所知者,可依據本發明之不同實施例結合L-阿拉伯糖及不同類型之類黃酮。
在另一例子中,本發明之膳食補充劑組合物之L-阿拉伯糖係與銀杏(ginkgo biloba)結合,其中銀杏之生物活性成分係來自銀杏葉(ginkgo leaves),且其銀杏葉包含有類黃酮
配醣體(flavonoid glycosides)以及萜類(terpenoid)[主要係銀杏內酯(ginkgolides)及白果內酯(bilobalides)],並於許多研究顯示可治療痴呆(dementia);所屬領域所知者,可依據本發明之不同實施例結合L-阿拉伯糖及不同類型之類黃酮。
以下為不同組合物及方法之較佳實施例。
實施例1
一顆錠劑包含有L-阿拉伯糖以及至少一種選擇性化合物,其中該至少一種選擇性化合物係選自於由根皮酯、雲芝菌及武靴藤所組成的群組。
該錠劑包含有500 mg至1000 mg之L-阿拉伯糖以及50 mg至250 mg之雲芝菌萃取物;在此實施例中,該錠劑中,L-阿拉伯糖與雲芝菌萃取物之比例係10:1。
接下來,將有效劑量之可消化的黏合劑諸如麥牙糊精(maltodextrin)或蒟蒻(konjac)加入至上述錠劑中,以結合L-阿拉伯糖與雲芝菌萃取物;此外,亦可添加調味劑諸如洋茴香(anise)、薄荷(peppermint)、綠薄荷(spearmint)或香草(vanilla)並攪拌(agitate)以形成一混合物(mixture)。再將該混合物置於一錠劑壓片機(tablet press machine)[諸如TDP單冲壓片機(TDP single-punch tablet press)]中壓制成片並進行包裝。於其他實施例中,乾燥混合物可被製成顆粒(granulated)並包裝至可攝食之膠囊中。
在本實施例中,一顆錠劑可提供約500 mg之L-阿拉伯糖,即可抑制飲食中約10 g之蔗糖分解作用,此外,選擇性化合物諸如雲芝菌萃取物,可提供如前述之消炎、滋養等健康益處。
實施例2
一顆錠劑包含有L-阿拉伯糖以及至少一種選擇性化合物,其中該至少一種選擇性化合物係選自於由根皮酯、雲芝菌及武靴藤所組成的群組。
該錠劑包含有250 mg之L-阿拉伯糖、200 mg之根皮酯以及50mg之雲芝菌萃取物;在此實施例中,該錠劑中,L-阿拉伯糖之重量與根皮酯及雲芝菌萃取物之總重量之比例係1:1。
攪拌該錠劑,使其L-阿拉伯糖及根皮酯形成一混合物,並將該混合物置於可攝食之膠囊中,諸如明膠膠囊(gelatin capsules)。
在本實施例中,一顆錠劑可提供約250 mg之L-阿拉伯糖,即可抑制飲食中約5 g之蔗糖分解作用,此外,選擇性化合物諸如雲芝菌萃取物及根皮酯,可提供如前述之健康益處。
實施例3
一顆錠劑包含有L-阿拉伯糖以及至少一種選擇性化合物,其中該至少一種選擇性化合物係選自於由根皮酯、雲芝菌及武靴藤所組成的群組。
該錠劑包含有300 mg之L-阿拉伯糖以及100 mg之武靴藤;在此實施例中,該錠劑之L-阿拉伯糖與雲芝菌萃取物之重量比例係3:1。
攪拌該錠劑,使其L-阿拉伯糖及根皮酯形成一混合物,並將該混合物置於可攝食之膠囊中,諸如明膠膠囊。
在本實施例中,一顆錠劑可提供約300 mg之L-阿拉伯
糖,即可抑制飲食中約6 g之蔗糖分解作用,此外,選擇性化合物諸如根皮酯,可提供如前述之健康益處。
本發明由上述之實施例做為進一步說明,這些實施例並不限制本發明所揭示的內容。熟習本發明之技藝者,可以做些許之改良與修飾,但不脫離本發明之範疇。
Claims (9)
- 一種膳食補充劑組合物,其包含L-阿拉伯糖及至少一種選擇性化合物,該至少一種選擇性化合物係分別選自由根皮酯(phlorizin)、雲芝菌(coriolus versicolor)、桑黃(fomes yucatensis murrill)等靈芝類提取的多糖、蒟蒻(Konjac)、白芸豆(white kidney bean)及武靴藤(gymnema sylvestre)萃取而得之化合物或萃取物所組成的群組。
- 一種膳食補充劑組合物,其包含L-阿拉伯糖及一種選擇性化合物,該至少一種選擇性化合物係分別選自由萜類(terpene)、多酚化合物(polyphenolic compound)及皂素(saponin)所組成的群組。
- 一種膳食補充劑組合物,其包含L-阿拉伯糖及銀杏(ginkgo biloba)。
- 一種膳食補充劑組合物,其包含L-阿拉伯糖及蛋白質抑制劑(protein inhibitors)。
- 一種膳食補充劑組合物,其包含L-阿拉伯糖及至少一種植物化合物(phytochemical compounds),該至少一種植物化合物係分別選自由根皮酯、雲芝菌、白芸豆、扶桑(Hibiscus rosa-sinensis L.)、綠茶、咖啡豆及武靴藤或其萃取物所組成的群組。
- 一種膳食補充劑組合物,其包含L-阿拉伯糖及至少一種選擇性化合物,該至少一種選擇性化合物係分別選自由酚類化合物(phenolic compounds)、萜類(terpene)[異戊二烯(isoprenoids)]、甜菜紅色素(betalains)、有機硫化物(organsufides)、吲哚(indoles)、葡萄糖苷(glucosinolates)及 蛋白質抑制劑(protein inhibitors)及有機酸(organic acids)所組成的群組。
- 一種調控血糖之方法,其包含以下步驟:將如請求項1所述之膳食補充劑組合物投予人體,其中該膳食補充劑組合物包含有效劑量之L-阿拉伯糖以及至少一種選擇性化合物。
- 如請求項7所述之膳食補充劑組合物,其中有效劑量之L-阿拉伯糖與該至少一種選擇性化合物之比例係10:1。
- 如請求項7所述之膳食補充劑組合物,其中有效劑量之L-阿拉伯糖與該至少一種選擇性化合物之比例係1:1。
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