IN2012DN02752A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN02752A IN2012DN02752A IN2752DEN2012A IN2012DN02752A IN 2012DN02752 A IN2012DN02752 A IN 2012DN02752A IN 2752DEN2012 A IN2752DEN2012 A IN 2752DEN2012A IN 2012DN02752 A IN2012DN02752 A IN 2012DN02752A
- Authority
- IN
- India
- Prior art keywords
- dii4
- vegf
- binding molecules
- binding component
- bispecific binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09172137 | 2009-10-02 | ||
EP10175316 | 2010-09-03 | ||
PCT/EP2010/064695 WO2011039370A1 (en) | 2009-10-02 | 2010-10-01 | Bispecific binding molecules for anti-angiogenesis therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN02752A true IN2012DN02752A (pt) | 2015-09-18 |
Family
ID=43431796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2752DEN2012 IN2012DN02752A (pt) | 2009-10-02 | 2010-10-01 |
Country Status (23)
Country | Link |
---|---|
US (2) | US20110172398A1 (pt) |
EP (1) | EP2483314A1 (pt) |
JP (2) | JP5833009B2 (pt) |
KR (1) | KR20120101375A (pt) |
CN (2) | CN102639566B (pt) |
AP (1) | AP2012006188A0 (pt) |
AR (1) | AR078515A1 (pt) |
AU (1) | AU2010302589A1 (pt) |
BR (1) | BR112012007239A2 (pt) |
CA (1) | CA2775422A1 (pt) |
CL (1) | CL2012000826A1 (pt) |
EA (1) | EA201200548A1 (pt) |
EC (1) | ECSP12011835A (pt) |
IL (1) | IL218542A0 (pt) |
IN (1) | IN2012DN02752A (pt) |
MA (1) | MA33607B1 (pt) |
MX (1) | MX2012003897A (pt) |
NZ (2) | NZ598956A (pt) |
PE (1) | PE20121024A1 (pt) |
TN (1) | TN2012000145A1 (pt) |
TW (1) | TW201124533A (pt) |
UY (1) | UY32920A (pt) |
WO (1) | WO2011039370A1 (pt) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3357932A1 (en) | 2006-09-29 | 2018-08-08 | OncoMed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
KR20110014607A (ko) | 2008-04-29 | 2011-02-11 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
NZ589434A (en) | 2008-06-03 | 2012-11-30 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
EP2297208A4 (en) | 2008-06-03 | 2012-07-11 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
US9493545B2 (en) | 2009-02-11 | 2016-11-15 | Albumedix A/S | Albumin variants and conjugates |
EP2424567B1 (en) | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
MX2012002605A (es) | 2009-08-29 | 2012-04-02 | Abbott Lab | Proteinas terapeutico de union a dll4. |
UY32920A (es) * | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moleculas de unión biespecíficas para la terapia anti-angiogénesis |
HUE029661T2 (en) | 2009-10-16 | 2017-03-28 | Oncomed Pharm Inc | A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents |
EP3421491A3 (en) | 2009-10-30 | 2019-03-27 | Albumedix Ltd | Albumin variants |
BR112012021941A2 (pt) | 2010-03-02 | 2022-02-01 | Abbvie Inc | Proteínas terapêuticas de ligação a dll4 |
KR20130066631A (ko) | 2010-05-06 | 2013-06-20 | 노파르티스 아게 | 치료적 저밀도 지단백질-관련 단백질 6 (lrp6) 다가 항체에 대한 조성물 및 사용 방법 |
ES2949159T3 (es) | 2010-05-06 | 2023-09-26 | Novartis Ag | Composiciones y métodos de uso para anticuerpos terapéuticos de proteína 6 relacionada con lipoproteínas de baja densidad (LRP6) |
KR20130126576A (ko) | 2010-07-19 | 2013-11-20 | 에프. 호프만-라 로슈 아게 | 항암요법에 반응할 가능성이 증가된 환자를 확인하는 방법 |
KR20130055647A (ko) | 2010-07-19 | 2013-05-28 | 에프. 호프만-라 로슈 아게 | 항암요법에 반응할 가능성이 증가된 환자를 확인하는 방법 |
AU2011285852B2 (en) | 2010-08-03 | 2014-12-11 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
PE20140229A1 (es) | 2010-08-26 | 2014-03-27 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y usos de las mismas |
US20120225081A1 (en) * | 2010-09-03 | 2012-09-06 | Boehringer Ingelheim International Gmbh | Vegf-binding molecules |
US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
WO2012068098A1 (en) * | 2010-11-15 | 2012-05-24 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer with dll4 antagonists |
US9527925B2 (en) * | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
US20130078247A1 (en) * | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
ES2707580T3 (es) * | 2011-09-23 | 2019-04-04 | Oncomed Pharm Inc | Agentes de unión a VEGF/DLL4 y usos de los mismos |
AU2015268749B2 (en) * | 2011-09-23 | 2017-05-25 | Oncomed Pharmaceuticals, Inc. | VEGF/DLL4 binding agents and uses thereof |
RU2014122602A (ru) | 2011-11-04 | 2015-12-10 | Новартис Аг | Конструкции на основе белка, родственного липопротеинам низкой плотности, 6(lrp6), и удлинителя полупериода существования |
EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
AU2012362326A1 (en) | 2011-12-30 | 2014-07-24 | Abbvie Inc. | Dual variable domain immunoglobulins against IL-13 and/or IL-17 |
BR112014018679A2 (pt) | 2012-03-16 | 2017-07-04 | Novozymes Biopharma Dk As | variantes de albumina |
HUE056217T2 (hu) | 2012-07-13 | 2022-02-28 | Roche Glycart Ag | Bispecifikus anti-VEGF/anti-ANG-2 antitestek és ezek alkalmazása szemészeti érbetegségek kezelésében |
US20140093499A1 (en) * | 2012-09-28 | 2014-04-03 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents |
JP2015532272A (ja) * | 2012-09-28 | 2015-11-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二重アンジオポエチン−2/Dll4結合剤および抗VEGF−R剤を含む薬学的組み合わせ |
WO2014062659A2 (en) * | 2012-10-15 | 2014-04-24 | Oncomed Pharmaceuticals, Inc. | Methods of treating ocular diseases |
WO2014071018A1 (en) * | 2012-10-31 | 2014-05-08 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a dll4 antagonist |
EP2914626A2 (en) * | 2012-11-01 | 2015-09-09 | Abbvie Inc. | Stable dual variable domain immunoglobulin protein formulations |
SG11201503412RA (en) | 2012-11-01 | 2015-05-28 | Abbvie Inc | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
BR112015010318A2 (pt) | 2012-11-08 | 2017-08-22 | Albumedix As | Variantes de albumina |
JP2016522793A (ja) | 2013-03-15 | 2016-08-04 | アッヴィ・インコーポレイテッド | IL−1βおよび/またはIL−17に対して指向された二重特異的結合タンパク質 |
PL3020731T3 (pl) * | 2013-07-09 | 2019-11-29 | Ablbio | Nowe podwójnie nakierowane białko specyficznie wiążące się z dll4 i vegf oraz zastosowanie tego białka |
WO2015123359A1 (en) * | 2014-02-11 | 2015-08-20 | Albany Medical College | Multi-functional mucosal vaccine platform |
EP3125937A4 (en) * | 2014-04-04 | 2017-11-01 | Oncomed Pharmaceuticals, Inc. | Treatment of gastric cancer |
US20170267784A1 (en) | 2014-10-23 | 2017-09-21 | Singh Molecular Medicine, Llc | Single domain antibodies directed against intracellular antigens |
JP6827415B2 (ja) | 2014-10-31 | 2021-02-10 | メレオ バイオファーマ 5 インコーポレイテッド | 疾患の処置のための併用療法 |
WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
WO2016192613A1 (zh) * | 2015-06-01 | 2016-12-08 | 中山大学 | 具有融合至常规Fab片段的单域抗原结合片段的二价抗体 |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
CN108137674B (zh) | 2015-08-20 | 2022-12-06 | 阿尔布梅迪克斯医疗有限公司 | 白蛋白变体和缀合物 |
EP3353204B1 (en) | 2015-09-23 | 2023-10-18 | Mereo BioPharma 5, Inc. | Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer |
TWI746473B (zh) * | 2015-11-02 | 2021-11-21 | 美商辛分子醫藥有限公司 | 針對細胞內抗原之單域抗體 |
AU2016365423A1 (en) * | 2015-12-04 | 2018-07-12 | The Regents Of The University Of California | Novel antibodies for the treatment of cancers |
US10941382B2 (en) * | 2016-01-29 | 2021-03-09 | Kyoto University | Platelet production promoter and method of producing platelets using same |
CN118184777A (zh) * | 2017-01-30 | 2024-06-14 | 亚力兄制药公司 | 单价抗备解素抗体及抗体片段 |
CA3090321A1 (en) * | 2018-02-05 | 2019-08-08 | Stichting Vu | Inverse agonistic anti-us28 antibodies |
CN111995686B (zh) * | 2019-05-27 | 2022-06-14 | 兰州大学 | 一种具有抗血管生成活性的药物及其制备方法 |
AU2020321977C1 (en) * | 2019-07-31 | 2024-04-18 | Eli Lilly And Company | Relaxin analogs and methods of using the same |
CN110452297B (zh) * | 2019-09-03 | 2020-04-14 | 上海洛启生物医药技术有限公司 | 抗vegf单域抗体及其应用 |
CN116234574A (zh) * | 2020-09-17 | 2023-06-06 | 江苏恒瑞医药股份有限公司 | 特异性结合vegf和ang-2的双特异性抗原结合分子 |
CN112535738B (zh) * | 2020-12-04 | 2022-09-09 | 中国科学技术大学 | 奥沙利铂偶联物及其制备方法和应用 |
CN115724968B (zh) * | 2021-08-27 | 2023-08-08 | 三优生物医药(上海)有限公司 | Vegf结合分子及其用途 |
CN116063469B (zh) * | 2022-08-29 | 2023-09-22 | 中山大学 | 一种寨卡病毒中和性纳米抗体及其制备方法与应用 |
WO2024055996A1 (zh) * | 2022-09-14 | 2024-03-21 | 寻济生物科技(北京)有限公司 | 一种抗vegfa抗体或其抗原结合片段及其应用 |
CN117860786B (zh) * | 2024-03-12 | 2024-06-04 | 北京贝来药业有限公司 | 基因修饰间充质干细胞在多种疾病中的制药用途和诊断用途 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0656946T4 (da) | 1992-08-21 | 2010-07-26 | Univ Bruxelles | Immunoglobuliner uden lette kæder |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
EP2267026A1 (en) | 2000-04-12 | 2010-12-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CN1911965B (zh) | 2001-01-17 | 2013-05-29 | 新兴产品开发西雅图有限公司 | 结合域-免疫球蛋白融合蛋白 |
EP1399484B1 (en) | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
AU2002364587A1 (en) | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
AU2003286003B2 (en) | 2002-11-08 | 2011-05-26 | Ablynx N.V. | Stabilized single domain antibodies |
WO2004041865A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Stabilized single domain antibodies |
DE60329627D1 (de) | 2002-12-31 | 2009-11-19 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
JP2006517789A (ja) * | 2003-01-10 | 2006-08-03 | アブリンクス エン.ヴェー. | 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用 |
CA2529819A1 (en) | 2003-06-30 | 2004-09-23 | Domantis Limited | Pegylated single domain antibodies |
WO2005040219A1 (en) * | 2003-10-28 | 2005-05-06 | Novo Nordisk A/S | Laminin-5 gamma2-binding peptides, related compositions, and use thereof |
ATE485307T1 (de) | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
US20050284249A1 (en) | 2004-06-29 | 2005-12-29 | Arnone David F | Worm type gear mover assembly |
KR20070084170A (ko) | 2004-10-13 | 2007-08-24 | 아블린쓰 엔.브이. | 알쯔하이머병 등의 퇴행성 신경 질환의 치료 및 진단을위한 단일 도메인 카멜리드 항-아밀로이드 베타 항체 및이를 포함하는 폴리펩타이드 |
US8048418B2 (en) * | 2004-10-29 | 2011-11-01 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists |
CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
CA2960105A1 (en) * | 2005-05-20 | 2006-11-23 | Ablynx Nv | Single domain vhh antibodies against von willebrand factor |
US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
NZ568739A (en) | 2005-12-16 | 2010-09-30 | Regeneron Pharma | Therapeutic methods for inhibiting tumor growth with delta-like ligand 4 antagonists |
SG175615A1 (en) * | 2006-06-06 | 2011-11-28 | Genentech Inc | Anti-dll4 antibodies and methods using same |
EP2029159A2 (en) * | 2006-06-06 | 2009-03-04 | Genentech, Inc. | Compositions and methods for modulating vascular development |
ZA200809100B (en) * | 2006-06-06 | 2009-12-30 | Genentech Inc | Anti-DLL4 antibodies and methods using same |
SI2054082T1 (sl) * | 2006-08-07 | 2013-04-30 | Regeneron Pharmaceuticals, Inc. | Uporaba DII4 antagonistov pri ishemični poškodbi ali vaskularni insuficienci |
US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
US20080132451A1 (en) * | 2006-12-01 | 2008-06-05 | Alcon Manufacturing Ltd. | Modulation of polysialylated neural adhesion molecules (psa-ncam) as a regulator of ocular disease |
RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
CA2678218A1 (en) * | 2007-02-21 | 2008-08-28 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
GB0709333D0 (en) * | 2007-05-15 | 2007-06-20 | Smart Targeting Ltd | Binding protein |
WO2009095489A2 (en) | 2008-02-01 | 2009-08-06 | Ablynx N.V. | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
CA2717015A1 (en) | 2008-03-05 | 2009-09-11 | Ablynx Nv | Novel antigen binding dimer-complexes, methods of making and uses thereof |
EP2260058A2 (en) * | 2008-04-07 | 2010-12-15 | Ablynx N.V. | Single variable domains against the notch pathways |
KR20110014607A (ko) * | 2008-04-29 | 2011-02-11 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
US8268314B2 (en) * | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
EP2424567B1 (en) * | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
UY32920A (es) * | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moleculas de unión biespecíficas para la terapia anti-angiogénesis |
-
2010
- 2010-09-30 UY UY0001032920A patent/UY32920A/es not_active Application Discontinuation
- 2010-09-30 US US12/894,989 patent/US20110172398A1/en not_active Abandoned
- 2010-10-01 CN CN201080054891.9A patent/CN102639566B/zh not_active Expired - Fee Related
- 2010-10-01 MX MX2012003897A patent/MX2012003897A/es not_active Application Discontinuation
- 2010-10-01 NZ NZ598956A patent/NZ598956A/en not_active IP Right Cessation
- 2010-10-01 BR BR112012007239A patent/BR112012007239A2/pt not_active IP Right Cessation
- 2010-10-01 CN CN201510363066.1A patent/CN105037542A/zh active Pending
- 2010-10-01 WO PCT/EP2010/064695 patent/WO2011039370A1/en active Application Filing
- 2010-10-01 IN IN2752DEN2012 patent/IN2012DN02752A/en unknown
- 2010-10-01 NZ NZ626302A patent/NZ626302A/en not_active IP Right Cessation
- 2010-10-01 KR KR1020127011329A patent/KR20120101375A/ko not_active Application Discontinuation
- 2010-10-01 JP JP2012531451A patent/JP5833009B2/ja not_active Expired - Fee Related
- 2010-10-01 EP EP10768428A patent/EP2483314A1/en not_active Withdrawn
- 2010-10-01 AR ARP100103596A patent/AR078515A1/es unknown
- 2010-10-01 EA EA201200548A patent/EA201200548A1/ru unknown
- 2010-10-01 AU AU2010302589A patent/AU2010302589A1/en not_active Abandoned
- 2010-10-01 TW TW099133632A patent/TW201124533A/zh unknown
- 2010-10-01 CA CA2775422A patent/CA2775422A1/en not_active Abandoned
- 2010-10-01 PE PE2012000422A patent/PE20121024A1/es not_active Application Discontinuation
- 2010-10-01 AP AP2012006188A patent/AP2012006188A0/xx unknown
-
2012
- 2012-03-08 IL IL218542A patent/IL218542A0/en unknown
- 2012-03-26 MA MA34720A patent/MA33607B1/fr unknown
- 2012-03-29 TN TNP2012000145A patent/TN2012000145A1/en unknown
- 2012-04-02 CL CL2012000826A patent/CL2012000826A1/es unknown
- 2012-04-26 EC ECSP12011835 patent/ECSP12011835A/es unknown
-
2013
- 2013-03-22 US US13/848,826 patent/US20140120095A1/en not_active Abandoned
-
2015
- 2015-10-28 JP JP2015211551A patent/JP2016026207A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN105037542A (zh) | 2015-11-11 |
JP5833009B2 (ja) | 2015-12-16 |
US20110172398A1 (en) | 2011-07-14 |
AU2010302589A1 (en) | 2012-04-19 |
CL2012000826A1 (es) | 2012-10-19 |
BR112012007239A2 (pt) | 2019-09-24 |
AP2012006188A0 (en) | 2012-04-30 |
JP2016026207A (ja) | 2016-02-12 |
KR20120101375A (ko) | 2012-09-13 |
AR078515A1 (es) | 2011-11-16 |
JP2013506411A (ja) | 2013-02-28 |
IL218542A0 (en) | 2012-05-31 |
US20140120095A1 (en) | 2014-05-01 |
CN102639566A (zh) | 2012-08-15 |
UY32920A (es) | 2011-04-29 |
WO2011039370A1 (en) | 2011-04-07 |
TW201124533A (en) | 2011-07-16 |
NZ626302A (en) | 2015-09-25 |
NZ598956A (en) | 2014-07-25 |
CA2775422A1 (en) | 2011-04-07 |
EP2483314A1 (en) | 2012-08-08 |
ECSP12011835A (es) | 2012-06-29 |
MX2012003897A (es) | 2012-05-08 |
CN102639566B (zh) | 2015-07-22 |
MA33607B1 (fr) | 2012-09-01 |
PE20121024A1 (es) | 2012-08-10 |
EA201200548A1 (ru) | 2012-12-28 |
TN2012000145A1 (en) | 2013-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2012DN02752A (pt) | ||
TN2013000390A1 (en) | Bispecific binding molecules binding to vegf and ang2 | |
MX353813B (es) | Moleculas de union a vegf. | |
TN2012000144A1 (en) | Dll4-binding molecules | |
CY1122007T1 (el) | Μορια δεσμευσης-ang2 | |
WO2014004549A3 (en) | Anti-mesothelin binding proteins | |
PH12018500520A1 (en) | Cd3 binding polypeptides | |
NZ623607A (en) | Anti-gcc antibody molecules and related compositions and methods | |
MX345226B (es) | Formulaciones de moleculas de union a antigeno de dominio sencillo. | |
WO2015108998A3 (en) | Cartilage targeting agents and their use | |
WO2013173761A3 (en) | St2 antigen binding proteins | |
WO2009073533A3 (en) | Anti-b7h4 monoclonal antibody-drug conjugate and methods of use | |
WO2013119966A3 (en) | Single-chain antibodies and other heteromultimers | |
TN2013000389A1 (en) | BISPECIFIC BINDING MOLECULES BINDING TO Dll4 AND Ang2 | |
NZ761636A (en) | Antigen binding proteins binding to 5t4 and 4-1bb and related compositions and methods | |
MX2016008478A (es) | Nuevo anticuerpo anti adam17 y su uso en el tratamiento del cancer. |