IN2012DN02610A - - Google Patents

Download PDF

Info

Publication number
IN2012DN02610A
IN2012DN02610A IN2610DEN2012A IN2012DN02610A IN 2012DN02610 A IN2012DN02610 A IN 2012DN02610A IN 2610DEN2012 A IN2610DEN2012 A IN 2610DEN2012A IN 2012DN02610 A IN2012DN02610 A IN 2012DN02610A
Authority
IN
India
Prior art keywords
compound
Prior art date
Application number
Other languages
English (en)
Inventor
Casebier David
P Robinson Simon
Purohit Ajay
S Radeke Heike
T Azure Michael
D Dischino Douglas
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of IN2012DN02610A publication Critical patent/IN2012DN02610A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0421—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Acoustics & Sound (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
IN2610DEN2012 2004-02-13 2005-02-11 IN2012DN02610A (he)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54486104P 2004-02-13 2004-02-13
US11/055,498 US7344702B2 (en) 2004-02-13 2005-02-10 Contrast agents for myocardial perfusion imaging
PCT/US2005/004687 WO2005079391A2 (en) 2004-02-13 2005-02-11 Contrast agents for myocardial perfusion imaging

Publications (1)

Publication Number Publication Date
IN2012DN02610A true IN2012DN02610A (he) 2015-09-04

Family

ID=34889838

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2610DEN2012 IN2012DN02610A (he) 2004-02-13 2005-02-11

Country Status (19)

Country Link
US (7) US7344702B2 (he)
EP (2) EP3385253B1 (he)
JP (3) JP5417578B2 (he)
KR (2) KR101186449B1 (he)
CN (2) CN1925878B (he)
AU (1) AU2005214898C1 (he)
BR (1) BRPI0507684B8 (he)
CA (3) CA2944947A1 (he)
DK (2) DK3385253T3 (he)
ES (2) ES2878171T3 (he)
HK (1) HK1164731A1 (he)
IL (4) IL177275A0 (he)
IN (1) IN2012DN02610A (he)
MX (1) MX348859B (he)
NO (2) NO344857B1 (he)
PT (1) PT1713512T (he)
RU (2) RU2457865C2 (he)
SG (1) SG149895A1 (he)
WO (1) WO2005079391A2 (he)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US7824659B2 (en) * 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
EP1940841B9 (fr) * 2005-10-07 2017-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009077A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
MX367292B (es) 2006-12-26 2019-08-13 Lantheus Medical Imaging Inc Ligandos para formacion de imagen de inervacion cardiaca.
WO2008128058A1 (en) * 2007-04-13 2008-10-23 The Trustees Of The University Of Pennsylvania New gallium bisaminothiolate complexes for myocardial imaging
CA2967254C (en) * 2008-02-29 2019-03-26 Lantheus Medical Imaging, Inc. Contrast agents for applications including imaging cancer
AU2015200027B2 (en) * 2008-02-29 2017-01-19 Lantheus Medical Imaging, Inc. Contrast agents for applications including perfusion imaging
WO2010004464A1 (en) * 2008-07-09 2010-01-14 Koninklijke Philips Electronics N.V. Physiological pharmacokinetic analysis for combined molecular mri and dynamic pet imaging
PT2419096T (pt) 2009-04-15 2020-02-19 Lantheus Medical Imaging Inc Estabilização de composições radiofarmacêuticas utilizando ácido ascórbico
EP2454216A1 (en) * 2009-07-11 2012-05-23 Bayer Pharma Aktiengesellschaft Non-polar and polar leaving groups
EP2289889A1 (en) * 2009-08-18 2011-03-02 Endura S.p.a. Substituted alkynyl phenoxy compounds and their uses
CN101993383A (zh) * 2009-08-26 2011-03-30 成都伊诺达博医药科技有限公司 决奈达隆关键中间体4-[3-(二丁氨基)丙氧基]苯甲酸甲酯的新合成方法
KR102438133B1 (ko) * 2010-02-08 2022-08-31 랜티우스 메디컬 이메징, 인크. 조영제 및 이의 중간체를 합성하는 방법 및 장치
EP2569019B1 (en) 2010-05-11 2019-10-02 Lantheus Medical Imaging, Inc. Compositions, methods and systems for the synthesis and use of imaging agents
CN102038964B (zh) * 2010-12-30 2012-01-25 上海师范大学 一种非晶态铁钴硼纳米磁共振造影剂材料及其制备方法
BR122019017259B1 (pt) 2011-09-09 2022-05-10 Lantheus Medical Imaging, Inc Compostos úteis como agentes de imageamento, composições que os compreende, métodos, e uso de agentes de imageamento
CA2852395C (en) * 2011-10-21 2020-04-28 Lantheus Medical Imaging, Inc. Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods
EP2793952B1 (en) 2011-12-22 2018-06-13 Respiratorius Ab Contrast agent for imagining myocardial perfusion
CN109125745B (zh) 2012-04-10 2022-07-26 蓝瑟斯医学影像公司 放射性药物合成方法
AU2013203000B9 (en) * 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN104583192B (zh) * 2012-08-24 2016-10-12 浜松光子学株式会社 适合于线粒体复合体-1检出的化合物
JP6447517B2 (ja) * 2013-12-26 2019-01-09 住友化学株式会社 ハロゲン置換フタリドの製造方法
US9745308B2 (en) 2014-09-12 2017-08-29 Chiesi Farmaceutici S.P.A. Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors
DK3321265T3 (da) 2015-03-04 2020-06-08 Gilead Sciences Inc 4,6-diamino-pyrido[3,2-d]pyrimidinforbindelser og deres udnyttelse som modulatorer af toll-lignende receptorer
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
CN109923106B (zh) 2016-09-02 2022-09-13 吉利德科学公司 toll样受体调节剂化合物
US20200009273A1 (en) * 2017-03-07 2020-01-09 Nihon Medi-Physics Co., Ltd. Radioactive fluorine-labeled precursor compound, and method for producing radioactive fluorine-labeled compound using same
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
GB201915206D0 (en) 2019-10-21 2019-12-04 Ge Healthcare Ltd Use of cyclodextrins as a radiostabilizer
CN111320620A (zh) * 2020-03-17 2020-06-23 四川大学华西医院 一种异喹啉并哒嗪酮类化合物及其合成方法和应用
CN116082670B (zh) * 2023-04-11 2023-06-27 中国人民解放军军事科学院军事医学研究院 一种含有季膦盐的声响应假性共轭聚合物纳米颗粒的制备方法及其在抗菌领域的应用

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1073999A (en) * 1965-01-29 1967-06-28 Ncr Co Process for forming stable images in photochromic material
JPS5888334A (ja) * 1981-11-20 1983-05-26 Takasago Corp ３−ｌ−メントキシプロパン−１、２−ジオ−ル
US4510125A (en) 1982-12-08 1985-04-09 Mallinckrodt, Inc. Process for making lyophilized radiographic imaging kit
JPS604173A (ja) 1983-06-23 1985-01-10 Nissan Chem Ind Ltd ピリダジノン誘導体，その製造法および殺虫・殺ダニ・殺菌剤
EP0169375B1 (en) 1984-06-23 1989-12-20 Nissan Chemical Industries Ltd. Process for producing 2-tert.-butyl-4,5-dichloro-3(2h)-pyridazinone
JPH07116161B2 (ja) 1984-07-04 1995-12-13 日産化学工業株式会社 ピリダジノン誘導体
EP0183212B1 (en) 1984-11-29 1990-06-20 Nissan Chemical Industries Ltd. Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions
JPS61130275A (ja) 1984-11-29 1986-06-18 Nissan Chem Ind Ltd ピリダジノン誘導体，その製造法および殺虫・殺ダニ・殺菌剤
EP0186817B1 (en) 1984-12-10 1989-08-02 Nissan Chemical Industries Ltd. 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
JPH0641454B2 (ja) 1985-02-27 1994-06-01 日産化学工業株式会社 ピリダジノン誘導体
JPS61260018A (ja) 1985-05-14 1986-11-18 Nissan Chem Ind Ltd 抗アレルギ−剤
JPH0739397B2 (ja) 1985-07-30 1995-05-01 日産化学工業株式会社 ピリダジノン誘導体および害虫防除剤
YU134686A (en) 1985-07-30 1988-02-29 Nissan Chemical Ind Ltd Process for preparing new derivatives 3-(2h)-pyridazinone
EP0247156B1 (en) * 1985-11-18 1993-06-23 Access Pharmaceuticals Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
JPS6315974A (ja) 1986-07-09 1988-01-23 小泉コンピユ−タ−株式会社 ボ−リングゲ−ム点数表表示装置
US5567411A (en) * 1986-11-10 1996-10-22 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group
US5252317A (en) * 1986-11-10 1993-10-12 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid
JPS63159374A (ja) 1986-12-24 1988-07-02 Nissan Chem Ind Ltd ピリダジノン誘導体および殺虫、殺ダニ、殺線虫剤
JPS63159372A (ja) 1986-12-24 1988-07-02 Nissan Chem Ind Ltd ピリダジノン化合物および殺虫、殺ダニ、殺線虫剤
JPS63159373A (ja) 1986-12-24 1988-07-02 Nissan Chem Ind Ltd ピリダジノン類および殺虫、殺ダニ、殺線虫剤
DE3824210A1 (de) 1988-07-16 1990-01-18 Basf Ag 3(2h)-pyridazinonderivate zur bekaempfung von schnecken
IT1229684B (it) * 1989-04-05 1991-09-06 Mini Ricerca Scient Tecnolog Piridazinoni ad attivita' insetticida ed acaricida
JPH02279676A (ja) 1989-04-19 1990-11-15 Otsuka Chem Co Ltd ピリダジノン誘導体
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
US5377681A (en) 1989-11-13 1995-01-03 University Of Florida Method of diagnosing impaired blood flow
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
JPH03220177A (ja) 1990-01-25 1991-09-27 Nissan Chem Ind Ltd 殺虫、殺ダニ剤組成物
US5250283A (en) * 1990-03-28 1993-10-05 Molecular Biosystems, Inc. Organic contrast agent analog and method of making same
WO1992017215A1 (en) 1990-03-28 1992-10-15 Nycomed Salutar, Inc. Contrast media
GB9006977D0 (en) 1990-03-28 1990-05-23 Nycomed As Compositions
JPH04235975A (ja) 1991-01-21 1992-08-25 Nissan Chem Ind Ltd ピリダジノン誘導体および害虫防除剤
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5093105A (en) * 1991-04-09 1992-03-03 Merck Frosst Canada, Inc. Radiopharmaceutical bacteriostats
US5306482A (en) * 1991-04-09 1994-04-26 Merck Frosst Canada, Inc. Radiopharmaceutical bacteriostats
ATE196428T1 (de) * 1991-08-29 2000-10-15 Mallinckrodt Medical Inc Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
US5169942A (en) * 1991-11-21 1992-12-08 General Electric Company Method for making 2-(18F)fluoro-2-deoxy-D-glucose
AU4530493A (en) * 1992-06-17 1994-01-04 Procter & Gamble Company, The Coolant compositions with reduced stinging
EP0627424A4 (en) 1992-12-03 1995-03-29 Otsuka Kagaku Kk PYRIDAZINE DERIVATIVES AND INCENTICIDES AND MITICIDES.
US5760191A (en) * 1993-02-05 1998-06-02 Nycomed Imaging As Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods
EP0641350A4 (en) * 1993-03-22 1995-08-23 Gen Electric METHOD FOR PRODUCING 2-FLUORO-2-DESOXYGLUCOSE.
HU222574B1 (hu) 1993-03-31 2003-08-28 Mallinckrodt Medical Inc. Redukálószerként foszfinokat tartalmazó radioaktív gyógyászati készítmények és az ezeket tartalmazó készletek
US5417959A (en) * 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
US5493026A (en) 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
GB9323028D0 (en) 1993-11-09 1994-01-05 Isis Innovation Asymmetric hydroboration
EP0665223A1 (en) 1994-01-28 1995-08-02 Takeda Chemical Industries, Ltd. Antitumor agent, novel 3(2H)-pyridazinone derivatives and their preparation
JPH07252236A (ja) 1994-01-28 1995-10-03 Takeda Chem Ind Ltd 抗癌剤
AU7312694A (en) 1994-06-03 1996-01-04 Mallinckrodt Medical, Inc. Rapidly clearing technetium-99m phosphonate skeletal imaging agents
US5520904A (en) * 1995-01-27 1996-05-28 Mallinckrodt Medical, Inc. Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging
EP0727225A3 (en) 1995-02-14 1997-01-15 Sonus Pharma Inc Compositions and methods for directed ultrasonic imaging
US5587491A (en) * 1995-03-15 1996-12-24 Regents Of The University Of Minnesota Method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins
US5801228A (en) * 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
US5811073A (en) 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
US5827073A (en) * 1995-07-05 1998-10-27 Ludwig Institute For Cancer Research Photoreactive peptide derivatives
US6066309A (en) * 1996-02-02 2000-05-23 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
US5804161A (en) * 1996-05-14 1998-09-08 Nycomed Salutar Inc. Contrast agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
ES2206689T3 (es) * 1996-10-28 2004-05-16 Amersham Health As Agentes de contraste.
US6565889B2 (en) * 1996-12-02 2003-05-20 The Regents Of The University Of California Bilayer structure which encapsulates multiple containment units and uses thereof
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
JP4017758B2 (ja) * 1998-08-04 2007-12-05 高砂香料工業株式会社 冷感剤組成物
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
JP2002525325A (ja) * 1998-09-29 2002-08-13 メルク エンド カムパニー インコーポレーテッド 放射標識化ニューロキニン−１受容体拮抗薬
US6645508B1 (en) 1999-06-18 2003-11-11 Jivn-Ren Chen Stable L-ascorbic acid composition
WO2001087354A2 (en) * 2000-05-17 2001-11-22 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
RU2174779C1 (ru) * 2000-05-29 2001-10-20 Научно-исследовательский институт пищеконцентратной промышленности и специальной пищевой технологии Способ производства плодово-ягодного десерта
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
US7410998B2 (en) * 2000-09-06 2008-08-12 The Scripps Research Institute Inhibitors of NADH:ubiquinone oxidoreductase
TWI247609B (en) * 2001-01-23 2006-01-21 Nihon Mediphysics Co Ltd Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease
GB0115927D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
US7344702B2 (en) * 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US20030044354A1 (en) 2001-08-16 2003-03-06 Carpenter Alan P. Gas microsphere liposome composites for ultrasound imaging and ultrasound stimulated drug release
US20030082191A1 (en) 2001-08-29 2003-05-01 Poduslo Joseph F. Treatment for central nervous system disorders
US20050009730A1 (en) 2001-10-16 2005-01-13 Dale Edgar Treatment of cns disorders using cns target modulators
US8524193B2 (en) * 2002-02-06 2013-09-03 The Johns Hopkins University Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts
MXPA04009435A (es) * 2002-03-29 2005-01-25 Janssen Pharmaceutica Nv Derivados de quinolina y quinolinona radiomarcados y su uso como ligandos de receptor de glutamato metabotropico.
WO2003086476A1 (en) 2002-04-08 2003-10-23 Biostream, Inc. Technetium-labeled rotenone derivatives, and methods of use thereof
GB0229683D0 (en) 2002-12-20 2003-01-29 Imaging Res Solutions Ltd Preparation of radiopharmaceuticals
WO2005003100A2 (en) * 2003-07-03 2005-01-13 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
WO2005007632A1 (en) 2003-07-18 2005-01-27 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
CA2526556C (en) 2003-07-24 2012-09-25 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
GB0317920D0 (en) 2003-07-31 2003-09-03 Amersham Plc Solid-phase synthesis
US7927616B2 (en) * 2004-01-16 2011-04-19 Thomas T. Yamashita Pesticide compositions and methods for their use
EP2388017B1 (en) 2004-02-24 2014-12-24 The General Hospital Corporation Catalytic radiofluorination
EP1741703A4 (en) 2004-03-05 2009-11-25 Banyu Pharma Co Ltd PYRIDONE DERIVATIVE
AT500838B1 (de) 2004-04-20 2007-11-15 Veterinaermedizinische Uni Wie Multiple hse
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US20060083681A1 (en) * 2004-10-18 2006-04-20 Ajay Purohit Compounds for myocardial perfusion imaging
US7534418B2 (en) * 2004-12-10 2009-05-19 The Regents Of The University Of Michigan Imaging agents
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
CA2612186A1 (en) * 2005-06-23 2007-01-04 Emory University Imaging agents
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
JP2007112725A (ja) 2005-10-18 2007-05-10 Inst Nuclear Energy Research Rocaec 無支持体の１８Ｆで標識したアミノ酸Ｏ−（２−［１８Ｆ］ｆｌｕｏｒｏｅｔｈｙｌ）−Ｌ−Ｔｙｒｏｓｉｎｅの製造方法。
US7871623B2 (en) 2005-12-21 2011-01-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for imaging pain and stress in vivo
US7700616B2 (en) 2006-05-08 2010-04-20 Molecular Neuroimaging, Llc. Compounds and amyloid probes thereof for therapeutic and imaging uses
CA2654369C (en) * 2006-06-21 2014-10-14 Ge Healthcare Limited Radiopharmaceutical products
BRPI0716579A2 (pt) 2006-08-25 2013-10-08 Boehringer Ingelheim Int Derivados de piridona com atividade antagonista ao mch e medicamentos que compreendem estes compostos
GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
MX367292B (es) 2006-12-26 2019-08-13 Lantheus Medical Imaging Inc Ligandos para formacion de imagen de inervacion cardiaca.
JP5504563B2 (ja) 2006-12-27 2014-05-28 住友化学株式会社 組成物及び該組成物を用いてなる発光素子
GB0718386D0 (en) * 2007-09-21 2007-10-31 Ge Healthcare As Improved radiopharmaceutical formulation
KR101068835B1 (ko) 2007-10-26 2011-09-30 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를가지는 이소인돌론 화합물 및 이의 제조 방법
CL2008003785A1 (es) 2007-12-21 2009-10-09 Du Pont Compuestos derivados de piridazina; composiciones herbicidas que comprenden a dichos compuestos; y método para controlar el crecimiento de la vegetación indeseada.
WO2009103478A1 (en) 2008-02-19 2009-08-27 Boehringer Ingelheim International Gmbh Pyridone and pyridazinone derivatives as mch antagonists
WO2010011367A2 (en) 2008-02-22 2010-01-28 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
CA2967254C (en) * 2008-02-29 2019-03-26 Lantheus Medical Imaging, Inc. Contrast agents for applications including imaging cancer
US8258134B2 (en) 2008-04-16 2012-09-04 Hoffmann-La Roche Inc. Pyridazinone glucokinase activators
EP2406233B1 (en) 2009-03-09 2013-11-13 Bristol-Myers Squibb Company Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists
PT2419096T (pt) 2009-04-15 2020-02-19 Lantheus Medical Imaging Inc Estabilização de composições radiofarmacêuticas utilizando ácido ascórbico
CN101555232B (zh) 2009-05-21 2011-01-05 北京师范大学 氟-18标记哒嗪酮类化合物及制备方法和应用
EP2454216A1 (en) 2009-07-11 2012-05-23 Bayer Pharma Aktiengesellschaft Non-polar and polar leaving groups
KR102438133B1 (ko) 2010-02-08 2022-08-31 랜티우스 메디컬 이메징, 인크. 조영제 및 이의 중간체를 합성하는 방법 및 장치
DE102010036356A1 (de) 2010-07-12 2012-01-12 Abx Advanced Biochemical Compounds Gmbh Vorrichtung zur Synthese radioaktiv markierter Verbindungen
JP5842594B2 (ja) 2010-12-27 2016-01-13 住友化学株式会社 ピリダジノン化合物、それを含有する除草剤及び有害節足動物防除剤
CN102336741B (zh) 2011-07-06 2013-04-10 北京师范大学 氟-18标记的心肌灌注显像剂及其制备方法和应用
BR122019017259B1 (pt) 2011-09-09 2022-05-10 Lantheus Medical Imaging, Inc Compostos úteis como agentes de imageamento, composições que os compreende, métodos, e uso de agentes de imageamento
CA2852395C (en) 2011-10-21 2020-04-28 Lantheus Medical Imaging, Inc. Compositions comprising ascorbic acid and pyridaben and pyridaben analogs attached to an imaging moiety and related methods
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
ES2893312T3 (es) 2012-08-13 2022-02-08 Massachusetts Gen Hospital Sistema y método para el mapeo cuantitativo del complejo mitocondrial 1

Also Published As

Publication number Publication date
RU2457865C2 (ru) 2012-08-10
CA2556213A1 (en) 2005-09-01
BRPI0507684B8 (pt) 2021-07-27
MX348859B (es) 2017-06-30
IL177275A (he) 2013-11-28
AU2005214898C1 (en) 2011-08-04
ES2878171T3 (es) 2021-11-18
BRPI0507684B1 (pt) 2021-02-23
US20080112884A1 (en) 2008-05-15
RU2006132814A (ru) 2008-03-20
KR101186449B1 (ko) 2012-09-27
IL243840A0 (he) 2016-04-21
KR101386851B1 (ko) 2014-04-17
IL228097A (he) 2016-02-29
JP2007526916A (ja) 2007-09-20
AU2005214898B2 (en) 2011-01-06
EP3385253A1 (en) 2018-10-10
EP1713512B1 (en) 2018-01-10
KR20120031243A (ko) 2012-03-30
US9161997B2 (en) 2015-10-20
US10125106B2 (en) 2018-11-13
RU2012113613A (ru) 2013-10-20
EP1713512A2 (en) 2006-10-25
US20190127333A1 (en) 2019-05-02
JP6124848B2 (ja) 2017-05-10
KR20060122920A (ko) 2006-11-30
CA2944947A1 (en) 2005-09-01
DK1713512T3 (en) 2018-04-23
WO2005079391A3 (en) 2006-02-16
JP2013047277A (ja) 2013-03-07
US8226929B2 (en) 2012-07-24
CA2828128A1 (en) 2005-09-01
CN1925878A (zh) 2007-03-07
US20160130235A1 (en) 2016-05-12
US9718786B2 (en) 2017-08-01
DK3385253T3 (da) 2021-06-28
US10889550B2 (en) 2021-01-12
CN102274527B (zh) 2015-04-29
SG149895A1 (en) 2009-02-27
IL177275A0 (en) 2006-12-10
US20180009763A1 (en) 2018-01-11
PT1713512T (pt) 2018-04-17
CN1925878B (zh) 2011-10-12
ES2665687T3 (es) 2018-04-26
CN102274527A (zh) 2011-12-14
RU2648358C2 (ru) 2018-03-23
IL228097A0 (he) 2013-09-30
NO20064011L (no) 2006-11-08
US20050191238A1 (en) 2005-09-01
CA2828128C (en) 2016-11-22
HK1164731A1 (en) 2012-09-28
WO2005079391A2 (en) 2005-09-01
AU2005214898A1 (en) 2005-09-01
NO20170638A1 (no) 2006-11-08
JP5847065B2 (ja) 2016-01-20
BRPI0507684A (pt) 2007-07-17
JP2014218525A (ja) 2014-11-20
EP1713512A4 (en) 2009-01-07
EP3385253B1 (en) 2021-04-07
CA2556213C (en) 2013-12-17
NO344857B1 (no) 2020-06-02
JP5417578B2 (ja) 2014-02-19
US20120276006A1 (en) 2012-11-01
US7344702B2 (en) 2008-03-18
US20210300878A1 (en) 2021-09-30

Similar Documents

Publication Publication Date Title
IN2012DN02610A (he)
IN2014CN03762A (he)
ZA200702266B (en) 2-morpholino-4-pyrimidone compound
TW200617019A (en) A process for the preparation of 7α-alkylated 19-norsteroids
GB0415663D0 (en) Compound
GB0512429D0 (en) Novel compound
HK1101881A1 (en) Antithrombotic compound
GB0408771D0 (en) Compound
GB0427403D0 (en) Novel compounds I
GB0421106D0 (en) Compound
GB0414760D0 (en) The alternative
EP1787334A4 (en) LIGHT-EMITTING STRUCTURES
GB0425969D0 (en) Compound
PL1674632T3 (pl) Gipsowa płyta budowlana
IN2014CN04215A (he)
GB0408654D0 (en) Luminaires
EP1961756A4 (en) NEW BISBORNET CONNECTION
GB0428295D0 (en) Compound
GB0413766D0 (en) Novel compound
GB0413769D0 (en) Novel compound
GB0413768D0 (en) Novel compound
GB0413765D0 (en) Novel compound
GB0413763D0 (en) Novel compound
GB0413756D0 (en) Novel compound
GB0412551D0 (en) Novel compound