US5912347A
(en)
*
|
1996-09-30 |
1999-06-15 |
Mallinckrodt Inc. |
Process for preparing a morphinan derivative
|
WO2000066588A1
(en)
*
|
1999-05-05 |
2000-11-09 |
The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services |
Direct c-14 oxidation of opioids
|
US6177567B1
(en)
*
|
1999-10-15 |
2001-01-23 |
Boehringer Ingelheim Chemicals, Inc. |
Method for preparing oxycodone
|
EP1421085B1
(en)
*
|
2001-08-23 |
2010-04-28 |
N.V. Organon |
Process for the preparation of a 14-hydroxynormorphinone derivative
|
JP3961796B2
(ja)
*
|
2001-08-27 |
2007-08-22 |
ソニー株式会社 |
情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
|
DE10161963A1
(de)
*
|
2001-12-17 |
2003-07-03 |
Johannes Schuetz |
6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
|
US20040001889A1
(en)
|
2002-06-25 |
2004-01-01 |
Guohua Chen |
Short duration depot formulations
|
US20040058946A1
(en)
*
|
2002-07-05 |
2004-03-25 |
Buchwald Stephen L. |
Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
|
RU2236412C2
(ru)
*
|
2002-07-18 |
2004-09-20 |
Власов Михаил Иванович |
Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
|
RU2215742C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
|
RU2215741C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
|
DE60329520D1
(de)
*
|
2002-11-08 |
2009-11-12 |
Mallinckrodt Inc |
Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen
|
DK1575569T3
(da)
|
2002-12-13 |
2011-01-10 |
Durect Corp |
Oralt indgivelsessystem omfattende flydende bærematerialer med høj viskositet
|
US6790959B1
(en)
|
2003-06-05 |
2004-09-14 |
Halsey Drug Company, Inc. |
Process for manufacturing thebaine
|
US6864370B1
(en)
*
|
2003-06-05 |
2005-03-08 |
Zhaiwei Lin |
Process for manufacturing oxycodone
|
US7875718B2
(en)
*
|
2003-09-22 |
2011-01-25 |
Johnson Matthey Public Limited Company |
Process for the synthesis of morphinane compounds and intermediates thereof
|
EP1664061B1
(en)
|
2003-09-22 |
2017-03-15 |
GlaxoSmithKline Australia Pty Ltd |
Process for the synthesis of morphinane compounds and intermediates thereof
|
RS50663B
(sr)
|
2004-02-06 |
2010-06-30 |
Euro-Celtique S.A. |
Postupci za dobijanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata
|
TWI365880B
(en)
*
|
2004-03-30 |
2012-06-11 |
Euro Celtique Sa |
Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
|
SK286047B6
(sk)
*
|
2004-04-13 |
2008-01-07 |
Zentiva, A. S. |
Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
|
US6946556B1
(en)
*
|
2004-05-21 |
2005-09-20 |
Acura Pharmaceuticals, Inc. |
Preparation of opioid analgesics by a one-pot process
|
MXPA06014107A
(es)
*
|
2004-06-08 |
2007-03-07 |
Mallinckrodt Inc |
Extraccion de alcaloides del opio.
|
DK1765292T3
(en)
|
2004-06-12 |
2018-01-02 |
Collegium Pharmaceutical Inc |
ABUSE PREVENTIONAL PHARMACEUTICAL FORMULATIONS
|
PT2767292T
(pt)
|
2004-09-17 |
2016-11-23 |
Durect Corp |
Composição anestésica local prolongada contendo aibs
|
GB0421149D0
(en)
*
|
2004-09-23 |
2004-10-27 |
Johnson Matthey Plc |
Preparation of oxycodone
|
GB0421687D0
(en)
†
|
2004-09-30 |
2004-11-03 |
Johnson Matthey Plc |
Preparation of opiate analgesics
|
WO2006084389A1
(de)
*
|
2005-02-11 |
2006-08-17 |
Cilag Ltd. |
Verfahren zur reinigung von noroxymorphon-verbindungen
|
SI1861405T1
(sl)
*
|
2005-03-04 |
2009-10-31 |
Euro Celtique Sa |
Postopek za zmanjšanje alfa,beta-nenasičenih ketonov v opioidnih sestavkih
|
ES2568475T3
(es)
*
|
2005-04-06 |
2016-04-29 |
Toray Industries, Inc. |
Cristales de derivado de morfinano y procedimiento para producir los mismos
|
US8071768B2
(en)
*
|
2005-06-10 |
2011-12-06 |
Janssen Pharmaceutica, N.V. |
Alkylquinoline and alkylquinazoline kinase modulators
|
WO2006138020A2
(en)
*
|
2005-06-16 |
2006-12-28 |
Mallinckrodt Inc. |
A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
|
US20070027105A1
(en)
|
2005-07-26 |
2007-02-01 |
Alza Corporation |
Peroxide removal from drug delivery vehicle
|
US20070117826A1
(en)
*
|
2005-11-23 |
2007-05-24 |
Forest Laboratories, Inc. |
Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
|
EP1994034B1
(en)
*
|
2006-03-02 |
2009-11-11 |
Mallinckrodt, Inc. |
Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
|
SA07280459B1
(ar)
|
2006-08-25 |
2011-07-20 |
بيورديو فارما إل. بي. |
أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
|
RU2009112685A
(ru)
*
|
2006-09-20 |
2010-10-27 |
Маллинкродт Инк. (Us) |
Получение замещенных морфинан-6-онов и их солей и промежуточных соединений
|
ES2392594T3
(es)
*
|
2006-10-17 |
2012-12-12 |
Penick Corporation |
Procedimiento para preparar oximorfona
|
AU2012216358B2
(en)
*
|
2006-10-17 |
2014-11-20 |
Penick Corporation |
Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
|
CA2674915C
(en)
|
2006-10-17 |
2015-06-30 |
Penick Corporation |
Process for preparing oxymorphone
|
US20080125592A1
(en)
*
|
2006-10-17 |
2008-05-29 |
Penick Corporation |
Process for preparing oxymorphone, naltrexone, and buprenorphine
|
PL2117521T3
(pl)
|
2006-11-03 |
2012-11-30 |
Durect Corp |
Transdermalne systemy dostarczania zawierające bupiwakainę
|
AU2007329453B2
(en)
*
|
2006-12-04 |
2013-04-04 |
Noramco, Llc |
Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
|
EP2121698B1
(en)
*
|
2006-12-04 |
2012-02-01 |
Noramco, Inc. |
Process for reducing impurities in oxycodone base
|
GB0624880D0
(en)
*
|
2006-12-14 |
2007-01-24 |
Johnson Matthey Plc |
Improved method for making analgesics
|
US9040726B2
(en)
|
2007-03-06 |
2015-05-26 |
Mallinckrodt Llc |
Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
|
EP2137189B1
(en)
*
|
2007-03-06 |
2015-05-06 |
Mallinckrodt LLC |
Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
|
ES2438997T5
(es)
*
|
2007-03-23 |
2024-09-03 |
SpecGx LLC |
Preparación mejorada de oximorfona a partir de oripavina
|
CA2684458A1
(en)
*
|
2007-04-16 |
2008-10-30 |
Mallinckrodt Inc. |
Novel opiate reduction utilizing catalytic hydrogen transfer reaction
|
WO2008144320A2
(en)
*
|
2007-05-17 |
2008-11-27 |
Endo Pharmaceuticals, Inc. |
Opioid and methods of making and using the same
|
AU2008347158B8
(en)
|
2007-12-06 |
2013-08-22 |
Durect Corporation |
Oral pharmaceutical dosage forms
|
AU2008338970B2
(en)
*
|
2007-12-17 |
2013-08-22 |
SpecGx LLC |
Sinomenine derivatives and processes for their synthesis
|
CA2709886C
(en)
*
|
2007-12-17 |
2016-10-25 |
Mallinckrodt Inc. |
Processes for the production of (+)-"nal" morphinan compounds
|
ATE519765T1
(de)
*
|
2008-02-29 |
2011-08-15 |
Mallinckrodt Inc |
Verfahren zur herstellung von 3-hydroxymorphinan- derivaten
|
ATE523512T1
(de)
*
|
2008-04-24 |
2011-09-15 |
Janssen Pharmaceutica Nv |
Nalmefen-prodrugs
|
ES2549904T3
(es)
*
|
2008-05-27 |
2015-11-03 |
Mallinckrodt Llc |
Procesos y compuestos para la preparación de normorfinanos
|
US9458109B2
(en)
|
2008-09-03 |
2016-10-04 |
Mallinckrodt Llc |
Substituted berbines and processes for their synthesis
|
PL2344506T3
(pl)
*
|
2008-09-30 |
2016-08-31 |
SpecGx LLC |
Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowych
|
US20100260844A1
(en)
|
2008-11-03 |
2010-10-14 |
Scicinski Jan J |
Oral pharmaceutical dosage forms
|
UA102916C2
(uk)
|
2009-07-02 |
2013-08-27 |
Кемфарм, Інк. |
Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
|
US10668060B2
(en)
|
2009-12-10 |
2020-06-02 |
Collegium Pharmaceutical, Inc. |
Tamper-resistant pharmaceutical compositions of opioids and other drugs
|
EP2580218B1
(en)
|
2010-06-11 |
2015-02-25 |
Rhodes Technologies |
Process for n-dealkylation of tertiary amines
|
EP2580201B1
(en)
|
2010-06-11 |
2017-08-02 |
Rhodes Technologies |
Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
|
JP5988272B2
(ja)
|
2010-07-02 |
2016-09-07 |
ジョンソン、マッセイ、パブリック、リミテッド、カンパニーJohnson Matthey Public Limited Company |
オキシコドンの合成及び精製プロセス
|
RU2448709C1
(ru)
*
|
2011-02-01 |
2012-04-27 |
Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) |
Способ получения налтрексона
|
TWI560170B
(en)
*
|
2011-12-06 |
2016-12-01 |
Lundbeck & Co As H |
Process for recovery of nalmefene hydrochloride
|
US9315514B2
(en)
|
2012-08-27 |
2016-04-19 |
Rhodes Technologies |
1,3-dioxanomorphides and 1,3-dioxanocodides
|
JP6163210B2
(ja)
|
2012-12-14 |
2017-07-12 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
窒素含有モルフィナン誘導体およびその使用
|
TWI513697B
(zh)
|
2012-12-14 |
2015-12-21 |
Purdue Pharma Lp |
吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
|
TW201434837A
(zh)
|
2012-12-14 |
2014-09-16 |
Purdue Pharma Lp |
螺環嗎啡喃及其用途
|
WO2014102593A1
(en)
|
2012-12-28 |
2014-07-03 |
Purdue Pharma L.P. |
Substituted morphinans and the use thereof
|
WO2014102587A1
(en)
|
2012-12-28 |
2014-07-03 |
Purdue Pharma L.P. |
7,8-cyclicmorphinan analogs
|
AU2013369037C1
(en)
|
2012-12-31 |
2017-06-08 |
Rhodes Technologies |
Process for preparing 7beta-substituted 6alpha,14alpha -ethenomorphinans and 7beta-substituted 6alpha,14alpha-ethanomorphinans
|
WO2014144975A1
(en)
|
2013-03-15 |
2014-09-18 |
Durect Corporation |
Compositions with a rheological modifier to reduce dissolution variability
|
EP2829541A1
(en)
*
|
2013-07-26 |
2015-01-28 |
Siegfried AG |
Novel synthesis of noroxymorphone from morphine
|
EP3027622B8
(en)
|
2013-08-02 |
2019-06-12 |
Johnson Matthey Public Limited Company |
Process for the preparation of oxymorphone
|
EP3087078B1
(en)
|
2013-12-26 |
2019-05-15 |
Purdue Pharma LP |
7-beta-alkyl analogs of orvinols
|
US9862726B2
(en)
|
2013-12-26 |
2018-01-09 |
Purdue Pharma L.P. |
Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
|
WO2015097547A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
10-substituted morphinan hydantoins
|
US9340542B2
(en)
|
2013-12-26 |
2016-05-17 |
Purdue Pharma L.P. |
Propellane-based compounds and the use thereof
|
EP3089978B1
(en)
|
2013-12-30 |
2018-08-29 |
Purdue Pharma L.P. |
Pyridone-sulfone morphinan analogs as opioid receptor ligands
|
CN106999486A
(zh)
|
2014-11-25 |
2017-08-01 |
凯姆制药公司 |
羟考酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物
|
ES2701855T3
(es)
|
2016-05-31 |
2019-02-26 |
Alcaliber Investig Desarrollo E Innovacion Slu |
Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina
|
US9737530B1
(en)
|
2016-06-23 |
2017-08-22 |
Collegium Pharmaceutical, Inc. |
Process of making stable abuse-deterrent oral formulations
|
SG11201811760VA
(en)
|
2016-07-06 |
2019-01-30 |
Durect Corp |
Oral dosage form with drug composition, barrier layer and drug layer
|
DK3559010T3
(da)
|
2016-12-23 |
2022-08-15 |
Minoryx Therapeutics S L |
Fremgangsmåde til fremstilling af 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedion og salte deraf
|
SK592017A3
(sk)
|
2017-07-04 |
2019-01-08 |
Saneca Pharmaceuticals A. S. |
Spôsob prípravy morfínanových zlúčenín
|
WO2019165298A1
(en)
|
2018-02-23 |
2019-08-29 |
Rhodes Technologies |
Novel opioid compounds and uses thereof
|
CN110054656B
(zh)
*
|
2019-05-28 |
2021-02-02 |
宜昌人福药业有限责任公司 |
一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
|
WO2021007366A1
(en)
*
|
2019-07-08 |
2021-01-14 |
St. Louis College Of Pharmacy |
G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
|
BR112022013784A2
(pt)
|
2020-01-13 |
2022-10-11 |
Durect Corp |
Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
|
CN114621239A
(zh)
*
|
2020-12-10 |
2022-06-14 |
鲁南制药集团股份有限公司 |
一种纳曲酮的制备方法
|
EP4267583A4
(en)
*
|
2020-12-28 |
2024-10-30 |
Navin Saxena Research & Technology Pvt. Ltd. |
NEW PROCESS FOR THE PRODUCTION OF NOROXYMORPHONE FROM MORPHINE
|