IN190402B - - Google Patents

Info

Publication number
IN190402B
IN190402B IN1044CA1995A IN190402B IN 190402 B IN190402 B IN 190402B IN 1044CA1995 A IN1044CA1995 A IN 1044CA1995A IN 190402 B IN190402 B IN 190402B
Authority
IN
India
Prior art keywords
useful
benzodiazepines
chem
formula
receptor antagonists
Prior art date
Application number
Other languages
English (en)
Inventor
Benjamin Alan Anderson
Marvin Martin Hansen
Jeffrey Thomas Vicenzi
David Lee Varie
Milton Joseph Junior Zmijewski
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/413,036 external-priority patent/US5665878A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IN190402B publication Critical patent/IN190402B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/056Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN1044CA1995 1994-08-31 1995-08-30 IN190402B (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29864594A 1994-08-31 1994-08-31
US08/413,036 US5665878A (en) 1994-08-31 1995-03-28 Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
IN190402B true IN190402B (tr) 2003-07-26

Family

ID=26970799

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1044CA1995 IN190402B (tr) 1994-08-31 1995-08-30

Country Status (22)

Country Link
US (3) US5919954A (tr)
EP (1) EP0699677B1 (tr)
JP (1) JP3481019B2 (tr)
KR (1) KR100399518B1 (tr)
CN (1) CN1086705C (tr)
AT (1) ATE231867T1 (tr)
AU (1) AU702658B2 (tr)
BR (1) BR9503845A (tr)
CA (1) CA2157234C (tr)
CZ (1) CZ295675B6 (tr)
DE (1) DE69529499T2 (tr)
DK (1) DK0699677T3 (tr)
ES (1) ES2189819T3 (tr)
FI (1) FI113269B (tr)
HK (1) HK1013818A1 (tr)
HU (1) HU223776B1 (tr)
IL (1) IL115100A (tr)
IN (1) IN190402B (tr)
NO (1) NO312838B1 (tr)
PL (3) PL188796B1 (tr)
RU (1) RU2151149C1 (tr)
TR (1) TR199501071A2 (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA67749C2 (uk) 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
SK1792000A3 (en) * 1997-08-12 2000-09-12 Egyt Gyogyszervegyeszeti Gyar 1,3-DIOXOLO(4,5-H)(2,3)BENZODIAZEPINE DERIVATIVES, PROCESS FORì (54) THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION CO
WO1999023242A1 (en) * 1997-11-04 1999-05-14 Eli Lilly And Company Ketoreductase gene and protein from yeast
US20030219456A1 (en) * 2002-05-21 2003-11-27 Taing Ok Method of utilization of zygosaccharomyces rouxii
US6858605B2 (en) 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
ES2322069T3 (es) * 2005-12-05 2009-06-16 Deutsche Post Ag Procedimiento para la clasificacion de envios postales y dispositivo con una estructura de datos para un plan de clasificacion.
AU2006334172A1 (en) * 2005-12-30 2007-07-12 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
KR100841592B1 (ko) 2007-04-16 2008-06-26 한양대학교 산학협력단 벤조디옥솔 유도체와 이의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794642A (en) * 1973-01-15 1974-02-26 Lilly Co Eli Oxidation of substituted methanes to the corresponding substituted methanols
DE2816475A1 (de) * 1978-04-15 1979-10-25 Bayer Ag Isochroman-derivate, verfahren zu ihrer herstellung und ihre verwendung als synergisten in insektiziden und akariziden mitteln
US4358041A (en) 1980-06-12 1982-11-09 Olin Corporation Powder-actuated tool with power adjustment and angle-fire control
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU198494B (en) 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
EP0357787B1 (en) * 1988-02-12 1996-05-08 Daicel Chemical Industries, Ltd. Process for preparing optically active 2-hydroxy acid derivatives
JP2679145B2 (ja) * 1988-09-02 1997-11-19 ダイセル化学工業株式会社 オキシケトンの製造法
HU206719B (en) 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
JP3061422B2 (ja) * 1990-12-27 2000-07-10 ダイセル化学工業株式会社 光学活性(s)−2−クロロ−1−フェニルプロパノールの製造法
JPH04271789A (ja) * 1991-01-10 1992-09-28 Takeda Chem Ind Ltd D−パントラクトンの製造方法
HU219777B (hu) * 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására

Also Published As

Publication number Publication date
US6160133A (en) 2000-12-12
FI113269B (fi) 2004-03-31
NO953396L (no) 1996-03-01
HU9502545D0 (en) 1995-10-30
KR960007595A (ko) 1996-03-22
NO312838B1 (no) 2002-07-08
DE69529499T2 (de) 2003-12-04
HU223776B1 (hu) 2005-01-28
EP0699677A1 (en) 1996-03-06
HUT72644A (en) 1996-05-28
ATE231867T1 (de) 2003-02-15
KR100399518B1 (ko) 2004-04-30
AU702658B2 (en) 1999-02-25
DE69529499D1 (de) 2003-03-06
CN1123282A (zh) 1996-05-29
NO953396D0 (no) 1995-08-30
PL190318B1 (pl) 2005-11-30
ES2189819T3 (es) 2003-07-16
DK0699677T3 (da) 2003-04-22
IL115100A (en) 2000-07-26
US5986114A (en) 1999-11-16
JP3481019B2 (ja) 2003-12-22
CA2157234C (en) 2005-05-03
JPH0881468A (ja) 1996-03-26
BR9503845A (pt) 1996-04-16
PL188796B1 (pl) 2005-04-29
FI954064A (fi) 1996-03-01
CZ295675B6 (cs) 2005-09-14
RU2151149C1 (ru) 2000-06-20
HK1013818A1 (en) 1999-09-10
IL115100A0 (en) 1995-12-08
FI954064A0 (fi) 1995-08-30
PL190640B1 (pl) 2005-12-30
CA2157234A1 (en) 1996-03-01
CZ221995A3 (en) 1996-03-13
TR199501071A2 (tr) 1996-06-21
CN1086705C (zh) 2002-06-26
EP0699677B1 (en) 2003-01-29
PL310226A1 (en) 1996-03-04
AU3035595A (en) 1996-03-14
US5919954A (en) 1999-07-06

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