IN183798B - - Google Patents

Info

Publication number
IN183798B
IN183798B IN751CA1998A IN183798B IN 183798 B IN183798 B IN 183798B IN 751CA1998 A IN751CA1998 A IN 751CA1998A IN 183798 B IN183798 B IN 183798B
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Andrew David Carison
Theodore Arsay Sheliga
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IN183798B publication Critical patent/IN183798B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
IN751CA1998 1997-04-28 1998-04-27 IN183798B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4525597P 1997-04-28 1997-04-28

Publications (1)

Publication Number Publication Date
IN183798B true IN183798B (hu) 2000-04-15

Family

ID=21936854

Family Applications (2)

Application Number Title Priority Date Filing Date
IN752CA1998 IN187157B (hu) 1997-04-28 1998-04-27
IN751CA1998 IN183798B (hu) 1997-04-28 1998-04-27

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IN752CA1998 IN187157B (hu) 1997-04-28 1998-04-27

Country Status (35)

Country Link
US (4) US6162629A (hu)
EP (2) EP0875563A3 (hu)
JP (2) JP4383547B2 (hu)
KR (2) KR100450856B1 (hu)
CN (2) CN1235638C (hu)
AR (2) AR012010A1 (hu)
AT (1) ATE285788T1 (hu)
AU (2) AU743531B2 (hu)
BR (2) BR9809304B1 (hu)
CA (2) CA2288143C (hu)
CO (2) CO4950523A1 (hu)
CZ (1) CZ298429B6 (hu)
DE (1) DE69828330T2 (hu)
DK (1) DK0875252T3 (hu)
EA (2) EA002149B1 (hu)
EG (1) EG23685A (hu)
ES (1) ES2234072T3 (hu)
HK (1) HK1016472A1 (hu)
HU (2) HU224826B1 (hu)
ID (2) ID23172A (hu)
IL (2) IL132502A0 (hu)
IN (2) IN187157B (hu)
MY (2) MY118591A (hu)
NO (2) NO995134L (hu)
NZ (2) NZ337828A (hu)
PE (2) PE84799A1 (hu)
PL (2) PL195642B1 (hu)
PT (1) PT875252E (hu)
SI (1) SI0875252T1 (hu)
SV (2) SV1998000051A (hu)
TR (2) TR199902529T2 (hu)
TW (2) TWI242443B (hu)
UA (2) UA55448C2 (hu)
WO (2) WO1998048818A1 (hu)
ZA (2) ZA983496B (hu)

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US20070142272A1 (en) * 2003-01-24 2007-06-21 Zlokovic Berislav V Neuroprotective activity of activated protein c independent of its anticoagulant activity
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EP2041338A4 (en) * 2006-06-09 2009-09-30 Univ British Columbia INTERFERON GAMMA POLYMORPHISMS AS INDICATORS OF PATIENT RESULTS IN FATIGUE PATIENTS
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WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2013151727A1 (en) 2012-04-03 2013-10-10 Smith Medical Asd, Inc. Heparin-bulking agent compositions and methods thereof
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US20150150954A1 (en) 2012-07-04 2015-06-04 The University Of Sydney Treatment of inflammatory skin disorders
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
KR20150043523A (ko) 2012-09-02 2015-04-22 애브비 인코포레이티드 단백질 불균일성의 제어 방법
SG11201507230PA (en) 2013-03-12 2015-10-29 Abbvie Inc Human antibodies that bind human tnf-alpha and methods of preparing the same
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
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Also Published As

Publication number Publication date
JP4383547B2 (ja) 2009-12-16
UA55448C2 (uk) 2003-04-15
IL132325A (en) 2005-07-25
PE84799A1 (es) 1999-09-16
EA199900980A1 (ru) 2000-04-24
AU740753C (en) 2002-10-10
DE69828330T2 (de) 2005-10-13
PE86299A1 (es) 1999-09-17
ZA983497B (en) 1999-10-25
NO995198L (no) 1999-10-25
AU743531B2 (en) 2002-01-31
PL195090B1 (pl) 2007-08-31
HUP0003401A3 (en) 2003-01-28
TR199902529T2 (xx) 2000-02-21
ES2234072T3 (es) 2005-06-16
EA004881B1 (ru) 2004-08-26
SV1998000050A (es) 1999-01-13
NO995198D0 (no) 1999-10-25
DK0875252T3 (da) 2005-04-25
IN187157B (hu) 2002-02-16
HUP0003401A2 (hu) 2001-02-28
CA2287267C (en) 2006-08-15
NZ500346A (en) 2001-08-31
PL336420A1 (en) 2000-06-19
US6162629A (en) 2000-12-19
AU7161898A (en) 1998-11-24
IL132325A0 (en) 2001-03-19
CN1235638C (zh) 2006-01-11
CZ381099A3 (cs) 2000-03-15
KR100564189B1 (ko) 2006-03-27
EP0875252A3 (en) 2000-07-26
EP0875252A2 (en) 1998-11-04
ID23172A (id) 2000-03-23
CA2288143A1 (en) 1998-11-05
MY120984A (en) 2005-12-30
TR199902631T2 (xx) 2000-01-21
UA73071C2 (en) 2005-06-15
ATE285788T1 (de) 2005-01-15
US6436397B1 (en) 2002-08-20
TWI242443B (en) 2005-11-01
AU740753B2 (en) 2001-11-15
EA002149B1 (ru) 2001-12-24
WO1998048822A1 (en) 1998-11-05
SV1998000051A (es) 1998-12-11
AR012010A1 (es) 2000-09-13
CA2287267A1 (en) 1998-11-05
HUP0100284A2 (hu) 2001-06-28
AU7258998A (en) 1998-11-24
CO4950523A1 (es) 2000-09-01
EP0875563A3 (en) 2000-08-02
ID22933A (id) 1999-12-16
CN1227025C (zh) 2005-11-16
EA199900979A1 (ru) 2000-06-26
AR015598A1 (es) 2001-05-16
HUP0100284A3 (en) 2003-08-28
CO4940438A1 (es) 2000-07-24
NO995134L (no) 1999-12-21
CA2288143C (en) 2012-08-21
BR9809292A (pt) 2000-07-04
HU224826B1 (en) 2006-02-28
NO995134D0 (no) 1999-10-21
PT875252E (pt) 2005-03-31
EG23685A (en) 2007-05-09
ZA983496B (en) 1999-10-25
PL195642B1 (pl) 2007-10-31
CZ298429B6 (cs) 2007-10-03
NZ337828A (en) 2001-06-29
KR20010020242A (ko) 2001-03-15
CN1254284A (zh) 2000-05-24
EP0875563A2 (en) 1998-11-04
JP2001527543A (ja) 2001-12-25
DE69828330D1 (de) 2005-02-03
BR9809304A (pt) 2000-10-17
KR20010020325A (ko) 2001-03-15
US6395270B1 (en) 2002-05-28
TW585871B (en) 2004-05-01
BR9809304B1 (pt) 2011-02-08
MY118591A (en) 2004-12-31
EP0875252B1 (en) 2004-12-29
JP2001524111A (ja) 2001-11-27
SI0875252T1 (en) 2005-06-30
JP4383546B2 (ja) 2009-12-16
HK1016472A1 (en) 1999-11-05
WO1998048818A1 (en) 1998-11-05
IL132502A0 (en) 2001-03-19
US6159468A (en) 2000-12-12
PL336889A1 (en) 2000-07-17
KR100450856B1 (ko) 2004-10-02
CN1261280A (zh) 2000-07-26

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