IN179820B - - Google Patents

Info

Publication number
IN179820B
IN179820B IN1452CA1995A IN179820B IN 179820 B IN179820 B IN 179820B IN 1452CA1995 A IN1452CA1995 A IN 1452CA1995A IN 179820 B IN179820 B IN 179820B
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Jeffrey Clayton Baker
Victor John Chen
Aidas Vladas Kriauciunas
Brian Alden Moser
Jose Michael Hanquiter
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IN179820B publication Critical patent/IN179820B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IN1452CA1995 1994-11-17 1995-11-14 IN179820B (cg-RX-API-DMAC10.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
IN179820B true IN179820B (cg-RX-API-DMAC10.html) 1997-12-13

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1452CA1995 IN179820B (cg-RX-API-DMAC10.html) 1994-11-17 1995-11-14

Country Status (27)

Country Link
US (2) US5646242A (cg-RX-API-DMAC10.html)
EP (2) EP1227107A1 (cg-RX-API-DMAC10.html)
JP (1) JP4312828B2 (cg-RX-API-DMAC10.html)
CN (1) CN1171742A (cg-RX-API-DMAC10.html)
AR (1) AR003915A1 (cg-RX-API-DMAC10.html)
AT (1) ATE328902T1 (cg-RX-API-DMAC10.html)
AU (2) AU691066B2 (cg-RX-API-DMAC10.html)
BR (1) BR9509652A (cg-RX-API-DMAC10.html)
CA (1) CA2205061A1 (cg-RX-API-DMAC10.html)
CO (1) CO4520285A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ287731B6 (cg-RX-API-DMAC10.html)
DE (1) DE69535031T2 (cg-RX-API-DMAC10.html)
DK (1) DK0712862T3 (cg-RX-API-DMAC10.html)
ES (1) ES2264124T3 (cg-RX-API-DMAC10.html)
HU (2) HU9903007D0 (cg-RX-API-DMAC10.html)
IL (1) IL115972A (cg-RX-API-DMAC10.html)
IN (1) IN179820B (cg-RX-API-DMAC10.html)
NO (1) NO972185D0 (cg-RX-API-DMAC10.html)
NZ (1) NZ297256A (cg-RX-API-DMAC10.html)
PL (1) PL320556A1 (cg-RX-API-DMAC10.html)
PT (1) PT712862E (cg-RX-API-DMAC10.html)
RU (1) RU2155773C2 (cg-RX-API-DMAC10.html)
SI (1) SI0712862T1 (cg-RX-API-DMAC10.html)
TR (1) TR199501421A2 (cg-RX-API-DMAC10.html)
WO (1) WO1996015803A1 (cg-RX-API-DMAC10.html)
YU (1) YU71495A (cg-RX-API-DMAC10.html)
ZA (1) ZA959680B (cg-RX-API-DMAC10.html)

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US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
PL340255A1 (en) * 1997-10-24 2001-01-29 Lilly Co Eli Non-dissolving insulin compositions
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US5985263A (en) * 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US5981709A (en) * 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
US7181349B1 (en) 1999-05-27 2007-02-20 Cecil Yip Identification of compounds for modulating dimeric receptors
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
JP2003532691A (ja) * 2000-05-05 2003-11-05 ノボ ノルディスク アクティーゼルスカブ 重症疾患神経障害
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
CN1406131A (zh) * 2000-12-25 2003-03-26 株式会社资生堂 活化交感神经的香料组合物
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
AU2002355160A1 (en) * 2001-07-24 2003-02-17 Novo Nordisk A/S Method for making acylated polypeptides
US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
US20030082671A1 (en) * 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
RU2004105155A (ru) * 2001-07-24 2005-04-20 Ново Нордиск А/С (DK) Способ получения ацилированных полипептидов
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
MY127575A (en) 2001-09-07 2006-12-29 Biocon Ltd Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
WO2003105768A2 (en) 2002-06-13 2003-12-24 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
WO2004029077A2 (en) * 2002-09-25 2004-04-08 Novo Nordisk A/S Method for producing acylated peptides
WO2005012347A2 (en) * 2003-08-05 2005-02-10 Novo Nordisk A/S Novel insulin derivatives
WO2005047508A1 (en) 2003-11-14 2005-05-26 Novo Nordisk A/S Processes for making acylated insulin
RU2527893C2 (ru) 2004-07-19 2014-09-10 Биокон Лимитед Инсулин-олигомерные конъюгаты, их препараты и применения
CN102660614A (zh) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
DK1969004T3 (da) * 2005-12-28 2011-11-28 Novo Nordisk As Insulinsammensætninger og metode til at lave en sammensætning
WO2007096431A1 (en) * 2006-02-27 2007-08-30 Novo Nordisk A/S Insulin derivatives
US8927015B2 (en) * 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
AU2007298919C1 (en) 2006-09-22 2014-02-06 Novo Nordisk A/S Protease resistant insulin analogues
EP2069502B1 (en) 2006-09-27 2014-02-26 Novo Nordisk A/S Method for making maturated insulin polypeptides
EP2152245B1 (en) 2007-04-30 2015-12-02 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
NZ585135A (en) 2007-10-16 2012-08-31 Biocon Ltd An orally administerable solid pharmaceutical composition comprising in-105 and a process thereof
EP2254905B1 (en) 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
KR101755434B1 (ko) 2008-03-18 2017-07-10 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
JP5591243B2 (ja) 2008-09-12 2014-09-17 ノボ・ノルデイスク・エー／エス ペプチド又はタンパク質のアシル化の方法
BRPI0919946A2 (pt) * 2008-10-30 2016-02-16 Novo Nordisk As tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente
WO2010096188A2 (en) * 2009-02-20 2010-08-26 Ipsen Pharma S.A.S Analogues of neuropeptide y having proline substitution at position 34
BR112012012945A2 (pt) 2009-11-25 2020-12-29 Arisgen Sa Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo
HRP20191793T1 (hr) 2010-10-27 2019-12-27 Novo Nordisk A/S Liječenje dijabetesa melitusa injekcijama inzulina koje se primijenjuje u različitim intervalima injiciranja
KR20150002777A (ko) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 인슐린 제제
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
RS57004B1 (sr) 2013-10-07 2018-05-31 Novo Nordisk As Novi derivat analoga insulina
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
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US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation
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Also Published As

Publication number Publication date
EP0712862B1 (en) 2006-06-07
EP0712862A2 (en) 1996-05-22
PL320556A1 (en) 1997-10-13
RU2155773C2 (ru) 2000-09-10
EP1227107A1 (en) 2002-07-31
NO972185L (no) 1997-05-13
EP0712862A3 (en) 1998-03-04
DE69535031D1 (de) 2006-07-20
NO972185D0 (no) 1997-05-13
CA2205061A1 (en) 1996-05-30
AU4237296A (en) 1996-06-17
JPH10509176A (ja) 1998-09-08
SI0712862T1 (sl) 2006-10-31
HUT77737A (hu) 1998-07-28
AR003915A1 (es) 1998-09-30
TR199501421A2 (tr) 1996-06-21
YU71495A (sh) 1998-09-18
HK1014007A1 (en) 1999-09-17
HU217585B (hu) 2000-02-28
JP4312828B2 (ja) 2009-08-12
CZ145697A3 (en) 1997-12-17
ES2264124T3 (es) 2006-12-16
AU7885498A (en) 1998-11-05
PT712862E (pt) 2006-08-31
USRE37971E1 (en) 2003-01-28
NZ297256A (en) 2000-01-28
AU691066B2 (en) 1998-05-07
IL115972A0 (en) 1996-01-31
IL115972A (en) 2000-09-28
HU9903007D0 (en) 1999-11-29
CZ287731B6 (en) 2001-01-17
BR9509652A (pt) 1997-09-16
ATE328902T1 (de) 2006-06-15
MX9703506A (es) 1997-07-31
US5646242A (en) 1997-07-08
ZA959680B (en) 1997-05-14
DE69535031T2 (de) 2006-12-28
CO4520285A1 (es) 1997-10-15
CN1171742A (zh) 1998-01-28
WO1996015803A1 (en) 1996-05-30
AU720820B2 (en) 2000-06-15
DK0712862T3 (da) 2006-09-25

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