IL99769A - History of mercaptoacetylamide of benzene C (tricyclic azapinones effective as inhibitors of encephalinase and ECA and their pharmaceutical preparations) - Google Patents

History of mercaptoacetylamide of benzene C (tricyclic azapinones effective as inhibitors of encephalinase and ECA and their pharmaceutical preparations)

Info

Publication number
IL99769A
IL99769A IL9976991A IL9976991A IL99769A IL 99769 A IL99769 A IL 99769A IL 9976991 A IL9976991 A IL 9976991A IL 9976991 A IL9976991 A IL 9976991A IL 99769 A IL99769 A IL 99769A
Authority
IL
Israel
Prior art keywords
oxo
compound
amino
phenylpropyl
benzazepine
Prior art date
Application number
IL9976991A
Other languages
English (en)
Hebrew (he)
Other versions
IL99769A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL99769A0 publication Critical patent/IL99769A0/xx
Publication of IL99769A publication Critical patent/IL99769A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9976991A 1990-10-18 1991-10-16 History of mercaptoacetylamide of benzene C (tricyclic azapinones effective as inhibitors of encephalinase and ECA and their pharmaceutical preparations) IL99769A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60005290A 1990-10-18 1990-10-18
US73549691A 1991-07-25 1991-07-25

Publications (2)

Publication Number Publication Date
IL99769A0 IL99769A0 (en) 1992-08-18
IL99769A true IL99769A (en) 1998-12-27

Family

ID=27083513

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9976991A IL99769A (en) 1990-10-18 1991-10-16 History of mercaptoacetylamide of benzene C (tricyclic azapinones effective as inhibitors of encephalinase and ECA and their pharmaceutical preparations)

Country Status (18)

Country Link
EP (1) EP0481522B1 (de)
JP (1) JP3181335B2 (de)
KR (1) KR100372491B1 (de)
CN (2) CN1036590C (de)
AT (1) ATE161536T1 (de)
AU (1) AU642535B2 (de)
CA (1) CA2053340C (de)
DE (1) DE69128516T2 (de)
DK (1) DK0481522T3 (de)
ES (1) ES2114870T3 (de)
FI (2) FI95255C (de)
GR (1) GR3026222T3 (de)
HU (1) HU210008B (de)
IE (1) IE913648A1 (de)
IL (1) IL99769A (de)
NO (1) NO180718C (de)
NZ (1) NZ240230A (de)
PT (1) PT99267B (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
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US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
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US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078758C (en) * 1991-09-27 2003-12-09 Alan M. Warshawsky 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
JP3460838B2 (ja) * 1992-02-14 2003-10-27 メレルファーマスーティカルズインコーポレイテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な，アミノアセチルメルカプトアセチルアミド誘導体類
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
DE69325904T2 (de) * 1992-05-15 1999-12-09 Merrell Pharma Inc MERCAPTOACETYLAMIDE VON PYRIDAZO[1,2-a][1,2]-DIAZEPIN -DERIVATEN ALS EUKEPHALINASE UND ACE-INHIBITOREN
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5298492A (en) * 1992-08-04 1994-03-29 Schering Corporation Diamino acid derivatives as antihypertensives
DE69326474T2 (de) * 1992-08-24 2000-02-17 Merrell Pharma Inc Neue 2-substituierte tricyclische derivate von indan-2-mercaptoacetylamid verwendbar als enkephalinase inhibitoren
US5208236A (en) * 1992-09-23 1993-05-04 Schering Corporation N-(acylaminomethyl)glutaryl amino acids and use
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
PT669936E (pt) * 1992-10-30 2001-04-30 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
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US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5644055A (en) * 1993-06-30 1997-07-01 Ciba-Geigy Corporation Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ACE
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US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
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WO1995021840A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
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US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
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ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
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Also Published As

Publication number Publication date
PT99267B (pt) 1999-04-30
ATE161536T1 (de) 1998-01-15
HU913282D0 (en) 1992-01-28
JPH04282382A (ja) 1992-10-07
CN1036590C (zh) 1997-12-03
HU210008B (en) 1995-01-30
FI914905A0 (fi) 1991-10-17
CN1058013C (zh) 2000-11-01
AU8581991A (en) 1992-04-30
PT99267A (pt) 1992-08-31
KR100372491B1 (ko) 2003-05-27
IL99769A0 (en) 1992-08-18
FI95255B (fi) 1995-09-29
NO914092D0 (no) 1991-10-17
CN1166490A (zh) 1997-12-03
CN1061971A (zh) 1992-06-17
EP0481522B1 (de) 1997-12-29
DE69128516D1 (de) 1998-02-05
NO914092L (no) 1992-04-21
HUT63419A (en) 1993-08-30
DE69128516T2 (de) 1998-07-23
FI95255C (fi) 1996-01-10
FI943363A (fi) 1994-07-14
DK0481522T3 (da) 1998-03-09
FI96691B (fi) 1996-04-30
KR920008040A (ko) 1992-05-27
GR3026222T3 (en) 1998-05-29
JP3181335B2 (ja) 2001-07-03
EP0481522A1 (de) 1992-04-22
FI96691C (fi) 1996-08-12
FI914905A (fi) 1992-04-19
AU642535B2 (en) 1993-10-21
IE913648A1 (en) 1992-04-22
NO180718C (no) 1997-06-04
NO180718B (no) 1997-02-24
NZ240230A (en) 1993-01-27
FI943363A0 (fi) 1994-07-14
CA2053340A1 (en) 1992-04-19
CA2053340C (en) 2002-04-02
ES2114870T3 (es) 1998-06-16

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