IL99183A0 - Water soluble derivatives of taxol,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Water soluble derivatives of taxol,processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL99183A0
IL99183A0 IL99183A IL9918391A IL99183A0 IL 99183 A0 IL99183 A0 IL 99183A0 IL 99183 A IL99183 A IL 99183A IL 9918391 A IL9918391 A IL 9918391A IL 99183 A0 IL99183 A0 IL 99183A0
Authority
IL
Israel
Prior art keywords
taxol
processes
preparation
pharmaceutical compositions
same
Prior art date
Application number
IL99183A
Other languages
English (en)
Original Assignee
Virginia Tech Intell Prop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intell Prop filed Critical Virginia Tech Intell Prop
Publication of IL99183A0 publication Critical patent/IL99183A0/xx
Priority to IL103675A priority Critical patent/IL103675A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL99183A 1990-08-28 1991-08-14 Water soluble derivatives of taxol,processes for the preparation thereof and pharmaceutical compositions containing the same IL99183A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL103675A IL103675A0 (en) 1991-08-14 1992-11-06 Water soluble derivatives of taxol,processes for the preparation thereof and pharmaceutical compositions containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/573,731 US5059699A (en) 1990-08-28 1990-08-28 Water soluble derivatives of taxol

Publications (1)

Publication Number Publication Date
IL99183A0 true IL99183A0 (en) 1992-07-15

Family

ID=24293168

Family Applications (1)

Application Number Title Priority Date Filing Date
IL99183A IL99183A0 (en) 1990-08-28 1991-08-14 Water soluble derivatives of taxol,processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (24)

Country Link
US (2) US5059699A (cs)
EP (1) EP0473326A1 (cs)
JP (1) JPH0699410B2 (cs)
KR (1) KR0132157B1 (cs)
CN (1) CN1059337A (cs)
AU (2) AU645340B2 (cs)
CA (1) CA2049160C (cs)
CS (1) CS263291A3 (cs)
EG (1) EG19914A (cs)
FI (1) FI913651A7 (cs)
HU (1) HU210326B (cs)
IE (1) IE913015A1 (cs)
IL (1) IL99183A0 (cs)
MX (2) MX9100832A (cs)
MY (1) MY107794A (cs)
NO (1) NO913007L (cs)
NZ (1) NZ239377A (cs)
OA (1) OA10035A (cs)
PL (4) PL166213B1 (cs)
PT (1) PT98787A (cs)
RU (2) RU2059630C1 (cs)
TW (1) TW209214B (cs)
YU (1) YU144891A (cs)
ZA (1) ZA916450B (cs)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469868A (en) * 1982-05-24 1984-09-04 Warner-Lambert Company Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5475120A (en) * 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5430160A (en) * 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5250683A (en) * 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
AU2333892A (en) * 1992-01-31 1993-09-01 Trustees Of Columbia University In The City Of New York, The Taxol as a radiation sensitizer
US6080777A (en) * 1992-01-31 2000-06-27 The Trustees Of Columbia University In The City Of New York Taxol as a radiation sensitizer
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
IT1254515B (it) * 1992-03-06 1995-09-25 Indena Spa Tassani di interesse oncologico, loro metodo di preparazione ed uso
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
WO1993024476A1 (en) * 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5364947A (en) * 1992-07-02 1994-11-15 Hauser Chemical Research, Inc. Process for separating cephalomannine from taxol using ozone and water-soluble hydrazines or hydrazides
US5470866A (en) * 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US5789189A (en) * 1993-09-24 1998-08-04 The Regents Of The University Of California Inhibition of cyst formation by cytoskeletal specific drugs
FR2697019B1 (fr) * 1992-10-15 1994-11-25 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5411984A (en) * 1992-10-16 1995-05-02 Virginia Tech Intellectual Properties, Inc. Water soluble analogs and prodrugs of taxol
AU5735094A (en) * 1992-12-02 1994-06-22 Thomas Jefferson University Methods of killing protozoal parasites
US5356927A (en) * 1992-12-02 1994-10-18 Thomas Jefferson University Methods of treating plasmodium and babesia parasitic infections
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
HU222175B1 (hu) * 1992-12-23 2003-04-28 Bristol-Myers Squibb Co. Oldalláncot hordozó taxánszármazékok és eljárások előállításukra
RU2136673C1 (ru) * 1992-12-24 1999-09-10 Бристоль-Мейерз Сквибб Компани Фосфонооксиметиловые эфиры таксановых производных, промежуточные соединения, противоопухолевая фармацевтическая композиция, способ ингибирования роста опухоли у млекопитающих
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US20030068362A1 (en) * 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
CN1245156C (zh) * 1993-02-22 2006-03-15 美国生物科学有限公司 用于体内传送生物制品的方法及用于该方法的组合物
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
EP0687260B1 (en) * 1993-03-05 2003-02-19 Florida State University Process for the preparation of 9-desoxotaxanes
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
WO1994020089A1 (en) * 1993-03-09 1994-09-15 Enzon, Inc. Taxol-based compositions with enhanced bioactivity
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
US5336684A (en) * 1993-04-26 1994-08-09 Hauser Chemical Research, Inc. Oxidation products of cephalomannine
HU213200B (en) * 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
DK0703909T3 (da) * 1993-06-11 2000-09-11 Upjohn Co Delta6,7-taxoler, antineoplastisk anvendelse og farmaceutiske præparater indeholdende dem
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
EP0727992A4 (en) * 1993-10-20 2001-01-31 Enzon Inc SUBSTITUTED TAXOID SUBSTANCES IN 2 'AND / OR 7' POSITION
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
WO1995018798A1 (en) * 1994-01-11 1995-07-13 The Scripps Research Institute Chemical switching of taxo-diterpenoids between low solubility active forms and high solubility inactive forms
US5731334A (en) * 1994-01-11 1998-03-24 The Scripps Research Institute Method for treating cancer using taxoid onium salt prodrugs
ATE220322T1 (de) 1994-01-11 2002-07-15 Scripps Research Inst Sich selbst bildende taxo-diterpenoid nanostrukturen
JP3778928B2 (ja) * 1994-01-11 2006-05-24 ザ スクリップス リサーチ インスティチュート タキソ−ジテルペノイドの水溶性オニウム塩
IL127597A (en) * 1994-01-28 2003-07-31 Upjohn Co Iso-taxol analogs
GB9405400D0 (en) * 1994-03-18 1994-05-04 Erba Carlo Spa Taxane derivatives
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
US6458976B1 (en) 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
WO1996013495A1 (en) * 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5489589A (en) * 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
EP1229030B1 (en) * 1995-09-12 2005-11-09 Zeneus Pharma Limited Hydrolysis-promoting taxane hydrophobic derivates
NZ318300A (en) * 1995-09-12 1999-08-30 Liposome Co Inc Hydrolysis-promoting taxane hydrophobic derivatives
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
US5840748A (en) * 1995-10-02 1998-11-24 Xechem International, Inc. Dihalocephalomannine and methods of use therefor
US5854278A (en) * 1995-12-13 1998-12-29 Xechem International, Inc. Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
EP0932399B1 (en) 1996-03-12 2006-01-04 PG-TXL Company, L.P. Water soluble paclitaxel prodrugs
EP0927175A4 (en) 1996-05-06 2002-05-22 Univ Florida State 1-DEOXYBACCATIN III, 1-DEOXYTAXOL AND 1-DEOXYTAXOL ANALOG AND METHOD FOR THE PRODUCTION THEREOF
US5696152A (en) * 1996-05-07 1997-12-09 Wisconsin Alumni Research Foundation Taxol composition for use as organ preservation and cardioplegic agents
IT1283633B1 (it) * 1996-05-10 1998-04-23 Indena Spa Derivati tassanici loro sintesi e formulazioni che li contengono
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
GB9705903D0 (en) 1997-03-21 1997-05-07 Elliott Gillian D VP22 Proteins and uses thereof
SG165156A1 (en) 1997-06-27 2010-10-28 Abraxis Bioscience Llc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
DK1023050T3 (da) * 1997-06-27 2013-10-14 Abraxis Bioscience Llc Nye formuleringer af farmakologiske midler, fremgangsmåder til fremstillingen deraf og fremgangsmåder til anvendelsen deraf
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
JP2002523407A (ja) * 1998-08-21 2002-07-30 ファルマヘミー ベー.フェー. パクリタキセルの水溶性類似体およびプロドラッグ
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
CN1088703C (zh) * 1999-09-17 2002-08-07 漆又毛 水溶性紫杉醇衍生物
US20030054977A1 (en) * 1999-10-12 2003-03-20 Cell Therapeutics, Inc. Manufacture of polyglutamate-therapeutic agent conjugates
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US20020077290A1 (en) * 2000-03-17 2002-06-20 Rama Bhatt Polyglutamic acid-camptothecin conjugates and methods of preparation
CN1098846C (zh) * 2000-04-20 2003-01-15 复旦大学 紫杉醇的多羟基水溶性衍生物及其制备方法
US6395771B1 (en) * 2000-05-31 2002-05-28 Dabur Research Foundation Paclitaxel derivatives for the treatment of cancer
AU2001288805A1 (en) 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
AU2002240755B2 (en) * 2001-03-13 2007-07-05 Angiotech International Ag Micellar drug delivery vehicles and uses thereof
US8552054B2 (en) * 2001-03-23 2013-10-08 Luitpold Pharmaceuticals, Inc. Fatty amine drug conjugates
EP1423107B1 (en) * 2001-03-23 2012-05-09 Luitpold Pharmaceuticals, Inc. Fatty alcohol drug conjugates
DK1392254T3 (da) 2001-04-20 2007-07-02 Univ British Columbia Micelle-lægemiddelindgivelsessystem for hydrofobe lægemidler
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
EP1451168A4 (en) * 2001-11-30 2005-08-24 Bristol Myers Squibb Co PACLITAXELSOLVATE
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
US7846940B2 (en) * 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US8003122B2 (en) 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US7989490B2 (en) * 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US20070073385A1 (en) * 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
EP2043704B2 (en) 2006-06-30 2017-04-19 Cook Medical Technologies LLC Methods of manufacturing and modifying taxane coatings for implantable medical devices
US20080241215A1 (en) * 2007-03-28 2008-10-02 Robert Falotico Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke
US8409601B2 (en) * 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
US8420110B2 (en) 2008-03-31 2013-04-16 Cordis Corporation Drug coated expandable devices
AU2009234127B2 (en) * 2008-04-10 2015-04-30 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
US8273404B2 (en) * 2008-05-19 2012-09-25 Cordis Corporation Extraction of solvents from drug containing polymer reservoirs
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US9198968B2 (en) 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
CA2803646A1 (en) 2010-07-02 2012-01-05 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
US20120303115A1 (en) 2011-05-25 2012-11-29 Dadino Ronald C Expandable devices coated with a rapamycin composition
US20120302954A1 (en) 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
SI2833905T1 (en) 2012-04-04 2018-08-31 Halozyme, Inc. Combination therapy with hyaluronidase and tumane-directed taxane
CN103044363B (zh) * 2012-04-17 2015-04-22 湘北威尔曼制药股份有限公司 紫杉醇衍生物及其制备与应用
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
WO2015018380A2 (en) 2014-07-03 2015-02-12 Cspc Zhongqi Pharmaceutical Technology(Shijiazhuang)Co., Ltd. Therapeutic nanoparticles and the preparation methods thereof
KR20180058759A (ko) 2015-09-25 2018-06-01 제트와이 테라퓨틱스 인코포레이티드 폴리사카라이드-비타민 접합체를 포함하는 미립자를 기재로 하는 약물 제제
CN106800542A (zh) * 2016-12-31 2017-06-06 辰欣药业股份有限公司 一种亲水性紫杉醇类化合物及其制备方法
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
CN115385875B (zh) * 2022-07-18 2023-06-13 中国药科大学 一类紫杉醇衍生物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof

Also Published As

Publication number Publication date
US5059699A (en) 1991-10-22
PL166213B1 (pl) 1995-04-28
NZ239377A (en) 1993-09-27
PL166242B1 (pl) 1995-04-28
PL295892A1 (en) 1993-03-08
FI913651A0 (fi) 1991-07-31
PL291546A1 (en) 1993-01-25
RU2043346C1 (ru) 1995-09-10
KR920004370A (ko) 1992-03-27
PL166224B1 (pl) 1995-04-28
IE913015A1 (en) 1992-03-11
ZA916450B (en) 1994-09-26
YU144891A (sh) 1994-01-20
EG19914A (en) 1996-06-30
RU2059630C1 (ru) 1996-05-10
TW209214B (cs) 1993-07-11
NO913007D0 (no) 1991-08-01
EP0473326A1 (en) 1992-03-04
HU912755D0 (en) 1992-01-28
HU210326B (en) 1995-03-28
AU8274591A (en) 1992-03-05
MX9100832A (es) 1992-04-01
JPH0699410B2 (ja) 1994-12-07
PL295891A1 (en) 1993-03-08
PT98787A (pt) 1992-07-31
CS263291A3 (en) 1992-05-13
KR0132157B1 (ko) 1998-04-17
AU654085B1 (en) 1994-10-20
MY107794A (en) 1996-06-15
FI913651A7 (fi) 1992-02-29
US5352805A (en) 1994-10-04
MX9205895A (es) 1994-04-29
CA2049160C (en) 1997-11-18
PL295890A1 (en) 1993-03-08
PL166218B1 (pl) 1995-04-28
JPH04230676A (ja) 1992-08-19
AU645340B2 (en) 1994-01-13
OA10035A (en) 1996-10-14
CA2049160A1 (en) 1992-03-01
NO913007L (no) 1992-03-02
CN1059337A (zh) 1992-03-11
HUT59119A (en) 1992-04-28

Similar Documents

Publication Publication Date Title
IL99183A0 (en) Water soluble derivatives of taxol,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0419653A4 (en) Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
IL98393A0 (en) Thiophene derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL96019A0 (en) Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL91360A0 (en) Cyclodextrin derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL100899A0 (en) Beta-amino-alpha-hydroxycarboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL99225A0 (en) 3-amidopyrazole derivatives,their preparation and pharmaceutical compositions containing them
IL100262A0 (en) Alpha-oxoacetamide derivatives,their preparation and pharmaceutical compositions containing them
IL90350A0 (en) Benzopyran derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL98873A0 (en) Benzodiazepine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL97050A0 (en) 4-isoxazolecarboxamide derivatives,pharmaceutical compositions containing them and their preparation
IL92939A0 (en) Thiazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL98542A0 (en) Benzoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL98756A0 (en) Pharmaceutical compositions containing benzeneacetamid derivatives,certain such novel compounds and their preparation
IL99393A0 (en) Thiazolidine derivatives,methods for the preparation thereof and pharmaceutical composition containing the same
IL92425A0 (en) Alpha-d-glucofuranose derivatives,pharmaceutical compositions containing the same and processes for the preparation thereof
NZ238864A (en) Heterocyclically-substituted oxazole derivatives, preparation and pharmaceutical compositions thereof
HUT67014A (en) Benzofuran derivatives, pharmaceutical compositions containing them and process for the preparation of thereof
IL88903A0 (en) Indolylpiperidine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL107358A0 (en) a-Phosphonosulfonate derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same
IL95548A0 (en) Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
IL97931A0 (en) Pyridazine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL93321A0 (en) Acetamide derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
GB9123353D0 (en) New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
IL102116A0 (en) Hetaryloxy-beta-carboline derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same