IL98393A0 - Thiophene derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents
Thiophene derivatives,processes for the preparation thereof and pharmaceutical compositions containing the sameInfo
- Publication number
- IL98393A0 IL98393A0 IL98393A IL9839391A IL98393A0 IL 98393 A0 IL98393 A0 IL 98393A0 IL 98393 A IL98393 A IL 98393A IL 9839391 A IL9839391 A IL 9839391A IL 98393 A0 IL98393 A0 IL 98393A0
- Authority
- IL
- Israel
- Prior art keywords
- processes
- preparation
- same
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/12—Radicals substituted by halogen atoms or nitro or nitroso radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909012936A GB9012936D0 (en) | 1990-06-11 | 1990-06-11 | Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
Publications (1)
Publication Number | Publication Date |
---|---|
IL98393A0 true IL98393A0 (en) | 1992-07-15 |
Family
ID=10677388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL98393A IL98393A0 (en) | 1990-06-11 | 1991-06-06 | Thiophene derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0593761A1 (en) |
JP (1) | JPH06501919A (en) |
CN (1) | CN1059142A (en) |
AU (1) | AU7973191A (en) |
GB (1) | GB9012936D0 (en) |
IE (1) | IE911942A1 (en) |
IL (1) | IL98393A0 (en) |
PT (1) | PT97906B (en) |
WO (1) | WO1991019708A1 (en) |
ZA (1) | ZA914241B (en) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06135961A (en) * | 1992-10-23 | 1994-05-17 | Nippon Iyakuhin Kogyo Kk | New diphynelpyrrolylfuran derivative |
US6492413B2 (en) | 1993-01-15 | 2002-12-10 | G.D. Searle & Co. | 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
GB9420616D0 (en) * | 1994-10-12 | 1994-11-30 | Merck Sharp & Dohme | Method, compositions and use |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
EP0739340A1 (en) * | 1994-01-10 | 1996-10-30 | Merck Frosst Canada Inc. | Phenyl heterocycles as cox-2 inhibitors |
JP2636819B2 (en) | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | Oxazole-based heterocyclic aromatic compounds |
FR2730996B1 (en) * | 1995-02-23 | 1997-06-20 | Adir | NOVEL THIOPHENE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
CA2213537A1 (en) * | 1995-02-24 | 1996-08-29 | Kiyomi Tanaka | Phenylamidinothiophene derivatives and anti-inflammatory agent containing the same |
WO1996038418A1 (en) * | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6515014B2 (en) | 1995-06-02 | 2003-02-04 | G. D. Searle & Co. | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
CA2224517A1 (en) * | 1995-06-12 | 1996-12-27 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor |
US5677318A (en) * | 1996-07-11 | 1997-10-14 | Merck Frosst Canada, Inc. | Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents |
FR2752576B1 (en) * | 1996-08-22 | 1999-02-26 | Adir | NOVEL THIOPHENE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
JP3409029B2 (en) * | 1997-10-03 | 2003-05-19 | メルク フロスト カナダ アンド カンパニー | Arylthiophene derivatives as PDEIV inhibitors |
US6034089A (en) * | 1997-10-03 | 2000-03-07 | Merck & Co., Inc. | Aryl thiophene derivatives as PDE IV inhibitors |
US20020183362A1 (en) | 2000-04-25 | 2002-12-05 | Pharmacia Corporation | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation |
JP2002037784A (en) * | 2000-05-17 | 2002-02-06 | Nikken Chem Co Ltd | New thiophenamide compound |
AUPR283801A0 (en) * | 2001-02-01 | 2001-03-01 | Australian National University, The | Chemical compounds and methods |
US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
CN1309717C (en) * | 2003-06-03 | 2007-04-11 | 李小虎 | 4-aryl group-5H-thoifuran-2-ketone derivative, producing method and use thereof |
FR2860792B1 (en) * | 2003-10-10 | 2006-02-24 | Sanofi Synthelabo | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
FR2880023B1 (en) | 2004-12-23 | 2007-02-23 | Sanofi Aventis Sa | N - [(4,5-DIPHENYL-3-ALKYL-2-THIENYL) METHYL] AMINE DERIVATIVES AND THEIR PREPARATION AND THERAPEUTIC USE |
WO2006071940A2 (en) | 2004-12-23 | 2006-07-06 | Deciphera Pharmaceuticals, Llc | Enzyme modulators and treatments |
FR2880890B1 (en) | 2005-01-19 | 2007-03-30 | Sanofi Aventis Sa | N - [(4,5-DIPHENYL-2-THIENYL) METHYL] SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
FR2881744B1 (en) | 2005-02-09 | 2007-04-27 | Sanofi Aventis Sa | N - [(4,5-DIPHENYL-2-THIENYL) METHYL] AMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
WO2007129745A1 (en) | 2006-05-09 | 2007-11-15 | Daiichi Sankyo Company, Limited | Heteroarylamide lower carboxylic acid derivative |
US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
JP2010524970A (en) | 2007-04-20 | 2010-07-22 | デシフェラ ファーマシューティカルズ,エルエルシー | Kinase inhibitors useful for the treatment of myeloproliferative disorders and other proliferative disorders |
DE102008015032A1 (en) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituted pyrazolamides and their use |
DE102008015033A1 (en) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituted (pyrazolyl-carbonyl) imidazolidinones and their use |
FR2934594B1 (en) * | 2008-08-01 | 2010-09-10 | Sanofi Aventis | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
BRPI0920765A2 (en) | 2008-10-29 | 2015-08-18 | Deciphera Pharmaceuticals Llc | Cilopropane amides and analogs that exhibit anticancer and antiproliferative activities |
DE102008062878A1 (en) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituted furancarboxamides and their use |
DE102008062863A1 (en) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituted (thiophenyl-carbonyl) imidazolidinones and their use |
EP2681208B1 (en) * | 2011-03-03 | 2016-05-18 | Denovamed Inc. | Antimicrobial/adjuvant compounds |
JPWO2013146754A1 (en) * | 2012-03-27 | 2015-12-14 | 塩野義製薬株式会社 | Aromatic hetero 5-membered ring derivative having TRPV4 inhibitory activity |
UY34832A (en) | 2012-05-31 | 2013-12-31 | Phenex Pharmaceuticals Ag | TIAZOLS REPLACED BY CARBOXAMIDE OR SULFONAMIDE AND RELATED DERIVATIVES AS MODULATORS FOR THE NURLEAR RECEPTOR HUÉRFANO RORy (lambda) |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
JO3215B1 (en) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | Carboxamide or Sulfonamide Substituted Nitrogen-Containing 5-Membered Heterocycles as Modulators for the Orphan Nuclear Receptor RORy |
US20170266173A1 (en) | 2014-08-25 | 2017-09-21 | Bing Hui Wang | Mapk inhibitors |
CN112166109B (en) * | 2018-03-05 | 2023-09-12 | 德诺瓦姆德有限公司 | Diphenyl-substituted thiophene-2-amide derivatives as antimicrobial agents and pharmaceutical compositions thereof |
TW202122082A (en) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | Methods of treating gastrointestinal stromal tumors |
CA3150433A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
CA3163051A1 (en) | 2019-12-30 | 2021-07-08 | Michael D. Kaufman | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
FI4084778T3 (en) | 2019-12-30 | 2023-12-18 | Deciphera Pharmaceuticals Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4302461A (en) * | 1979-08-09 | 1981-11-24 | E. I. Du Pont De Nemours And Company | Antiinflammatory 5-substituted-2,3-diarylthiophenes |
EP0055471A1 (en) * | 1980-12-29 | 1982-07-07 | E.I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-alpha,alpha-bis(polyhalomethyl)-2-thiophenemethanamines |
US4381311A (en) * | 1980-12-29 | 1983-04-26 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols |
DE3361812D1 (en) * | 1982-03-03 | 1986-02-27 | Du Pont | Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes |
US4432974A (en) * | 1982-03-04 | 1984-02-21 | E. I. Du Pont De Nemours And Company | Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes |
US4749712A (en) * | 1983-03-01 | 1988-06-07 | E. I. Du Pont De Nemours And Company | Antiinflammatory and/or analgesic 5-alkylthiophenes |
-
1990
- 1990-06-11 GB GB909012936A patent/GB9012936D0/en active Pending
-
1991
- 1991-05-31 EP EP91910169A patent/EP0593761A1/en not_active Ceased
- 1991-05-31 JP JP3509612A patent/JPH06501919A/en active Pending
- 1991-05-31 AU AU79731/91A patent/AU7973191A/en not_active Abandoned
- 1991-05-31 WO PCT/JP1991/000744 patent/WO1991019708A1/en not_active Application Discontinuation
- 1991-06-04 ZA ZA914241A patent/ZA914241B/en unknown
- 1991-06-06 IL IL98393A patent/IL98393A0/en unknown
- 1991-06-06 IE IE194291A patent/IE911942A1/en unknown
- 1991-06-07 PT PT97906A patent/PT97906B/en not_active IP Right Cessation
- 1991-06-10 CN CN91104746A patent/CN1059142A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
PT97906A (en) | 1992-03-31 |
EP0593761A1 (en) | 1994-04-27 |
CN1059142A (en) | 1992-03-04 |
PT97906B (en) | 1998-10-30 |
WO1991019708A1 (en) | 1991-12-26 |
JPH06501919A (en) | 1994-03-03 |
IE911942A1 (en) | 1991-12-18 |
AU7973191A (en) | 1992-01-07 |
ZA914241B (en) | 1992-03-25 |
GB9012936D0 (en) | 1990-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC | Change of name of proprietor(s) |