IL99007A - Refined polylactides, their preparation and pharmaceutical preparations containing them - Google Patents

Refined polylactides, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL99007A
IL99007A IL9900791A IL9900791A IL99007A IL 99007 A IL99007 A IL 99007A IL 9900791 A IL9900791 A IL 9900791A IL 9900791 A IL9900791 A IL 9900791A IL 99007 A IL99007 A IL 99007A
Authority
IL
Israel
Prior art keywords
polylactide
pharmaceutical composition
glycolide
purified
solution
Prior art date
Application number
IL9900791A
Other languages
English (en)
Hebrew (he)
Other versions
IL99007A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016840A external-priority patent/GB9016840D0/en
Priority claimed from GB909016882A external-priority patent/GB9016882D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL99007A0 publication Critical patent/IL99007A0/xx
Publication of IL99007A publication Critical patent/IL99007A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
IL9900791A 1990-08-01 1991-07-30 Refined polylactides, their preparation and pharmaceutical preparations containing them IL99007A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016840A GB9016840D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB909016882A GB9016882D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
IL99007A0 IL99007A0 (en) 1992-07-15
IL99007A true IL99007A (en) 1994-12-29

Family

ID=26297417

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9900791A IL99007A (en) 1990-08-01 1991-07-30 Refined polylactides, their preparation and pharmaceutical preparations containing them

Country Status (27)

Country Link
EP (2) EP0469520B1 (zh)
JP (1) JP3137368B2 (zh)
KR (1) KR100255904B1 (zh)
AT (1) AT402503B (zh)
AU (1) AU650277B2 (zh)
CA (1) CA2048200C (zh)
CH (1) CH683772A5 (zh)
CY (1) CY1986A (zh)
DE (1) DE4124468B4 (zh)
DK (2) DK0816413T3 (zh)
ES (2) ES2112259T3 (zh)
FI (2) FI108040B (zh)
FR (1) FR2665453B1 (zh)
GB (1) GB2246573B (zh)
GR (1) GR3026322T3 (zh)
HK (1) HK11797A (zh)
HU (1) HUT59837A (zh)
IE (1) IE66185B1 (zh)
IL (1) IL99007A (zh)
IT (1) IT1252944B (zh)
LU (1) LU87985A1 (zh)
MY (1) MY108621A (zh)
NO (1) NO912960D0 (zh)
NZ (1) NZ239184A (zh)
PH (1) PH31047A (zh)
PT (1) PT98491B (zh)
TW (2) TW282477B (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
JPH06116381A (ja) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc ポリヒドロキシカルボン酸の精製方法
DE4412317A1 (de) * 1993-04-21 1994-10-27 Basf Ag Polylactid mit verbreiterter Molmassenverteilung
US5359026A (en) * 1993-07-30 1994-10-25 Cargill, Incorporated Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) * 1993-09-20 1996-03-05 Mitsui Toatsu Chemicals, Inc. Purification process of aliphatic polyester
WO1995013814A1 (en) * 1993-11-19 1995-05-26 Janssen Pharmaceutica N.V. Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
ZA951877B (en) * 1994-03-07 1996-09-09 Dow Chemical Co Bioactive and/or targeted dendrimer conjugates
WO2000015273A1 (de) 1998-09-11 2000-03-23 Gerhard Schmidmaier Biologisch aktive implantate
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
JP4231781B2 (ja) 2001-07-10 2009-03-04 株式会社クレハ ポリグリコール酸及びその製造方法
FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
EP1450766B1 (fr) * 2001-10-10 2015-04-22 Pierre Fabre Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
AU2013204972B2 (en) * 2002-11-19 2016-04-21 Novartis Ag Pharmaceutical composition comprising octreotide microparticles
GB0226993D0 (en) * 2002-11-19 2002-12-24 Novartis Ag Organic compounds
SI1787658T1 (sl) 2005-11-10 2012-07-31 Chemi Spa Formulacije z trajnim sproščanjem somatostatin analognih inhibitorjev rastnega hormona
CN101193531B (zh) 2006-11-29 2010-12-01 富准精密工业(深圳)有限公司 散热装置
JP5576291B2 (ja) * 2007-12-31 2014-08-20 サムヤン バイオファーマシューティカルズ コーポレイション ポリ（α−ヒドロキシ酸）の疎水性高分子ブロックを含む高純度の両親媒性ブロック共重合体及びその製造方法
CA2756388C (en) * 2009-03-23 2015-10-27 Micell Technologies, Inc. Biodegradable polymers with low acidic impurity
JP5594996B2 (ja) 2009-09-14 2014-09-24 三菱重工業株式会社 航空機の操縦システム
CN102947367B (zh) 2010-06-21 2014-11-12 Lg化学株式会社 具有优异耐热性的聚交酯树脂及其制备方法
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
CN105820332B (zh) * 2015-01-09 2018-06-29 北京化工大学 一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法
US10556999B2 (en) 2016-01-29 2020-02-11 Tolmar, Inc. Purification and decolorization of polymers
US11261293B2 (en) 2017-08-31 2022-03-01 Evonik Corporation Resorbable polymer purification process
GR1009392B (el) * 2017-09-19 2018-10-25 Φαρματεν Αβεε Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467970A (en) * 1975-05-02 1977-03-23 Ici Ltd Purification of polyethers
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
CA1236641A (en) * 1984-07-06 1988-05-10 Motoaki Tanaka Copolymer of lactic acid and glycolic acid and method for producing same
EP0181621B1 (en) * 1984-11-13 1991-09-04 Asahi Kasei Kogyo Kabushiki Kaisha Process for purification of polyalkylene ether
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
JPH0610252B2 (ja) * 1985-08-21 1994-02-09 和光純薬工業株式会社 重合体の製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
EP0452111B1 (en) * 1990-04-13 1998-07-15 Takeda Chemical Industries, Ltd. Biodegradable high-molecular polymers, production and use thereof

Also Published As

Publication number Publication date
FR2665453B1 (fr) 1995-01-27
FI108040B (fi) 2001-11-15
ITRM910553A1 (it) 1993-01-23
GR3026322T3 (en) 1998-06-30
GB2246573B (en) 1994-05-11
KR100255904B1 (ko) 2000-05-01
CA2048200C (en) 1999-06-29
IE912697A1 (en) 1992-02-12
NZ239184A (en) 1994-09-27
DK0469520T3 (da) 1998-09-23
CA2048200A1 (en) 1992-02-02
AU650277B2 (en) 1994-06-16
KR920003990A (ko) 1992-03-27
EP0816413A2 (en) 1998-01-07
FI111268B (fi) 2003-06-30
TW282477B (zh) 1996-08-01
EP0469520B1 (en) 1998-02-25
ES2112259T3 (es) 1998-04-01
JPH0641279A (ja) 1994-02-15
EP0816413B1 (en) 2005-06-08
DE4124468A1 (de) 1992-02-06
GB2246573A (en) 1992-02-05
AU8143091A (en) 1992-02-27
PH31047A (en) 1998-02-03
HU912452D0 (en) 1991-12-30
EP0469520A2 (en) 1992-02-05
IT1252944B (it) 1995-07-05
IL99007A0 (en) 1992-07-15
PT98491B (pt) 1997-12-31
EP0469520A3 (en) 1992-10-07
FR2665453A1 (fr) 1992-02-07
FI913641A0 (fi) 1991-07-30
PT98491A (pt) 1992-06-30
CH683772A5 (de) 1994-05-13
AT402503B (de) 1997-06-25
DK0816413T3 (da) 2005-08-29
ATA151591A (de) 1996-10-15
TW218025B (zh) 1993-12-21
IE66185B1 (en) 1995-12-13
FI20011189A (fi) 2001-06-05
HUT59837A (en) 1992-07-28
HK11797A (en) 1997-02-14
CY1986A (en) 1997-09-05
NO912960D0 (no) 1991-07-30
FI913641A (fi) 1992-02-02
DE4124468B4 (de) 2010-10-28
GB9116396D0 (en) 1991-09-11
JP3137368B2 (ja) 2001-02-19
MY108621A (en) 1996-10-31
ITRM910553A0 (it) 1991-07-23
EP0816413A3 (en) 1998-11-11
ES2243966T3 (es) 2005-12-01
LU87985A1 (fr) 1993-02-15

Similar Documents

Publication Publication Date Title
EP0469520B1 (en) Process for the preparation of pure polylactide.
US6353030B1 (en) Relating to organic compounds
CA2678350C (en) Low-burst poly(lactide-glycolide)
Li et al. Hydrolytic degradation of poly (DL-lactic acid) in the presence of caffeine base
CN1361684A (zh) 能溶解在有机溶剂中的生物可降解的聚环氧烷－聚(对－二噁烷酮)嵌段共聚物及含该共聚物的药物供送组合物
GB1592830A (en) Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
KR101964222B1 (ko) 미셀 안정성이 향상된 양친성 블록 공중합체 조성물 및 이를 포함하는 약학 조성물
EP2692368B1 (en) Biodegradable particle, vascular embolization material and method for producing biodegradable particles
JP7374081B2 (ja) 改善された再吸収性ポリマーの精製方法
NO306068B1 (no) FremgangsmÕte for fremstilling av rene polylaktider
SA91120200B1 (ar) تحضير poylactide وتنقيته
KR930002707B1 (ko) 폴리올 에스테르의 제조방법
Wang Paclitaxel-loaded microspheres incorporated into chitosan and hyaluronic acid films for prevention of post-surgical adhesions

Legal Events

Date Code Title Description
HC Change of name of proprietor(s)
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired