IL97638A - תרכובות והרכבים דו-פונקציונליים, תכשירי רוקחות המכילים אותם ושיטה לטיפול עמהם במחלות נברואימונולוגיותביונקים לא-אנושיים - Google Patents
תרכובות והרכבים דו-פונקציונליים, תכשירי רוקחות המכילים אותם ושיטה לטיפול עמהם במחלות נברואימונולוגיותביונקים לא-אנושייםInfo
- Publication number
- IL97638A IL97638A IL9763891A IL9763891A IL97638A IL 97638 A IL97638 A IL 97638A IL 9763891 A IL9763891 A IL 9763891A IL 9763891 A IL9763891 A IL 9763891A IL 97638 A IL97638 A IL 97638A
- Authority
- IL
- Israel
- Prior art keywords
- oxo
- dihydro
- purin
- ait
- solution
- Prior art date
Links
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- 238000011282 treatment Methods 0.000 claims description 22
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 18
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- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/500,789 US5091432A (en) | 1990-03-28 | 1990-03-28 | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL97638A0 IL97638A0 (en) | 1992-06-21 |
| IL97638A true IL97638A (he) | 1999-03-12 |
Family
ID=23990941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9763891A IL97638A (he) | 1990-03-28 | 1991-03-21 | תרכובות והרכבים דו-פונקציונליים, תכשירי רוקחות המכילים אותם ושיטה לטיפול עמהם במחלות נברואימונולוגיותביונקים לא-אנושיים |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5091432A (he) |
| EP (1) | EP0522082B1 (he) |
| JP (1) | JP3198335B2 (he) |
| KR (1) | KR100194162B1 (he) |
| AT (1) | ATE154880T1 (he) |
| AU (1) | AU7678191A (he) |
| CA (1) | CA2079342C (he) |
| CS (1) | CS85991A3 (he) |
| DE (1) | DE69126701T2 (he) |
| DK (1) | DK0522082T3 (he) |
| ES (1) | ES2104700T3 (he) |
| GR (1) | GR3024904T3 (he) |
| IE (1) | IE81123B1 (he) |
| IL (1) | IL97638A (he) |
| NZ (1) | NZ237574A (he) |
| TW (1) | TW279865B (he) |
| WO (1) | WO1991014434A1 (he) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801184A (en) * | 1994-07-25 | 1998-09-01 | Glasky; Alvin J. | Carbon monoxide dependent guanylyl cyclase modifiers and methods of use |
| US6338963B1 (en) * | 1994-07-25 | 2002-01-15 | Neotherapeutics, Inc. | Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis |
| US5447939A (en) * | 1994-07-25 | 1995-09-05 | Glasky; Alvin J. | Carbon monoxide dependent guanylyl cyclase modifiers and methods of use |
| HUT76294A (en) * | 1994-07-25 | 1997-07-28 | Alvin J Glasky | Use of purine derivatives for preparing co-dependent guanilyl-cyclase modificating pharmaceutical compns. |
| US20020022657A1 (en) * | 1998-02-11 | 2002-02-21 | Francine Gervais | Methods for modulating neuronal cell death |
| AU3786299A (en) * | 1998-05-04 | 1999-11-23 | Neotherapeutics, Inc. | Novel serotonin-like 9-substituted hypoxanthine and methods of use |
| AU3879899A (en) * | 1998-05-04 | 1999-11-23 | Neotherapeutics, Inc. | Novel dopamine-like 9-substituted hypoxanthine and methods of use |
| US6297226B1 (en) * | 1999-10-15 | 2001-10-02 | Neotherapeutics, Inc. | Synthesis and methods of use of 9-substituted guanine derivatives |
| US6288069B1 (en) * | 1999-11-16 | 2001-09-11 | Neotherapeutics, Inc. | Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue |
| DE60033071T2 (de) * | 1999-12-06 | 2007-08-23 | Euro-Celtique S.A. | Triazospiroverbindungen mit nociceptin-rezeptoraffinität |
| US6407237B1 (en) * | 2001-02-21 | 2002-06-18 | Neotherapeutics, Inc. | Crystal forms of 9-substituted hypoxanthine derivatives |
| US6849735B1 (en) * | 2000-06-23 | 2005-02-01 | Merck Eprova Ag | Methods of synthesis for 9-substituted hypoxanthine derivatives |
| US20020040031A1 (en) * | 2000-07-07 | 2002-04-04 | Glasky Michelle S. | Methods for prevention of accumulation of amyloid beta peptide in the central nervous system |
| US20020040032A1 (en) * | 2000-07-07 | 2002-04-04 | Glasky Michelle S. | Methods for stimulation of synthesis of synaptophysin in the central nervous system |
| US20020128264A1 (en) * | 2000-07-07 | 2002-09-12 | Taylor Eve M. | Methods for treatment of conditions affected by activity of multidrug transporters |
| EP1790344B1 (en) * | 2000-07-07 | 2011-02-23 | Spectrum Pharmaceuticals, Inc. | Methods for treatment of disease-induced peripheral neuropathy and related conditions |
| US20020091133A1 (en) * | 2000-12-12 | 2002-07-11 | Eve M. Taylor | Use of 9-substituted purine analogues and other molecules to stimulate neurogenesis |
| US20020156277A1 (en) * | 2001-04-20 | 2002-10-24 | Fick David B. | Synthesis and methods of use of purine analogues and derivatives |
| US6759427B2 (en) * | 2001-04-20 | 2004-07-06 | Spectrum Pharmaceuticals, Inc. | Synthesis and methods of use of tetrahydroindolone analogues and derivatives |
| US20030055249A1 (en) * | 2001-07-17 | 2003-03-20 | Fick David B. | Synthesis and methods of use of pyrimidine analogues and derivatives |
| US6906190B2 (en) * | 2002-01-04 | 2005-06-14 | Ribapharm Inc. | Inhibitors for de novo-RNA polymerases and methods of identifying targets for same |
| JP2007509898A (ja) | 2003-11-03 | 2007-04-19 | プロビオドルグ エージー | 神経障害治療に有用な組合せ |
| US7473728B2 (en) * | 2004-12-16 | 2009-01-06 | The Goodyear Tire & Rubber Company | Dual phase rubber composition and tire with nanocomposite-containing sidewall thereof |
| US8044100B2 (en) | 2004-12-22 | 2011-10-25 | Bellus Health Inc. | Methods and compositions for treating amyloid-related diseases |
| ES2352801T3 (es) * | 2005-12-22 | 2011-02-23 | Kiacta Sàrl | Tratamiento de nefropatía diabética. |
| CA2830727C (en) | 2006-10-12 | 2016-11-29 | Bhi Limited Partnership | Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid |
| CA2673022A1 (en) * | 2006-12-22 | 2008-07-03 | Bellus Health (International) Limited | Methods, compounds, and compositions for treating metabolic disorders and diabetes |
| ES2916805T3 (es) | 2012-11-21 | 2022-07-06 | Zoetis Services Llc | Síntesis de derivados de isoxazolina espirocíclicos |
| CN115521306B (zh) * | 2022-09-26 | 2024-03-26 | 贵州大学 | 一种1,2,3,4-四氢-β-咔啉衍生物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3321369A (en) * | 1965-05-26 | 1967-05-23 | Abbott Lab | Method of enhancing learning rate and retention level in warm blooded animals |
| US3484521A (en) * | 1966-06-23 | 1969-12-16 | Int Chem & Nuclear Corp | Enhancement of memory processes in mammals with basic addition salts of ribonucleic acid |
| US4221909A (en) * | 1978-09-15 | 1980-09-09 | Sloan-Kettering Institute For Cancer Research | P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines |
| US4221910A (en) * | 1978-09-15 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | 9-(Hydroxy alkyl)purines |
| US4221794A (en) * | 1979-06-21 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | Method of imparting immunomodulating and antiviral activity |
| IL64501A (en) * | 1980-12-22 | 1985-07-31 | Astra Laekemedel Ab | 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use |
| US4728605A (en) * | 1984-07-31 | 1988-03-01 | Fudenberg Herman H | Methods for recognizing and diagnosing subsets of Alzheimer's disease associated with immune system dysfunction, and for the in vitro testing of possible therapeutic agents for treatment of same |
| US4952693A (en) * | 1984-10-12 | 1990-08-28 | Warner-Lambert Company | Oxazolo-pyrimidine derivatives |
-
1990
- 1990-03-28 US US07/500,789 patent/US5091432A/en not_active Expired - Lifetime
-
1991
- 1991-03-21 IL IL9763891A patent/IL97638A/he not_active IP Right Cessation
- 1991-03-26 IE IE99491A patent/IE81123B1/en not_active IP Right Cessation
- 1991-03-26 NZ NZ237574A patent/NZ237574A/xx unknown
- 1991-03-26 AU AU76781/91A patent/AU7678191A/en not_active Abandoned
- 1991-03-26 AT AT91908058T patent/ATE154880T1/de not_active IP Right Cessation
- 1991-03-26 ES ES91908058T patent/ES2104700T3/es not_active Expired - Lifetime
- 1991-03-26 CA CA002079342A patent/CA2079342C/en not_active Expired - Fee Related
- 1991-03-26 EP EP91908058A patent/EP0522082B1/en not_active Expired - Lifetime
- 1991-03-26 DK DK91908058.0T patent/DK0522082T3/da active
- 1991-03-26 KR KR1019920702359A patent/KR100194162B1/ko not_active Expired - Fee Related
- 1991-03-26 WO PCT/US1991/002066 patent/WO1991014434A1/en not_active Ceased
- 1991-03-26 JP JP50760291A patent/JP3198335B2/ja not_active Expired - Fee Related
- 1991-03-26 DE DE69126701T patent/DE69126701T2/de not_active Expired - Fee Related
- 1991-03-27 TW TW080102367A patent/TW279865B/zh active
- 1991-03-28 CS CS91859A patent/CS85991A3/cs unknown
-
1997
- 1997-10-01 GR GR970402551T patent/GR3024904T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0522082B1 (en) | 1997-07-02 |
| JPH05508390A (ja) | 1993-11-25 |
| ES2104700T3 (es) | 1997-10-16 |
| IE910994A1 (en) | 1991-10-09 |
| TW279865B (he) | 1996-07-01 |
| WO1991014434A1 (en) | 1991-10-03 |
| US5091432A (en) | 1992-02-25 |
| DE69126701T2 (de) | 1997-12-04 |
| IE81123B1 (en) | 2000-03-22 |
| KR100194162B1 (ko) | 1999-06-15 |
| JP3198335B2 (ja) | 2001-08-13 |
| EP0522082A1 (en) | 1993-01-13 |
| DE69126701D1 (de) | 1997-08-07 |
| CA2079342A1 (en) | 1991-09-29 |
| EP0522082A4 (en) | 1993-06-09 |
| ATE154880T1 (de) | 1997-07-15 |
| CS85991A3 (en) | 1992-02-19 |
| DK0522082T3 (da) | 1997-07-21 |
| NZ237574A (en) | 1993-09-27 |
| CA2079342C (en) | 2001-10-23 |
| GR3024904T3 (en) | 1998-01-30 |
| IL97638A0 (en) | 1992-06-21 |
| AU7678191A (en) | 1991-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |