DE69126701T2 - Multifunktionelle pharmazeutische verbindungen und verfahren zu ihrer verwendung - Google Patents

Multifunktionelle pharmazeutische verbindungen und verfahren zu ihrer verwendung

Info

Publication number
DE69126701T2
DE69126701T2 DE69126701T DE69126701T DE69126701T2 DE 69126701 T2 DE69126701 T2 DE 69126701T2 DE 69126701 T DE69126701 T DE 69126701T DE 69126701 T DE69126701 T DE 69126701T DE 69126701 T2 DE69126701 T2 DE 69126701T2
Authority
DE
Germany
Prior art keywords
compounds
novel
treating
pharmaceutical compounds
multifunctional pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69126701T
Other languages
English (en)
Other versions
DE69126701D1 (de
Inventor
Alvin J Glasky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69126701D1 publication Critical patent/DE69126701D1/de
Application granted granted Critical
Publication of DE69126701T2 publication Critical patent/DE69126701T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
DE69126701T 1990-03-28 1991-03-26 Multifunktionelle pharmazeutische verbindungen und verfahren zu ihrer verwendung Expired - Fee Related DE69126701T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/500,789 US5091432A (en) 1990-03-28 1990-03-28 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
PCT/US1991/002066 WO1991014434A1 (en) 1990-03-28 1991-03-26 Multi-functional pharmaceutical compounds and methods of use

Publications (2)

Publication Number Publication Date
DE69126701D1 DE69126701D1 (de) 1997-08-07
DE69126701T2 true DE69126701T2 (de) 1997-12-04

Family

ID=23990941

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69126701T Expired - Fee Related DE69126701T2 (de) 1990-03-28 1991-03-26 Multifunktionelle pharmazeutische verbindungen und verfahren zu ihrer verwendung

Country Status (17)

Country Link
US (1) US5091432A (de)
EP (1) EP0522082B1 (de)
JP (1) JP3198335B2 (de)
KR (1) KR100194162B1 (de)
AT (1) ATE154880T1 (de)
AU (1) AU7678191A (de)
CA (1) CA2079342C (de)
CS (1) CS85991A3 (de)
DE (1) DE69126701T2 (de)
DK (1) DK0522082T3 (de)
ES (1) ES2104700T3 (de)
GR (1) GR3024904T3 (de)
IE (1) IE81123B1 (de)
IL (1) IL97638A (de)
NZ (1) NZ237574A (de)
TW (1) TW279865B (de)
WO (1) WO1991014434A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10504814A (ja) * 1994-07-25 1998-05-12 ジェイ． グラスキー，アルヴィン 一酸化炭素依存性グアニリルシクラーゼ修飾因子
US5447939A (en) * 1994-07-25 1995-09-05 Glasky; Alvin J. Carbon monoxide dependent guanylyl cyclase modifiers and methods of use
US6338963B1 (en) * 1994-07-25 2002-01-15 Neotherapeutics, Inc. Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis
US5801184A (en) * 1994-07-25 1998-09-01 Glasky; Alvin J. Carbon monoxide dependent guanylyl cyclase modifiers and methods of use
US20020022657A1 (en) * 1998-02-11 2002-02-21 Francine Gervais Methods for modulating neuronal cell death
AU3879899A (en) * 1998-05-04 1999-11-23 Neotherapeutics, Inc. Novel dopamine-like 9-substituted hypoxanthine and methods of use
AU3786299A (en) * 1998-05-04 1999-11-23 Neotherapeutics, Inc. Novel serotonin-like 9-substituted hypoxanthine and methods of use
US6297226B1 (en) * 1999-10-15 2001-10-02 Neotherapeutics, Inc. Synthesis and methods of use of 9-substituted guanine derivatives
US6288069B1 (en) 1999-11-16 2001-09-11 Neotherapeutics, Inc. Use of 9-substituted hypoxanthine derivatives to stimulate regeneration of nervous tissue
DE60033071T2 (de) * 1999-12-06 2007-08-23 Euro-Celtique S.A. Triazospiroverbindungen mit nociceptin-rezeptoraffinität
US6407237B1 (en) * 2001-02-21 2002-06-18 Neotherapeutics, Inc. Crystal forms of 9-substituted hypoxanthine derivatives
US6849735B1 (en) 2000-06-23 2005-02-01 Merck Eprova Ag Methods of synthesis for 9-substituted hypoxanthine derivatives
US20020040032A1 (en) * 2000-07-07 2002-04-04 Glasky Michelle S. Methods for stimulation of synthesis of synaptophysin in the central nervous system
US20020040031A1 (en) * 2000-07-07 2002-04-04 Glasky Michelle S. Methods for prevention of accumulation of amyloid beta peptide in the central nervous system
AU2001271867A1 (en) * 2000-07-07 2002-01-21 Neotherapeutics, Inc. Methods for treatment of conditions affected by activity of multidrug transporters
DK1790344T3 (da) * 2000-07-07 2011-05-02 Spectrum Pharmaceuticals Inc Fremgangsmåder til behandling af sygdomsfremkaldt perifer neuropati og beslægtede tilstande
WO2002058736A2 (en) * 2000-12-12 2002-08-01 Neotherapetics, Inc. Use of 9-substituted purine analogues and other molecules to stimulate neurogenesis
US20020156277A1 (en) * 2001-04-20 2002-10-24 Fick David B. Synthesis and methods of use of purine analogues and derivatives
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
US20030055249A1 (en) * 2001-07-17 2003-03-20 Fick David B. Synthesis and methods of use of pyrimidine analogues and derivatives
US6906190B2 (en) * 2002-01-04 2005-06-14 Ribapharm Inc. Inhibitors for de novo-RNA polymerases and methods of identifying targets for same
ZA200603165B (en) 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
US7473728B2 (en) * 2004-12-16 2009-01-06 The Goodyear Tire & Rubber Company Dual phase rubber composition and tire with nanocomposite-containing sidewall thereof
AU2005326962A1 (en) 2004-12-22 2006-08-17 Bellus Health (International) Limited Methods and compositions for treating amyloid-related diseases
DE602006016990D1 (de) * 2005-12-22 2010-10-28 Bellus Health Int Ltd Behandlung von diabetischer nephropathie
WO2009019534A2 (en) * 2006-10-12 2009-02-12 Bellus Health (International) Limited Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
EP2120905A1 (de) * 2006-12-22 2009-11-25 BELLUS Health (International) Limited Verfahren, verbindungen und zusammensetzungen zur behandlung von stoffwechselerkrankungen und diabetes
US9593126B2 (en) 2012-11-21 2017-03-14 Zoetis Services Llc Synthesis of spirocyclic isoxazoline derivatives
CN115521306B (zh) * 2022-09-26 2024-03-26 贵州大学 一种1,2,3,4-四氢-β-咔啉衍生物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3321369A (en) * 1965-05-26 1967-05-23 Abbott Lab Method of enhancing learning rate and retention level in warm blooded animals
US3438968A (en) * 1966-06-23 1969-04-15 Int Chem & Nuclear Corp Substituted ammonium basic addition salts of ribonucleic acid
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4221909A (en) * 1978-09-15 1980-09-09 Sloan-Kettering Institute For Cancer Research P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4728605A (en) * 1984-07-31 1988-03-01 Fudenberg Herman H Methods for recognizing and diagnosing subsets of Alzheimer's disease associated with immune system dysfunction, and for the in vitro testing of possible therapeutic agents for treatment of same
US4952693A (en) * 1984-10-12 1990-08-28 Warner-Lambert Company Oxazolo-pyrimidine derivatives

Also Published As

Publication number Publication date
ES2104700T3 (es) 1997-10-16
CA2079342C (en) 2001-10-23
DE69126701D1 (de) 1997-08-07
CS85991A3 (en) 1992-02-19
IL97638A0 (en) 1992-06-21
ATE154880T1 (de) 1997-07-15
KR100194162B1 (ko) 1999-06-15
EP0522082A1 (de) 1993-01-13
EP0522082B1 (de) 1997-07-02
TW279865B (de) 1996-07-01
AU7678191A (en) 1991-10-21
JP3198335B2 (ja) 2001-08-13
DK0522082T3 (da) 1997-07-21
WO1991014434A1 (en) 1991-10-03
GR3024904T3 (en) 1998-01-30
IE81123B1 (en) 2000-03-22
CA2079342A1 (en) 1991-09-29
EP0522082A4 (en) 1993-06-09
NZ237574A (en) 1993-09-27
JPH05508390A (ja) 1993-11-25
US5091432A (en) 1992-02-25
IL97638A (en) 1999-03-12
IE910994A1 (en) 1991-10-09

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