IL97592A - Tetraazacyclododecane butyltriol derivatives processes for the production thereof and pharmaceutical compositions containing the same - Google Patents

Tetraazacyclododecane butyltriol derivatives processes for the production thereof and pharmaceutical compositions containing the same

Info

Publication number
IL97592A
IL97592A IL9759291A IL9759291A IL97592A IL 97592 A IL97592 A IL 97592A IL 9759291 A IL9759291 A IL 9759291A IL 9759291 A IL9759291 A IL 9759291A IL 97592 A IL97592 A IL 97592A
Authority
IL
Israel
Prior art keywords
compound
tetraazacyclododecane
triscarboxymethyl
hydroxymethyl
metal ion
Prior art date
Application number
IL9759291A
Other languages
English (en)
Other versions
IL97592A0 (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL97592A0 publication Critical patent/IL97592A0/xx
Publication of IL97592A publication Critical patent/IL97592A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL9759291A 1990-03-19 1991-03-19 Tetraazacyclododecane butyltriol derivatives processes for the production thereof and pharmaceutical compositions containing the same IL97592A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4009119A DE4009119A1 (de) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (2)

Publication Number Publication Date
IL97592A0 IL97592A0 (en) 1992-06-21
IL97592A true IL97592A (en) 1995-10-31

Family

ID=6402765

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9759291A IL97592A (en) 1990-03-19 1991-03-19 Tetraazacyclododecane butyltriol derivatives processes for the production thereof and pharmaceutical compositions containing the same

Country Status (17)

Country Link
US (4) US5980864A (sv)
EP (1) EP0448191B1 (sv)
JP (1) JP2968367B2 (sv)
AT (1) ATE124405T1 (sv)
AU (1) AU647091B2 (sv)
CA (1) CA2038493C (sv)
DE (3) DE4009119A1 (sv)
DK (1) DK0448191T3 (sv)
ES (1) ES2074219T3 (sv)
FI (1) FI109695B (sv)
HK (1) HK1002811A1 (sv)
HU (1) HU215964B (sv)
IE (1) IE67643B1 (sv)
IL (1) IL97592A (sv)
NO (2) NO179610C (sv)
NZ (1) NZ237461A (sv)
PT (1) PT97065B (sv)

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DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
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DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
DE19652387A1 (de) * 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
US20080125344A1 (en) * 2006-11-28 2008-05-29 Daryle Hadley Busch Bleach compositions
US20030017941A1 (en) * 1997-03-07 2003-01-23 The Procter & Gamble Company Catalysts and methods for catalytic oxidation
ZA981883B (en) * 1997-03-07 1998-09-01 Univ Kansas Catalysts and methods for catalytic oxidation
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US20050187126A1 (en) * 2002-08-27 2005-08-25 Busch Daryle H. Catalysts and methods for catalytic oxidation
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IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
DE19816370B4 (de) * 1998-04-03 2004-09-09 Schering Ag Substituierte Mangan-D02A-Komplexe, diese enthaltende diagnostische Mittel und ihre Verwendung
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
DE10064467C2 (de) * 2000-12-15 2002-10-31 Schering Ag Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
US7011816B2 (en) * 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
WO2004006934A2 (de) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions
EP1635878B1 (en) * 2003-06-25 2010-12-29 Guerbet Peptide conjugate for magnetic resonance imaging of matrix metalloproteinases
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
CN1993357B (zh) * 2004-07-02 2011-10-19 伯拉考成像股份公司 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
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DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
EP2457594A1 (en) 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
PE20141325A1 (es) 2011-04-21 2014-10-08 Bayer Ip Gmbh Preparacion de gadobutrol de alta pureza
RU2743167C2 (ru) 2015-12-10 2021-02-15 Бракко Имэджинг Спа Контрастные агенты
SI3753929T1 (sl) 2015-12-10 2023-01-31 Bracco Imaging Spa Dimerna kontrastna sredstva
CN108779082B (zh) 2016-04-13 2022-08-02 伯拉考成像股份公司 造影剂
IL265536B (en) 2016-09-27 2022-07-01 Bayer Pharma AG A method for the production of a crystalline form of the a modification of calcobuterol
WO2018069176A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
WO2018069179A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
WO2018108780A1 (en) 2016-12-12 2018-06-21 Bracco Imaging Spa Dimeric contrast agents
EP3392254A1 (en) * 2017-04-20 2018-10-24 Koninklijke Philips N.V. Compounds for use in the diagnosis of a disease
KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
EP3820853A4 (en) * 2018-07-10 2022-08-17 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF 2,2',2''-( 10-((2R,3S)-1,3,4-TRIHYDROXY BUTAN-2-YL)-1,4,7,10-TETRAAZACYCLODODECAN-1,4 ,7-TRIYL)-TRIACETIC ACID AND THEIR COMPLEXES
KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
CN114573521B (zh) * 2020-12-01 2023-10-27 威智医药股份有限公司 一种钆布醇及其中间体的制备方法

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Also Published As

Publication number Publication date
IE910902A1 (en) 1991-09-25
JPH05320146A (ja) 1993-12-03
US20060078503A1 (en) 2006-04-13
NO911063D0 (no) 1991-03-18
PT97065A (pt) 1991-10-31
US6951639B2 (en) 2005-10-04
DE10075007I2 (de) 2003-06-12
HK1002811A1 (en) 1998-09-18
FI109695B (sv) 2002-09-30
CA2038493C (en) 2002-07-02
DK0448191T3 (da) 1995-11-20
ATE124405T1 (de) 1995-07-15
ES2074219T3 (es) 1995-09-01
NZ237461A (en) 1993-12-23
HU910874D0 (en) 1991-09-30
AU647091B2 (en) 1994-03-17
IE67643B1 (en) 1996-04-17
IL97592A0 (en) 1992-06-21
NO179610C (no) 1996-11-13
NO911063L (no) 1991-09-20
DE4009119A1 (de) 1991-09-26
NO179610B (no) 1996-08-05
NO2001003I1 (no) 2001-03-05
AU7361091A (en) 1991-09-19
DE59105815D1 (de) 1995-08-03
EP0448191A1 (de) 1991-09-25
US5980864A (en) 1999-11-09
US20020176823A1 (en) 2002-11-28
EP0448191B1 (de) 1995-06-28
PT97065B (pt) 1998-07-31
FI911330A (fi) 1991-09-20
CA2038493A1 (en) 1991-09-20
HUT60478A (en) 1992-09-28
HU215964B (hu) 1999-03-29
FI911330A0 (fi) 1991-03-19
US6399043B1 (en) 2002-06-04
JP2968367B2 (ja) 1999-10-25

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