IL94566A0 - Monoclonal antibodies for inducing tolerance to an antigen - Google Patents

Monoclonal antibodies for inducing tolerance to an antigen

Info

Publication number
IL94566A0
IL94566A0 IL94566A IL9456690A IL94566A0 IL 94566 A0 IL94566 A0 IL 94566A0 IL 94566 A IL94566 A IL 94566A IL 9456690 A IL9456690 A IL 9456690A IL 94566 A0 IL94566 A0 IL 94566A0
Authority
IL
Israel
Prior art keywords
antigen
monoclonal antibodies
depleting
inducing tolerance
monoclonal antibody
Prior art date
Application number
IL94566A
Other languages
English (en)
Original Assignee
Cobbold Stephen P
Waldmann Herman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cobbold Stephen P, Waldmann Herman filed Critical Cobbold Stephen P
Publication of IL94566A0 publication Critical patent/IL94566A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL94566A 1989-05-31 1990-05-31 Monoclonal antibodies for inducing tolerance to an antigen IL94566A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898912497A GB8912497D0 (en) 1989-05-31 1989-05-31 Monoclonal antibodies

Publications (1)

Publication Number Publication Date
IL94566A0 true IL94566A0 (en) 1991-03-10

Family

ID=10657649

Family Applications (1)

Application Number Title Priority Date Filing Date
IL94566A IL94566A0 (en) 1989-05-31 1990-05-31 Monoclonal antibodies for inducing tolerance to an antigen

Country Status (19)

Country Link
EP (1) EP0474691B1 (pt)
JP (1) JP2763197B2 (pt)
KR (1) KR0183029B1 (pt)
AT (1) ATE145246T1 (pt)
AU (1) AU657255B2 (pt)
CA (1) CA2055615C (pt)
DD (1) DD296843A5 (pt)
DE (1) DE69029134T2 (pt)
DK (1) DK0474691T3 (pt)
ES (1) ES2096588T3 (pt)
GB (1) GB8912497D0 (pt)
HU (1) HUT61341A (pt)
IE (1) IE80735B1 (pt)
IL (1) IL94566A0 (pt)
MY (1) MY135673A (pt)
NZ (1) NZ233889A (pt)
PT (1) PT94214B (pt)
WO (1) WO1990015152A1 (pt)
ZA (1) ZA904174B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100741D0 (en) * 1991-01-14 1991-02-27 Univ London Treatment of disease
US6136310A (en) 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
WO1994004188A1 (en) * 1992-08-21 1994-03-03 Genentech, Inc. Method for treating an lfa-1-mediated disorder
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
WO1996036359A1 (en) * 1995-05-18 1996-11-21 Ortho Pharmaceutical Corporation Induction of immunological tolerance by the use of non-depleting anti-cd4 antibodies
ES2282133T3 (es) 1999-08-24 2007-10-16 Medarex, Inc. Anticuerpos frente a la ctla-4 humano y sus usos.
US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
DE60136272D1 (de) 2000-04-29 2008-12-04 Univ Iowa Res Found Diagnostika und therapeutika für makula degeneration erkrankungen
JP4448906B2 (ja) * 2001-06-14 2010-04-14 イシス イノベーション リミテッド Cd4特異的抗体trx1およびその使用
US7541443B2 (en) * 2001-06-14 2009-06-02 Tolerrx, Inc. Anti-CD4 antibodies
EP1460088A1 (en) 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
GB0314461D0 (en) * 2003-06-20 2003-07-23 Isis Innovation Suppression of transplant rejection
AU2005258276A1 (en) * 2004-06-22 2006-01-05 Tolerrx, Inc. Optimized dosing with anti-CD4 antibodies for tolerance induction in primates
AU2009235622C9 (en) 2008-03-13 2015-07-02 Biotest Ag Agent for treating disease
BRPI0909179A2 (pt) 2008-03-13 2015-08-25 Biotest Ag Composição farmacêutica, e, método de tratamento de uma doença autoimune.
JP5597553B2 (ja) 2008-03-13 2014-10-01 バイオテスト・アクチエンゲゼルシヤフト 疾患治療剤
CN102112491A (zh) * 2008-06-06 2011-06-29 贝勒研究院 抗-cd8抗体阻断细胞毒素效应物的引发并导致调节性cd8+t细胞的产生
TW201016233A (en) * 2008-07-15 2010-05-01 Genentech Inc Methods of treating autoimmune diseases using CD4 antibodies
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies

Also Published As

Publication number Publication date
WO1990015152A1 (en) 1990-12-13
NZ233889A (en) 1997-06-24
DK0474691T3 (da) 1996-12-02
DD296843A5 (de) 1991-12-19
MY135673A (en) 2008-06-30
AU657255B2 (en) 1995-03-09
HU905134D0 (en) 1992-02-28
KR0183029B1 (ko) 1999-04-01
ZA904174B (en) 1992-02-26
IE901949L (en) 1990-11-30
PT94214B (pt) 1997-03-31
GB8912497D0 (en) 1989-07-19
DE69029134D1 (de) 1996-12-19
ATE145246T1 (de) 1996-11-15
ES2096588T3 (es) 1997-03-16
DE69029134T2 (de) 1997-03-06
CA2055615A1 (en) 1990-12-13
PT94214A (pt) 1991-02-08
IE80735B1 (en) 1998-12-30
HUT61341A (en) 1992-12-28
CA2055615C (en) 2001-07-17
JPH04505919A (ja) 1992-10-15
AU5725890A (en) 1991-01-07
EP0474691A1 (en) 1992-03-18
JP2763197B2 (ja) 1998-06-11
EP0474691B1 (en) 1996-11-13

Similar Documents

Publication Publication Date Title
IL94566A0 (en) Monoclonal antibodies for inducing tolerance to an antigen
IL93840A0 (en) Novel monoclonal antibody to novel antigen associated with human tumors
EP0285059A3 (en) Monoclonal antibodies against glycolipid antigens and their use
EP0387286A4 (en) Monoclonal antibody specific to a novel epitope of the lfa-1 antigen of human t lymphocytes
IL74156A (en) Method for the preparation of a monoclonal antibody and of an immortalized cell producing the same and pharmaceutical compositions containing the monoclonal antibody
EP0359063A3 (en) Antibody having high affinity to hapten as antigen and immunogen for obtaining the same
ES2013328A6 (es) Un metodo para detectar anticuerpos contra antigenos hiv-1.
EP0584715A3 (de) Gewinnung und Kultivierung transformierter Zellen und Herstellung gegen sie gerichteter Antikörper.
MY107079A (en) Method of reducing immunoglobulin e responses
EP0335134A3 (en) Mouse monoclonal antibody to human immunodeficiency virus gp41 protein
EP0153871A3 (en) Antibody enhancement of immunogenicity of antigen
GB2254326B (en) Monoclonal antibodies produced by in vitro immunization of lymphocytes
MY107386A (en) Method of preventing or reducing eosinophilia
EP0320866A3 (en) A protective immunodominant epitope included in the s1 subunit of pertussis toxin
CA2054689A1 (en) An immunoassay method for determining the specificity of binding of a monoclonal antibody to an antigen
EP0537168A4 (en) Ctaa 28a32, the antigen recognized by mca 28a32
SE8705137D0 (sv) Diagnostic method for primary biliary cirrhosis and antibodies suitable to be used in certain versions of the method
EP0334076A3 (en) Monoclonal antibody capable of recognizing an antigen associated with human arteriosclerosis, and process for preparing the same
EP0407586A4 (en) Human monoclonal antibody and process for its preparation
IT1254570B (it) Antigeni legati alla superfice esterna di eritrociti e procedimento per la loro preparazione.
GB1155683A (en) New Polyvalent Immunizing Agents and Methods for their Production
AU1508088A (en) Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and methods for use
GB2233559B (en) Antibodies for use in antilymphocyte antibody therapy
BG51731A1 (en) Hybridome cellular line mus musculus balb/c, secreting monoclonal antibody against antigenic deternimant, common for the strains hantaan and finnish of the virus of haemorrhagic fever with nephritic syndrome
MX9707295A (es) Metodo para mejorar la respuesta de los anticuerpos a los antigenos especificos con interleucina-10.