BRPI0909180A2 - composição farmacêutica, e, método de tratamento de uma doença autoimune - Google Patents
composição farmacêutica, e, método de tratamento de uma doença autoimuneInfo
- Publication number
- BRPI0909180A2 BRPI0909180A2 BRPI0909180A BRPI0909180A BRPI0909180A2 BR PI0909180 A2 BRPI0909180 A2 BR PI0909180A2 BR PI0909180 A BRPI0909180 A BR PI0909180A BR PI0909180 A BRPI0909180 A BR PI0909180A BR PI0909180 A2 BRPI0909180 A2 BR PI0909180A2
- Authority
- BR
- Brazil
- Prior art keywords
- treating
- pharmaceutical composition
- autoimmune disease
- autoimmune
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0804684A GB0804684D0 (en) | 2008-03-13 | 2008-03-13 | Humanized antibody |
GB0817810A GB0817810D0 (en) | 2008-09-29 | 2008-09-29 | Agent for treating disease |
PCT/EP2009/052811 WO2009124815A1 (en) | 2008-03-13 | 2009-03-10 | Agent for treating disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0909180A2 true BRPI0909180A2 (pt) | 2016-08-09 |
Family
ID=40677801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0909180A BRPI0909180A2 (pt) | 2008-03-13 | 2009-03-10 | composição farmacêutica, e, método de tratamento de uma doença autoimune |
Country Status (19)
Country | Link |
---|---|
US (1) | US9512226B2 (pt) |
EP (1) | EP2262838B1 (pt) |
JP (2) | JP5795167B2 (pt) |
KR (1) | KR20100135807A (pt) |
CN (1) | CN102027016A (pt) |
AU (1) | AU2009235622C9 (pt) |
BR (1) | BRPI0909180A2 (pt) |
CA (1) | CA2718191C (pt) |
CO (1) | CO6311006A2 (pt) |
ES (1) | ES2569217T3 (pt) |
HK (1) | HK1151533A1 (pt) |
HU (1) | HUE028962T2 (pt) |
IL (1) | IL207890A0 (pt) |
MX (1) | MX2010010026A (pt) |
PL (1) | PL2262838T3 (pt) |
RU (1) | RU2540013C2 (pt) |
SG (1) | SG10201503135RA (pt) |
WO (1) | WO2009124815A1 (pt) |
ZA (1) | ZA201007216B (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
EP1460088A1 (en) | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
US20080269762A1 (en) * | 2007-04-25 | 2008-10-30 | Biomet Manufacturing Corp. | Method and device for repair of cartilage defects |
EP2259774B1 (en) | 2008-02-27 | 2012-12-12 | Biomet Biologics, LLC | Methods and compositions for delivering interleukin-1 receptor antagonist |
US8753690B2 (en) * | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
KR20100135257A (ko) * | 2008-03-13 | 2010-12-24 | 바이오테스트 아게 | 질병 치료제 |
BRPI0909179A2 (pt) * | 2008-03-13 | 2015-08-25 | Biotest Ag | Composição farmacêutica, e, método de tratamento de uma doença autoimune. |
CA2738598C (en) * | 2008-09-29 | 2017-11-21 | Biotest Ag | Composition for treating disease |
US20110052561A1 (en) * | 2009-08-27 | 2011-03-03 | Biomet Biologics,LLC | Osteolysis treatment |
EP2470162B1 (en) | 2009-08-27 | 2019-03-27 | Biomet Biologics, LLC | Implantable device for production of interleukin-1 receptor antagonist |
GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
EP2977054A1 (en) | 2010-09-03 | 2016-01-27 | Biomet Biologics, LLC | Methods and compositions for delivering interleukin-1 receptor antagonist |
US20140112883A1 (en) * | 2011-04-20 | 2014-04-24 | Liquidating Trust | Methods for reducing an adverse immune response to a foreign antigen in a human subject with anti-cd4 antibodies or cd4-binding fragments thereof or cd4-binding molecules |
US9011846B2 (en) | 2011-05-02 | 2015-04-21 | Biomet Biologics, Llc | Thrombin isolated from blood and blood fractions |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US9878011B2 (en) | 2013-03-15 | 2018-01-30 | Biomet Biologics, Llc | Treatment of inflammatory respiratory disease using biological solutions |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
EP3074507B1 (en) | 2013-11-26 | 2022-01-05 | Biomet Biologics, LLC | Methods of mediating macrophage phenotypes |
US10441635B2 (en) | 2014-11-10 | 2019-10-15 | Biomet Biologics, Llc | Methods of treating pain using protein solutions |
US9763800B2 (en) | 2015-03-18 | 2017-09-19 | Biomet C. V. | Implant configured for hammertoe and small bone fixation |
US20210147800A1 (en) * | 2017-06-22 | 2021-05-20 | Board Of Regents, The University Of Texas System | Methods for producing regulatory immune cells and uses thereof |
GB202017681D0 (en) | 2020-11-09 | 2020-12-23 | T Balance Therapeutics Gmbh | Anti-CD4 antibody or fragment thereof for medical use |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT90657B (pt) | 1988-05-27 | 1995-03-01 | Ortho Pharma Corp | Processo para a preparacao de peptidos que bloqueiam a ligacao de hiv-1 a proteina cd4 receptora |
JPH0768273B2 (ja) | 1988-12-02 | 1995-07-26 | カルピス食品工業株式会社 | 抗hivペプチド |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
EP0462229A4 (en) | 1989-05-02 | 1992-03-11 | Genelabs Incorporated | Chemically modified cd4 peptide fragments having anti-retroviral properties |
US5690933A (en) * | 1989-05-31 | 1997-11-25 | Glaxo Wellcome Inc. | Monoclonal antibodies for inducing tolerance |
GB8912497D0 (en) | 1989-05-31 | 1989-07-19 | Cobbold Stephen P | Monoclonal antibodies |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US20020099179A1 (en) * | 1989-12-21 | 2002-07-25 | Linda K. Jolliffe | Cdr-grafted antibodies |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
HUT60768A (en) | 1990-03-16 | 1992-10-28 | Sandoz Ag | Process for producing cd25 fixing molecules |
US7084260B1 (en) * | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
JPH05505112A (ja) * | 1990-11-27 | 1993-08-05 | バイオジェン,インコーポレイテッド | Aids、arcおよびhiv感染の予防および治療に有用な抗cd4抗体ホモログ |
US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
JPH05244982A (ja) * | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
US5777085A (en) * | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
IL101769A (en) | 1992-05-03 | 2007-02-11 | Yeda Res & Dev | Modulation of TNF receptor action |
US6270766B1 (en) * | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
WO1995009652A1 (en) | 1993-10-06 | 1995-04-13 | The Kennedy Institute For Rheumatology | Treatment of autoimmune and inflammatory disorders |
US5741488A (en) | 1992-10-08 | 1998-04-21 | The Kennedy Institute For Rheumatology | Treatment of rheumatoid arthritis with anti-CD4 antibodies in conjunction with anti-TNF antibodies |
EP0614984B2 (en) * | 1993-03-05 | 2010-11-03 | Bayer HealthCare LLC | Anti-TNF alpha human monoclonal antibodies |
EP0631783A1 (en) | 1993-06-03 | 1995-01-04 | Mitsubishi Chemical Corporation | Antiviral combinations of 2',3'-di-deoxyribonucleosides with 6-benzyl-1-ethoxymethyl-5-substituted uracil derivatives |
US20020068057A1 (en) * | 1994-03-10 | 2002-06-06 | Marc Feldmann | Treatment of autoimmune and inflammatory disorders |
CA2221350A1 (en) | 1995-05-18 | 1996-11-21 | Ortho Pharmaceutical Corporation | Induction of immunological tolerance by the use of non-depleting anti-cd4 antibodies |
CN103275221B (zh) | 1996-02-09 | 2016-08-17 | 艾伯维生物技术有限公司 | 结合人TNFα的人抗体 |
US20010056066A1 (en) * | 1996-07-26 | 2001-12-27 | Smithkline Beecham Corporation | Method of treating immune cell mediated systemic diseases |
WO1998014211A1 (en) | 1996-10-01 | 1998-04-09 | Celltech Therapeutics Limited | Pharmaceutical products containing protein-tyrosine kinase inhibitors and anti-cd4 antibodies |
US6037454A (en) * | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
DE19722888A1 (de) * | 1997-05-28 | 1998-12-03 | Thomas Prof Dr Huenig | Human-CD28 spezifische monoklonale Antikörper zur antigenunspezifischen Aktivierung von T-Lymphozyten |
AU3633000A (en) | 1999-03-26 | 2000-10-16 | Human Genome Sciences, Inc. | Neutrokine-alpha binding proteins and methods based thereon |
EP1194167B1 (en) * | 1999-06-09 | 2009-08-19 | Immunomedics, Inc. | Immunotherapy of autoimmune disorders using antibodies which target b-cells |
US7304127B2 (en) | 1999-08-27 | 2007-12-04 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use |
AU6941000A (en) | 1999-08-27 | 2001-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Polypeptides that bind hiv gp120 and related nucleic acids, antibodies, compositions, and methods of use |
EP1289554A4 (en) | 2000-06-02 | 2004-05-26 | Univ Minnesota | IMMUNOTHERAPEUTIC PROCESS FOR PREVENTING REJECTION OF ISLAND CELLS |
WO2002022212A2 (en) | 2000-09-18 | 2002-03-21 | Idec Pharmaceuticals Corporation | Combination therapy for treatment of autoimmune diseases using b cell depleting/immunoregulatory antibody combination |
DE10050935A1 (de) * | 2000-10-11 | 2002-05-02 | Tegenero Gmbh | Verwendung CD28 spezifischer monoklonaler Antikörper zur Stimulation von Blutzellen, welche kein CD28 tragen |
RU2285541C2 (ru) * | 2000-12-22 | 2006-10-20 | Байоджен Айдек Инк. | Комбинированная терапия для лечения аутоиммунных заболеваний с использованием комбинации элиминирующего в-клетки/иммунорегуляторного антител |
RU2345719C2 (ru) | 2001-01-16 | 2009-02-10 | Васкулар Терапиез, Ллс. | Способ предотвращения или лечения уменьшения доступа для гемодиализа сосудов и устройство для его осуществления и другие сосудистые графты |
CA2440649A1 (en) * | 2001-03-07 | 2002-09-19 | Children's Medical Center Corporation | Method to screen peptide display libraries using minicell display |
EP1241249A1 (en) | 2001-03-12 | 2002-09-18 | Gerold Schuler | CD4+CD25+regulatory T cells from human blood |
US20040136949A1 (en) | 2001-04-24 | 2004-07-15 | Matthias Grell | Combination therapy using anti-angiogenic agents and tnf alpha |
GB2376466A (en) | 2001-06-14 | 2002-12-18 | Mark Frewin | TRX1 antibody |
DE60238533D1 (de) | 2001-06-14 | 2011-01-20 | Cambridge Entpr Ltd | Nicht-depletierender Antikörper TRX-1 gegen CD4 und dessen Verwendungen |
US7541443B2 (en) | 2001-06-14 | 2009-06-02 | Tolerrx, Inc. | Anti-CD4 antibodies |
WO2003048194A2 (de) * | 2001-12-04 | 2003-06-12 | Tegenero Ag | Peptid oder protein enthaltend ein c'-d loop der cd28 rezeptorfamilie |
DE10212108A1 (de) * | 2002-03-13 | 2003-10-02 | Tegenero Ag | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung |
DE10230223A1 (de) * | 2002-07-04 | 2004-01-22 | Tegenero Ag | Mikropartikel mit CD28-spezifischen monoklonalen Antikörpern |
EP1578364A4 (en) | 2002-09-16 | 2011-06-08 | Genentech Inc | COMPOSITIONS AND METHODS FOR TREATING IMMUNE DISEASES |
US7388079B2 (en) | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
US7501494B2 (en) * | 2003-01-15 | 2009-03-10 | United Biomedical, Inc. | Designed deimmunized monoclonal antibodies for protection against HIV exposure and treatment of HIV infection |
EP1460088A1 (en) * | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
WO2004091657A2 (en) * | 2003-04-09 | 2004-10-28 | Genentech, Inc. | Therapy of autoimmune disease in a patient with an inadequate response to a tnf-alpha inhibitor |
GB0314461D0 (en) | 2003-06-20 | 2003-07-23 | Isis Innovation | Suppression of transplant rejection |
EP1658308A1 (en) | 2003-08-25 | 2006-05-24 | Pieris ProteoLab AG | Muteins of a bilin-binding protein with affinity for a given target |
EP1600164A3 (de) * | 2003-09-22 | 2006-05-17 | TeGenero AG | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer Pharmazeutischen Zusammensetzung mit dosisabhängiger Wirkung |
DE10352900A1 (de) * | 2003-11-11 | 2005-06-16 | Tegenero Ag | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung zur Behandlung von B-CLL |
EP1758936A2 (en) | 2004-06-22 | 2007-03-07 | Tolerrx Inc. | Optimized dosing with anti-cd4 antibodies for tolerance induction in primates |
CN101031305A (zh) * | 2004-09-29 | 2007-09-05 | 兴和株式会社 | 类风湿性关节炎的预防和/或治疗药物 |
EP2171060B1 (de) | 2004-11-11 | 2013-10-02 | TheraMAB LLC | Superagonistische anti-cd28 antikörper |
WO2006055077A2 (en) | 2004-11-12 | 2006-05-26 | The University Of North Carolina At Charlotte | Modulation of cd4+ t cell responses by a tick saliva protein, salp15 and polypeptides derived therefrom |
DE102004063494A1 (de) * | 2004-12-23 | 2006-07-13 | Tegenero Ag | Antikörper |
JP4730733B2 (ja) * | 2005-05-02 | 2011-07-20 | 国立大学法人京都大学 | 4型葉酸受容体の発現を指標とした制御性t細胞の検出方法、及び免疫賦活剤 |
SG163615A1 (en) * | 2005-07-11 | 2010-08-30 | Macrogenics Inc | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
CN101287493A (zh) | 2005-08-18 | 2008-10-15 | 根马布股份公司 | 采用cd4结合肽和辐射的疗法 |
SG192479A1 (en) * | 2005-08-26 | 2013-08-30 | Roche Glycart Ag | Modified antigen binding molecules with altered cell signaling activity |
TWI596111B (zh) | 2006-01-05 | 2017-08-21 | 建南德克公司 | 抗ephb4抗體及使用該抗體之方法 |
EP2001510A4 (en) | 2006-03-16 | 2010-06-09 | Genentech Inc | METHODS OF TREATING LUPUS USING CD4 ANTIBODIES |
JP2009529915A (ja) | 2006-03-20 | 2009-08-27 | ゾーマ テクノロジー リミテッド | ガストリン物質に対して特異的なヒト抗体および方法 |
US20090208471A1 (en) | 2006-04-07 | 2009-08-20 | Yun Theodore J | Isolation and Use of Human Regulatory T Cells |
WO2007135684A2 (en) | 2006-05-22 | 2007-11-29 | Hadasit Medical Research Services & Development Limited | Method of treatment of anti-cd4 autoimmunity |
JP5867795B2 (ja) | 2007-02-01 | 2016-02-24 | テーツェーエフ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 調節性t細胞の特異的活性化ならびに喘息、アレルギー疾患、自己免疫疾患、移植片拒絶の治療および免疫寛容の誘導のためのその使用 |
EP2599791A1 (en) | 2007-04-27 | 2013-06-05 | Genentech, Inc. | Potent, stable and non-immunosuppressive anti-CD4 antibodies |
BRPI0909179A2 (pt) * | 2008-03-13 | 2015-08-25 | Biotest Ag | Composição farmacêutica, e, método de tratamento de uma doença autoimune. |
KR20100135257A (ko) * | 2008-03-13 | 2010-12-24 | 바이오테스트 아게 | 질병 치료제 |
EP2101173A1 (en) | 2008-03-14 | 2009-09-16 | Vivalis | In vitro method to determine whether a drug candidate active against a target protein is active against a variant of said protein |
WO2010022341A1 (en) | 2008-08-21 | 2010-02-25 | The United State Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of enriching and using regulatory t cells |
ES2335381B1 (es) | 2008-09-24 | 2011-02-28 | Fundacio Institut De Recerca De L'hospital Universitari Vall D'hebron | Metodo in vitro y kit para el pronostico o prediccion de la respuestapor parte de pacientes con artritis reumatoide al tratamiento con agentes bloqueantes del factor tnfalfa. |
CA2738598C (en) * | 2008-09-29 | 2017-11-21 | Biotest Ag | Composition for treating disease |
-
2009
- 2009-03-10 CA CA2718191A patent/CA2718191C/en active Active
- 2009-03-10 MX MX2010010026A patent/MX2010010026A/es active IP Right Grant
- 2009-03-10 BR BRPI0909180A patent/BRPI0909180A2/pt not_active Application Discontinuation
- 2009-03-10 EP EP09729626.3A patent/EP2262838B1/en active Active
- 2009-03-10 SG SG10201503135RA patent/SG10201503135RA/en unknown
- 2009-03-10 CN CN2009801173062A patent/CN102027016A/zh active Pending
- 2009-03-10 PL PL09729626.3T patent/PL2262838T3/pl unknown
- 2009-03-10 WO PCT/EP2009/052811 patent/WO2009124815A1/en active Application Filing
- 2009-03-10 ES ES09729626.3T patent/ES2569217T3/es active Active
- 2009-03-10 JP JP2010550183A patent/JP5795167B2/ja active Active
- 2009-03-10 HU HUE09729626A patent/HUE028962T2/en unknown
- 2009-03-10 AU AU2009235622A patent/AU2009235622C9/en not_active Ceased
- 2009-03-10 RU RU2010141858/10A patent/RU2540013C2/ru not_active IP Right Cessation
- 2009-03-10 KR KR1020107022911A patent/KR20100135807A/ko not_active Application Discontinuation
-
2010
- 2010-08-31 IL IL207890A patent/IL207890A0/en unknown
- 2010-09-13 US US12/880,623 patent/US9512226B2/en active Active
- 2010-10-08 ZA ZA2010/07216A patent/ZA201007216B/en unknown
- 2010-10-13 CO CO10127112A patent/CO6311006A2/es not_active Application Discontinuation
-
2011
- 2011-05-25 HK HK11105223.5A patent/HK1151533A1/zh not_active IP Right Cessation
-
2014
- 2014-01-17 JP JP2014006520A patent/JP2014122224A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2718191C (en) | 2018-05-15 |
IL207890A0 (en) | 2010-12-30 |
EP2262838B1 (en) | 2016-04-13 |
EP2262838A1 (en) | 2010-12-22 |
KR20100135807A (ko) | 2010-12-27 |
JP2011515345A (ja) | 2011-05-19 |
CO6311006A2 (es) | 2011-08-22 |
AU2009235622A1 (en) | 2009-10-15 |
HK1151533A1 (zh) | 2012-02-03 |
US9512226B2 (en) | 2016-12-06 |
ZA201007216B (en) | 2016-08-31 |
WO2009124815A1 (en) | 2009-10-15 |
HUE028962T2 (en) | 2017-01-30 |
PL2262838T3 (pl) | 2016-10-31 |
US20110059082A1 (en) | 2011-03-10 |
CA2718191A1 (en) | 2009-10-15 |
JP5795167B2 (ja) | 2015-10-14 |
CN102027016A (zh) | 2011-04-20 |
AU2009235622C1 (en) | 2015-06-04 |
RU2010141858A (ru) | 2012-04-20 |
MX2010010026A (es) | 2011-03-21 |
ES2569217T3 (es) | 2016-05-09 |
AU2009235622B2 (en) | 2014-10-23 |
JP2014122224A (ja) | 2014-07-03 |
RU2540013C2 (ru) | 2015-01-27 |
SG10201503135RA (en) | 2015-06-29 |
AU2009235622C9 (en) | 2015-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0909180A2 (pt) | composição farmacêutica, e, método de tratamento de uma doença autoimune | |
BRPI0909048A2 (pt) | composição farmacêutica, e, método de tratamento de uma doença autoimune | |
BRPI0909179A2 (pt) | Composição farmacêutica, e, método de tratamento de uma doença autoimune. | |
BRPI0915267A2 (pt) | Composto, composição farmacêutica livre de pirogênio, e, método de tratamento de uma doença ou uma condição | |
BRPI0815387A2 (pt) | composição farmacêutica, método para fazer uma composição farmacêutica e método de tratar uma condição | |
BRPI0922122A2 (pt) | composições e métodos para tratamento de doença celíaca. | |
BRPI0820139A2 (pt) | Composição antiperspirante ativa, e, processo de obtenção de uma composição antiperspirante ativa | |
HK1202312A1 (zh) | 用以診斷疾病的分子分析的方法和成分 | |
BRPI1007477A2 (pt) | método, e, composição de tratamento de poço | |
BRPI0922440A2 (pt) | dispositivo protético e método de fabricação do mesmo . | |
CY2016053I2 (el) | Μεθοδοι αγωγης χρησιμοποιωντας φαρμακευτικες ουσιες συλληψης αμμωνιας | |
BRPI0813725A2 (pt) | Métodos e composições para tratamento de doenças | |
BRPI0820474A2 (pt) | método de tratamento de uma doença, uso de composto, e, composto | |
BRPI1013112A2 (pt) | método de cimentação, e, composição de cimento | |
BRPI1013705A2 (pt) | compostos, composição farmacêutica, método de tratamento de doença ou condição associada com função de trap1 e usos de compostos e de composição farmacêutica | |
BRPI0919575A2 (pt) | método, e, composição | |
BRPI0913518A2 (pt) | composto, composição farmacêutica, e, método de tratamento de um distúrbio mediado por função imune | |
BRPI0918170A2 (pt) | método, e, composição endurecível | |
BRPI1007600A2 (pt) | composições e métodos para tratamento de doenças cardiovasculares | |
BRPI0823277A2 (pt) | Composição, e , método | |
BRPI1009418A2 (pt) | nanocapsula de proteina, metodo de pdroduzir uma nanocapsula, e metodo de distribuir uma proteina | |
BRPI0908635A2 (pt) | composto, composição farmacêutica e método de tratamento de câncer | |
BRPI1011012A2 (pt) | composição de lubrificante, e, método | |
BRPI0820644A2 (pt) | método de preparação de uma composição, e, composição | |
BR112012002001A2 (pt) | método para tratar uma doença e/ou distúrbio do olho, formulação farmacêutica, e, kit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |