ATE145246T1 - Monoklonale antikörper zur induzierung von toleranz - Google Patents

Monoklonale antikörper zur induzierung von toleranz

Info

Publication number
ATE145246T1
ATE145246T1 AT90908270T AT90908270T ATE145246T1 AT E145246 T1 ATE145246 T1 AT E145246T1 AT 90908270 T AT90908270 T AT 90908270T AT 90908270 T AT90908270 T AT 90908270T AT E145246 T1 ATE145246 T1 AT E145246T1
Authority
AT
Austria
Prior art keywords
depleting
monoclonal antibodies
inducing tolerance
monoclonal antibody
tolerance
Prior art date
Application number
AT90908270T
Other languages
English (en)
Inventor
Stephen Paul Cobbold
Herman Waldmann
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE145246T1 publication Critical patent/ATE145246T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT90908270T 1989-05-31 1990-05-31 Monoklonale antikörper zur induzierung von toleranz ATE145246T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898912497A GB8912497D0 (en) 1989-05-31 1989-05-31 Monoclonal antibodies

Publications (1)

Publication Number Publication Date
ATE145246T1 true ATE145246T1 (de) 1996-11-15

Family

ID=10657649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90908270T ATE145246T1 (de) 1989-05-31 1990-05-31 Monoklonale antikörper zur induzierung von toleranz

Country Status (19)

Country Link
EP (1) EP0474691B1 (de)
JP (1) JP2763197B2 (de)
KR (1) KR0183029B1 (de)
AT (1) ATE145246T1 (de)
AU (1) AU657255B2 (de)
CA (1) CA2055615C (de)
DD (1) DD296843A5 (de)
DE (1) DE69029134T2 (de)
DK (1) DK0474691T3 (de)
ES (1) ES2096588T3 (de)
GB (1) GB8912497D0 (de)
HU (1) HUT61341A (de)
IE (1) IE80735B1 (de)
IL (1) IL94566A0 (de)
MY (1) MY135673A (de)
NZ (1) NZ233889A (de)
PT (1) PT94214B (de)
WO (1) WO1990015152A1 (de)
ZA (1) ZA904174B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100741D0 (en) * 1991-01-14 1991-02-27 Univ London Treatment of disease
US6136310A (en) 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
DK0656789T3 (da) * 1992-08-21 1998-08-24 Genentech Inc Fremgangsmåde til behandling af en LFA-1-medieretforstyrrelse.
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
WO1996036359A1 (en) * 1995-05-18 1996-11-21 Ortho Pharmaceutical Corporation Induction of immunological tolerance by the use of non-depleting anti-cd4 antibodies
NZ517202A (en) 1999-08-24 2004-05-28 Medarex Inc Human CTLA-4 antibodies and their uses
US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
WO2001084149A2 (en) 2000-04-29 2001-11-08 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
DE60238533D1 (de) * 2001-06-14 2011-01-20 Cambridge Entpr Ltd Nicht-depletierender Antikörper TRX-1 gegen CD4 und dessen Verwendungen
US7541443B2 (en) 2001-06-14 2009-06-02 Tolerrx, Inc. Anti-CD4 antibodies
EP1460088A1 (de) 2003-03-21 2004-09-22 Biotest AG Humanisierter Antikörper gegen CD4 mit immunsuppressiven Merkmalen
GB0314461D0 (en) * 2003-06-20 2003-07-23 Isis Innovation Suppression of transplant rejection
BRPI0512017A (pt) * 2004-06-22 2008-02-06 Tolerrx Inc dosagem otimizada com anticorpos anti-cd4 para indução de toleráncia em primatas
CN102027016A (zh) 2008-03-13 2011-04-20 生物测试股份公司 一种治疗疾病的试剂
EP2265643B1 (de) 2008-03-13 2016-10-19 Biotest AG Dosierungsschema zur behandlung von psoriasis und rheumatoider arthritis
RU2540018C2 (ru) 2008-03-13 2015-01-27 Биотест Аг Средство для лечения заболевания
WO2009149382A2 (en) * 2008-06-06 2009-12-10 Baylor Research Institute Anti-cd8 antibodies block priming of cytotoxic effectors and lead to generation of regulatory cd8+t cells
WO2010009129A2 (en) * 2008-07-15 2010-01-21 Genentech, Inc. Methods of treating autoimmune diseases using cd4 antibodies
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
EP4622631A1 (de) 2022-11-23 2025-10-01 University of Georgia Research Foundation, Inc. Zusammensetzungen und verfahren zur verwendung davon zur erhöhung der immunreaktionen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies

Also Published As

Publication number Publication date
HUT61341A (en) 1992-12-28
ES2096588T3 (es) 1997-03-16
PT94214A (pt) 1991-02-08
DD296843A5 (de) 1991-12-19
PT94214B (pt) 1997-03-31
DE69029134T2 (de) 1997-03-06
CA2055615A1 (en) 1990-12-13
NZ233889A (en) 1997-06-24
MY135673A (en) 2008-06-30
KR0183029B1 (ko) 1999-04-01
EP0474691A1 (de) 1992-03-18
JP2763197B2 (ja) 1998-06-11
WO1990015152A1 (en) 1990-12-13
IE80735B1 (en) 1998-12-30
GB8912497D0 (en) 1989-07-19
ZA904174B (en) 1992-02-26
AU657255B2 (en) 1995-03-09
AU5725890A (en) 1991-01-07
DK0474691T3 (da) 1996-12-02
JPH04505919A (ja) 1992-10-15
DE69029134D1 (de) 1996-12-19
IL94566A0 (en) 1991-03-10
CA2055615C (en) 2001-07-17
HU905134D0 (en) 1992-02-28
EP0474691B1 (de) 1996-11-13
IE901949L (en) 1990-11-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time