ES2096588T3 - Anticuerpos monoclonales para inducir tolerancia. - Google Patents

Anticuerpos monoclonales para inducir tolerancia.

Info

Publication number
ES2096588T3
ES2096588T3 ES90908270T ES90908270T ES2096588T3 ES 2096588 T3 ES2096588 T3 ES 2096588T3 ES 90908270 T ES90908270 T ES 90908270T ES 90908270 T ES90908270 T ES 90908270T ES 2096588 T3 ES2096588 T3 ES 2096588T3
Authority
ES
Spain
Prior art keywords
depleting
monoclonal antibodies
induce tolerance
monoclonal antibody
tolerance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90908270T
Other languages
English (en)
Inventor
Stephen Paul Cobbold
Herman Waldmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2096588T3 publication Critical patent/ES2096588T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE INDUCE TOLERANCIA A UN ANTIGENO EN UN SUJETO ADMINISTRANDOLE UN ANTICUERPO MONOCLONAL CD4 NO-DESCONGESTIONANTE Y UN ANTICUERPO MONOCLONAL CD8 NO DESCONGESTIONANTE. SE PUEDE INDUCIR TOLERANCIA AL ANTIGENO BAJO LA CUBIERTA DE ESTOS ANTICUERPOS. SE PUEDE ADMINISTRAR UN ANTICUERPO MONOCLONAL DESCONGESTIONANTE CD4 Y/O CD8 PREVIO A LOS ANTICUERPOS NO DESCONGESTIONANTES.
ES90908270T 1989-05-31 1990-05-31 Anticuerpos monoclonales para inducir tolerancia. Expired - Lifetime ES2096588T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898912497A GB8912497D0 (en) 1989-05-31 1989-05-31 Monoclonal antibodies

Publications (1)

Publication Number Publication Date
ES2096588T3 true ES2096588T3 (es) 1997-03-16

Family

ID=10657649

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90908270T Expired - Lifetime ES2096588T3 (es) 1989-05-31 1990-05-31 Anticuerpos monoclonales para inducir tolerancia.

Country Status (19)

Country Link
EP (1) EP0474691B1 (es)
JP (1) JP2763197B2 (es)
KR (1) KR0183029B1 (es)
AT (1) ATE145246T1 (es)
AU (1) AU657255B2 (es)
CA (1) CA2055615C (es)
DD (1) DD296843A5 (es)
DE (1) DE69029134T2 (es)
DK (1) DK0474691T3 (es)
ES (1) ES2096588T3 (es)
GB (1) GB8912497D0 (es)
HU (1) HUT61341A (es)
IE (1) IE80735B1 (es)
IL (1) IL94566A0 (es)
MY (1) MY135673A (es)
NZ (1) NZ233889A (es)
PT (1) PT94214B (es)
WO (1) WO1990015152A1 (es)
ZA (1) ZA904174B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100741D0 (en) * 1991-01-14 1991-02-27 Univ London Treatment of disease
US6136310A (en) 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
ZA936128B (en) * 1992-08-21 1995-02-20 Genentech Inc Method for treating a LFA-1 mediated disorder
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
EP0840618B1 (en) * 1995-05-18 2003-04-23 Ortho-McNeil Pharmaceutical, Inc. Induction of immunological tolerance by the use of non-depleting anti-cd4 antibodies
NZ517202A (en) 1999-08-24 2004-05-28 Medarex Inc Human CTLA-4 antibodies and their uses
US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
ES2316446T3 (es) 2000-04-29 2009-04-16 University Of Iowa Research Foundation Diagnostico y terapeutica para trastornos relacionados con la degeneracion macular.
US7541443B2 (en) 2001-06-14 2009-06-02 Tolerrx, Inc. Anti-CD4 antibodies
ATE490783T1 (de) * 2001-06-14 2010-12-15 Isis Innovation Nicht-depletierender antikörper trx-1 gegen cd4 und dessen verwendungen
EP1460088A1 (en) 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
GB0314461D0 (en) * 2003-06-20 2003-07-23 Isis Innovation Suppression of transplant rejection
WO2006002377A2 (en) * 2004-06-22 2006-01-05 Tolerrx, Inc. Optimized dosing with anti-cd4 antibodies for tolerance induction in primates
AU2009224690B2 (en) 2008-03-13 2014-10-09 Biotest Ag Agent for treating disease
AU2009235622C9 (en) 2008-03-13 2015-07-02 Biotest Ag Agent for treating disease
BRPI0909048A2 (pt) 2008-03-13 2015-11-24 Biotest Ag composição farmacêutica, e, método de tratamento de uma doença autoimune
EP2297204A4 (en) * 2008-06-06 2013-10-23 Baylor Res Inst ANTI-CD8 ANTIBODIES BLOCK THE PRIMES OF CYTOTOXIC EFFECTORS AND LEAD TO THE FORMATION OF REGULATORY CD8 + T CELLS
US20100021460A1 (en) * 2008-07-15 2010-01-28 Genentech, Inc. Methods of Treating Autoimmune Diseases Using CD4 Antibodies
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
WO2024112867A1 (en) 2022-11-23 2024-05-30 University Of Georgia Research Foundation, Inc. Compositions and methods of use thereof for increasing immune responses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies

Also Published As

Publication number Publication date
EP0474691A1 (en) 1992-03-18
IE901949L (en) 1990-11-30
JPH04505919A (ja) 1992-10-15
CA2055615A1 (en) 1990-12-13
CA2055615C (en) 2001-07-17
DE69029134T2 (de) 1997-03-06
IL94566A0 (en) 1991-03-10
DD296843A5 (de) 1991-12-19
ZA904174B (en) 1992-02-26
AU5725890A (en) 1991-01-07
MY135673A (en) 2008-06-30
GB8912497D0 (en) 1989-07-19
IE80735B1 (en) 1998-12-30
PT94214B (pt) 1997-03-31
EP0474691B1 (en) 1996-11-13
NZ233889A (en) 1997-06-24
PT94214A (pt) 1991-02-08
HUT61341A (en) 1992-12-28
AU657255B2 (en) 1995-03-09
ATE145246T1 (de) 1996-11-15
WO1990015152A1 (en) 1990-12-13
JP2763197B2 (ja) 1998-06-11
DK0474691T3 (da) 1996-12-02
HU905134D0 (en) 1992-02-28
KR0183029B1 (ko) 1999-04-01
DE69029134D1 (de) 1996-12-19

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