IL94539A - Outcome of glycylation-free tissue plasminogen activator with prolonged half-life Increased thrombolytic activity and reduced fibrin binding DNA encoded for its preparation - Google Patents

Outcome of glycylation-free tissue plasminogen activator with prolonged half-life Increased thrombolytic activity and reduced fibrin binding DNA encoded for its preparation

Info

Publication number
IL94539A
IL94539A IL9453990A IL9453990A IL94539A IL 94539 A IL94539 A IL 94539A IL 9453990 A IL9453990 A IL 9453990A IL 9453990 A IL9453990 A IL 9453990A IL 94539 A IL94539 A IL 94539A
Authority
IL
Israel
Prior art keywords
ser
gly
leu
arg
ala
Prior art date
Application number
IL9453990A
Other languages
English (en)
Hebrew (he)
Other versions
IL94539A0 (en
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of IL94539A0 publication Critical patent/IL94539A0/xx
Publication of IL94539A publication Critical patent/IL94539A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL9453990A 1989-05-31 1990-05-28 Outcome of glycylation-free tissue plasminogen activator with prolonged half-life Increased thrombolytic activity and reduced fibrin binding DNA encoded for its preparation IL94539A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3917781 1989-05-31
DE3923339A DE3923339A1 (de) 1989-05-31 1989-07-14 Gewebs-plasminogen-aktivator-derivat

Publications (2)

Publication Number Publication Date
IL94539A0 IL94539A0 (en) 1991-03-10
IL94539A true IL94539A (en) 1996-08-04

Family

ID=25881452

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9453990A IL94539A (en) 1989-05-31 1990-05-28 Outcome of glycylation-free tissue plasminogen activator with prolonged half-life Increased thrombolytic activity and reduced fibrin binding DNA encoded for its preparation

Country Status (17)

Country Link
EP (1) EP0400545B1 (hu)
JP (1) JPH0327286A (hu)
AT (1) ATE119940T1 (hu)
AU (1) AU623781B2 (hu)
CA (1) CA2017636C (hu)
CZ (1) CZ282035B6 (hu)
DD (1) DD300109A5 (hu)
DE (2) DE3923339A1 (hu)
ES (1) ES2070210T3 (hu)
FI (1) FI101475B (hu)
HU (1) HU216870B (hu)
IE (1) IE66006B1 (hu)
IL (1) IL94539A (hu)
NO (1) NO902405L (hu)
NZ (1) NZ233796A (hu)
PT (1) PT94227B (hu)
ZA (1) ZA904089B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942144A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von k1k2p pro
AU2660397A (en) * 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT198302091A (es) * 1982-05-05 1984-10-25 Activador de plasminogeno de tejido humano a),b),c).
FR2594845B1 (fr) * 1986-02-21 1989-12-01 Genetica Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active
DE3643158A1 (de) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat

Also Published As

Publication number Publication date
IE901848L (en) 1990-11-30
NZ233796A (en) 1992-07-28
CZ267690A3 (en) 1997-04-16
IE66006B1 (en) 1995-11-29
CA2017636C (en) 2000-05-02
JPH0327286A (ja) 1991-02-05
FI101475B1 (fi) 1998-06-30
DE59008693D1 (de) 1995-04-20
ES2070210T3 (es) 1995-06-01
EP0400545A1 (de) 1990-12-05
PT94227B (pt) 1997-01-31
HU216870B (hu) 1999-09-28
DE3923339A1 (de) 1990-12-06
DD300109A5 (de) 1992-05-21
NO902405D0 (no) 1990-05-30
NO902405L (no) 1990-12-03
EP0400545B1 (de) 1995-03-15
FI902700A0 (fi) 1990-05-30
ZA904089B (en) 1991-03-27
HU903267D0 (en) 1990-10-28
IL94539A0 (en) 1991-03-10
HUT54734A (en) 1991-03-28
PT94227A (pt) 1991-02-08
CZ282035B6 (cs) 1997-04-16
CA2017636A1 (en) 1990-11-30
ATE119940T1 (de) 1995-04-15
FI101475B (fi) 1998-06-30
AU5600990A (en) 1990-12-06
AU623781B2 (en) 1992-05-21

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees