IL93733A - History of Dissolved Drug Sulphides Antibacterial and Antibacterial, Prepared from Compounds Containing Methyl-Thriteo Groups and Their Target Form - Google Patents

History of Dissolved Drug Sulphides Antibacterial and Antibacterial, Prepared from Compounds Containing Methyl-Thriteo Groups and Their Target Form

Info

Publication number
IL93733A
IL93733A IL9373390A IL9373390A IL93733A IL 93733 A IL93733 A IL 93733A IL 9373390 A IL9373390 A IL 9373390A IL 9373390 A IL9373390 A IL 9373390A IL 93733 A IL93733 A IL 93733A
Authority
IL
Israel
Prior art keywords
formula
compound
hereinbefore
reacting
produce
Prior art date
Application number
IL9373390A
Other languages
English (en)
Hebrew (he)
Other versions
IL93733A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/339,343 external-priority patent/US5053394A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to IL11577090A priority Critical patent/IL115770A/xx
Publication of IL93733A0 publication Critical patent/IL93733A0/xx
Publication of IL93733A publication Critical patent/IL93733A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Treating Waste Gases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Lubricants (AREA)
  • Engine Equipment That Uses Special Cycles (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
IL9373390A 1989-04-14 1990-03-13 History of Dissolved Drug Sulphides Antibacterial and Antibacterial, Prepared from Compounds Containing Methyl-Thriteo Groups and Their Target Form IL93733A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL11577090A IL115770A (en) 1989-04-14 1990-03-13 Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33932389A 1989-04-14 1989-04-14
US07/339,343 US5053394A (en) 1988-09-21 1989-04-14 Targeted forms of methyltrithio antitumor agents

Publications (2)

Publication Number Publication Date
IL93733A0 IL93733A0 (en) 1990-12-23
IL93733A true IL93733A (en) 1996-01-19

Family

ID=26991573

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11577090A IL115770A (en) 1989-04-14 1990-03-13 Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections
IL9373390A IL93733A (en) 1989-04-14 1990-03-13 History of Dissolved Drug Sulphides Antibacterial and Antibacterial, Prepared from Compounds Containing Methyl-Thriteo Groups and Their Target Form
IL11577095A IL115770A0 (en) 1989-04-14 1995-10-25 Substituted disulfides of formula q-sp-ss-w their preparation and use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL11577090A IL115770A (en) 1989-04-14 1990-03-13 Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11577095A IL115770A0 (en) 1989-04-14 1995-10-25 Substituted disulfides of formula q-sp-ss-w their preparation and use

Country Status (16)

Country Link
EP (1) EP0392384B1 (pt)
JP (1) JP2951684B2 (pt)
CN (2) CN1046333A (pt)
AT (1) ATE163293T1 (pt)
AU (1) AU633069B2 (pt)
CZ (1) CZ293228B6 (pt)
DE (1) DE69032051T2 (pt)
DK (1) DK0392384T3 (pt)
ES (1) ES2112244T3 (pt)
FI (1) FI100105B (pt)
GR (1) GR3026177T3 (pt)
IL (3) IL115770A (pt)
NO (2) NO176717C (pt)
NZ (1) NZ233148A (pt)
PT (1) PT93716B (pt)
SK (1) SK284270B6 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
EP0342341A3 (en) * 1988-05-17 1991-07-24 American Cyanamid Company Process for producing antitumor antibiotic ll-e33288gamma2
GB9120467D0 (en) * 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
US6015562A (en) * 1992-09-22 2000-01-18 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
US5773001A (en) * 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US6441163B1 (en) * 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
SI3066074T1 (sl) * 2013-11-04 2020-03-31 Pfizer Inc. Intermediati in postopki za sintetizacijo derivatov kaliheamicina
MA45326A (fr) * 2015-10-20 2018-08-29 Genentech Inc Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
JP6917049B2 (ja) * 2017-02-22 2021-08-11 公立大学法人大阪 特定のサルファイド化合物に結合する抗体及びその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE219096T1 (de) * 1987-01-30 2002-06-15 American Cyanamid Co Dihydroderivate der antibiotika vom typ ll-e33288
DE3851682T2 (de) * 1987-10-30 1995-05-04 American Cyanamid Co Targetformer von Antitumor-Methyltrithioagenzien.

Also Published As

Publication number Publication date
CN1046333A (zh) 1990-10-24
SK284270B6 (sk) 2004-12-01
NO932192D0 (no) 1993-06-14
NO932192L (no) 1990-10-15
CZ293228B6 (cs) 2004-03-17
NO177308C (no) 1995-08-23
IL93733A0 (en) 1990-12-23
FI901866A0 (fi) 1990-04-12
SK188490A3 (en) 2000-08-16
ES2112244T3 (es) 1998-04-01
IL115770A0 (en) 1996-01-19
AU5324190A (en) 1990-11-01
CN1109041C (zh) 2003-05-21
CN1110280A (zh) 1995-10-18
CZ188490A3 (cs) 2000-08-16
NO177308B (no) 1995-05-15
PT93716B (pt) 1996-08-30
NO901655D0 (no) 1990-04-11
GR3026177T3 (en) 1998-05-29
DK0392384T3 (da) 1998-03-16
NO176717C (no) 1995-05-16
EP0392384A2 (en) 1990-10-17
NO901655L (no) 1990-10-15
EP0392384A3 (en) 1991-11-06
EP0392384B1 (en) 1998-02-18
JP2951684B2 (ja) 1999-09-20
AU633069B2 (en) 1993-01-21
IL115770A (en) 1999-03-12
NZ233148A (en) 1996-02-27
NO176717B (no) 1995-02-06
DE69032051T2 (de) 1998-06-10
JPH02292294A (ja) 1990-12-03
PT93716A (pt) 1990-11-20
FI100105B (fi) 1997-09-30
DE69032051D1 (de) 1998-03-26
ATE163293T1 (de) 1998-03-15

Similar Documents

Publication Publication Date Title
US5053394A (en) Targeted forms of methyltrithio antitumor agents
US5770701A (en) Process for preparing targeted forms of methyltrithio antitumor agents
US5157104A (en) Trichothecene conjugates
US4952394A (en) Drug-monoclonal antibody conjugates
EP0428534B1 (en) Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
EP0313873B1 (en) Targeted forms of methyltrithio antitumor agents
US5006652A (en) Intermediates for antibody-vinca drug conjugates
PL172837B1 (pl) Preparat farmaceutyczny zawierajacy koniugaty tioeterowe PL PL PL PL PL
HU208161B (en) Process for producing cytotoxic active ingredient - antibody conjugates and pharmaceutical compositions
CZ393997A3 (cs) Způsoby přípravy monomerních konjugátů nosiče a derivátu calicheamicinu
IL93733A (en) History of Dissolved Drug Sulphides Antibacterial and Antibacterial, Prepared from Compounds Containing Methyl-Thriteo Groups and Their Target Form
CA1341315C (en) Targeted forms of methyltrithio antitumor agents
NZ212118A (en) Conjugate of macromolecule and ionophore; use as immunotoxin potentiator
CA2014459C (en) Targeted forms of methyltrithio antitumor agents
KR0159767B1 (ko) 메틸-트리티오기를 갖는 화합물로 부터 제조된 항종양항균 물질인 치환 디설파이드, 그의 목적 형태및 그의 제조 방법
US5405966A (en) Trichothecene conjugates

Legal Events

Date Code Title Description
FF Patent granted
RH Patent void
NP Permission for amending the patent specification granted (section 66, patents law 1967)
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired