NO932192D0 - Fremgangsmaate ved fremstilling av metyltritio - anti - tumorforbindelser - Google Patents

Fremgangsmaate ved fremstilling av metyltritio - anti - tumorforbindelser

Info

Publication number
NO932192D0
NO932192D0 NO932192A NO932192A NO932192D0 NO 932192 D0 NO932192 D0 NO 932192D0 NO 932192 A NO932192 A NO 932192A NO 932192 A NO932192 A NO 932192A NO 932192 D0 NO932192 D0 NO 932192D0
Authority
NO
Norway
Prior art keywords
tritio
procedure
tumor compounds
manufacturing methyl
methyl
Prior art date
Application number
NO932192A
Other languages
English (en)
Other versions
NO177308C (no
NO932192L (no
NO177308B (no
Inventor
George A Ellestad
William James Mcgahren
Martin Leon Sassiver
Philip R Hamann
Lois Hinman
Janis Upeslacis
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/339,343 external-priority patent/US5053394A/en
Publication of NO932192L publication Critical patent/NO932192L/no
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to NO932192A priority Critical patent/NO177308C/no
Publication of NO932192D0 publication Critical patent/NO932192D0/no
Publication of NO177308B publication Critical patent/NO177308B/no
Publication of NO177308C publication Critical patent/NO177308C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Treating Waste Gases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Engine Equipment That Uses Special Cycles (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO932192A 1989-04-14 1993-06-14 Analogifremgangsmåte ved fremstilling av anti-tumorforbindelser NO177308C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO932192A NO177308C (no) 1989-04-14 1993-06-14 Analogifremgangsmåte ved fremstilling av anti-tumorforbindelser

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33932389A 1989-04-14 1989-04-14
US07/339,343 US5053394A (en) 1988-09-21 1989-04-14 Targeted forms of methyltrithio antitumor agents
NO901655A NO176717C (no) 1989-04-14 1990-04-11 Analogifremgangsmåte ved fremstilling av målsökende anti-tumorforbindelser
NO932192A NO177308C (no) 1989-04-14 1993-06-14 Analogifremgangsmåte ved fremstilling av anti-tumorforbindelser

Publications (4)

Publication Number Publication Date
NO932192L NO932192L (no) 1990-10-15
NO932192D0 true NO932192D0 (no) 1993-06-14
NO177308B NO177308B (no) 1995-05-15
NO177308C NO177308C (no) 1995-08-23

Family

ID=26991573

Family Applications (2)

Application Number Title Priority Date Filing Date
NO901655A NO176717C (no) 1989-04-14 1990-04-11 Analogifremgangsmåte ved fremstilling av målsökende anti-tumorforbindelser
NO932192A NO177308C (no) 1989-04-14 1993-06-14 Analogifremgangsmåte ved fremstilling av anti-tumorforbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO901655A NO176717C (no) 1989-04-14 1990-04-11 Analogifremgangsmåte ved fremstilling av målsökende anti-tumorforbindelser

Country Status (16)

Country Link
EP (1) EP0392384B1 (no)
JP (1) JP2951684B2 (no)
CN (2) CN1046333A (no)
AT (1) ATE163293T1 (no)
AU (1) AU633069B2 (no)
CZ (1) CZ293228B6 (no)
DE (1) DE69032051T2 (no)
DK (1) DK0392384T3 (no)
ES (1) ES2112244T3 (no)
FI (1) FI100105B (no)
GR (1) GR3026177T3 (no)
IL (3) IL115770A (no)
NO (2) NO176717C (no)
NZ (1) NZ233148A (no)
PT (1) PT93716B (no)
SK (1) SK284270B6 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
EP0342341A3 (en) * 1988-05-17 1991-07-24 American Cyanamid Company Process for producing antitumor antibiotic ll-e33288gamma2
GB9120467D0 (en) * 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
US6015562A (en) * 1992-09-22 2000-01-18 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
US5773001A (en) * 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US6441163B1 (en) * 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
DK3066074T3 (da) * 2013-11-04 2020-02-10 Pfizer Mellemprodukter og fremgangsmåder til syntetisering af calicheamicin-derivater
MA45326A (fr) 2015-10-20 2018-08-29 Genentech Inc Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
JP6917049B2 (ja) * 2017-02-22 2021-08-11 公立大学法人大阪 特定のサルファイド化合物に結合する抗体及びその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2177518T3 (es) * 1987-01-30 2002-12-16 American Cyanamid Co Derivados dihidro de los antibioticos ll-e33288.
EP0313873B1 (en) * 1987-10-30 1994-09-28 American Cyanamid Company Targeted forms of methyltrithio antitumor agents

Also Published As

Publication number Publication date
ES2112244T3 (es) 1998-04-01
NO901655L (no) 1990-10-15
NO176717C (no) 1995-05-16
NZ233148A (en) 1996-02-27
IL93733A0 (en) 1990-12-23
CZ188490A3 (cs) 2000-08-16
IL93733A (en) 1996-01-19
IL115770A (en) 1999-03-12
NO177308C (no) 1995-08-23
DE69032051T2 (de) 1998-06-10
ATE163293T1 (de) 1998-03-15
GR3026177T3 (en) 1998-05-29
EP0392384A2 (en) 1990-10-17
CZ293228B6 (cs) 2004-03-17
SK188490A3 (en) 2000-08-16
NO932192L (no) 1990-10-15
IL115770A0 (en) 1996-01-19
CN1046333A (zh) 1990-10-24
JPH02292294A (ja) 1990-12-03
PT93716A (pt) 1990-11-20
AU633069B2 (en) 1993-01-21
PT93716B (pt) 1996-08-30
CN1109041C (zh) 2003-05-21
NO177308B (no) 1995-05-15
DK0392384T3 (da) 1998-03-16
AU5324190A (en) 1990-11-01
NO176717B (no) 1995-02-06
NO901655D0 (no) 1990-04-11
SK284270B6 (sk) 2004-12-01
FI901866A0 (fi) 1990-04-12
FI100105B (fi) 1997-09-30
DE69032051D1 (de) 1998-03-26
JP2951684B2 (ja) 1999-09-20
EP0392384A3 (en) 1991-11-06
EP0392384B1 (en) 1998-02-18
CN1110280A (zh) 1995-10-18

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