IL90527A - Preparation of (r) and (s) 2-hydroxy-4- phenylbutyric acid - Google Patents

Preparation of (r) and (s) 2-hydroxy-4- phenylbutyric acid

Info

Publication number
IL90527A
IL90527A IL90527A IL9052789A IL90527A IL 90527 A IL90527 A IL 90527A IL 90527 A IL90527 A IL 90527A IL 9052789 A IL9052789 A IL 9052789A IL 90527 A IL90527 A IL 90527A
Authority
IL
Israel
Prior art keywords
phenylbutyric acid
hydroxy
preparation
dehydrogenase
enzyme
Prior art date
Application number
IL90527A
Other languages
English (en)
Other versions
IL90527A0 (en
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of IL90527A0 publication Critical patent/IL90527A0/xx
Publication of IL90527A publication Critical patent/IL90527A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL90527A 1988-06-06 1989-06-05 Preparation of (r) and (s) 2-hydroxy-4- phenylbutyric acid IL90527A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH213888 1988-06-06

Publications (2)

Publication Number Publication Date
IL90527A0 IL90527A0 (en) 1990-01-18
IL90527A true IL90527A (en) 1993-05-13

Family

ID=4226761

Family Applications (1)

Application Number Title Priority Date Filing Date
IL90527A IL90527A (en) 1988-06-06 1989-06-05 Preparation of (r) and (s) 2-hydroxy-4- phenylbutyric acid

Country Status (14)

Country Link
US (1) US5098841A (da)
EP (1) EP0347374B1 (da)
JP (1) JP2873236B2 (da)
KR (1) KR0165102B1 (da)
AT (1) ATE98697T1 (da)
CA (1) CA1336081C (da)
DE (1) DE58906409D1 (da)
DK (1) DK172667B1 (da)
ES (1) ES2059817T3 (da)
FI (1) FI95047C (da)
IE (1) IE63497B1 (da)
IL (1) IL90527A (da)
MX (1) MX170725B (da)
PT (1) PT90747B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2752754B2 (ja) * 1988-02-08 1998-05-18 ダイセル化学工業株式会社 光学活性２―ヒドロキシ―４―フェニル酪酸の製造法
US5256552A (en) * 1988-02-08 1993-10-26 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy-4-phenylbutyric acid
US5371014A (en) * 1988-02-12 1994-12-06 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor
CA2117340C (en) * 1991-12-23 2003-06-10 Genzyme Limited Synthesis of homochiral 2-hydroxy acids
US5770410A (en) * 1992-01-30 1998-06-23 Genzyme Corporation Chiral synthesis with modified enzymes
GB9413710D0 (en) * 1994-07-07 1994-08-24 Genzyme Ltd Chiral synthesis
RU2278612C2 (ru) * 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
DE60128581T2 (de) * 2000-10-17 2008-02-14 Excelsyn Molecular Develpopment Ltd., Holywell Herstellung von alpha -hydroxy-carboxy säure mit hilfe von einem gekoppelten enzym system
EP1902084A2 (en) * 2005-06-01 2008-03-26 Yissum Research Development Company, of The Hebrew University of Jerusalem Biodegradable polymers having a pre-determined chirality
CA2664855C (en) * 2006-09-29 2014-04-29 Council Of Scientific & Industrial Research Organic-inorganic hybrid chiral sorbent and process for the preparation thereof
CN101302503B (zh) * 2007-05-08 2011-04-06 上海医药工业研究院 突变的植物乳杆菌d-乳酸脱氢酶及其基因、重组酶和应用
WO2011009849A2 (en) 2009-07-21 2011-01-27 Basf Se Method for preparing optically active hydroxy acid esters
CN110382503B (zh) * 2017-03-03 2022-07-19 吉利德科学公司 制备acc抑制剂及其固体形式的方法
CN109234325A (zh) * 2017-07-11 2019-01-18 上海弈柯莱生物医药科技有限公司 一种乳酸脱氢酶在不对称合成手性羟基化合物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628009A5 (de) * 1977-07-26 1982-02-15 Hoffmann La Roche Verfahren zur herstellung von optisch aktiven alpha-hydroxycarbonsaeuren.
DE2930087A1 (de) * 1979-07-25 1981-02-26 Biotechnolog Forschung Gmbh Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation

Also Published As

Publication number Publication date
KR910001065A (ko) 1991-01-30
KR0165102B1 (ko) 1999-01-15
IL90527A0 (en) 1990-01-18
CA1336081C (en) 1995-06-27
PT90747B (pt) 1994-10-31
JPH0239893A (ja) 1990-02-08
JP2873236B2 (ja) 1999-03-24
IE891821L (en) 1989-12-06
FI892702A0 (fi) 1989-06-02
EP0347374B1 (de) 1993-12-15
FI95047C (fi) 1995-12-11
DK172667B1 (da) 1999-05-10
ATE98697T1 (de) 1994-01-15
FI892702A (fi) 1989-12-07
ES2059817T3 (es) 1994-11-16
PT90747A (pt) 1989-12-29
DK271289A (da) 1989-12-07
US5098841A (en) 1992-03-24
EP0347374A1 (de) 1989-12-20
MX170725B (es) 1993-09-09
FI95047B (fi) 1995-08-31
IE63497B1 (en) 1995-05-03
DK271289D0 (da) 1989-06-02
DE58906409D1 (de) 1994-01-27

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