IL89482A - Hypoglycemic and hypocholesterolemic thiazolidinedione derivatives and compositions containing them - Google Patents

Hypoglycemic and hypocholesterolemic thiazolidinedione derivatives and compositions containing them

Info

Publication number
IL89482A
IL89482A IL89482A IL8948289A IL89482A IL 89482 A IL89482 A IL 89482A IL 89482 A IL89482 A IL 89482A IL 8948289 A IL8948289 A IL 8948289A IL 89482 A IL89482 A IL 89482A
Authority
IL
Israel
Prior art keywords
alkyl
hydrogen
hypoglycemic
hypocholesterolemic
compositions containing
Prior art date
Application number
IL89482A
Other languages
English (en)
Other versions
IL89482A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL89482A0 publication Critical patent/IL89482A0/xx
Publication of IL89482A publication Critical patent/IL89482A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Paints Or Removers (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL89482A 1988-03-08 1989-03-03 Hypoglycemic and hypocholesterolemic thiazolidinedione derivatives and compositions containing them IL89482A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1988/000733 WO1989008651A1 (en) 1988-03-08 1988-03-08 Hypoglycemic thiazolidinedione derivatives

Publications (2)

Publication Number Publication Date
IL89482A0 IL89482A0 (en) 1989-09-10
IL89482A true IL89482A (en) 1993-04-04

Family

ID=22208589

Family Applications (1)

Application Number Title Priority Date Filing Date
IL89482A IL89482A (en) 1988-03-08 1989-03-03 Hypoglycemic and hypocholesterolemic thiazolidinedione derivatives and compositions containing them

Country Status (25)

Country Link
EP (1) EP0332332B1 (pt)
JP (1) JP2610990B2 (pt)
KR (1) KR910000723B1 (pt)
AT (1) ATE87624T1 (pt)
AU (1) AU593754B2 (pt)
CA (1) CA1328873C (pt)
CZ (1) CZ285957B6 (pt)
DD (1) DD279245A5 (pt)
DE (1) DE68905639T2 (pt)
DK (1) DK108089A (pt)
EG (1) EG19168A (pt)
ES (1) ES2053977T3 (pt)
FI (1) FI93115C (pt)
IE (1) IE62776B1 (pt)
IL (1) IL89482A (pt)
MX (1) MX15171A (pt)
MY (1) MY103979A (pt)
NO (1) NO177008C (pt)
NZ (1) NZ228249A (pt)
PH (1) PH26572A (pt)
PL (1) PL159728B1 (pt)
PT (1) PT89912B (pt)
WO (1) WO1989008651A1 (pt)
YU (1) YU47066B (pt)
ZA (1) ZA891680B (pt)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
CA2087437A1 (en) * 1990-08-23 1992-02-24 Steven W. Goldstein Hypoglycemic hydroxyurea derivatives
GB9023585D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
TW222626B (pt) * 1991-07-22 1994-04-21 Pfizer
US5175179A (en) * 1991-09-25 1992-12-29 Pfizer Inc. Method for treating hypertension
FR2696743B1 (fr) * 1992-10-12 1994-12-23 Adir Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.
TW245716B (pt) * 1992-12-28 1995-04-21 Takeda Pharm Industry Co
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
FI961213L (fi) * 1993-09-15 1996-05-14 Sankyo Co Tiatsolidinidionien käyttö insuliinista riippumattoman sokeritaudin syntymisen ehkäisemiseksi tai viivyttämiseksi
US5478852C1 (en) * 1993-09-15 2001-03-13 Sankyo Co Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus
US6046222A (en) * 1993-09-15 2000-04-04 Warner-Lambert Company Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
US5874454A (en) * 1993-09-15 1999-02-23 Warner-Lambert Company Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
TW420669B (en) * 1994-03-28 2001-02-01 Nissan Chemical Ind Ltd Pyridine type thiazolidines
AU3192195A (en) * 1994-08-10 1996-03-07 Takeda Chemical Industries Ltd. Thiazolidinedione derivatives, their production and use
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5708012A (en) * 1995-04-28 1998-01-13 Sankyo Company, Limited Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus
HUP9601808A3 (en) * 1995-07-03 2000-06-28 Sankyo Co Treatment of arteriosclerosis and xanthoma
NZ314406A (en) * 1996-03-18 2000-12-22 Sankyo Co Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CA2257284C (en) * 1996-05-31 2005-10-04 Sankyo Company Limited Remedy for autoimmune diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
CZ298812B6 (cs) 1996-07-01 2008-02-13 Dr. Reddy's Laboratories Limited Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí
IL128059A (en) * 1996-07-15 2003-12-10 Sankyo Co Pharmaceutical compositions for treatment and prevention of arteriosclerosis containing insulin resistance improving agents, angiotensin ii receptor antagonists and angiotensin converting enzyme inhibitors
WO1997041120A1 (en) * 1996-07-26 1997-11-06 Dr. Reddy's Research Foundation Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof
WO1998039967A1 (en) 1997-03-12 1998-09-17 The General Hospital Corporation A method for treating or preventing alzheimer's disease
DE19711616A1 (de) 1997-03-20 1998-09-24 Boehringer Mannheim Gmbh Verbessertes Verfahren zur Herstellung von Thiazolidindionen
ATE353654T1 (de) 1997-06-18 2007-03-15 Smithkline Beecham Plc Behandlung der diabetes mit thiazolidindione und sulphonylurea
GB9715295D0 (en) * 1997-07-18 1997-09-24 Smithkline Beecham Plc Novel method of treatment
GB9715306D0 (en) * 1997-07-18 1997-09-24 Smithkline Beecham Plc Novel method of treatment
HUP9902721A2 (hu) 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
AU1507799A (en) * 1997-12-16 1999-07-05 Sankyo Company Limited Leukemia remedy
AR023699A1 (es) * 1998-11-12 2002-09-04 Smithkline Beecham Corp Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
GB9824893D0 (en) * 1998-11-12 1999-01-06 Smithkline Beckman Corp Novel method of treatment
IL143002A0 (en) * 1998-11-12 2002-04-21 Smithkline Beecham Plc Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
JP2001072592A (ja) 1999-07-01 2001-03-21 Kyowa Hakko Kogyo Co Ltd テロメラーゼ阻害剤
AU6340600A (en) * 1999-07-01 2001-01-22 Geron Corporation Telomerase inhibitors and methods of their use
AR028299A1 (es) 1999-09-17 2003-05-07 Novartis Ag Una composicion farmaceutica que comprende nateglinida, un proceso para su preparacion y el uso de dicha composicion para la preparacion de un medicamento para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con diabetes.
US6878749B2 (en) 1999-09-17 2005-04-12 Novartis Ag Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
ES2275654T5 (es) 2000-01-21 2012-06-07 Novartis Ag Combinaciones que contienen inhibidores de la dipeptidilpeptidasa-IV y agentes antidiabéticos
JP2001199888A (ja) 2000-01-24 2001-07-24 Fujimoto Brothers:Kk 糖尿病治療剤
US6680387B2 (en) 2000-04-24 2004-01-20 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US6784199B2 (en) 2000-09-21 2004-08-31 Aryx Therapeutics Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
US6452014B1 (en) 2000-12-22 2002-09-17 Geron Corporation Telomerase inhibitors and methods of their use
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
RU2418793C2 (ru) * 2005-11-15 2011-05-20 Оцука Фармасьютикал Ко., Лтд. Соединение оксазола и фармацевтическая композиция
US20120094959A1 (en) 2010-10-19 2012-04-19 Bonnie Blazer-Yost Treatment of cystic diseases
DK2914250T3 (en) 2012-11-05 2018-06-18 Commissariat Energie Atomique COMBINATION OF ANTICANCER SUCH AS A TYROSINKINASE INHIBITOR AND A STAT5 ANTAGONIST, PRIOR TO A THIAZOLIDE INDION FOR ELIMINATING HEMATOLOGICAL CANCER STAM CELLS IN VIVO AND FOR THE PREVENTION OF RECIDIVISM OF RECIDIVES
US10034868B2 (en) 2014-11-04 2018-07-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the prevention and the treatment of rapidly progressive glomerulonephritis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物,其制备方法和用途
US4703052A (en) * 1985-05-21 1987-10-27 Pfizer Inc. Hypoglycemic thiazolidinediones
HU217432B (hu) * 1988-03-08 2000-01-28 Pfizer Inc. Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények
US5061717A (en) * 1988-03-08 1991-10-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents

Also Published As

Publication number Publication date
CA1328873C (en) 1994-04-26
MX15171A (es) 1993-05-01
AU3107889A (en) 1989-09-14
KR890014533A (ko) 1989-10-24
EP0332332B1 (en) 1993-03-31
CZ143989A3 (cs) 1999-06-16
EG19168A (en) 1995-02-28
WO1989008651A1 (en) 1989-09-21
JPH01272574A (ja) 1989-10-31
DK108089A (da) 1989-10-27
PT89912A (pt) 1989-11-10
ES2053977T3 (es) 1994-08-01
FI93115B (fi) 1994-11-15
PT89912B (pt) 1994-05-31
MY103979A (en) 1993-10-30
EP0332332A1 (en) 1989-09-13
AU593754B2 (en) 1990-02-15
YU47989A (en) 1990-12-31
PL159728B1 (en) 1993-01-29
PL278115A1 (en) 1989-10-30
NZ228249A (en) 1990-05-28
NO177008C (no) 1995-07-05
IE890738L (en) 1989-09-08
DE68905639D1 (de) 1993-05-06
DK108089D0 (da) 1989-03-07
NO894425L (no) 1989-11-07
YU47066B (sh) 1994-12-28
NO894425D0 (no) 1989-11-07
CZ285957B6 (cs) 1999-12-15
DE68905639T2 (de) 1993-07-08
KR910000723B1 (ko) 1991-01-31
FI93115C (fi) 1995-02-27
JP2610990B2 (ja) 1997-05-14
IE62776B1 (en) 1995-02-22
ZA891680B (en) 1990-10-31
FI895258A0 (fi) 1989-11-06
IL89482A0 (en) 1989-09-10
PH26572A (en) 1992-08-19
DD279245A5 (de) 1990-05-30
NO177008B (no) 1995-03-27
ATE87624T1 (de) 1993-04-15

Similar Documents

Publication Publication Date Title
IL89482A (en) Hypoglycemic and hypocholesterolemic thiazolidinedione derivatives and compositions containing them
MY103837A (en) Thiazolidinedione derivatives as hypoglycemic agents.
AU3107589A (en) Thiazolidinedione hypoglycemic agents
AU2001277723A1 (en) Ppardelta activators
AU3822193A (en) Azole compounds, their production and use
CA2163028A1 (en) New thiazolidinediones and pharmaceutical agents containing them
DE69327944D1 (de) Thiazolidindione-Derivate, ihre Herstellung und Verwendung
IL102573A (en) Hypoglycemic thiazolidinediones
HU9301866D0 (en) Benzoxa-condensed-ring-compounds and medical preparatives containing these compounds and processes for production of these compounds and of pharmaceutical composition
HU9203284D0 (en) Method for producing thiazolidine-2,4-dione derivatives and medical preparatives containing these compounds
EP0757988A4 (en) IMIDAZOLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
CA2285208A1 (en) Improved method for producing thiazolidinediones, and new thiazolidinediones
AU2983792A (en) Diaminomethyleneamino substituted substituted phenyl thiazoles
WO1994003425A3 (en) Carbostyril derivatives for the treatment of arrhythmia
CA2111096A1 (en) Thiazolidinedione Hypoglycemic Agents
DK0534655T3 (da) Thiazolidin-2,4-dioner til behandling af hypertension

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees