IL89033A - Bifunctional growth modulating glycoprotein named amphiregulin and its production - Google Patents
Bifunctional growth modulating glycoprotein named amphiregulin and its productionInfo
- Publication number
- IL89033A IL89033A IL8903389A IL8903389A IL89033A IL 89033 A IL89033 A IL 89033A IL 8903389 A IL8903389 A IL 8903389A IL 8903389 A IL8903389 A IL 8903389A IL 89033 A IL89033 A IL 89033A
- Authority
- IL
- Israel
- Prior art keywords
- amphiregulin
- protein
- cells
- cell
- growth
- Prior art date
Links
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
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- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
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- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US14832788A | 1988-01-25 | 1988-01-25 | |
US18188488A | 1988-04-15 | 1988-04-15 | |
US07/297,816 US5115096A (en) | 1988-04-15 | 1989-01-17 | Amphiregulin: a bifunctional growth modulating glycoprotein |
Publications (2)
Publication Number | Publication Date |
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IL89033A0 IL89033A0 (en) | 1989-08-15 |
IL89033A true IL89033A (en) | 1994-05-30 |
Family
ID=27386678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL8903389A IL89033A (en) | 1988-01-25 | 1989-01-23 | Bifunctional growth modulating glycoprotein named amphiregulin and its production |
Country Status (24)
Country | Link |
---|---|
US (1) | US5830995A (da) |
JP (1) | JPH02104596A (da) |
CN (1) | CN1038126A (da) |
AT (1) | AT399720B (da) |
AU (1) | AU623109B2 (da) |
BE (1) | BE1004201A5 (da) |
CH (1) | CH681080A5 (da) |
DE (1) | DE3902157A1 (da) |
DK (1) | DK29989A (da) |
ES (1) | ES2016432A6 (da) |
FI (1) | FI890312A (da) |
FR (1) | FR2628109B1 (da) |
GB (1) | GB2214185B (da) |
GR (1) | GR1000849B (da) |
HU (1) | HUT52545A (da) |
IE (1) | IE61146B1 (da) |
IL (1) | IL89033A (da) |
IT (1) | IT1229504B (da) |
MY (1) | MY104980A (da) |
NL (1) | NL8900178A (da) |
NO (1) | NO177788C (da) |
NZ (1) | NZ227729A (da) |
SE (1) | SE504554C2 (da) |
YU (1) | YU16989A (da) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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US5262298A (en) * | 1989-05-12 | 1993-11-16 | The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University | Method to assess the ability of a substance to inhibit or stimulate keratinocyte autocrine factor production |
EP0444961A1 (en) * | 1990-03-02 | 1991-09-04 | Bristol-Myers Squibb Company | Her3: A novel EGF receptor homolog |
EP0559769B1 (en) * | 1990-10-16 | 2001-02-07 | The Children's Medical Center Corporation | Heparin binding mitogen with homology to epidermal growth factor (egf) |
US5302706A (en) * | 1991-12-16 | 1994-04-12 | Baylor College Of Medicine | Senescent cell derived inhibitors of DNA synthesis |
US6235884B1 (en) | 1993-06-15 | 2001-05-22 | Scios Nova, Inc. | Heparin binding mitogen with homology to epidermal growth factor (EGF) |
US5633147A (en) * | 1994-03-08 | 1997-05-27 | Human Genome Sciences, Inc. | Transforming growth factor αH1 |
CA2237543A1 (en) * | 1995-12-22 | 1997-07-03 | Innogenetics N.V. | New form of amphiregulin, methods for producing and using the same and compositions comprising the same |
US6852506B1 (en) | 1996-04-10 | 2005-02-08 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
US5948889A (en) * | 1996-05-21 | 1999-09-07 | Case Western Reserve University | Compositions and methods for screening antimicrobials |
WO1998046746A1 (en) * | 1997-04-11 | 1998-10-22 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor like protein |
US20060276629A9 (en) * | 1999-12-17 | 2006-12-07 | Hildebrand William H | Purification and characterization of soluble human HLA proteins |
US20050003483A1 (en) * | 2000-10-10 | 2005-01-06 | Hildebrand William H. | Comparative ligand mapping from MHC class 1 positive cells |
DE60138922D1 (de) * | 2000-10-10 | 2009-07-16 | Univ Oklahoma | Vergleichende ligandenabbildung aus mhc-positiven zellen |
US20090062512A1 (en) * | 2000-10-10 | 2009-03-05 | Hildebrand William H | Comparative ligand mapping from MHC class I positive cells |
US20070099182A1 (en) * | 2000-10-10 | 2007-05-03 | Hildebrand William H | Comparative ligand mapping from MHC class I positive cells |
US20070026433A1 (en) * | 2001-03-09 | 2007-02-01 | Hildebrand William H | Epitope testing using soluble HLA |
US20020122820A1 (en) * | 2001-01-16 | 2002-09-05 | Hildebrand William H. | Soluble MHC artificial antigen presenting cells |
US20030054366A1 (en) * | 2001-01-23 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of human colon cancer |
WO2002072606A2 (en) * | 2001-03-09 | 2002-09-19 | Hildebrand William H | Epitope testing using hla |
US20040126829A1 (en) * | 2001-12-18 | 2004-07-01 | Hildebrand William H. | Anti-HLA assay and methods |
CA2496732A1 (en) * | 2002-08-20 | 2004-03-04 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
US7598224B2 (en) * | 2002-08-20 | 2009-10-06 | Biosurface Engineering Technologies, Inc. | Dual chain synthetic heparin-binding growth factor analogs |
US8227411B2 (en) | 2002-08-20 | 2012-07-24 | BioSurface Engineering Technologies, Incle | FGF growth factor analogs |
CA2515081A1 (en) * | 2003-02-07 | 2004-08-19 | Protein Design Labs, Inc. | Amphiregulin antibodies and their use to treat cancer and psoriasis |
EP1449538A1 (en) * | 2003-02-21 | 2004-08-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation |
US20050130897A1 (en) * | 2003-12-11 | 2005-06-16 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
ATE482228T1 (de) * | 2004-02-20 | 2010-10-15 | Biosurface Eng Tech Inc | Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2) |
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US5115096A (en) * | 1988-04-15 | 1992-05-19 | Oncogen | Amphiregulin: a bifunctional growth modulating glycoprotein |
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- 1989-01-24 DK DK029989A patent/DK29989A/da not_active Application Discontinuation
- 1989-01-24 HU HU89297A patent/HUT52545A/hu unknown
- 1989-01-24 SE SE8900247A patent/SE504554C2/sv unknown
- 1989-01-24 NO NO890299A patent/NO177788C/no unknown
- 1989-01-24 ES ES8900236A patent/ES2016432A6/es not_active Expired - Fee Related
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- 1989-01-25 BE BE8900074A patent/BE1004201A5/fr not_active IP Right Cessation
- 1989-01-25 CN CN89101545A patent/CN1038126A/zh active Pending
- 1989-01-25 AT AT0014789A patent/AT399720B/de not_active IP Right Cessation
- 1989-01-25 GR GR890100037A patent/GR1000849B/el unknown
- 1989-01-25 AU AU28769/89A patent/AU623109B2/en not_active Ceased
- 1989-01-25 FR FR8900914A patent/FR2628109B1/fr not_active Expired - Fee Related
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- 1989-01-25 NL NL8900178A patent/NL8900178A/nl not_active Application Discontinuation
- 1989-01-25 NZ NZ227729A patent/NZ227729A/en unknown
- 1989-01-25 JP JP1014232A patent/JPH02104596A/ja active Pending
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1992
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