IL85736A - Method for producing ibuprofen by high pressure carbonylation of 1-(4'-isobutylphenyl)ethanol - Google Patents

Method for producing ibuprofen by high pressure carbonylation of 1-(4'-isobutylphenyl)ethanol

Info

Publication number
IL85736A
IL85736A IL85736A IL8573688A IL85736A IL 85736 A IL85736 A IL 85736A IL 85736 A IL85736 A IL 85736A IL 8573688 A IL8573688 A IL 8573688A IL 85736 A IL85736 A IL 85736A
Authority
IL
Israel
Prior art keywords
isobutylphenyl
ethanol
high pressure
pressure carbonylation
producing ibuprofen
Prior art date
Application number
IL85736A
Other languages
English (en)
Other versions
IL85736A0 (en
Original Assignee
Hoechst Celanese Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Celanese Corp filed Critical Hoechst Celanese Corp
Publication of IL85736A0 publication Critical patent/IL85736A0/xx
Publication of IL85736A publication Critical patent/IL85736A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/10—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide
    • C07C51/12—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide on an oxygen-containing group in organic compounds, e.g. alcohols
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL85736A 1987-03-20 1988-03-14 Method for producing ibuprofen by high pressure carbonylation of 1-(4'-isobutylphenyl)ethanol IL85736A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2851487A 1987-03-20 1987-03-20
US15814188A 1988-03-04 1988-03-04

Publications (2)

Publication Number Publication Date
IL85736A0 IL85736A0 (en) 1988-08-31
IL85736A true IL85736A (en) 1992-07-15

Family

ID=26703780

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85736A IL85736A (en) 1987-03-20 1988-03-14 Method for producing ibuprofen by high pressure carbonylation of 1-(4'-isobutylphenyl)ethanol

Country Status (22)

Country Link
EP (1) EP0284310B1 (pt)
JP (1) JPH0686403B2 (pt)
KR (1) KR960007822B1 (pt)
CN (1) CN1029679C (pt)
AU (1) AU620322B2 (pt)
BR (1) BR8801238A (pt)
CA (1) CA1329396C (pt)
DE (1) DE3864713D1 (pt)
DK (1) DK148488A (pt)
ES (1) ES2026251T3 (pt)
FI (1) FI90861C (pt)
GR (1) GR3002693T3 (pt)
HU (1) HU200983B (pt)
IE (1) IE60502B1 (pt)
IL (1) IL85736A (pt)
MX (1) MX168833B (pt)
NO (1) NO169890C (pt)
NZ (1) NZ223950A (pt)
PL (1) PL153826B1 (pt)
PT (1) PT87014B (pt)
SG (1) SG22892G (pt)
YU (1) YU46539B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981995A (en) * 1987-03-20 1991-01-01 Varadaraj Elango Method for producing ibuprofen
EP0337803A1 (en) * 1988-04-15 1989-10-18 Hoechst Celanese Corporation Catalyst recycle in the carbonylation of isobutylphenylethanol to ibuprofen
JP2782080B2 (ja) * 1989-03-06 1998-07-30 日本石油化学株式会社 α―（３―ベンゾイルフェニル）プロピオン酸誘導体の製造方法
HU209123B (en) * 1990-06-04 1994-03-28 Hoechst Celanese Corp Process for producing 2-(4'-isobutylphenyl)-propionic acid
US5166418A (en) * 1990-06-04 1992-11-24 Hoechst Celanese Corporation Method for producing ibuprofen
US5179229A (en) * 1992-04-24 1993-01-12 Hoechst Celanese Corporation Preparation of 2,2-diorgano-3-arylpropionic acids and esters thereof
US5315030A (en) * 1993-09-29 1994-05-24 Ethyl Corporation Catalytic carbonylation of ethers and thioethers
US5482596A (en) * 1994-01-27 1996-01-09 Albemarle Corporation Mixed ligand catalyst for preparing aryl-substituted aliphatic carboxylic esters
EP0701987A1 (de) 1994-09-16 1996-03-20 Cu Chemie Uetikon Ag Verfahren zur Herstellung von aromatischen Ketonen
US6268526B1 (en) 1998-12-16 2001-07-31 Albemarle Corporation Palladium catalyzed carbonylation process utilizing aromatic substituted alcohols and/or aromatic substituted alkyl halides
CN1309700C (zh) * 2005-05-27 2007-04-11 中国科学院上海有机化学研究所 一种制备2－芳基乳酸酯及萘普生、布洛芬的方法
CN102329194A (zh) * 2011-07-15 2012-01-25 浙江工业大学 一种布洛芬中间体对异丁基苯乙醇的制备方法
CN103254070B (zh) * 2013-02-03 2014-11-05 青岛科技大学 一种由1-(4-异丁基苯基)乙醇制备2-(4-异丁基苯基)丙酸酯的方法
JP7472133B2 (ja) * 2018-12-03 2024-04-22 ビーエーエスエフ ソシエタス・ヨーロピア 銅を含む触媒組成物の存在下で１－（４－イソブチルフェニル）エタノンの水素化により１－（４－イソブチルフェニル）エタノールを製造する方法
CN111689847B (zh) * 2020-06-12 2022-05-17 浙江新和成股份有限公司 芳基丙酸类化合物的制备方法
EP4423045A1 (en) * 2021-10-28 2024-09-04 Centre National de la Recherche Scientifique Process for preparing acyl derivatives
CN114195633A (zh) * 2021-12-24 2022-03-18 浙江新和成股份有限公司 一种布洛芬杂质f的合成方法
CN116392986B (zh) * 2023-06-09 2023-08-04 北京思达流体科技有限公司 1-(4-异丁基苯基)乙醇羰基化的连续化生产系统及操作方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6702884A (pt) * 1966-03-22 1967-09-25
SE364254B (pt) * 1967-04-05 1974-02-18 Monsanto Co
JPS5995238A (ja) * 1982-11-19 1984-06-01 Mitsubishi Petrochem Co Ltd フエニル酢酸誘導体の製造法
DE3460753D1 (en) * 1983-05-02 1986-10-23 Shell Int Research A process for the preparation of carboxylic acids and/or esters

Also Published As

Publication number Publication date
GR3002693T3 (en) 1993-01-25
AU620322B2 (en) 1992-02-20
JPH0686403B2 (ja) 1994-11-02
FI881303A (fi) 1988-09-21
NO169890B (no) 1992-05-11
PT87014B (pt) 1992-07-31
HUT46646A (en) 1988-11-28
DE3864713D1 (de) 1991-10-17
DK148488D0 (da) 1988-03-18
NO881213D0 (no) 1988-03-18
NZ223950A (en) 1990-02-26
KR890014436A (ko) 1989-10-23
EP0284310B1 (en) 1991-09-11
HU200983B (en) 1991-04-29
CN1029679C (zh) 1995-09-06
IE880800L (en) 1988-09-20
BR8801238A (pt) 1988-10-25
PL153826B1 (en) 1991-06-28
KR960007822B1 (ko) 1996-06-12
IE60502B1 (en) 1994-07-27
FI90861B (fi) 1993-12-31
EP0284310A1 (en) 1988-09-28
PL271283A1 (en) 1988-12-08
YU46539B (sh) 1993-11-16
ES2026251T3 (es) 1992-04-16
FI90861C (fi) 1994-04-11
DK148488A (da) 1988-09-20
JPS63284143A (ja) 1988-11-21
SG22892G (en) 1992-05-15
IL85736A0 (en) 1988-08-31
YU55188A (en) 1989-12-31
NO169890C (no) 1992-08-19
AU1328488A (en) 1988-09-22
NO881213L (no) 1988-09-21
CN88102150A (zh) 1988-11-23
CA1329396C (en) 1994-05-10
FI881303A0 (fi) 1988-03-18
PT87014A (pt) 1988-04-01
MX168833B (es) 1993-06-10

Similar Documents

Publication Publication Date Title
IL85736A (en) Method for producing ibuprofen by high pressure carbonylation of 1-(4'-isobutylphenyl)ethanol
AR240675A1 (es) Procedimiento para preparar derivados de acido 1-(n-aquilaminoalcanoil)-cis-endo-2-aza-biciclo3.3. 0-octancarboxilico
EP0198570A3 (en) Process for producing a thin-walled tubing from a zirconium-niobium alloy
FR2551434B1 (fr) Procede pour la production d'acides carboxyliques
EP0551596A3 (en) Process for producing naphtalenedicarboxylic acid
GB8824155D0 (en) Method & apparatus for producing double faced corrugated fiberboard
DE3264218D1 (en) Process for preparing racemized cyclopropanecarboxylic acids
HUT58253A (en) Method for producing package for liquid medium
HUT47306A (en) Process for producing 9(11)-dehydrosteroids
DE3567645D1 (en) Process for producing optically active carboxylic acid amides
HUT52822A (en) Continuous biotechnological process for producing s(+) optical isomer of 2(6-methoxy-2-naphthyl)-propionic acid
HU9202164D0 (en) Method for producing 2-azabicyclo-[2.2.1]hept-5-ene-2-yl acetic acid derivatives
EP0283194A3 (en) Process for producing carboxylic acids
KR960015807B1 (en) Process for the preparation of purified bis(2-hydrozyethyl) ester of 2,60naphthalenedi carboxylic acid
GB8804424D0 (en) Process for producing unsaturated carboxylic acids
EP0520815A3 (en) Method for producing ortho-alkoxybenzoic acid
PL248314A1 (en) Process for preparing derivatives of bicyclo/3,2,1/-octano-3-carboxylic acid
EP0215949A4 (en) PRODUCTION PROCESS 16-SUBSTITUTED PROSTAGLANDINE-E.
HUT44777A (en) Process for producing halogen-thiophene-2-carboxylic acids
ITMI930492A1 (it) Procedimento per preparare acido 1-(25)-metil-3-mercaptopropionil pirrolidina-(2s)-carbossilico.
HUT46656A (en) Process for producing aryl-amino-sulfonic acids
HU9203897D0 (en) Method for producing 4-amino-5-hexenic acid
EP0506059A3 (en) Process for producing 2-fluoroisobutyric acid ester
FR2611708B1 (fr) Procede de production d'acides alcane-sulfoniques
HU9302320D0 (en) Method for producing new isobutyl substituted methene-sulphonyl-quinolyl-metoxy-phenyl-cycloalkyl-acetic acid amides