IL85701A0 - Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzyme - Google Patents

Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzyme

Info

Publication number
IL85701A0
IL85701A0 IL85701A IL8570188A IL85701A0 IL 85701 A0 IL85701 A0 IL 85701A0 IL 85701 A IL85701 A IL 85701A IL 8570188 A IL8570188 A IL 8570188A IL 85701 A0 IL85701 A0 IL 85701A0
Authority
IL
Israel
Prior art keywords
dna sequences
enzyme
hmn
sod
express
Prior art date
Application number
IL85701A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873708306 external-priority patent/DE3708306A1/de
Priority claimed from DE19873717695 external-priority patent/DE3717695A1/de
Priority claimed from DE19873722884 external-priority patent/DE3722884A1/de
Priority claimed from DE19873744038 external-priority patent/DE3744038A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IL85701A0 publication Critical patent/IL85701A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
IL85701A 1987-03-14 1988-03-11 Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzyme IL85701A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19873708306 DE3708306A1 (de) 1987-03-14 1987-03-14 Humane mangan-superoxiddismutase (hmn-sod)
DE19873717695 DE3717695A1 (de) 1987-05-26 1987-05-26 Humane mangan-superoxiddismutase (hmn-sod)
DE19873722884 DE3722884A1 (de) 1987-07-10 1987-07-10 Humane mangan-superoxiddismutase (hmn-sod)
DE19873744038 DE3744038A1 (de) 1987-12-24 1987-12-24 Humane mangan-superoxiddismutase (hmn-sod)

Publications (1)

Publication Number Publication Date
IL85701A0 true IL85701A0 (en) 1988-08-31

Family

ID=27433860

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85701A IL85701A0 (en) 1987-03-14 1988-03-11 Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzyme

Country Status (18)

Country Link
US (3) US5240847A (ko)
EP (2) EP0676472A1 (ko)
JP (1) JP2860100B2 (ko)
KR (1) KR880011339A (ko)
AT (1) ATE132902T1 (ko)
AU (1) AU618526B2 (ko)
CA (1) CA1341387C (ko)
DE (1) DE3854872D1 (ko)
DK (1) DK133388A (ko)
ES (1) ES2083357T3 (ko)
FI (1) FI881185A (ko)
GR (1) GR3019091T3 (ko)
HU (1) HU212920B (ko)
IE (2) IE71940B1 (ko)
IL (1) IL85701A0 (ko)
MX (1) MX9203619A (ko)
NO (1) NO176884C (ko)
PT (1) PT86955B (ko)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714362A (en) * 1983-04-29 1998-02-03 Yeda Research And Development Co. Ltd. Human superoxide dismutase cDNA
US6610520B1 (en) 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
EP0676472A1 (de) * 1987-03-14 1995-10-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Humane Mangan-Superoxiddismutase (hMn-SOD)
EP0284105B1 (en) * 1987-03-27 1995-11-15 Bio-Technology General Corporation Human manganese superoxide dismutase and methods of treatment
JP2500543B2 (ja) * 1991-05-24 1996-05-29 住友化学工業株式会社 キメラｐ４５０産生菌株
EP0587055B1 (de) * 1992-09-09 2001-12-05 Bio-Technology General Corporation Verwendung von Mangan-Superoxiddismutase (Mn-SOD) zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen in niedriger Dosierung
US5843641A (en) * 1993-02-26 1998-12-01 Massachusetts Institute Of Technology Methods for the daignosis, of familial amyotrophic lateral sclerosis
ZA942073B (en) * 1993-03-24 1994-10-27 Boehringer Ingelheim Pharma Method for inhibiting pulmonary oxygen toxicity using manganese superoxide dismutase
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US6887856B1 (en) * 1993-10-15 2005-05-03 University Of Pittsburgh Protection from ionizing irradiation or chemotherapeutic drug damage by in vivo gene therapy
US6127356A (en) * 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5506133A (en) 1994-04-11 1996-04-09 Human Genome Sciences, Inc. Superoxide dismutase-4
JP2517894B2 (ja) * 1994-08-12 1996-07-24 住友化学工業株式会社 フェレドキシン及びフェレドキシン還元酵素を同時に発現させるキメラｐ４５０産生菌株
AU3758695A (en) * 1994-09-20 1996-04-09 Duke University Oxidoreductase activity of manganic porphyrins
US5968770A (en) * 1995-02-10 1999-10-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd523 as a target
US6359194B1 (en) 1995-02-10 2002-03-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
WO1997030065A1 (en) * 1996-02-16 1997-08-21 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
US6099823A (en) * 1996-02-16 2000-08-08 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease
US6171856B1 (en) 1997-07-30 2001-01-09 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
AU8671798A (en) * 1997-07-30 1999-02-22 Betagene, Inc. Methods and compositions relating to no-mediated cytotoxicity
ES2198767T3 (es) 1997-11-03 2004-02-01 Duke University Porfirinas sustituidas.
AU3311699A (en) * 1998-02-25 1999-09-15 Board Of Regents Of The University And Community College System Of Nevada, The Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
US6737506B1 (en) * 1998-02-25 2004-05-18 Paul Anziano Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
ATE311206T1 (de) 1998-04-24 2005-12-15 Univ Duke Substituierte porphyrine
US6190658B1 (en) 1998-05-08 2001-02-20 Webb-Waring Institute For Biomedical Research Genetically modified manganese superoxide dismutase for treating oxidative damage
US6221848B1 (en) 1998-05-11 2001-04-24 University Of Pittsburgh Protection of the esophagus from chemotherapeutic or irradiation damage by gene therapy
GB9824282D0 (en) * 1998-11-05 1998-12-30 Microbiological Research Agenc Delivery of superoxide dismutase to neuronal cells
JP4501128B2 (ja) 1999-01-25 2010-07-14 ナショナル ジュウィッシュ ヘルス 置換ポルフィリン
US6265172B1 (en) * 1999-02-08 2001-07-24 University Of Kentucky Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases
FR2806911B1 (fr) * 2000-03-28 2003-01-10 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
CN1322825A (zh) * 2000-05-09 2001-11-21 上海博德基因开发有限公司 一种新的多肽——超氧化物歧化酶11和编码这种多肽的多核苷酸
CA2436245C (en) 2001-01-19 2013-04-23 National Jewish Medical And Research Center Medicament for protection in radiotherapy
AU2002312194B8 (en) 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
AU2002345699A1 (en) * 2001-06-13 2002-12-23 Webb-Waring Institute For Biomedical Research A diagnostic and prognostic method for evaluating ocular inflammation and oxidative stress and the treatment of the same
AU2003237500A1 (en) 2002-06-07 2003-12-22 Duke University Substituted porphyrins
WO2005038013A1 (en) * 2003-10-07 2005-04-28 Isis Pharmaceuticals, Inc. Artisense oligonucleotides optimized for kidney targeting
US20050191653A1 (en) * 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
US7232808B2 (en) * 2004-08-02 2007-06-19 University Of Iowa Research Foundation Methods of inhibiting manganese-containing superoxide dismutase 2 (MnSOD)
US9546312B2 (en) * 2007-08-31 2017-01-17 Hayes & Associates Endotherm systems and methods utilizing carbohydrate in non-oxidizing environment
EP2300003B1 (en) 2008-05-23 2014-03-05 National Jewish Health Compounds for use in treating injury associated with exposure to an alkylating species

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2225443B1 (ko) * 1973-04-16 1976-11-12 Anvar
FR2240277B2 (ko) * 1973-08-10 1976-12-17 Anvar
BE813485A (fr) * 1973-04-16 1974-10-09 Superoxyde dismutases et leur application comme inhibiteurs d'oxydation
US4029819A (en) * 1973-04-16 1977-06-14 Etablissement Public Det: Agence Nationale De Valorisation De La Recherche Anver Superoxide dismutase and its application as an oxidation inhibitor
JPS5816685A (ja) * 1981-07-22 1983-01-31 Takeda Chem Ind Ltd 固定化酵素，その製造法および製剤
US5196335A (en) * 1983-04-29 1993-03-23 Yeda Research And Development Co., Ltd. Human superoxide dismutase cDNA
ATE155527T1 (de) * 1983-10-03 1997-08-15 Chiron Corp Superoxiddismutase und deren expression in mikroorganismen
US5066591A (en) * 1983-10-03 1991-11-19 Chiron Corporation Polypeptides of human copper/zinc superoxide dimutase
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
DK402785D0 (da) * 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
IE59498B1 (en) * 1985-11-22 1994-03-09 Bio Technology General Corp Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form
US5246847A (en) * 1985-11-22 1993-09-21 Bio-Technology General Corp. Polypeptide analogs of human manganese superoxide dismutase and compositions and complexes thereof
US5270195A (en) * 1985-11-22 1993-12-14 Bio-Technology General Corp. Plasmids for expression and method of producing a human manganese superoxide dimutase analog
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
EP0676472A1 (de) * 1987-03-14 1995-10-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Humane Mangan-Superoxiddismutase (hMn-SOD)
EP0284105B1 (en) * 1987-03-27 1995-11-15 Bio-Technology General Corporation Human manganese superoxide dismutase and methods of treatment
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
NZ225760A (en) * 1987-08-14 1991-02-26 Bio Technology General Corp Expression plasmids containing the deo promoter and bacterial hosts containing these plasmids
JPH0283398A (ja) * 1988-09-21 1990-03-23 Ube Ind Ltd 合成ペプチド、それを用いたヒトＭｎ−スーパーオキシドジスムターゼの測定キットおよび測定法
EP0462836A3 (en) * 1990-06-20 1992-08-26 Mitsui Toatsu Chemicals, Inc. Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme

Also Published As

Publication number Publication date
US5436162A (en) 1995-07-25
NO176884B (no) 1995-03-06
PT86955B (pt) 1992-06-30
NO881089D0 (no) 1988-03-11
DE3854872D1 (de) 1996-02-22
ES2083357T3 (es) 1996-04-16
FI881185A (fi) 1988-09-15
NO881089L (no) 1988-09-15
AU1302788A (en) 1988-09-15
IE71940B1 (en) 1997-03-12
ATE132902T1 (de) 1996-01-15
JPS6463383A (en) 1989-03-09
HUT46739A (en) 1988-11-28
DK133388D0 (da) 1988-03-11
IE880717L (en) 1988-09-14
NO176884C (no) 1995-06-14
GR3019091T3 (en) 1996-05-31
HU212920B (en) 1996-12-30
EP0282899A2 (de) 1988-09-21
MX9203619A (es) 1992-09-01
AU618526B2 (en) 1992-01-02
US5589371A (en) 1996-12-31
EP0282899A3 (en) 1989-11-15
KR880011339A (ko) 1988-10-27
IE960190L (en) 1988-09-14
FI881185A0 (fi) 1988-03-14
EP0676472A1 (de) 1995-10-11
DK133388A (da) 1988-09-15
JP2860100B2 (ja) 1999-02-24
PT86955A (pt) 1988-04-01
EP0282899B1 (de) 1996-01-10
CA1341387C (en) 2002-09-03
US5240847A (en) 1993-08-31

Similar Documents

Publication Publication Date Title
IL85701A0 (en) Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzyme
UA19765A (uk) Фрагмеhт hуклеїhової кислоти, що кодує людський проаполіпопротеїн а-1
AU568067B2 (en) Oligonucleotide therapeutic agent and methods of making same
LTIP1656A (en) Alpha-amidating enzyme compositions and process for their production
WO2002031134A3 (en) Novel serine protease genes related to dppiv
NO172548C (no) Saccharomyces cerevisiae hybride vektorer og anvendelse av disse ved fremstilling av polypeptider
DE69930955D1 (de) Polypeptide mit lysophospholipaseaktivität und nukleinesäuren die sie kodieren
IL70414A (en) Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
IL85878A (en) Dna coding for anticoagulant proteins (vac), vac proteins encoded thereby, processes for preparing them, pharmaceutical compositions containing the proteins, monoclunal antibodies against such proteins and hybrid cell lines which secrete these antibodies
CA2102702A1 (en) Vitamin K-Dependent Carboxylase
IL75963A0 (en) Interferon derivatives,their preparation and pharmaceutical compositions containing them
EP1449849A3 (en) Protease-resistant thrombomodulin analog
IL86058A (en) Specifically glycosylates urokinase-type plasminogen activators, their preparation, hybrid vectors and transformed yeast containing them and pharmaceutical compositions containing such activators
AU5653294A (en) Use of a dna sequence coding for an oxalic acid degrading protein as a selection gene
AU7949991A (en) Cloned n-methylhydantoinase
EP0643719A4 (en) NUCLEIC ACID SEQUENCES ENCODING NUCLEIC ACID SEQUENCES ENCODING THE INTERLEUKIN-9 RECEPTOR, OR COMPLEMENTARY TO THESE SEQUENCES.
EP0422217A4 (en) Human recombinant placental ribonuclease inhibitor and method of production
ATE87977T1 (de) Herstellung menschlichen somatomedins c.
FR2603040A1 (fr) Proteine, sequence d'adn, poxvirus, cellules et leur procede de culture, ainsi que les compositions pharmaceutiques les contenant, utiles dans la prevention de la schistosomose
WO1998044094A3 (en) Helicobacter aliphatic amidase polypeptides, dna sequences encoding those polypeptides and uses thereof
IL121408A0 (en) Human recombinant manganese superoxide dismutase (hMn-SOD) its preparation DNA sequences coding therefor vectors containing these DNA sequences and host cells which can express them and pharmaceutical compositions containing said enzyme
DK544789A (da) Transkaryot implantering

Legal Events

Date Code Title Description
HC Change of name of proprietor(s)