IL84766A - Phosphinic acid derivatives, their manufacture and pharmaceutical compositions containing them - Google Patents

Phosphinic acid derivatives, their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL84766A
IL84766A IL8476687A IL8476687A IL84766A IL 84766 A IL84766 A IL 84766A IL 8476687 A IL8476687 A IL 8476687A IL 8476687 A IL8476687 A IL 8476687A IL 84766 A IL84766 A IL 84766A
Authority
IL
Israel
Prior art keywords
methyl
group
carbamoyl
pentyl
butyl
Prior art date
Application number
IL8476687A
Other languages
English (en)
Other versions
IL84766A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868629876A external-priority patent/GB8629876D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL84766A0 publication Critical patent/IL84766A0/xx
Publication of IL84766A publication Critical patent/IL84766A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL8476687A 1986-12-15 1987-12-09 Phosphinic acid derivatives, their manufacture and pharmaceutical compositions containing them IL84766A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868629876A GB8629876D0 (en) 1986-12-15 1986-12-15 Phosphinic acid derivatives
GB878722245A GB8722245D0 (en) 1986-12-15 1987-09-22 Phosphinic acid derivatives

Publications (2)

Publication Number Publication Date
IL84766A0 IL84766A0 (en) 1988-05-31
IL84766A true IL84766A (en) 1994-02-27

Family

ID=26291694

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8476687A IL84766A (en) 1986-12-15 1987-12-09 Phosphinic acid derivatives, their manufacture and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (2) US4885283A (pt)
EP (1) EP0276436B1 (pt)
CN (1) CN1017337B (pt)
AU (1) AU606901B2 (pt)
CA (1) CA1326737C (pt)
CS (1) CS272231B2 (pt)
DE (1) DE3786250T2 (pt)
DK (1) DK641687A (pt)
ES (1) ES2056810T3 (pt)
FI (1) FI89059C (pt)
HU (1) HU203109B (pt)
IE (1) IE62334B1 (pt)
IL (1) IL84766A (pt)
MC (1) MC1881A1 (pt)
NO (1) NO171788C (pt)
NZ (1) NZ222824A (pt)
PH (1) PH25030A (pt)
PT (1) PT86366B (pt)
ZW (1) ZW23187A1 (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347840B1 (en) * 1988-06-23 1995-12-27 Banyu Pharmaceutical Co., Ltd. Phosphinic acid derivates
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5239078A (en) 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
US5114953A (en) * 1990-11-21 1992-05-19 University Of Florida Treatment for tissue ulceration
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
FR2676059B1 (fr) * 1991-05-02 1993-07-23 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
EP0520573A1 (en) * 1991-06-27 1992-12-30 Glaxo Inc. Cyclic imide derivatives
CA2126687A1 (en) * 1992-01-15 1993-07-22 Charles G. Caldwell Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
US6037472A (en) 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
AU5825094A (en) * 1993-11-19 1995-06-06 Astra Aktiebolag Novel dipeptide derivatives
GB9405076D0 (en) 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
US5476847A (en) * 1994-06-29 1995-12-19 Schering Corporation Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US6011021A (en) * 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
FR2730235A1 (fr) * 1995-02-06 1996-08-09 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
DE69626684T2 (de) * 1995-12-08 2004-04-29 Agouron Pharmaceuticals, Inc., La Jolla Metallproteinasehemmer, diesen enthaltende pharmazeutische zusammensetzung und dessen pharmazeutische verwendung und verfahren zu ihrer herstellung
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
DE69624081T2 (de) * 1995-12-20 2003-06-12 Agouron Pharmaceuticals, Inc. Matrix-metalloprotease Inhibitoren
US5795877A (en) * 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5672592A (en) * 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
US6071965A (en) * 1996-06-17 2000-06-06 Guilford Pharmaceuticals Inc. Phosphinic alkanoic acid derivatives
US6384022B1 (en) 1996-06-17 2002-05-07 Guilford Pharmaceuticals Inc. Prodrugs of NAALAdase inhibitors
US5902817A (en) * 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US6054444A (en) 1997-04-24 2000-04-25 Guilford Pharmaceuticals Inc. Phosphonic acid derivatives
US6025345A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US6046180A (en) * 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
US5977090A (en) * 1996-09-27 1999-11-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
US5863536A (en) * 1996-12-31 1999-01-26 Guilford Pharmaceuticals Inc. Phosphoramidate derivatives
NZ333235A (en) 1996-06-17 2000-06-23 Guilford Pharm Inc Methods of cancer treatment using naaladase inhibitors
HUP9903014A3 (en) * 1996-07-18 2000-08-28 Pfizer Phosphinate derivatives having matrix metalloprotease inhibitor effect and medicaments containing the same
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US5962521A (en) * 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5981209A (en) * 1997-12-04 1999-11-09 Guilford Pharmaceuticals Inc. Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia
US6028216A (en) * 1997-12-31 2000-02-22 Guilford Pharmaceuticals Inc. Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives
US6121252A (en) * 1998-03-30 2000-09-19 Guilford Pharmaceuticals Inc. Phosphinic acid derivatives
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6265609B1 (en) 1998-07-06 2001-07-24 Guilford Pharmaceuticals Inc. Thio-substituted pentanedioic acid derivatives
KR100672965B1 (ko) 1998-07-06 2007-02-28 길포드 파마슈티컬스 인코포레이티드 약제학적 화합물로 유용한 나알라다제 억제제 및 그의조성물
US6395718B1 (en) 1998-07-06 2002-05-28 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
EP1129355B1 (en) * 1998-11-12 2005-07-20 Bristol-Myers Squibb Pharma Company Use of radioligands to screen inhibitors of amyloid-beta peptide production
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
GB9922577D0 (en) * 1999-09-23 1999-11-24 Center For Clinical & Basic Re Substituted phosphinate based peptide derivatives
US6696456B1 (en) 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
AU2001249269A1 (en) * 2000-03-21 2001-10-03 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
CN1425004A (zh) * 2000-03-21 2003-06-18 宝洁公司 含杂环侧链的n－取代的金属蛋白酶抑制剂
WO2001070693A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
MXPA02000862A (es) 2000-06-01 2003-07-14 Bristol Myers Squibb Pharma Co Lactamas substituidas por succinatos ciclicos como inhibidores de la produccion de proteina abeta.
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
WO2003104224A1 (en) 2002-06-10 2003-12-18 Pfizer Inc. Metabolites of prinomastat and their sythesis
US10464955B2 (en) 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226610A (en) * 1978-04-15 1980-10-07 Meiji Selka Kaisha, Ltd. Herbicidal compounds, preparation thereof and herbicides containing the same
JPS60163899A (ja) * 1984-02-03 1985-08-26 Sankyo Co Ltd レニン阻害ペプチド類
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
EP0210545A3 (en) * 1985-07-24 1988-07-20 Merck & Co. Inc. Phosphorous containing enzyme inhibitors
EP0209848A3 (en) * 1985-07-24 1988-07-27 Merck & Co. Inc. Enzyme inhibitors

Also Published As

Publication number Publication date
IE873383L (en) 1988-06-15
FI875484A7 (fi) 1988-06-16
ZW23187A1 (en) 1988-06-29
PH25030A (en) 1991-01-28
NO171788C (no) 1993-05-05
NO875214L (no) 1988-06-16
CA1326737C (en) 1994-02-01
CN87101164A (zh) 1988-06-29
AU8217687A (en) 1988-06-16
EP0276436A1 (en) 1988-08-03
EP0276436B1 (en) 1993-06-16
AU606901B2 (en) 1991-02-21
NO875214D0 (no) 1987-12-14
DK641687A (da) 1988-06-16
CS900287A2 (en) 1990-03-14
HUT46699A (en) 1988-11-28
CN1017337B (zh) 1992-07-08
PT86366A (en) 1988-01-01
IE62334B1 (en) 1995-01-25
ES2056810T3 (es) 1994-10-16
US5006651A (en) 1991-04-09
US4885283A (en) 1989-12-05
IL84766A0 (en) 1988-05-31
MC1881A1 (fr) 1989-01-24
NZ222824A (en) 1990-08-28
DE3786250D1 (en) 1993-07-22
NO171788B (no) 1993-01-25
CS272231B2 (en) 1991-01-15
DK641687D0 (da) 1987-12-07
FI89059B (fi) 1993-04-30
HU203109B (en) 1991-05-28
FI875484A0 (fi) 1987-12-14
PT86366B (pt) 1990-11-20
FI89059C (fi) 1993-08-10
DE3786250T2 (de) 1993-10-07

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