IL83062A - Cloning and expression of acidic fibroblast growth factor - Google Patents

Cloning and expression of acidic fibroblast growth factor

Info

Publication number
IL83062A
IL83062A IL83062A IL8306287A IL83062A IL 83062 A IL83062 A IL 83062A IL 83062 A IL83062 A IL 83062A IL 8306287 A IL8306287 A IL 8306287A IL 83062 A IL83062 A IL 83062A
Authority
IL
Israel
Prior art keywords
cloning
expression
growth factor
fibroblast growth
acidic fibroblast
Prior art date
Application number
IL83062A
Other languages
English (en)
Other versions
IL83062A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL83062A0 publication Critical patent/IL83062A0/xx
Publication of IL83062A publication Critical patent/IL83062A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL83062A 1986-07-11 1987-07-02 Cloning and expression of acidic fibroblast growth factor IL83062A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88446086A 1986-07-11 1986-07-11
US5499187A 1987-06-04 1987-06-04

Publications (2)

Publication Number Publication Date
IL83062A0 IL83062A0 (en) 1987-12-31
IL83062A true IL83062A (en) 1993-07-08

Family

ID=26733717

Family Applications (1)

Application Number Title Priority Date Filing Date
IL83062A IL83062A (en) 1986-07-11 1987-07-02 Cloning and expression of acidic fibroblast growth factor

Country Status (12)

Country Link
EP (1) EP0259953B1 (fi)
JP (2) JPH0714347B2 (fi)
KR (1) KR960009725B1 (fi)
AU (1) AU614262B2 (fi)
DE (1) DE3789530T2 (fi)
DK (1) DK175786B1 (fi)
ES (1) ES2062982T3 (fi)
FI (1) FI98915C (fi)
IE (1) IE62101B1 (fi)
IL (1) IL83062A (fi)
NZ (1) NZ220917A (fi)
PT (1) PT85306B (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE105868T1 (de) * 1985-09-12 1994-06-15 Scios Nova Inc Rekombinanter fibroblast-wachstumsfaktor.
DE3721081A1 (de) * 1987-06-26 1989-01-19 Progen Biotechnik Gmbh Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5656458A (en) * 1988-11-04 1997-08-12 Chiron Corporation Expression and processing of amino terminus acetylated FGF's in yeast
WO1990005184A1 (en) * 1988-11-04 1990-05-17 Chiron Corporation Expression and processing of authentic fgf's in yeast
EP0392605A1 (en) * 1989-04-13 1990-10-17 Merck & Co. Inc. Method of enhancing acidic fibroblast growth factor expression
JPH0343088A (ja) * 1989-09-29 1991-02-25 Takeda Chem Ind Ltd ａＦＧＦ蛋白質の製造法
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
US5726152A (en) * 1990-09-21 1998-03-10 Merck & Co., Inc. Vascular endothelial cell growth factor II
EP0506477B1 (en) 1991-03-28 1999-06-23 Merck & Co. Inc. Vascular endothelial cell growth factor C subunit
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
US6746859B1 (en) 1993-01-15 2004-06-08 Genetics Institute, Llc Cloning of enterokinase and method of use
ATE242330T1 (de) * 1993-01-15 2003-06-15 Inst Genetics Llc Klonierung von enterokinase und verfahren zu deren verwendung
FR2724665B1 (fr) * 1994-09-16 1996-12-20 Rhone Poulenc Rorer Sa Procede de production de proteines recombinantes, plasmides et cellules modifiees
JP2014193870A (ja) * 2014-04-23 2014-10-09 Eu Sol Biotech Co Ltd ヒト酸性繊維芽細胞増殖因子の改変ペプチド

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
ATE105868T1 (de) * 1985-09-12 1994-06-15 Scios Nova Inc Rekombinanter fibroblast-wachstumsfaktor.
US4935352A (en) * 1985-10-21 1990-06-19 Takeda Chemical Industries, Ltd. Expression vector for animal cell line and use thereof
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor

Also Published As

Publication number Publication date
FI98915B (fi) 1997-05-30
KR880001817A (ko) 1988-04-27
JP2565666B2 (ja) 1996-12-18
JPH07224096A (ja) 1995-08-22
DK358787A (da) 1988-01-12
JPS6394991A (ja) 1988-04-26
NZ220917A (en) 1991-05-28
KR960009725B1 (ko) 1996-07-23
FI98915C (fi) 1997-09-10
FI873033A (fi) 1988-01-12
IL83062A0 (en) 1987-12-31
DE3789530D1 (de) 1994-05-11
DK358787D0 (da) 1987-07-10
IE871871L (en) 1988-01-11
DE3789530T2 (de) 1994-09-15
EP0259953B1 (en) 1994-04-06
PT85306B (pt) 1990-03-30
AU7554487A (en) 1988-01-14
JPH0714347B2 (ja) 1995-02-22
ES2062982T3 (es) 1995-01-01
AU614262B2 (en) 1991-08-29
IE62101B1 (en) 1994-12-14
DK175786B1 (da) 2005-02-21
EP0259953A1 (en) 1988-03-16
FI873033A0 (fi) 1987-07-08
PT85306A (en) 1987-08-01

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Legal Events

Date Code Title Description
KB Patent renewed
RH Patent void
KB Patent renewed