IL78772A - Depolymerization of heparins and heparan and dermatan sulfates,products thereof and pharmaceutical compositions containing such products - Google Patents

Depolymerization of heparins and heparan and dermatan sulfates,products thereof and pharmaceutical compositions containing such products

Info

Publication number
IL78772A
IL78772A IL78772A IL7877286A IL78772A IL 78772 A IL78772 A IL 78772A IL 78772 A IL78772 A IL 78772A IL 7877286 A IL7877286 A IL 7877286A IL 78772 A IL78772 A IL 78772A
Authority
IL
Israel
Prior art keywords
products
heparins
heparan
depolymerization
pharmaceutical compositions
Prior art date
Application number
IL78772A
Other languages
English (en)
Other versions
IL78772A0 (en
Original Assignee
Opocrin Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opocrin Spa filed Critical Opocrin Spa
Publication of IL78772A0 publication Critical patent/IL78772A0/xx
Publication of IL78772A publication Critical patent/IL78772A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IL78772A 1985-05-17 1986-05-13 Depolymerization of heparins and heparan and dermatan sulfates,products thereof and pharmaceutical compositions containing such products IL78772A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8520769A IT1214609B (it) 1985-05-17 1985-05-17 Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.

Publications (2)

Publication Number Publication Date
IL78772A0 IL78772A0 (en) 1986-08-31
IL78772A true IL78772A (en) 1991-08-16

Family

ID=11171798

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78772A IL78772A (en) 1985-05-17 1986-05-13 Depolymerization of heparins and heparan and dermatan sulfates,products thereof and pharmaceutical compositions containing such products

Country Status (16)

Country Link
US (1) US4973580A (de)
EP (1) EP0221977B1 (de)
JP (1) JP2510177B2 (de)
CN (1) CN1009096B (de)
AR (1) AR240461A1 (de)
AT (1) ATE55396T1 (de)
AU (1) AU601910B2 (de)
CA (1) CA1283098C (de)
DD (1) DD251355A5 (de)
DE (1) DE3673329D1 (de)
DK (1) DK173804B1 (de)
HU (1) HU203565B (de)
IL (1) IL78772A (de)
IT (1) IT1214609B (de)
WO (1) WO1986006729A1 (de)
ZA (1) ZA863651B (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
AR243204A1 (es) * 1986-11-21 1993-07-30 Ajorca Sa Un metodo para la depolimerizacion quimica de polisacaridos.
US5668116A (en) * 1987-03-19 1997-09-16 Anthropharm Pty. Limited Anti-inflammatory compounds and compositions
EP0356435B1 (de) * 1987-03-19 1995-10-18 Arthropharm Pty. Limited Antientzündungsmittel und zusammensetzungen
WO1990003791A1 (en) * 1988-10-05 1990-04-19 Nicola Diferrante Methods for interfering with hiv multiplication and composition for the treatment of aids
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
GB8826448D0 (en) * 1988-11-11 1988-12-14 Thrombosis Res Inst Improvements in/relating to organic compounds
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
IT1240615B (it) * 1990-04-03 1993-12-17 Mediolanum Farmaceutici Spa Impiego del dermatan solfato nella prevenzione e terapia dell'invecchiamento cerebrale e degli stati di deficit funzionale del sistema nervoso centrale
WO1991015217A1 (en) * 1990-04-06 1991-10-17 Washington University Anticoagulant oligosaccharides
IT1243987B (it) * 1990-10-29 1994-06-28 Derivati Organici Lab Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
CA2102207A1 (en) * 1991-05-02 1992-11-03 Irun R. Cohen Compositions for the prevention and/or treatment of patholigical processes
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
IT1251183B (it) * 1991-08-28 1995-05-04 Opocrin Spa Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono.
FR2682388B1 (fr) * 1991-10-10 1995-06-09 Pasteur Merieux Serums Vacc Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.
GB2266239B (en) * 1992-03-25 1996-03-06 Jevco Ltd Wound healing compositions containing chondroitin sulphate oligosaccharides
US6750207B1 (en) * 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
DE69429576T2 (de) * 1993-09-30 2002-08-22 Seikagaku Kogyo K.K., Tokio/Tokyo Dermatansulfatezusammensetzung als antithromotisches mittel
US5514665A (en) * 1993-12-30 1996-05-07 University Of British Columbia Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans
CA2121952A1 (en) * 1994-04-22 1995-10-23 Francesco Della Valle Topical preparations for the treatment of acne and acneiform dermatitis
US5585361A (en) * 1994-06-07 1996-12-17 Genzyme Corporation Methods for the inhibition of platelet adherence and aggregation
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
FR2738009B1 (fr) * 1995-08-24 1997-10-31 Centre Nat Rech Scient Procede d'obtention de polysaccharides sulfates
US6537977B1 (en) * 1995-09-19 2003-03-25 Seikagaku Corporation Anti-inflammatory agent
IT1285546B1 (it) * 1996-01-16 1998-06-18 Alfa Wassermann Spa Uso del dermatano solfato a basso peso molecolare e delle specialita' medicinali che lo contengono nella terapia e nella prevenzione della
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US6206914B1 (en) 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
JP2003504428A (ja) * 1999-06-30 2003-02-04 ハミルトン シビック ホスピタルズ リサーチ ディベロップメント インコーポレイテッド クロット関連凝固因子を阻害するヘパリン組成物
KR100369518B1 (ko) * 2000-02-02 2003-01-30 김공수 저분자 다당류의 제조방법
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
AU2001291549A1 (en) * 2000-09-08 2002-03-22 Hamilton Civic Hospitals Research Development Inc. Antithrombotic compositions
PE20030263A1 (es) * 2001-07-31 2003-04-17 Novartis Ag Composicion farmaceutica oftalmica
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
US8071569B2 (en) * 2002-09-20 2011-12-06 Mousa Shaker A Oxidized heparin fractions and their use in inhibiting angiogenesis
ITMI20031618A1 (it) * 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
JP2007514718A (ja) * 2003-12-18 2007-06-07 テイボテク・フアーマシユーチカルズ・リミテツド 呼吸器シンシチウムウイルス複製のインヒビターとしてのアミノ−ベンズイミダゾール誘導体
FR2871379B1 (fr) 2004-06-14 2006-09-29 Ifremer Utilisation de derives polysaccharidiques hautement sulfates et de faible masse molaire pour moduler l'angiogenese
ES2284398B2 (es) 2006-04-27 2008-12-16 Universidad Complutense De Madrid Formulacion de vesiculas liposomales en soluciones acuosas con caracteristicas de pelicula lagrimal.
US9539202B2 (en) 2006-04-28 2017-01-10 Universidad Complutense De Madrid Formulation of liposomal vesicles in aqueous solutions with lachrymal film characteristics
CN101735336B (zh) * 2009-11-06 2012-07-18 深圳海王药业有限公司 低聚岩藻糖化糖胺聚糖及其制备方法
CA2974062C (en) * 2010-09-14 2018-07-17 Fuso Pharmaceutical Industries, Ltd. High purity heparin and production method therefor
US20130336937A1 (en) 2011-03-18 2013-12-19 Institut National de la Sante et de Ia Recherche Medicale Chondrogenic differentiation media and methods for inducing chondrogenic differentiation of cells
US20150011501A1 (en) * 2012-02-17 2015-01-08 Kimflexor, S.L. Partially depolymerized glycosaminoglycan silver and gold salts
EP2870974A1 (de) * 2013-11-08 2015-05-13 Novartis AG Salmonella-Konjugatimpfstoffe
EP3146971A1 (de) 2015-09-28 2017-03-29 Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER) Antimetastatisches derivat aus marinen bakteriellen exopolysacchariden und verwendungen davon
CN105461830A (zh) * 2016-01-08 2016-04-06 东营天东制药有限公司 一种聚螯合树脂去除铜离子的方法
CN106947004A (zh) * 2017-03-02 2017-07-14 浙江大学 一种低分子量肝素的制备方法
US11066684B2 (en) * 2017-06-20 2021-07-20 The Regents Of The University Of California Production of bioactive oligosaccharides
CN109748984A (zh) * 2018-12-28 2019-05-14 河北常山生化药业股份有限公司 一种那屈肝素钙制备方法
FR3091870B1 (fr) * 2019-01-18 2021-11-05 Adisseo France Sas Agent pour l’initiation d’une reaction d’addition radicalaire et procede le mettant en œuvre
US20220372175A1 (en) * 2019-11-14 2022-11-24 Bcd Bioscience, Inc. High-yield peroxide quench-controlled polysaccharide depolymerization and compositions thereof
JP2023533383A (ja) 2020-07-02 2023-08-02 アンスティテュ・フランセ・ドゥ・レシェルシェ・プール・レクスプローテシオン・ドゥ・ラ・メール （イエフエルウメール） 海洋性細菌性エキソポリサッカライド誘導体及びムコ多糖症の処置におけるその使用
CN111909288B (zh) * 2020-08-13 2021-09-03 山东辰龙药业有限公司 一种肝素钠的精制方法
EP4112060A1 (de) 2021-07-01 2023-01-04 Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER) Niedermolekulare he800-exopolysaccharidderivate mit antikrebs-eigenschaften und ihre verwendungen
WO2025021972A1 (en) 2023-07-27 2025-01-30 Institut Francais De Recherche Pour L'exploitation De La Mer (Ifremer) A marine bacterial exopolysaccharide derivative with anticancer properties and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US408030A (en) * 1889-07-30 Kenzie hughes
NL123338C (de) * 1961-12-08
US3935187A (en) * 1973-10-19 1976-01-27 Standard Brands Incorporated Process for depolymerizing amylaceous polymers
USB408030I5 (de) * 1973-10-19 1975-01-28
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
DE3118588C2 (de) * 1981-05-11 1983-07-07 Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung
ZA829463B (en) * 1982-07-19 1983-10-26 Hepar Ind Inc Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
FR2538404B1 (de) * 1982-12-28 1985-08-23 Anic Spa
US4533549A (en) * 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
US4687765A (en) * 1983-07-25 1987-08-18 Choay S.A. Method and composition for thrombolytic treatment
JPS624703A (ja) * 1985-07-02 1987-01-10 Tooa Eiyoo Kk 低分子量へパリン画分の製法
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
US4745108A (en) * 1986-08-20 1988-05-17 Foley Kevin M Heparin derivatives having decreased anti-Xa specificity

Also Published As

Publication number Publication date
DK173804B1 (da) 2001-11-05
JP2510177B2 (ja) 1996-06-26
WO1986006729A1 (en) 1986-11-20
DK15787A (da) 1987-01-13
CN1009096B (zh) 1990-08-08
DE3673329D1 (de) 1990-09-13
DK15787D0 (da) 1987-01-13
EP0221977A1 (de) 1987-05-20
EP0221977B1 (de) 1990-08-08
ATE55396T1 (de) 1990-08-15
JPS63500184A (ja) 1988-01-21
AU601910B2 (en) 1990-09-20
HU203565B (en) 1991-08-28
CN86104301A (zh) 1987-03-04
US4973580A (en) 1990-11-27
IL78772A0 (en) 1986-08-31
AR240461A1 (es) 1990-04-30
IT1214609B (it) 1990-01-18
DD251355A5 (de) 1987-11-11
HUT46028A (en) 1988-09-28
CA1283098C (en) 1991-04-16
IT8520769A0 (it) 1985-05-17
AU5953386A (en) 1986-12-04
ZA863651B (en) 1987-01-28

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