IL76894A - Aryl-substituted tricyclic pyridinone derivatives,their manufacture and pharmaceutical compositions containing them - Google Patents
Aryl-substituted tricyclic pyridinone derivatives,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL76894A IL76894A IL76894A IL7689485A IL76894A IL 76894 A IL76894 A IL 76894A IL 76894 A IL76894 A IL 76894A IL 7689485 A IL7689485 A IL 7689485A IL 76894 A IL76894 A IL 76894A
- Authority
- IL
- Israel
- Prior art keywords
- aryl
- manufacture
- pharmaceutical compositions
- compositions containing
- substituted tricyclic
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000005299 pyridinones Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL88046A IL88046A (en) | 1984-11-06 | 1985-10-31 | Aryl-substituted tricyclic thiazolium derivatives |
| IL88046A IL88046A0 (en) | 1984-11-06 | 1988-10-14 | Tricyclic pyridine derivatives |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH530484 | 1984-11-06 | ||
| CH383685 | 1985-09-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL76894A0 IL76894A0 (en) | 1986-02-28 |
| IL76894A true IL76894A (en) | 1989-06-30 |
Family
ID=25693960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL76894A IL76894A (en) | 1984-11-06 | 1985-10-31 | Aryl-substituted tricyclic pyridinone derivatives,their manufacture and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US4735940A (fr) |
| EP (2) | EP0183994B1 (fr) |
| JP (1) | JPH0692405B2 (fr) |
| CN (1) | CN1016871B (fr) |
| AR (1) | AR242579A1 (fr) |
| AT (1) | ATE51232T1 (fr) |
| AU (1) | AU584132B2 (fr) |
| CA (1) | CA1277659C (fr) |
| DE (2) | DE3576691D1 (fr) |
| DK (1) | DK507685A (fr) |
| DO (1) | DOP1985004378A (fr) |
| ES (8) | ES8705436A1 (fr) |
| FI (1) | FI89049C (fr) |
| GB (1) | GB2169288B (fr) |
| HU (1) | HU205353B (fr) |
| IE (1) | IE58850B1 (fr) |
| IL (1) | IL76894A (fr) |
| IS (1) | IS1469B6 (fr) |
| MC (1) | MC1707A1 (fr) |
| MY (1) | MY103172A (fr) |
| NO (1) | NO171914C (fr) |
| PT (1) | PT81431B (fr) |
| ZW (1) | ZW17385A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889848A (en) * | 1984-11-06 | 1989-12-26 | Hoffmann-La Roche Inc. | Tricyclic pyridine derivatives |
| NO162285C (no) * | 1984-11-23 | 1989-12-06 | Fujisawa Pharmaceutical Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolizinon-derivater. |
| CA1317945C (fr) * | 1985-12-13 | 1993-05-18 | Ulf Fischer | Derives de pyridazopyridone tricyclique |
| EP0294599A3 (fr) * | 1987-06-12 | 1990-05-09 | F. Hoffmann-La Roche Ag | Dérivés tricycliques de la pyridone |
| EP0465254B1 (fr) * | 1990-07-06 | 1996-11-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Composés condensés de thiophen et leur usage |
| CA2058640A1 (fr) * | 1991-01-25 | 1992-07-26 | Richard R. Scherschlicht | Derive tricyclique de pyridone |
| US5532240A (en) * | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
| FR2689129B1 (fr) * | 1992-03-27 | 1995-05-12 | Atochem Elf Sa | Nouveaux dérivés de l'acide 3-mercapto-2-thénoique et leurs procédés de préparation. |
| EP0650966A1 (fr) * | 1993-10-28 | 1995-05-03 | F. Hoffmann-La Roche Ag | Procédé pour la préparation d'un dérivé de benzo(a)quinolizinone |
| US5869500A (en) * | 1996-12-13 | 1999-02-09 | Hoffmann-La Roche Inc. | Pyridone compounds useful in treating Alzheimer's disease |
| GB9708945D0 (en) * | 1997-05-01 | 1997-06-25 | Merck Sharp & Dohme | Therapeutic agents |
| GB0119803D0 (en) * | 2001-08-14 | 2001-10-10 | Merck Sharp & Dohme | Therapeutic agents |
| GB0119828D0 (en) * | 2001-08-14 | 2001-10-10 | Merck Sharp & Dohme | Therapeutic agents |
| AU2007208452B2 (en) | 2006-01-13 | 2012-07-05 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same |
| RS59991B1 (sr) | 2013-08-08 | 2020-04-30 | Scripps Research Inst | Metoda enzimskog in vitro obeležavanja specifičnog za položaj nukleinskih kiselina uvođenjem neprirodnih nukleotida |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ191763A (en) * | 1978-10-13 | 1984-05-31 | Hoffmann La Roche | 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions |
| EP0067565A1 (fr) * | 1981-06-16 | 1982-12-22 | Beecham Group Plc | Benzamides bicycliques, leur procédé de préparation et leur application |
| GB8408292D0 (en) * | 1984-03-30 | 1984-05-10 | Fujisawa Pharmaceutical Co | Quinolizinone compound |
| GB8420602D0 (en) * | 1984-08-14 | 1984-09-19 | Wyeth John & Brother Ltd | Thienoquinolizines |
| NO162285C (no) * | 1984-11-23 | 1989-12-06 | Fujisawa Pharmaceutical Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolizinon-derivater. |
| GB8509435D0 (en) * | 1985-04-12 | 1985-05-15 | Beecham Group Plc | Intermediates & process |
| AU582663B2 (en) * | 1985-08-10 | 1989-04-06 | John Wyeth & Brother Limited | Sulphonamides |
| US4686226A (en) * | 1985-09-03 | 1987-08-11 | Merck & Co., Inc. | Substituted benzo[b]furo- and benzo[b]thieno quinolizines |
-
1985
- 1985-10-02 ZW ZW173/85A patent/ZW17385A1/xx unknown
- 1985-10-10 CA CA000492742A patent/CA1277659C/fr not_active Expired - Lifetime
- 1985-10-28 FI FI854211A patent/FI89049C/fi not_active IP Right Cessation
- 1985-10-31 AT AT85113864T patent/ATE51232T1/de not_active IP Right Cessation
- 1985-10-31 US US06/793,511 patent/US4735940A/en not_active Expired - Fee Related
- 1985-10-31 DE DE8585113864T patent/DE3576691D1/de not_active Expired - Fee Related
- 1985-10-31 EP EP85113864A patent/EP0183994B1/fr not_active Expired - Lifetime
- 1985-10-31 DE DE8888117164T patent/DE3587235D1/de not_active Expired - Fee Related
- 1985-10-31 EP EP88117164A patent/EP0318682B1/fr not_active Expired - Lifetime
- 1985-10-31 IL IL76894A patent/IL76894A/xx not_active IP Right Cessation
- 1985-10-31 AU AU49241/85A patent/AU584132B2/en not_active Ceased
- 1985-11-04 CN CN85108120A patent/CN1016871B/zh not_active Expired
- 1985-11-04 DK DK507685A patent/DK507685A/da not_active Application Discontinuation
- 1985-11-04 AR AR85302161A patent/AR242579A1/es active
- 1985-11-04 HU HU854211A patent/HU205353B/hu not_active IP Right Cessation
- 1985-11-04 MC MC851800A patent/MC1707A1/fr unknown
- 1985-11-05 PT PT81431A patent/PT81431B/pt not_active IP Right Cessation
- 1985-11-05 ES ES548532A patent/ES8705436A1/es not_active Expired
- 1985-11-05 GB GB8527196A patent/GB2169288B/en not_active Expired
- 1985-11-05 JP JP60246439A patent/JPH0692405B2/ja not_active Expired - Lifetime
- 1985-11-05 IE IE275185A patent/IE58850B1/en not_active IP Right Cessation
- 1985-11-05 DO DO1985004378A patent/DOP1985004378A/es unknown
- 1985-11-05 NO NO854404A patent/NO171914C/no unknown
- 1985-11-05 IS IS3054A patent/IS1469B6/is unknown
-
1986
- 1986-04-28 ES ES554431A patent/ES8800936A1/es not_active Expired
- 1986-04-28 ES ES554427A patent/ES8800933A1/es not_active Expired
- 1986-04-28 ES ES554426A patent/ES8800932A1/es not_active Expired
- 1986-04-28 ES ES554432A patent/ES8800937A1/es not_active Expired
- 1986-04-28 ES ES554430A patent/ES8800939A1/es not_active Expired
- 1986-04-28 ES ES554428A patent/ES8800934A1/es not_active Expired
- 1986-04-28 ES ES554429A patent/ES8800935A1/es not_active Expired
-
1987
- 1987-09-07 MY MYPI87001572A patent/MY103172A/en unknown
-
1989
- 1989-10-16 US US07/422,397 patent/US5036066A/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH1 | Patent not in force |