MC1707A1 - Dérivés de pyridine tricycliques - Google Patents

Dérivés de pyridine tricycliques

Info

Publication number
MC1707A1
MC1707A1 MC851800A MC1800A MC1707A1 MC 1707 A1 MC1707 A1 MC 1707A1 MC 851800 A MC851800 A MC 851800A MC 1800 A MC1800 A MC 1800A MC 1707 A1 MC1707 A1 MC 1707A1
Authority
MC
Monaco
Prior art keywords
pyridine derivatives
tricyclic pyridine
tricyclic
derivatives
pyridine
Prior art date
Application number
MC851800A
Other languages
English (en)
Inventor
Ulf Fischer
Fernand Schneider
Ulrich Widmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1707A1 publication Critical patent/MC1707A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
MC851800A 1984-11-06 1985-11-04 Dérivés de pyridine tricycliques MC1707A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH530484 1984-11-06
CH383685 1985-09-05

Publications (1)

Publication Number Publication Date
MC1707A1 true MC1707A1 (fr) 1986-09-22

Family

ID=25693960

Family Applications (1)

Application Number Title Priority Date Filing Date
MC851800A MC1707A1 (fr) 1984-11-06 1985-11-04 Dérivés de pyridine tricycliques

Country Status (23)

Country Link
US (2) US4735940A (fr)
EP (2) EP0183994B1 (fr)
JP (1) JPH0692405B2 (fr)
CN (1) CN1016871B (fr)
AR (1) AR242579A1 (fr)
AT (1) ATE51232T1 (fr)
AU (1) AU584132B2 (fr)
CA (1) CA1277659C (fr)
DE (2) DE3587235D1 (fr)
DK (1) DK507685A (fr)
DO (1) DOP1985004378A (fr)
ES (8) ES8705436A1 (fr)
FI (1) FI89049C (fr)
GB (1) GB2169288B (fr)
HU (1) HU205353B (fr)
IE (1) IE58850B1 (fr)
IL (1) IL76894A (fr)
IS (1) IS1469B6 (fr)
MC (1) MC1707A1 (fr)
MY (1) MY103172A (fr)
NO (1) NO171914C (fr)
PT (1) PT81431B (fr)
ZW (1) ZW17385A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889848A (en) * 1984-11-06 1989-12-26 Hoffmann-La Roche Inc. Tricyclic pyridine derivatives
NO162285C (no) * 1984-11-23 1989-12-06 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolizinon-derivater.
CA1317945C (fr) * 1985-12-13 1993-05-18 Ulf Fischer Derives de pyridazopyridone tricyclique
EP0294599A3 (fr) * 1987-06-12 1990-05-09 F. Hoffmann-La Roche Ag Dérivés tricycliques de la pyridone
DE69123090D1 (de) * 1990-07-06 1996-12-19 Yoshitomi Pharmaceutical Kondensierte Thiophenverbindungen und deren Verwendung
CA2058640A1 (fr) * 1991-01-25 1992-07-26 Richard R. Scherschlicht Derive tricyclique de pyridone
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
FR2689129B1 (fr) * 1992-03-27 1995-05-12 Atochem Elf Sa Nouveaux dérivés de l'acide 3-mercapto-2-thénoique et leurs procédés de préparation.
EP0650966A1 (fr) * 1993-10-28 1995-05-03 F. Hoffmann-La Roche Ag Procédé pour la préparation d'un dérivé de benzo(a)quinolizinone
US5869500A (en) * 1996-12-13 1999-02-09 Hoffmann-La Roche Inc. Pyridone compounds useful in treating Alzheimer's disease
GB9708945D0 (en) * 1997-05-01 1997-06-25 Merck Sharp & Dohme Therapeutic agents
GB0119803D0 (en) * 2001-08-14 2001-10-10 Merck Sharp & Dohme Therapeutic agents
GB0119828D0 (en) * 2001-08-14 2001-10-10 Merck Sharp & Dohme Therapeutic agents
US8178660B2 (en) 2006-01-13 2012-05-15 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same
JP2016531122A (ja) 2013-08-08 2016-10-06 ザ スクリップス リサーチ インスティテュートThe Scripps Research Institute 非天然ヌクレオチドの取り込みによるインビトロの核酸の部位特異的な酵素標識のための方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191763A (en) * 1978-10-13 1984-05-31 Hoffmann La Roche 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions
EP0067565A1 (fr) * 1981-06-16 1982-12-22 Beecham Group Plc Benzamides bicycliques, leur procédé de préparation et leur application
GB8408292D0 (en) * 1984-03-30 1984-05-10 Fujisawa Pharmaceutical Co Quinolizinone compound
GB8420602D0 (en) * 1984-08-14 1984-09-19 Wyeth John & Brother Ltd Thienoquinolizines
NO162285C (no) * 1984-11-23 1989-12-06 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolizinon-derivater.
GB8509435D0 (en) * 1985-04-12 1985-05-15 Beecham Group Plc Intermediates & process
AU582663B2 (en) * 1985-08-10 1989-04-06 John Wyeth & Brother Limited Sulphonamides
US4686226A (en) * 1985-09-03 1987-08-11 Merck & Co., Inc. Substituted benzo[b]furo- and benzo[b]thieno quinolizines

Also Published As

Publication number Publication date
IE58850B1 (en) 1993-11-17
IL76894A (en) 1989-06-30
NO171914C (no) 1993-05-19
GB2169288A (en) 1986-07-09
IS3054A7 (is) 1986-05-07
ES8800932A1 (es) 1987-12-01
MY103172A (en) 1993-05-29
CN1016871B (zh) 1992-06-03
ES554426A0 (es) 1987-12-01
ES554431A0 (es) 1987-12-01
ATE51232T1 (de) 1990-04-15
FI89049C (fi) 1993-08-10
JPH0692405B2 (ja) 1994-11-16
IS1469B6 (is) 1991-09-24
EP0318682A2 (fr) 1989-06-07
DK507685A (da) 1986-05-07
FI854211A0 (fi) 1985-10-28
AU4924185A (en) 1986-05-15
HUT38638A (en) 1986-06-30
US4735940A (en) 1988-04-05
ES8800939A1 (es) 1987-12-01
JPS61115082A (ja) 1986-06-02
ES554430A0 (es) 1987-12-01
EP0318682A3 (en) 1989-08-16
GB2169288B (en) 1989-06-01
ES554432A0 (es) 1987-12-01
ES554429A0 (es) 1987-12-01
HU205353B (en) 1992-04-28
CN85108120A (zh) 1986-11-05
ES548532A0 (es) 1987-05-01
AU584132B2 (en) 1989-05-18
PT81431A (en) 1985-12-01
CA1277659C (fr) 1990-12-11
EP0183994A1 (fr) 1986-06-11
ES8705436A1 (es) 1987-05-01
ES8800935A1 (es) 1987-12-01
DE3587235D1 (en) 1993-05-06
ES554427A0 (es) 1987-12-01
NO854404L (no) 1986-05-07
EP0183994B1 (fr) 1990-03-21
GB8527196D0 (en) 1985-12-11
US5036066A (en) 1991-07-30
DE3576691D1 (de) 1990-04-26
EP0318682B1 (fr) 1993-03-31
NO171914B (no) 1993-02-08
DK507685D0 (da) 1985-11-04
ES8800936A1 (es) 1987-12-01
FI89049B (fi) 1993-04-30
DOP1985004378A (es) 1991-04-05
ES8800934A1 (es) 1987-12-01
IL76894A0 (en) 1986-02-28
IE852751L (en) 1986-05-06
ES8800937A1 (es) 1987-12-01
ZW17385A1 (en) 1986-02-19
AR242579A1 (es) 1993-04-30
PT81431B (pt) 1988-03-03
ES554428A0 (es) 1987-12-01
ES8800933A1 (es) 1987-12-01

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