IL70618A - Disubstituted proline derivatives,a process for their preparation and their use - Google Patents

Disubstituted proline derivatives,a process for their preparation and their use

Info

Publication number
IL70618A
IL70618A IL70618A IL7061884A IL70618A IL 70618 A IL70618 A IL 70618A IL 70618 A IL70618 A IL 70618A IL 7061884 A IL7061884 A IL 7061884A IL 70618 A IL70618 A IL 70618A
Authority
IL
Israel
Prior art keywords
preparation
proline derivatives
disubstituted
disubstituted proline
aryl
Prior art date
Application number
IL70618A
Other languages
English (en)
Other versions
IL70618A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL70618A0 publication Critical patent/IL70618A0/xx
Publication of IL70618A publication Critical patent/IL70618A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/10—Mercury compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Golf Clubs (AREA)
  • Glass Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
IL70618A 1983-01-07 1984-01-05 Disubstituted proline derivatives,a process for their preparation and their use IL70618A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833300316 DE3300316A1 (de) 1983-01-07 1983-01-07 Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
IL70618A0 IL70618A0 (en) 1984-04-30
IL70618A true IL70618A (en) 1987-10-30

Family

ID=6187824

Family Applications (1)

Application Number Title Priority Date Filing Date
IL70618A IL70618A (en) 1983-01-07 1984-01-05 Disubstituted proline derivatives,a process for their preparation and their use

Country Status (21)

Country Link
US (1) US4684662A (ja)
EP (1) EP0115639B1 (ja)
JP (3) JPS59144755A (ja)
KR (1) KR900007216B1 (ja)
AT (1) ATE25677T1 (ja)
AU (1) AU575306B2 (ja)
CA (1) CA1220213A (ja)
DE (2) DE3300316A1 (ja)
DK (2) DK171641B1 (ja)
ES (2) ES8407471A1 (ja)
FI (1) FI81780C (ja)
GR (1) GR79462B (ja)
HU (1) HU190541B (ja)
IE (1) IE56520B1 (ja)
IL (1) IL70618A (ja)
MA (1) MA19996A1 (ja)
NO (1) NO165921C (ja)
NZ (1) NZ206733A (ja)
PH (1) PH19979A (ja)
PT (1) PT77924B (ja)
ZA (1) ZA84113B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
WO1990012005A1 (en) * 1989-04-13 1990-10-18 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
EP1228061A4 (en) * 1999-11-12 2004-12-15 Guilford Pharm Inc DIPEPTIDYL PEPTIDASE IV INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF
US20040152745A1 (en) * 1999-11-12 2004-08-05 Guilford Pharmaceuticals, Inc. Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors
MXPA05010165A (es) * 2003-04-15 2005-11-16 Warner Lambert Co Derivados de prolina biciclicos [c]-condensados y su uso para el tratamiento de estados artriticos.
BRPI0409560A (pt) * 2003-04-15 2006-04-18 Warner Lambert Co derivados bicìclicos [b]-condensados de prolina e sua utilização para tratar condições artrìticas
ZA200704767B (en) * 2004-11-05 2008-08-27 King Pharmaceuticals Res & Dev Stabilized individually coated ramipril particles, compositions and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE315190C (ja) *
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
DE3151690A1 (de) * 1981-12-29 1983-07-07 Hoechst Ag, 6230 Frankfurt "neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung"

Also Published As

Publication number Publication date
KR840007583A (ko) 1984-12-08
ES530311A0 (es) 1984-11-01
NZ206733A (en) 1988-02-29
AU575306B2 (en) 1988-07-28
AU2314684A (en) 1984-07-12
PT77924A (de) 1984-02-01
NO165921C (no) 1991-05-02
FI840027A0 (fi) 1984-01-05
DE3369980D1 (en) 1987-04-09
MA19996A1 (fr) 1984-10-01
JPH056542B2 (ja) 1993-01-26
GR79462B (ja) 1984-10-30
JPH0610190B2 (ja) 1994-02-09
US4684662A (en) 1987-08-04
HU190541B (en) 1986-09-29
DK171641B1 (da) 1997-03-03
FI81780C (fi) 1990-12-10
NO165921B (no) 1991-01-21
DE3300316A1 (de) 1984-07-12
EP0115639A1 (de) 1984-08-15
FI81780B (fi) 1990-08-31
IE840023L (en) 1984-07-07
DK33196A (da) 1996-03-21
DK6384A (da) 1984-07-08
CA1220213A (en) 1987-04-07
KR900007216B1 (ko) 1990-10-05
PT77924B (de) 1986-05-30
ZA84113B (en) 1984-08-29
JPH0583541B2 (ja) 1993-11-26
JPH0578312A (ja) 1993-03-30
PH19979A (en) 1986-08-26
EP0115639B1 (de) 1987-03-04
NO840048L (no) 1984-07-09
ES8500900A1 (es) 1984-11-01
ATE25677T1 (de) 1987-03-15
JPS59144755A (ja) 1984-08-18
IL70618A0 (en) 1984-04-30
JPH0570423A (ja) 1993-03-23
DK171642B1 (da) 1997-03-03
DK6384D0 (da) 1984-01-06
IE56520B1 (en) 1991-08-28
ES528703A0 (es) 1984-09-16
ES8407471A1 (es) 1984-09-16
FI840027A (fi) 1984-07-08

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Legal Events

Date Code Title Description
KB Patent renewed
HP Change in proprietorship
EXP Patent expired