ZA875727B - 1,4-dihydropyridine derivatives,the process for preparing them and the pharmaceutical compositions which contain them - Google Patents
1,4-dihydropyridine derivatives,the process for preparing them and the pharmaceutical compositions which contain themInfo
- Publication number
- ZA875727B ZA875727B ZA875727A ZA875727A ZA875727B ZA 875727 B ZA875727 B ZA 875727B ZA 875727 A ZA875727 A ZA 875727A ZA 875727 A ZA875727 A ZA 875727A ZA 875727 B ZA875727 B ZA 875727B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparing
- contain
- radical
- pharmaceutical compositions
- dihydropyridine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
Compounds of general formula I: <IMAGE> in which: Ar represents a phenyl radical optionally containing one to five identical or different substituents, representing a halogen atom, an alkoxy radical containing 1 to 4 carbon atoms, an alkylthio radical containing 1 to 4 carbon atoms, a trihalomethyl radical or a methylenedioxy radical, Y, Z, Y1, Z1, W, V, U, m, n, R1, R2 are as defined in the specification. The compounds are used as calcium modulators.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8611260A FR2602231B1 (en) | 1986-08-04 | 1986-08-04 | NOVEL 1,4-DIHYDRO PYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA875727B true ZA875727B (en) | 1988-04-27 |
Family
ID=9338004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA875727A ZA875727B (en) | 1986-08-04 | 1987-08-03 | 1,4-dihydropyridine derivatives,the process for preparing them and the pharmaceutical compositions which contain them |
Country Status (16)
Country | Link |
---|---|
US (1) | US4870091A (en) |
EP (1) | EP0259206B1 (en) |
JP (1) | JPS6341460A (en) |
AT (1) | ATE68178T1 (en) |
AU (1) | AU595353B2 (en) |
CA (1) | CA1338637C (en) |
DE (1) | DE3773597D1 (en) |
DK (1) | DK406587A (en) |
ES (1) | ES2004467A6 (en) |
FR (1) | FR2602231B1 (en) |
GR (1) | GR871231B (en) |
IE (1) | IE59985B1 (en) |
NZ (1) | NZ221314A (en) |
OA (1) | OA08646A (en) |
PT (1) | PT85482B (en) |
ZA (1) | ZA875727B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2649395B1 (en) * | 1989-07-04 | 1992-11-06 | Adir | NEW DERIVATIVE OF 1,4-DIHYDRO PYRIDINE NAMED (-) I1(((2-AMINO ETHOXY)-2 ETHOXY) METHYLI1) -2 (2,3-DICHLORO-PHENYL)-4 ETHOXYCARBONYL-3 METHOXYCARBONYL -5 METHYL-6 DIHYDRO-1,4 PYRIDINE, ITS PREPARATION PROCESS AND THE COMPOSITIONS WHICH CONTAIN IT |
IT1222591B (en) * | 1987-09-04 | 1990-09-05 | Boehringer Biochemia Srl | 1,4-DIHYDROPYRIDINS 2-ALCHIL- AND ALCHENYL-SUBSTITUTED, METHOD FOR THEIR PHARMACEUTICAL PREPARATION AND COMPOSITION CONTAINING THEM |
FR2652083B1 (en) * | 1989-09-20 | 1992-01-24 | Ador Cie | NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES. |
FR2686879B1 (en) * | 1992-02-05 | 1994-03-18 | Adir Cie | NOVEL 1,4-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
FR2700541B1 (en) * | 1993-01-21 | 1995-03-03 | Adir | New 1,4-dihydropyridine compounds, process for their preparation and pharmaceutical compositions containing them. |
CA2433181C (en) * | 2000-12-29 | 2005-11-22 | Pfizer Limited | Amlodipine hemifumarate |
WO2002053539A1 (en) * | 2000-12-29 | 2002-07-11 | Pfizer Limited | Amlodipine hemimaleate |
SI1309555T1 (en) * | 2000-12-29 | 2005-12-31 | Pfizer Ltd | Process for making amlodipine maleate |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2658183A1 (en) * | 1976-12-22 | 1978-07-06 | Bayer Ag | 2-POSITION SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS A MEDICINAL PRODUCT |
US4177278A (en) * | 1977-04-05 | 1979-12-04 | Bayer Aktiengesellschaft | 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use |
JPS5547656A (en) * | 1978-09-29 | 1980-04-04 | Dainippon Pharmaceut Co Ltd | 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative |
DE2844595A1 (en) * | 1978-10-13 | 1980-04-30 | Bayer Ag | 2-Acylamino:alkyl-di:hydro-pyridine derivs. - useful as cardiovascular agents acting as coronary dilators, hypotensives, antiarrhythmics, vascular spasmolytics and hypolipaemics |
CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
DE3207982A1 (en) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | NEW 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF IN MEDICINAL PRODUCTS |
DK161312C (en) * | 1982-03-11 | 1991-12-09 | Pfizer | CHANGES FOR THE PREPARATION FOR THE PREPARATION OF 2-Amino-CO-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-2-D-Hydroxy |
GB8306666D0 (en) * | 1983-03-10 | 1983-04-13 | Pfizer Ltd | Therapeutic agents |
GR851819B (en) * | 1984-08-17 | 1985-11-26 | Wyeth John & Brother Ltd | |
EP0174131A3 (en) * | 1984-09-01 | 1989-06-07 | FISONS plc | Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them |
JPS61140567A (en) * | 1984-12-13 | 1986-06-27 | Otsuka Pharmaceut Co Ltd | Dihydropyridine derivative |
IT1215298B (en) * | 1985-08-06 | 1990-01-31 | Boehringer Biochemia Srl | 2- (ETEROALCHIL) -1,4-DIHYDROPYRIDINE AND A PROCESS FOR THEIR PRODUCTION. |
DE3531498A1 (en) * | 1985-09-04 | 1987-03-05 | Bayer Ag | DIHYDROPYRIDIN-2-HYDROXYAMINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS |
-
1986
- 1986-08-04 FR FR8611260A patent/FR2602231B1/en not_active Expired
-
1987
- 1987-07-16 CA CA000542335A patent/CA1338637C/en not_active Expired - Fee Related
- 1987-08-03 ZA ZA875727A patent/ZA875727B/en unknown
- 1987-08-03 AU AU76505/87A patent/AU595353B2/en not_active Ceased
- 1987-08-03 JP JP62194274A patent/JPS6341460A/en active Pending
- 1987-08-03 NZ NZ221314A patent/NZ221314A/en unknown
- 1987-08-03 US US07/081,303 patent/US4870091A/en not_active Expired - Lifetime
- 1987-08-03 GR GR871231A patent/GR871231B/en unknown
- 1987-08-04 PT PT85482A patent/PT85482B/en not_active IP Right Cessation
- 1987-08-04 OA OA59176A patent/OA08646A/en unknown
- 1987-08-04 AT AT87401808T patent/ATE68178T1/en not_active IP Right Cessation
- 1987-08-04 IE IE209087A patent/IE59985B1/en not_active IP Right Cessation
- 1987-08-04 EP EP87401808A patent/EP0259206B1/en not_active Expired - Lifetime
- 1987-08-04 ES ES8702288A patent/ES2004467A6/en not_active Expired
- 1987-08-04 DE DE8787401808T patent/DE3773597D1/en not_active Expired - Lifetime
- 1987-08-04 DK DK406587A patent/DK406587A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0259206B1 (en) | 1991-10-09 |
DK406587D0 (en) | 1987-08-04 |
CA1338637C (en) | 1996-10-08 |
FR2602231A1 (en) | 1988-02-05 |
DE3773597D1 (en) | 1991-11-14 |
AU7650587A (en) | 1988-02-11 |
ES2004467A6 (en) | 1989-01-01 |
GR871231B (en) | 1987-12-04 |
PT85482B (en) | 1990-06-29 |
US4870091A (en) | 1989-09-26 |
EP0259206A1 (en) | 1988-03-09 |
IE59985B1 (en) | 1994-05-04 |
DK406587A (en) | 1988-02-05 |
JPS6341460A (en) | 1988-02-22 |
ATE68178T1 (en) | 1991-10-15 |
NZ221314A (en) | 1990-03-27 |
PT85482A (en) | 1987-09-01 |
OA08646A (en) | 1988-11-30 |
AU595353B2 (en) | 1990-03-29 |
IE872090L (en) | 1988-02-04 |
FR2602231B1 (en) | 1988-10-28 |
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