FR2652083B1 - NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES. - Google Patents

NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES.

Info

Publication number
FR2652083B1
FR2652083B1 FR8912323A FR8912323A FR2652083B1 FR 2652083 B1 FR2652083 B1 FR 2652083B1 FR 8912323 A FR8912323 A FR 8912323A FR 8912323 A FR8912323 A FR 8912323A FR 2652083 B1 FR2652083 B1 FR 2652083B1
Authority
FR
France
Prior art keywords
radical
carbon atoms
optical isomers
separating optical
novel process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR8912323A
Other languages
French (fr)
Other versions
FR2652083A1 (en
Inventor
Peglion Jean-Louis
Serkiz Bernard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADOR CIE
Original Assignee
ADOR CIE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADOR CIE filed Critical ADOR CIE
Priority to FR8912323A priority Critical patent/FR2652083B1/en
Priority to IE2890A priority patent/IE63293B1/en
Priority to PT92859A priority patent/PT92859B/en
Priority to JP2003680A priority patent/JPH03112965A/en
Priority to ZA90231A priority patent/ZA90231B/en
Priority to OA59725A priority patent/OA09436A/en
Priority to AU47926/90A priority patent/AU618444B2/en
Priority to NZ232089A priority patent/NZ232089A/en
Priority to CA002007718A priority patent/CA2007718A1/en
Priority to DK90400096.5T priority patent/DK0419297T3/en
Priority to AT90400096T priority patent/ATE106870T1/en
Priority to EP90400096A priority patent/EP0419297B1/en
Priority to ES90400096T priority patent/ES2057455T3/en
Priority to DE69009642T priority patent/DE69009642T2/en
Publication of FR2652083A1 publication Critical patent/FR2652083A1/en
Application granted granted Critical
Publication of FR2652083B1 publication Critical patent/FR2652083B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

New process for separating optical isomers of the compounds of general formula I: in which: - Ar denotes a phenyl radical optionally containing one to five identical or different substituents, each denoting a halogen atom, an alkoxy radical containing from 1 to 4 carbon atoms, an alkylthio radical containing from 1 to 4 carbon atoms, a trihalomethyl radical or a methylenedioxy radical, - each of Y, Z, Y1 and Z1, which are identical or different, denotes a hydrogen atom, a linear or branched lower alkyl radical containing from 1 to 4 carbon atoms, a cyclopropyl radical, a dicyclopropylmethyl radical, a 2,2-dicyclopropylethyl radical, a 2,2-dicyclopropylethylene radical, a 3,3-dicyclopropylpropyl radical, a 3,3-dicyclopropyl-1-propylene radical, a linear or branched alkylene radical containing from 2 to 5 carbon atoms or a phenyl radical optionally substituted by a nitro radical, and - n is equal to 1, 2 or 3.
FR8912323A 1989-09-20 1989-09-20 NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES. Expired - Fee Related FR2652083B1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FR8912323A FR2652083B1 (en) 1989-09-20 1989-09-20 NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES.
IE2890A IE63293B1 (en) 1989-09-20 1990-01-04 New process for separating optical isomers of 1,4-dihydropyridine derivatives
JP2003680A JPH03112965A (en) 1989-09-20 1990-01-12 Separation of optical isomer from 1, 4-dihydro- pyridine derivative
ZA90231A ZA90231B (en) 1989-09-20 1990-01-12 Process for separating optical isomers of 1,4-dihydropyridine derivatives
OA59725A OA09436A (en) 1989-09-20 1990-01-12 New process for the separation of optical isomers from 1,4-dihydro-pyridine derivatives.
AU47926/90A AU618444B2 (en) 1989-09-20 1990-01-12 New process for separating optical isomers of 1,4-dihydropyridine derivatives
NZ232089A NZ232089A (en) 1989-09-20 1990-01-12 Preparation of optical isomers of 6-(aminoethyleneoxymethyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid derivatives and intermediates
CA002007718A CA2007718A1 (en) 1989-09-20 1990-01-12 Process for the resolution of 1,4-dihydropyridine derivatives optical isomers
PT92859A PT92859B (en) 1989-09-20 1990-01-12 PROCESS FOR THE SEPARATION OF OPTICAL ISOMERS OF 1,4-DIHYDRO-PYRIDINE DERIVATIVES
AT90400096T ATE106870T1 (en) 1989-09-20 1990-01-15 PROCEDURE FOR THE SEPARATION OF OPTICAL ISOMERS OF 1,4-DIHYDROPYRIDINE DERIVATIVES.
DK90400096.5T DK0419297T3 (en) 1989-09-20 1990-01-15 New method for separating optical isomers of 1,4-dihydropyridine derivatives
EP90400096A EP0419297B1 (en) 1989-09-20 1990-01-15 Process for the separation of optical isomers from 1,4-dihydropyridine derivatives
ES90400096T ES2057455T3 (en) 1989-09-20 1990-01-15 PROCEDURE FOR THE PREPARATION OF OPTIC ISOMERS OF THE DERIVATIVES OF 1,4-DIHYDRO-PIRIDINE.
DE69009642T DE69009642T2 (en) 1989-09-20 1990-01-15 Process for the separation of optical isomers from derivatives of 1,4-dihydropyridine.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8912323A FR2652083B1 (en) 1989-09-20 1989-09-20 NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES.

Publications (2)

Publication Number Publication Date
FR2652083A1 FR2652083A1 (en) 1991-03-22
FR2652083B1 true FR2652083B1 (en) 1992-01-24

Family

ID=9385673

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8912323A Expired - Fee Related FR2652083B1 (en) 1989-09-20 1989-09-20 NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES.

Country Status (14)

Country Link
EP (1) EP0419297B1 (en)
JP (1) JPH03112965A (en)
AT (1) ATE106870T1 (en)
AU (1) AU618444B2 (en)
CA (1) CA2007718A1 (en)
DE (1) DE69009642T2 (en)
DK (1) DK0419297T3 (en)
ES (1) ES2057455T3 (en)
FR (1) FR2652083B1 (en)
IE (1) IE63293B1 (en)
NZ (1) NZ232089A (en)
OA (1) OA09436A (en)
PT (1) PT92859B (en)
ZA (1) ZA90231B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686879B1 (en) * 1992-02-05 1994-03-18 Adir Cie NOVEL 1,4-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (en) * 1982-03-11 1991-12-09 Pfizer CHANGES FOR THE PREPARATION FOR THE PREPARATION OF 2-Amino-CO-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-2-D-Hydroxy
FR2602231B1 (en) * 1986-08-04 1988-10-28 Adir NOVEL 1,4-DIHYDRO PYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2649395B1 (en) * 1989-07-04 1992-11-06 Adir NEW DERIVATIVE OF 1,4-DIHYDRO PYRIDINE NAMED (-) I1(((2-AMINO ETHOXY)-2 ETHOXY) METHYLI1) -2 (2,3-DICHLORO-PHENYL)-4 ETHOXYCARBONYL-3 METHOXYCARBONYL -5 METHYL-6 DIHYDRO-1,4 PYRIDINE, ITS PREPARATION PROCESS AND THE COMPOSITIONS WHICH CONTAIN IT

Also Published As

Publication number Publication date
DK0419297T3 (en) 1994-10-31
AU618444B2 (en) 1991-12-19
ZA90231B (en) 1990-11-28
DE69009642D1 (en) 1994-07-14
EP0419297A1 (en) 1991-03-27
JPH03112965A (en) 1991-05-14
IE63293B1 (en) 1995-04-05
PT92859A (en) 1990-07-31
OA09436A (en) 1992-10-15
NZ232089A (en) 1991-09-25
DE69009642T2 (en) 1994-10-27
IE900028A1 (en) 1991-03-27
ES2057455T3 (en) 1994-10-16
PT92859B (en) 1995-12-29
ATE106870T1 (en) 1994-06-15
CA2007718A1 (en) 1991-03-20
AU4792690A (en) 1991-03-28
FR2652083A1 (en) 1991-03-22
EP0419297B1 (en) 1994-06-08

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