DK0419297T3 - New method for separating optical isomers of 1,4-dihydropyridine derivatives - Google Patents

New method for separating optical isomers of 1,4-dihydropyridine derivatives

Info

Publication number
DK0419297T3
DK0419297T3 DK90400096.5T DK90400096T DK0419297T3 DK 0419297 T3 DK0419297 T3 DK 0419297T3 DK 90400096 T DK90400096 T DK 90400096T DK 0419297 T3 DK0419297 T3 DK 0419297T3
Authority
DK
Denmark
Prior art keywords
radical
carbon atoms
optical isomers
separating optical
new method
Prior art date
Application number
DK90400096.5T
Other languages
Danish (da)
Inventor
Jean Louis Peglion
Bernard Serkiz
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0419297T3 publication Critical patent/DK0419297T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

New process for separating optical isomers of the compounds of general formula I: <IMAGE> in which: - Ar denotes a phenyl radical optionally containing one to five identical or different substituents, each denoting a halogen atom, an alkoxy radical containing from 1 to 4 carbon atoms, an alkylthio radical containing from 1 to 4 carbon atoms, a trihalomethyl radical or a methylenedioxy radical, - each of Y, Z, Y1 and Z1, which are identical or different, denotes a hydrogen atom, a linear or branched lower alkyl radical containing from 1 to 4 carbon atoms, a cyclopropyl radical, a dicyclopropylmethyl radical, a 2,2-dicyclopropylethyl radical, a 2,2-dicyclopropylethylene radical, a 3,3-dicyclopropylpropyl radical, a 3,3-dicyclopropyl-1-propylene radical, a linear or branched alkylene radical containing from 2 to 5 carbon atoms or a phenyl radical optionally substituted by a nitro radical, and - n is equal to 1, 2 or 3.
DK90400096.5T 1989-09-20 1990-01-15 New method for separating optical isomers of 1,4-dihydropyridine derivatives DK0419297T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8912323A FR2652083B1 (en) 1989-09-20 1989-09-20 NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES.

Publications (1)

Publication Number Publication Date
DK0419297T3 true DK0419297T3 (en) 1994-10-31

Family

ID=9385673

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90400096.5T DK0419297T3 (en) 1989-09-20 1990-01-15 New method for separating optical isomers of 1,4-dihydropyridine derivatives

Country Status (14)

Country Link
EP (1) EP0419297B1 (en)
JP (1) JPH03112965A (en)
AT (1) ATE106870T1 (en)
AU (1) AU618444B2 (en)
CA (1) CA2007718A1 (en)
DE (1) DE69009642T2 (en)
DK (1) DK0419297T3 (en)
ES (1) ES2057455T3 (en)
FR (1) FR2652083B1 (en)
IE (1) IE63293B1 (en)
NZ (1) NZ232089A (en)
OA (1) OA09436A (en)
PT (1) PT92859B (en)
ZA (1) ZA90231B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686879B1 (en) * 1992-02-05 1994-03-18 Adir Cie NOVEL 1,4-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (en) * 1982-03-11 1991-12-09 Pfizer CHANGES FOR THE PREPARATION FOR THE PREPARATION OF 2-Amino-CO-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-2-D-Hydroxy
FR2602231B1 (en) * 1986-08-04 1988-10-28 Adir NOVEL 1,4-DIHYDRO PYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2649395B1 (en) * 1989-07-04 1992-11-06 Adir NEW DERIVATIVE OF 1,4-DIHYDRO PYRIDINE NAMED (-) I1(((2-AMINO ETHOXY)-2 ETHOXY) METHYLI1) -2 (2,3-DICHLORO-PHENYL)-4 ETHOXYCARBONYL-3 METHOXYCARBONYL -5 METHYL-6 DIHYDRO-1,4 PYRIDINE, ITS PREPARATION PROCESS AND THE COMPOSITIONS WHICH CONTAIN IT

Also Published As

Publication number Publication date
CA2007718A1 (en) 1991-03-20
JPH03112965A (en) 1991-05-14
IE63293B1 (en) 1995-04-05
NZ232089A (en) 1991-09-25
EP0419297A1 (en) 1991-03-27
OA09436A (en) 1992-10-15
ZA90231B (en) 1990-11-28
DE69009642D1 (en) 1994-07-14
IE900028A1 (en) 1991-03-27
AU618444B2 (en) 1991-12-19
PT92859A (en) 1990-07-31
ES2057455T3 (en) 1994-10-16
AU4792690A (en) 1991-03-28
DE69009642T2 (en) 1994-10-27
EP0419297B1 (en) 1994-06-08
ATE106870T1 (en) 1994-06-15
FR2652083A1 (en) 1991-03-22
FR2652083B1 (en) 1992-01-24
PT92859B (en) 1995-12-29

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