AU618444B2 - New process for separating optical isomers of 1,4-dihydropyridine derivatives - Google Patents

New process for separating optical isomers of 1,4-dihydropyridine derivatives

Info

Publication number
AU618444B2
AU618444B2 AU47926/90A AU4792690A AU618444B2 AU 618444 B2 AU618444 B2 AU 618444B2 AU 47926/90 A AU47926/90 A AU 47926/90A AU 4792690 A AU4792690 A AU 4792690A AU 618444 B2 AU618444 B2 AU 618444B2
Authority
AU
Australia
Prior art keywords
radical
carbon atoms
optical isomers
new process
separating optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47926/90A
Other versions
AU4792690A (en
Inventor
Jean-Louis Peglion
Bernard Serkiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of AU4792690A publication Critical patent/AU4792690A/en
Application granted granted Critical
Publication of AU618444B2 publication Critical patent/AU618444B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

New process for separating optical isomers of the compounds of general formula I: <IMAGE> in which: - Ar denotes a phenyl radical optionally containing one to five identical or different substituents, each denoting a halogen atom, an alkoxy radical containing from 1 to 4 carbon atoms, an alkylthio radical containing from 1 to 4 carbon atoms, a trihalomethyl radical or a methylenedioxy radical, - each of Y, Z, Y1 and Z1, which are identical or different, denotes a hydrogen atom, a linear or branched lower alkyl radical containing from 1 to 4 carbon atoms, a cyclopropyl radical, a dicyclopropylmethyl radical, a 2,2-dicyclopropylethyl radical, a 2,2-dicyclopropylethylene radical, a 3,3-dicyclopropylpropyl radical, a 3,3-dicyclopropyl-1-propylene radical, a linear or branched alkylene radical containing from 2 to 5 carbon atoms or a phenyl radical optionally substituted by a nitro radical, and - n is equal to 1, 2 or 3.
AU47926/90A 1989-09-20 1990-01-12 New process for separating optical isomers of 1,4-dihydropyridine derivatives Ceased AU618444B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8912323A FR2652083B1 (en) 1989-09-20 1989-09-20 NOVEL PROCESS FOR SEPARATING OPTICAL ISOMERS OF 1,4-DIHYDRO PYRIDINE DERIVATIVES.
FR8912323 1989-09-20

Publications (2)

Publication Number Publication Date
AU4792690A AU4792690A (en) 1991-03-28
AU618444B2 true AU618444B2 (en) 1991-12-19

Family

ID=9385673

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47926/90A Ceased AU618444B2 (en) 1989-09-20 1990-01-12 New process for separating optical isomers of 1,4-dihydropyridine derivatives

Country Status (14)

Country Link
EP (1) EP0419297B1 (en)
JP (1) JPH03112965A (en)
AT (1) ATE106870T1 (en)
AU (1) AU618444B2 (en)
CA (1) CA2007718A1 (en)
DE (1) DE69009642T2 (en)
DK (1) DK0419297T3 (en)
ES (1) ES2057455T3 (en)
FR (1) FR2652083B1 (en)
IE (1) IE63293B1 (en)
NZ (1) NZ232089A (en)
OA (1) OA09436A (en)
PT (1) PT92859B (en)
ZA (1) ZA90231B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686879B1 (en) * 1992-02-05 1994-03-18 Adir Cie NOVEL 1,4-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870091A (en) * 1986-08-04 1989-09-26 Adir Et Cie 1,4-dihydropyridine compounds
AU4239089A (en) * 1989-07-04 1991-01-10 Adir Et Compagnie New 1,4-dihydropyridinederivative, namely (-)-2-{(2- aminoethoxy) ethoxy)-4-(2,3-dichlorophenyl)-3- ethoxycarbonyl-50methoxycarbonyl-6-methyl}-1,4- dihydropyridine, process for preparing it and pharmaceutical compositions containing it

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (en) * 1982-03-11 1991-12-09 Pfizer CHANGES FOR THE PREPARATION FOR THE PREPARATION OF 2-Amino-CO-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-2-D-Hydroxy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870091A (en) * 1986-08-04 1989-09-26 Adir Et Cie 1,4-dihydropyridine compounds
AU4239089A (en) * 1989-07-04 1991-01-10 Adir Et Compagnie New 1,4-dihydropyridinederivative, namely (-)-2-{(2- aminoethoxy) ethoxy)-4-(2,3-dichlorophenyl)-3- ethoxycarbonyl-50methoxycarbonyl-6-methyl}-1,4- dihydropyridine, process for preparing it and pharmaceutical compositions containing it

Also Published As

Publication number Publication date
PT92859B (en) 1995-12-29
ATE106870T1 (en) 1994-06-15
EP0419297A1 (en) 1991-03-27
IE900028A1 (en) 1991-03-27
IE63293B1 (en) 1995-04-05
DE69009642T2 (en) 1994-10-27
FR2652083A1 (en) 1991-03-22
PT92859A (en) 1990-07-31
ES2057455T3 (en) 1994-10-16
CA2007718A1 (en) 1991-03-20
NZ232089A (en) 1991-09-25
FR2652083B1 (en) 1992-01-24
EP0419297B1 (en) 1994-06-08
JPH03112965A (en) 1991-05-14
DK0419297T3 (en) 1994-10-31
DE69009642D1 (en) 1994-07-14
AU4792690A (en) 1991-03-28
ZA90231B (en) 1990-11-28
OA09436A (en) 1992-10-15

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