IL70311A - 4-aminoalkyl-2(3h)-indolones,process for their preparation and pharmaceutical compositions containing them - Google Patents
4-aminoalkyl-2(3h)-indolones,process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL70311A IL70311A IL70311A IL7031183A IL70311A IL 70311 A IL70311 A IL 70311A IL 70311 A IL70311 A IL 70311A IL 7031183 A IL7031183 A IL 7031183A IL 70311 A IL70311 A IL 70311A
- Authority
- IL
- Israel
- Prior art keywords
- indolones
- aminoalkyl
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/447,564 US4452808A (en) | 1982-12-07 | 1982-12-07 | 4-Aminoalkyl-2(3H)-indolones |
Publications (2)
Publication Number | Publication Date |
---|---|
IL70311A0 IL70311A0 (en) | 1984-02-29 |
IL70311A true IL70311A (en) | 1986-11-30 |
Family
ID=23776840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL70311A IL70311A (en) | 1982-12-07 | 1983-11-23 | 4-aminoalkyl-2(3h)-indolones,process for their preparation and pharmaceutical compositions containing them |
Country Status (27)
Country | Link |
---|---|
US (1) | US4452808A (fi) |
EP (1) | EP0113964B1 (fi) |
JP (1) | JPS59112964A (fi) |
KR (1) | KR910001042B1 (fi) |
AU (1) | AU560170B2 (fi) |
BR (1) | BR1100036A (fi) |
CA (1) | CA1208650A (fi) |
CY (1) | CY1497A (fi) |
CZ (1) | CZ398191A3 (fi) |
DE (1) | DE3367090D1 (fi) |
DK (1) | DK156514C (fi) |
DZ (1) | DZ587A1 (fi) |
EG (1) | EG16556A (fi) |
ES (2) | ES8600239A1 (fi) |
FI (1) | FI77849C (fi) |
GR (1) | GR79121B (fi) |
HK (1) | HK82089A (fi) |
IE (1) | IE56347B1 (fi) |
IL (1) | IL70311A (fi) |
LU (1) | LU90097I2 (fi) |
NL (1) | NL970005I2 (fi) |
NO (2) | NO160135C (fi) |
NZ (1) | NZ206344A (fi) |
PH (1) | PH22067A (fi) |
PT (1) | PT77739B (fi) |
ZA (1) | ZA839094B (fi) |
ZW (1) | ZW25883A1 (fi) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588740A (en) * | 1982-12-07 | 1986-05-13 | Smithkline Beckman Corporation | Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones |
US4657929A (en) * | 1983-10-25 | 1987-04-14 | Fisons Plc | Compounds |
US4554284A (en) * | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones |
GB8621040D0 (en) * | 1986-08-30 | 1986-10-08 | Smith Kline French Lab | Process |
GB8712073D0 (en) * | 1987-05-21 | 1987-06-24 | Smith Kline French Lab | Medicament |
GB8714371D0 (en) * | 1987-06-19 | 1987-07-22 | Smith Kline French Lab | Process |
GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
GB9015095D0 (en) * | 1990-07-09 | 1990-08-29 | Smith Kline French Lab | Therapeutic method |
IE914003A1 (en) * | 1990-11-20 | 1992-05-20 | Astra Pharma Prod | Biologically Active Amines |
AU4312593A (en) * | 1992-05-18 | 1993-12-13 | Smithkline Beecham Plc | Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and Parkinson's disease |
GB9300309D0 (en) * | 1993-01-08 | 1993-03-03 | Smithkline Beecham Plc | Process |
TW356468B (en) * | 1995-09-15 | 1999-04-21 | Astra Pharma Prod | Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same |
US5807570A (en) * | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
GB9526511D0 (en) * | 1995-12-23 | 1996-02-28 | Astra Pharma Prod | Pharmaceutically active compounds |
JP2000516959A (ja) * | 1996-08-27 | 2000-12-19 | アメリカン・ホーム・プロダクツ・コーポレイション | 4―アミノエトキシインドロン誘導体 |
ZA992670B (en) * | 1998-04-13 | 2000-10-12 | American Home Prod | 4-amino-(ethylamino)-oxindole dopamine autoreceptor agonists. |
US6218421B1 (en) * | 1999-07-01 | 2001-04-17 | Smithkline Beecham P.L.C. | Method of promoting smoking cessation |
AR030557A1 (es) | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
US6277875B1 (en) * | 2000-07-17 | 2001-08-21 | Andrew J. Holman | Use of dopamine D2/D3 receptor agonists to treat fibromyalgia |
DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
US20020165246A1 (en) * | 2001-03-05 | 2002-11-07 | Andrew Holman | Administration of sleep restorative agents |
FR2821843B1 (fr) * | 2001-03-12 | 2003-05-09 | Servier Lab | Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US20030068356A1 (en) * | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
DK1545546T3 (da) * | 2002-09-13 | 2007-08-06 | Motac Neuroscience Ltd | Behandling af dyskinesi med 2,3-benzodiazepiner |
AU2003267557B2 (en) * | 2002-09-17 | 2009-02-26 | Motac Neuroscience Limited | Treatment of dyskinesia |
ES2237307B1 (es) * | 2003-10-14 | 2006-11-01 | Urquima, S.A. | Procedimiento para la preparacion de ropinirol. |
WO2005074387A2 (en) * | 2003-12-30 | 2005-08-18 | Sun Pharmaceutical Industries Limited | Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride |
US7378439B2 (en) * | 2004-01-20 | 2008-05-27 | Usv, Ltd. | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride |
WO2005105741A1 (en) * | 2004-02-11 | 2005-11-10 | Sun Pharmaceutical Industries Limited | Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride |
WO2005080333A1 (en) * | 2004-02-19 | 2005-09-01 | Torrent Pharmaceuticals Ltd | Process for purification of ropinirole |
RS20060620A (en) * | 2004-05-11 | 2008-09-29 | Egis Gyogyszergyar Nyrt., | Piperazine derivatives of alkyl oxindoles |
HUP0400953A3 (en) * | 2004-05-11 | 2008-02-28 | Egis Gyogyszergyar Nyilvanosan | Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use |
US20050267096A1 (en) * | 2004-05-26 | 2005-12-01 | Pfizer Inc | New indazole and indolone derivatives and their use pharmaceuticals |
US20050288270A1 (en) * | 2004-05-27 | 2005-12-29 | Pfizer Inc | New aminopyridine derivatives and their use as pharmaceuticals |
JP2008533193A (ja) * | 2005-03-21 | 2008-08-21 | ファイザー・リミテッド | オキシトシン拮抗薬としての置換トリアゾール誘導体 |
CN100457711C (zh) * | 2005-06-27 | 2009-02-04 | 上海奥博生物医药技术有限公司 | 2-甲基-3-硝基苯基烷基胺衍生物或其盐的制备方法 |
WO2007010557A2 (en) * | 2005-07-22 | 2007-01-25 | Ind-Swift Laboratorie Limted | Process for the preparation of highly pure ropinirole |
WO2007110879A2 (en) | 2006-03-29 | 2007-10-04 | Alembic Limited | A process for the purification of ropinirole hydrochloride |
DK2010184T3 (da) * | 2006-04-06 | 2013-03-25 | Nupathe Inc | Implatanter til behandlingen af dopamin associerede tilstande |
US20070254941A1 (en) * | 2006-04-21 | 2007-11-01 | Glenmark Pharmaceuticals Limited | Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation |
CN100457732C (zh) * | 2006-05-25 | 2009-02-04 | 药源药物化学(上海)有限公司 | 罗匹尼罗的制备方法 |
WO2008001204A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal compositions of pramipexole having enhanced permeation properties |
TW200815045A (en) * | 2006-06-29 | 2008-04-01 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of ropinirole and methods of use thereof |
JP2008308488A (ja) * | 2007-05-11 | 2008-12-25 | Santen Pharmaceut Co Ltd | 非麦角系の選択的d2受容体アゴニストを有効成分として含有する後眼部疾患の予防又は治療剤 |
US20090076124A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched ropinirole |
US20090247537A1 (en) * | 2008-03-25 | 2009-10-01 | William Dale Overfield | Methods for preventing or treating bruxism using dopaminergic agents |
CN101574341B (zh) * | 2008-05-05 | 2012-12-19 | 北京德众万全医药科技有限公司 | 一种罗匹尼罗的口服固体药物组合物 |
WO2010023693A2 (en) * | 2008-09-01 | 2010-03-04 | Lupin Limited | Novel controlled release compositions of ropinirole |
CA2738414C (en) | 2008-09-29 | 2014-05-27 | Wockhardt Research Centre | Extended release dosage form of ropinirole |
US20100130582A1 (en) * | 2008-11-24 | 2010-05-27 | Auspex Pharmaceuticals, Inc. | Indolinone modulators of dopamine receptor |
EP2438917B1 (en) | 2009-05-21 | 2014-09-03 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal preparation |
AU2009356855A1 (en) * | 2009-12-16 | 2012-08-09 | Pharmathen S.A. | Process for the preparation of Ropinirole and salts thereof |
EA023786B1 (ru) | 2010-04-30 | 2016-07-29 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Трансдермальные композиции на основе пропиниламиноиндана |
CN101891641B (zh) * | 2010-07-27 | 2015-06-10 | 北京华禧联合科技发展有限公司 | 盐酸罗匹尼罗关键中间体的稳定形态及其制备 |
TWI537274B (zh) | 2011-03-14 | 2016-06-11 | 橘生藥品工業股份有限公司 | 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途 |
EP2688561B1 (en) | 2011-03-24 | 2018-08-22 | Teikoku Pharma USA, Inc. | Transdermal compositions comprising an active agent layer and an active agent conversion layer |
US9913812B2 (en) | 2011-11-09 | 2018-03-13 | Teikoku Pharma Usa, Inc. | Methods for the treatment of skin neoplasms |
JP6050896B2 (ja) | 2012-11-02 | 2016-12-21 | テイコク ファーマ ユーエスエー インコーポレーテッド | プロピニルアミノインダン経皮組成物 |
US9585885B2 (en) | 2012-12-10 | 2017-03-07 | Kissei Pharmaceutical Co., Ltd. | Substituted pyrido[2,3-g]quinazolines as dopamine D2 receptor agonists |
US9155695B2 (en) | 2013-03-14 | 2015-10-13 | Medtronic, Inc. | Injectable ropinirole compositions and methods for making and using same |
EP3640240B1 (en) | 2017-06-16 | 2020-12-09 | Zhejiang Huahai Licheng Pharmaceutical Co., Ltd. | Method for purifying ropinirole hydrochloride |
CN115466209A (zh) * | 2022-09-29 | 2022-12-13 | 南通大学 | 一种罗匹尼罗环戊烷并吲哚酮杂质的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA895875A (en) * | 1972-03-21 | Bourdais Jacques | Mercapto indole derivatives | |
US3573310A (en) * | 1967-09-28 | 1971-03-30 | Miles Lab | 1-substituted derivatives of 2-indolinone |
JPS5825673B2 (ja) * | 1976-03-31 | 1983-05-28 | 大塚製薬株式会社 | オキシインド−ル誘導体 |
JPS5840539B2 (ja) * | 1976-03-31 | 1983-09-06 | 大塚製薬株式会社 | α−置換アミノアルカノイルオキシインド−ル誘導体 |
JPS5919537B2 (ja) * | 1976-08-02 | 1984-05-07 | 大塚製薬株式会社 | オキシインド−ル誘導体 |
US4317944A (en) * | 1980-08-15 | 1982-03-02 | General Electric Company | Preparation of 2,2-bis(4-hydroxyphenyl) propane |
US4314944A (en) * | 1980-08-22 | 1982-02-09 | Smithkline Corporation | 4-Aminoalkyl-7-hydroxy-2(3H)-indolones |
-
1982
- 1982-12-07 US US06/447,564 patent/US4452808A/en not_active Expired - Lifetime
-
1983
- 1983-11-17 CA CA000441416A patent/CA1208650A/en not_active Expired
- 1983-11-21 NZ NZ206344A patent/NZ206344A/en unknown
- 1983-11-22 AU AU21585/83A patent/AU560170B2/en not_active Expired
- 1983-11-23 IL IL70311A patent/IL70311A/xx not_active IP Right Cessation
- 1983-11-25 PT PT77739A patent/PT77739B/pt unknown
- 1983-11-25 ZW ZW258/83A patent/ZW25883A1/xx unknown
- 1983-11-28 PH PH29901A patent/PH22067A/en unknown
- 1983-11-30 CY CY1497A patent/CY1497A/xx unknown
- 1983-11-30 LU LU90097C patent/LU90097I2/fr unknown
- 1983-11-30 DE DE8383307289T patent/DE3367090D1/de not_active Expired
- 1983-11-30 EP EP83307289A patent/EP0113964B1/en not_active Expired
- 1983-12-02 FI FI834421A patent/FI77849C/fi not_active IP Right Cessation
- 1983-12-05 GR GR73156A patent/GR79121B/el unknown
- 1983-12-05 EG EG753/83A patent/EG16556A/xx active
- 1983-12-06 DK DK562183A patent/DK156514C/da not_active IP Right Cessation
- 1983-12-06 ES ES527827A patent/ES8600239A1/es not_active Expired
- 1983-12-06 NO NO834485A patent/NO160135C/no unknown
- 1983-12-06 JP JP58231215A patent/JPS59112964A/ja active Granted
- 1983-12-06 IE IE2866/83A patent/IE56347B1/en not_active IP Right Cessation
- 1983-12-07 KR KR1019830005790A patent/KR910001042B1/ko not_active IP Right Cessation
- 1983-12-07 ZA ZA839094A patent/ZA839094B/xx unknown
-
1984
- 1984-12-07 DZ DZ847014A patent/DZ587A1/fr active
-
1985
- 1985-05-29 ES ES543593A patent/ES8604143A1/es not_active Expired
-
1989
- 1989-10-12 HK HK820/89A patent/HK82089A/xx not_active IP Right Cessation
-
1991
- 1991-12-20 CZ CS913981A patent/CZ398191A3/cs unknown
-
1996
- 1996-08-30 BR BR1100036-8A patent/BR1100036A/pt active IP Right Grant
-
1997
- 1997-02-05 NL NL970005C patent/NL970005I2/nl unknown
-
1999
- 1999-06-18 NO NO1999011C patent/NO1999011I1/no unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
HP | Change in proprietorship | ||
KB | Patent renewed | ||
PEL | Intention of commissioner to extend period of protection | ||
EXTG | Extension of patent term granted | ||
EXTN | Extension order renewed | ||
EXTN | Extension order renewed | ||
EXTN | Extension order renewed | ||
EXTN | Extension order renewed | ||
EXP | Patent expired |