IL63959A - 6-and 7-(1-(2-aminothiazol-4-yl)-ethencarbamido)-penicillins and cephalosporins,their preparation and pharmaceutical compositions containing them - Google Patents
6-and 7-(1-(2-aminothiazol-4-yl)-ethencarbamido)-penicillins and cephalosporins,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL63959A IL63959A IL63959A IL6395981A IL63959A IL 63959 A IL63959 A IL 63959A IL 63959 A IL63959 A IL 63959A IL 6395981 A IL6395981 A IL 6395981A IL 63959 A IL63959 A IL 63959A
- Authority
- IL
- Israel
- Prior art keywords
- ethencarbamido
- aminothiazol
- penicillins
- cephalosporins
- preparation
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 239000002132 β-lactam antibiotic Substances 0.000 abstract 1
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL7243581A IL72435A (en) | 1980-10-08 | 1981-09-28 | 2-(2-aminothiazol-4-yl)-3-(substituted)propenoic acid derivatives |
| IL72435A IL72435A0 (en) | 1980-10-08 | 1984-07-18 | 2-(2-aminothiazol-4-yl)-3-(substituted)propenoic acid derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803037997 DE3037997A1 (de) | 1980-10-08 | 1980-10-08 | (beta) -lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL63959A0 IL63959A0 (en) | 1981-12-31 |
| IL63959A true IL63959A (en) | 1985-07-31 |
Family
ID=6113915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL63959A IL63959A (en) | 1980-10-08 | 1981-09-28 | 6-and 7-(1-(2-aminothiazol-4-yl)-ethencarbamido)-penicillins and cephalosporins,their preparation and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4416880A (da) |
| EP (1) | EP0049448B1 (da) |
| JP (4) | JPS5793982A (da) |
| AT (1) | ATE36714T1 (da) |
| AU (1) | AU554294B2 (da) |
| CA (1) | CA1178946A (da) |
| DE (2) | DE3037997A1 (da) |
| DK (1) | DK165924C (da) |
| ES (1) | ES8206532A1 (da) |
| FI (1) | FI75825C (da) |
| GR (1) | GR75073B (da) |
| HK (1) | HK6191A (da) |
| HU (1) | HU186429B (da) |
| IL (1) | IL63959A (da) |
| ZA (1) | ZA816932B (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3145727A1 (de) * | 1981-11-19 | 1983-05-26 | Bayer Ag, 5090 Leverkusen | Zwischenprodukte, verfahren zu deren herstellung und verfahren zur herstellung von cephalosporinen |
| CA1201431A (en) * | 1981-12-17 | 1986-03-04 | Daiei Tunemoto | .beta.-LACTAM COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND INTERMEDIATE PRODUCTS FOR THE PREPARATION THEREOF |
| DE3224866A1 (de) * | 1982-07-02 | 1984-01-05 | Bayer Ag, 5090 Leverkusen | Ss-lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel |
| DE3239365A1 (de) * | 1982-10-23 | 1984-04-26 | Bayer Ag, 5090 Leverkusen | Neue cephalosporine und verfahren zu ihrer herstellung |
| DE3300593A1 (de) * | 1983-01-11 | 1984-07-12 | Bayer Ag, 5090 Leverkusen | Neue cephalosporine und verfahren zu ihrer herstellung |
| JPS6034957A (ja) * | 1983-08-05 | 1985-02-22 | Meiji Seika Kaisha Ltd | ２−置換メチレン−２−（２−アミノチアゾ−ル−４−イル）酢酸誘導体及びその製造方法 |
| DE3329427A1 (de) * | 1983-08-13 | 1985-02-21 | Bayer Ag, 5090 Leverkusen | 7-amino-3(1-pyridiniomethyl)-8-oxo-5-oxa-1-azabicyclo(4.2.0)oct-2-en-2-carboxylate, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte zur synthese von ss-lactam-antibiotika |
| AU575854B2 (en) * | 1983-10-04 | 1988-08-11 | Shionogi & Co., Ltd. | 7beta-(carboxyalkenamido) cephalosporins |
| DE3343208A1 (de) * | 1983-11-30 | 1985-06-05 | Bayer Ag, 5090 Leverkusen | Neue cephalosporine und verfahren zu ihrer herstellung |
| DE3418376A1 (de) * | 1984-05-17 | 1985-11-21 | Bayer Ag, 5090 Leverkusen | Zwischenprodukte sowie verfahren zur herstellung von zwischenprodukten fuer die synthese von cephalosporinen |
| DE3419012A1 (de) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien |
| JP2501785B2 (ja) * | 1984-07-09 | 1996-05-29 | 明治製菓株式会社 | 新規セフアロスポリン系化合物 |
| JPS6153272A (ja) * | 1984-08-24 | 1986-03-17 | Shionogi & Co Ltd | グルタル酸誘導体の製法 |
| JPS61205282A (ja) * | 1985-03-08 | 1986-09-11 | Sagami Chem Res Center | β−ラクタム化合物類 |
| AU580855B2 (en) * | 1985-03-29 | 1989-02-02 | Shionogi & Co., Ltd. | Alkeneamidocephalosporin esters |
| AT397963B (de) * | 1985-03-29 | 1994-08-25 | Shionogi & Co | Verfahren zur herstellung von neuen 7 beta-(2-(2- amino-4-thiazolyl)-alkenoylamimo)-3-cephem-4- carbonsäureestern |
| US4731362A (en) * | 1985-08-05 | 1988-03-15 | Shionogi & Co., Ltd. | Alkylcarbamoyloxymethylcephem compounds |
| DE3541095A1 (de) * | 1985-11-21 | 1987-05-27 | Bayer Ag | Neue cephalosporine, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel |
| NZ220764A (en) * | 1986-07-02 | 1989-09-27 | Shionogi & Co | Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions |
| US5017380A (en) * | 1986-07-02 | 1991-05-21 | Shionogi & Co., Ltd. | Gelatin hard capsule containing crystalline hydrate of oral cephalosporin |
| US5079242A (en) * | 1987-03-11 | 1992-01-07 | Pfizer Inc. | Substituted 3-cephem compounds as antibacterial agents |
| IL89836A0 (en) * | 1988-04-06 | 1989-12-15 | Beecham Group Plc | Penicilanic acid derivatives,process for their preparation and pharmaceutical compositions containing them |
| GB8906592D0 (en) * | 1989-03-22 | 1989-05-04 | Beecham Group Plc | Novel compounds |
| MA21969A1 (fr) * | 1989-10-05 | 1991-07-01 | Beecham Group Plc | Procede de preparation de nouveaux composes contenant un cycle beta - lactame . |
| GB8922410D0 (en) * | 1989-10-05 | 1989-11-22 | Beecham Group Plc | Novel compounds |
| GB9117783D0 (en) * | 1991-08-17 | 1991-10-09 | Smithkline Beecham Plc | Novel compounds |
| JP3217191B2 (ja) * | 1992-07-16 | 2001-10-09 | ビーエーエスエフ アクチェンゲゼルシャフト | ヘテロ芳香族化合物およびこれを含有する植物保護剤 |
| CA2287663C (en) * | 1998-11-02 | 2008-04-08 | Isao Kurimoto | Process for producing 2-alkylidene-4-bromoacetoacetic acid ester |
| RU2218338C2 (ru) | 1998-11-12 | 2003-12-10 | Сумитомо Кемикал Компани, Лимитед | Получение z-изомера бромоводородной соли производного 2-аминотиазола |
| CN102827188B (zh) * | 2012-08-25 | 2014-09-10 | 河北农业大学 | 一种青霉素类药物通用半抗原、人工抗原、广谱单克隆抗体及其制备方法与应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS435888B1 (da) * | 1964-03-14 | 1968-03-04 | ||
| US3622569A (en) * | 1969-08-05 | 1971-11-23 | R & L Molecular Research Ltd | 6-(2-aryl-3-azido-and-3-amino-methyl-isocrotonamido)penicillanic acids |
| GB1497039A (en) * | 1973-12-05 | 1978-01-05 | Glaxo Lab Ltd | Penicillins and cephalosporins |
| US4182868A (en) * | 1974-10-29 | 1980-01-08 | Takeda Chemical Industries, Ltd. | 7-Methoxycephalosporin derivatives |
| US4298606A (en) * | 1974-12-19 | 1981-11-03 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido compounds |
| FR2340093A1 (fr) * | 1976-02-05 | 1977-09-02 | Roussel Uclaf | Derives de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
| DE2758000A1 (de) * | 1977-12-24 | 1979-07-05 | Hoechst Ag | Verfahren zur herstellung von penicillinen und cephalosporinen |
| FR2387235A1 (fr) * | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne |
| US4310459A (en) * | 1978-04-03 | 1982-01-12 | Bristol-Myers Company | Process for producing carbamoyl substituted penams and carbamoyl substituted cephams from penicillin sulfoxide esters |
| DE2818263A1 (de) * | 1978-04-26 | 1979-11-08 | Bayer Ag | Beta-lactamantibiotika |
| US4275062A (en) * | 1979-09-19 | 1981-06-23 | E. R. Squibb & Sons, Inc. | Aminothiazolyl ureido sulfoxide cephalosporins |
| GB2076801A (en) * | 1980-04-14 | 1981-12-09 | Erba Farmitalia | alpha , beta -Disubstituted Acrylamido Cephalosporins |
| CA1178947A (en) * | 1980-09-26 | 1984-12-04 | Sagami Chemical Research Center | .beta.-LACTAM COMPOUNDS AND PROCESS FOR THEIR PREPARATION |
-
1980
- 1980-10-08 DE DE19803037997 patent/DE3037997A1/de not_active Withdrawn
-
1981
- 1981-09-21 US US06/304,280 patent/US4416880A/en not_active Expired - Lifetime
- 1981-09-28 IL IL63959A patent/IL63959A/xx not_active IP Right Cessation
- 1981-09-28 AT AT81107679T patent/ATE36714T1/de not_active IP Right Cessation
- 1981-09-28 DE DE8181107679T patent/DE3176851D1/de not_active Expired
- 1981-09-28 EP EP81107679A patent/EP0049448B1/de not_active Expired
- 1981-10-05 GR GR66208A patent/GR75073B/el unknown
- 1981-10-06 CA CA000387441A patent/CA1178946A/en not_active Expired
- 1981-10-06 JP JP56158247A patent/JPS5793982A/ja not_active Expired - Lifetime
- 1981-10-06 FI FI813089A patent/FI75825C/fi not_active IP Right Cessation
- 1981-10-07 DK DK444581A patent/DK165924C/da not_active IP Right Cessation
- 1981-10-07 ZA ZA816932A patent/ZA816932B/xx unknown
- 1981-10-08 ES ES506115A patent/ES8206532A1/es not_active Expired
- 1981-10-08 AU AU76133/81A patent/AU554294B2/en not_active Expired
- 1981-10-08 HU HU812910A patent/HU186429B/hu unknown
-
1985
- 1985-10-25 JP JP60237800A patent/JPS61106579A/ja active Pending
- 1985-10-25 JP JP60237801A patent/JPS6193173A/ja active Granted
-
1989
- 1989-06-13 JP JP1150323A patent/JPH0662631B2/ja not_active Expired - Lifetime
-
1991
- 1991-01-17 HK HK61/91A patent/HK6191A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7613381A (en) | 1982-04-22 |
| JPS5793982A (en) | 1982-06-11 |
| ES506115A0 (es) | 1982-08-16 |
| ES8206532A1 (es) | 1982-08-16 |
| AU554294B2 (en) | 1986-08-14 |
| DK165924B (da) | 1993-02-08 |
| FI75825B (fi) | 1988-04-29 |
| ATE36714T1 (de) | 1988-09-15 |
| FI75825C (fi) | 1988-08-08 |
| JPS61106579A (ja) | 1986-05-24 |
| JPH02209877A (ja) | 1990-08-21 |
| HU186429B (en) | 1985-07-29 |
| JPS6337107B2 (da) | 1988-07-22 |
| ZA816932B (en) | 1982-09-29 |
| CA1178946A (en) | 1984-12-04 |
| DE3176851D1 (en) | 1988-09-29 |
| EP0049448A2 (de) | 1982-04-14 |
| DK165924C (da) | 1993-06-28 |
| EP0049448A3 (en) | 1983-05-11 |
| US4416880A (en) | 1983-11-22 |
| DK444581A (da) | 1982-04-09 |
| DE3037997A1 (de) | 1982-05-13 |
| IL63959A0 (en) | 1981-12-31 |
| GR75073B (da) | 1984-07-13 |
| HK6191A (en) | 1991-01-25 |
| FI813089L (fi) | 1982-04-09 |
| JPS6193173A (ja) | 1986-05-12 |
| EP0049448B1 (de) | 1988-08-24 |
| JPH0662631B2 (ja) | 1994-08-17 |
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| DE68919273D1 (de) | Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate. | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| EXP | Patent expired |