ES471770A1 - Procedimiento para la obtencion de compuestos de b-lactama - Google Patents

Procedimiento para la obtencion de compuestos de b-lactama

Info

Publication number
ES471770A1
ES471770A1 ES471770A ES471770A ES471770A1 ES 471770 A1 ES471770 A1 ES 471770A1 ES 471770 A ES471770 A ES 471770A ES 471770 A ES471770 A ES 471770A ES 471770 A1 ES471770 A1 ES 471770A1
Authority
ES
Spain
Prior art keywords
penicillins
cephalosporins
processes
preparation
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471770A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES471770A1 publication Critical patent/ES471770A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Procedimiento para la obtención de beta-lactama de fórmula (I) **(Fórmula 1)** donde R significa hidrógeno o alcoxi inferior, Z significa los grupos **(Fórmula 2)** donde R1 y R2 son iguales o diferentes y significan hidrógeno, alquilo o alquenilo, en caso dado sustituido, cicloalquilo, cicloalquenilo y cicloalcadienilo, en caso dado sustituido, aralquilo, en caso dado sustituido, arilo, en caso dado sustituido, heterociclilo, en caso dado sustituido, carboxi, metoxicarbonilo, etoxicarbonilo, ciano, nitro, alquilo inferior-carbonilo, -CONH2, CONHCH3, CON(CH3)2, -SO2NH2, -SO2-NHCH3 o -SO2N(CH3)2 y R1 y R2 junto con el átomo de carbono al cual están enlazados pueden formar un anillo carbocíclico o heterocíclico, saturado o insaturado, de 3 a 7 miembros, que puede estar sustituido.
ES471770A 1977-07-16 1978-07-14 Procedimiento para la obtencion de compuestos de b-lactama Expired ES471770A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772732283 DE2732283A1 (de) 1977-07-16 1977-07-16 Beta-lactam-verbindungen

Publications (1)

Publication Number Publication Date
ES471770A1 true ES471770A1 (es) 1979-02-01

Family

ID=6014140

Family Applications (1)

Application Number Title Priority Date Filing Date
ES471770A Expired ES471770A1 (es) 1977-07-16 1978-07-14 Procedimiento para la obtencion de compuestos de b-lactama

Country Status (11)

Country Link
US (2) US4215118A (es)
EP (1) EP0000392B1 (es)
JP (1) JPS5439091A (es)
AT (1) AT365193B (es)
AU (1) AU525027B2 (es)
CA (1) CA1122593A (es)
DE (2) DE2732283A1 (es)
DK (1) DK318278A (es)
ES (1) ES471770A1 (es)
IL (1) IL55130A (es)
IT (1) IT1097816B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA813610B (en) * 1980-06-06 1982-06-30 Beecham Group Plc Penicillin derivatives,processes for their preparation and compositions containing them
NZ197416A (en) * 1980-06-26 1983-11-18 Beecham Group Ltd Penicillin derivatives and pharmaceutical compositions
US4436904A (en) * 1981-02-14 1984-03-13 Kanto Ishi Pharmaceutical Co., Ltd. Cephalosporins
EP0066406A1 (en) * 1981-05-28 1982-12-08 Beecham Group Plc Beta-lactam antibiotics
DE3215085A1 (de) * 1982-04-22 1983-10-27 Bayer Ag, 5090 Leverkusen Ss-lactam-antibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3431273A1 (de) * 1984-08-25 1986-03-06 Bayer Ag, 5090 Leverkusen Kristallines natriumsalz der d-6-((alpha)-(2-oxo-3-furfuryl-iden-amino-imidazolidin-1-yl)-carbonylamino)-thienyl-2-acetamido)-penicillansaeure, verfahren zur herstellung und seine verwendung in arzneimitteln
GB8519264D0 (en) * 1985-07-31 1985-09-04 Baldwin J E Chemical compounds
GB8713061D0 (en) * 1987-06-04 1987-07-08 Beecham Group Plc Compounds
AU782938B2 (en) * 2001-08-28 2005-09-08 Boss Rubber Technologies Pty Ltd Resilient product

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687949A (en) * 1969-01-21 1972-08-29 Bristol Myers Co Synthetic cephalosporins
US3959258A (en) * 1970-05-25 1976-05-25 Bayer Aktiengesellschaft Ureidoacetamido-penicillins
US3974142A (en) * 1971-10-23 1976-08-10 Bayer Aktiengesellschaft Penicillins
US4086340A (en) * 1974-02-18 1978-04-25 Bayer Aktiengesellschaft Cephalosporins and their production
US4087424A (en) * 1974-05-09 1978-05-02 Toyama Chemical Co., Ltd. Novel penicillins and cephalosporins and process for producing the same
GB1486349A (en) * 1974-11-28 1977-09-21 Bayer Ag Beta-lactam antibiotics process for their preparation and their use as medicaments
JPS5852996B2 (ja) * 1975-03-25 1983-11-26 バイエル・アクチエンゲゼルシヤフト β−ラクタム及び抗バクテリア剤
DE2633317A1 (de) * 1976-07-23 1978-01-26 Bayer Ag Beta-lactamantibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
CA1122593A (en) 1982-04-27
AT365193B (de) 1981-12-28
IT7825714A0 (it) 1978-07-14
EP0000392A2 (de) 1979-01-24
US4338434A (en) 1982-07-06
DE2732283A1 (de) 1979-01-25
IL55130A (en) 1982-01-31
EP0000392A3 (en) 1979-08-22
ATA510878A (de) 1981-05-15
DE2861766D1 (en) 1982-06-09
AU525027B2 (en) 1982-10-14
IL55130A0 (en) 1978-09-29
DK318278A (da) 1979-01-17
EP0000392B1 (de) 1982-04-28
AU3801878A (en) 1980-01-17
IT1097816B (it) 1985-08-31
JPS5439091A (en) 1979-03-24
US4215118A (en) 1980-07-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990503