IL61408A - Enzyme derivatives comprising binary complexes between streptokinase and plasminogen,their preparation and pharmaceutical compositions containing them - Google Patents
Enzyme derivatives comprising binary complexes between streptokinase and plasminogen,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL61408A IL61408A IL61408A IL6140880A IL61408A IL 61408 A IL61408 A IL 61408A IL 61408 A IL61408 A IL 61408A IL 6140880 A IL6140880 A IL 6140880A IL 61408 A IL61408 A IL 61408A
- Authority
- IL
- Israel
- Prior art keywords
- streptokinase
- plasminogen
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7938279 | 1979-11-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL61408A0 IL61408A0 (en) | 1980-12-31 |
IL61408A true IL61408A (en) | 1983-10-31 |
Family
ID=10508982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL61408A IL61408A (en) | 1979-11-05 | 1980-11-04 | Enzyme derivatives comprising binary complexes between streptokinase and plasminogen,their preparation and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
US (1) | US4808405A (hu) |
EP (1) | EP0028489B1 (hu) |
JP (1) | JPS5678590A (hu) |
AR (1) | AR224786A1 (hu) |
CA (1) | CA1174621A (hu) |
CS (2) | CS391991A3 (hu) |
DE (1) | DE3065190D1 (hu) |
DK (1) | DK158994C (hu) |
ES (1) | ES8204467A1 (hu) |
GR (1) | GR72121B (hu) |
HK (1) | HK65886A (hu) |
HU (1) | HU185223B (hu) |
IE (1) | IE50174B1 (hu) |
IL (1) | IL61408A (hu) |
NL (1) | NL930029I2 (hu) |
NO (1) | NO163867C (hu) |
NZ (1) | NZ195469A (hu) |
ZA (1) | ZA806641B (hu) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3361610D1 (en) * | 1982-04-07 | 1986-02-06 | Beecham Group Plc | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them |
EP0125269A1 (en) * | 1982-11-11 | 1984-11-21 | Beecham Group Plc | Pharmaceutically active compounds |
GB8400653D0 (en) * | 1984-01-11 | 1984-02-15 | Beecham Group Plc | Conjugates |
GB8430253D0 (en) * | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
US5231006A (en) * | 1986-10-16 | 1993-07-27 | Behringwerke Aktiengesellschaft | Method for the determination of plasminogen |
US5256642A (en) * | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
JPH0296536A (ja) * | 1988-09-29 | 1990-04-09 | Green Cross Corp:The | プラスミノゲン乾燥製剤 |
WO1990013640A1 (en) * | 1989-05-01 | 1990-11-15 | The University Of Notre Dame Du Lac | Methods and materials for expression of human plasminogen in a eukaryotic cell system |
EP0397366A1 (en) * | 1989-05-09 | 1990-11-14 | The Board Of Regents Of The University Of Oklahoma | Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same |
JPH05501855A (ja) * | 1989-05-17 | 1993-04-08 | リサーチ、コーポレーション、テクノロジーズ、インコーポレーテッド | 哺乳動物における血栓症の治療に関する方法及び組成物 |
CA2027936C (en) | 1989-10-23 | 2001-07-24 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
US5190756A (en) * | 1989-12-01 | 1993-03-02 | Genentech, Inc. | Methods and materials for expression of human plasminogen variant |
US5087572A (en) * | 1989-12-01 | 1992-02-11 | Genentech, Inc. | Dna encoding human plasminogen modified at the cleavage site |
GB8928163D0 (en) * | 1989-12-13 | 1990-02-14 | Beecham Group Plc | Novel treatment |
US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
US5187069A (en) * | 1990-08-06 | 1993-02-16 | Henry Ford Health System | Active site labelling of plasminogen |
AU1873092A (en) * | 1991-04-09 | 1992-11-17 | Brigham And Women's Hospital | Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques |
US5520912A (en) * | 1993-07-02 | 1996-05-28 | Immuno Aktiengesellschaft | Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen |
DE4411143C2 (de) * | 1994-03-30 | 1996-08-01 | Immuno Ag | Thrombosemittel |
US5760028A (en) * | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
US6004955A (en) * | 1996-08-15 | 1999-12-21 | Dupont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists |
PL337831A1 (en) | 1997-06-19 | 2000-09-11 | Du Pont Pharm Co | Inhibitors of factor xa containing a specificity giving p1 group |
EP1203026A4 (en) * | 1999-07-29 | 2005-03-16 | Dyax Corp | FRACTIONS BINDING FIBRIN |
US6388073B1 (en) | 2000-07-26 | 2002-05-14 | Shire Us Inc. | Method for the manufacture of anagrelide |
KR20010000669A (ko) * | 2000-10-12 | 2001-01-05 | 김기환 | 스트렙토키나제와 사람 혈청알부민의 포합체를유효성분으로 함유하는 전신투여용 지속성 혈전 용해제 |
US6984373B2 (en) * | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
CN104744461A (zh) | 2001-09-21 | 2015-07-01 | 百时美施贵宝公司 | 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂 |
US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US20060030574A1 (en) * | 2004-08-04 | 2006-02-09 | Shire Holdings Ag | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors |
US7700608B2 (en) * | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
CN101137412B (zh) | 2005-01-13 | 2012-11-07 | 布里斯托尔-迈尔斯·斯奎布公司 | 用作凝血因子XIa抑制剂的取代的二芳基化合物 |
MX2007008434A (es) | 2005-01-19 | 2007-07-25 | Squibb Bristol Myers Co | Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos. |
EP1896466B1 (en) | 2005-06-27 | 2011-04-13 | Bristol-Myers Squibb Company | N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
WO2007002584A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
WO2007002634A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
JP2009539873A (ja) | 2006-06-08 | 2009-11-19 | ブリストル−マイヤーズ スクイブ カンパニー | 抗凝固剤として有用な第VIIa因子インヒビターとしての2−アミノカルボニルフェニルアミノ−2−フェニルアセトアミド類 |
US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US7910597B2 (en) * | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
US8410155B2 (en) | 2006-12-15 | 2013-04-02 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors |
PE20081775A1 (es) | 2006-12-20 | 2008-12-18 | Bristol Myers Squibb Co | Compuestos macrociclicos como inhibidores del factor viia |
WO2008157162A1 (en) | 2007-06-13 | 2008-12-24 | Bristol-Myers Squibb Company | Dipeptide analogs as coagulation factor inhibitors |
US20090130017A1 (en) * | 2007-11-19 | 2009-05-21 | Searete Llc | Targeted short-lived drug delivery |
AR071823A1 (es) | 2008-05-19 | 2010-07-14 | Schering Corp | Derivados heterociclicos de imidazol y pirazol, inhibidores del factor ixa de coagulacion, composiciones farmaceuticas que los contienen y uso de los mismos para tratar diversos trastornos tromboembolicos. |
AU2010260208B2 (en) | 2009-06-16 | 2014-11-13 | Bristol-Myers Squibb Holdings Ireland Unlimited Company | Dosage forms of apixaban |
EP2462123B1 (en) | 2009-08-04 | 2013-10-02 | Merck Sharp & Dohme Corp. | 4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors |
CA2789622C (en) | 2010-02-11 | 2018-04-03 | Bristol-Myers Squibb Company | Macrocycles as factor xia inhibitors |
TW201311689A (zh) | 2011-08-05 | 2013-03-16 | 必治妥美雅史谷比公司 | 作為因子xia抑制劑之新穎巨環化合物 |
TW201319068A (zh) | 2011-08-05 | 2013-05-16 | 必治妥美雅史谷比公司 | 作為xia因子抑制劑之環狀p1接合劑 |
SG11201401384UA (en) | 2011-10-14 | 2014-09-26 | Bristol Myers Squibb Co | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
US9079929B2 (en) | 2011-10-14 | 2015-07-14 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
US9108951B2 (en) | 2011-10-14 | 2015-08-18 | Bristol-Myers Squibb Company | Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors |
WO2013068875A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | 2-thiopyrimidinones |
AU2013245353A1 (en) | 2012-04-06 | 2014-09-25 | Pfizer Inc. | Diacylglycerol acyltransferase 2 inhibitors |
KR20150038369A (ko) | 2012-08-03 | 2015-04-08 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 XIa 억제제로서의 디히드로피리돈 P1 |
WO2014022767A1 (en) | 2012-08-03 | 2014-02-06 | Bristol-Myers Squibb Company | Dihydropyridone p1 as factor xia inhibitors |
US9738655B2 (en) | 2013-03-25 | 2017-08-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors |
EP3055300B1 (en) | 2013-10-09 | 2018-03-07 | Pfizer Inc | Antagonists of prostaglandin ep3 receptor |
IL307212A (en) | 2014-01-31 | 2023-11-01 | Bristol Myers Squibb Co | Macrocyclines with P2' heterocyclic groups as factor XIA inhibitors |
NO2760821T3 (hu) | 2014-01-31 | 2018-03-10 | ||
AU2015233094B2 (en) | 2014-03-17 | 2017-04-27 | Pfizer Inc. | Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders |
ES2910128T3 (es) | 2014-04-04 | 2022-05-11 | Pfizer | Compuestos de heteroarilo o arilo fusionados con biciclo y su uso como inhibidores de IRAK4 |
WO2015160636A1 (en) | 2014-04-16 | 2015-10-22 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
NO2721243T3 (hu) | 2014-10-01 | 2018-10-20 | ||
CR20170498A (es) | 2015-05-05 | 2018-01-26 | Pfizer | 2-tiopirimidinonas |
CA2989456C (en) | 2015-06-17 | 2022-01-04 | Pfizer Inc. | Tricyclic compounds and their use as phosphodiesterase inhibitors |
WO2016203335A1 (en) | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
CN114805365B (zh) | 2015-07-29 | 2024-07-23 | 百时美施贵宝公司 | 携带非芳族p2′基团的因子xia新大环 |
JP6785838B2 (ja) | 2015-08-05 | 2020-11-18 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 新規な置換グリシン誘導のfxia阻害剤 |
DK3341367T3 (da) | 2015-08-27 | 2021-04-12 | Pfizer | Bicyklisk-fusionerede heteroaryl- eller arylforbindelser som irak4-modulatorer |
JP2019507167A (ja) | 2016-03-02 | 2019-03-14 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 第xia因子阻害活性を有するジアミド大員環 |
AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
AU2019329884B2 (en) | 2018-08-31 | 2022-01-27 | Pfizer Inc. | Combinations for treatment of NASH/NAFLD and related diseases |
US20220387402A1 (en) | 2019-05-20 | 2022-12-08 | Pfizer Inc. | Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases |
US20230312560A1 (en) | 2020-07-22 | 2023-10-05 | Janssen Pharmaceutica Nv | Compounds useful as factor xia inhibitors |
WO2023026180A1 (en) | 2021-08-26 | 2023-03-02 | Pfizer Inc. | Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide |
WO2024118524A1 (en) | 2022-11-28 | 2024-06-06 | Cerevel Therapeutics, Llc | Azaindole compounds and their use as phosphodiesterase inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4178368A (en) * | 1971-09-30 | 1979-12-11 | Behringwerke Aktiengesellschaft | Method for the treatment of thromboembolism |
JPS5325775A (en) * | 1976-08-24 | 1978-03-09 | Miller Fluid Power Corp | Module type fluid flow control element |
US4082612A (en) * | 1976-09-24 | 1978-04-04 | Michael Reese Research Foundation | Plasminogen activator complex |
NZ191320A (en) * | 1978-09-07 | 1982-09-14 | Beecham Group Ltd | In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions |
-
1980
- 1980-10-27 EP EP80303797A patent/EP0028489B1/en not_active Expired
- 1980-10-27 DE DE8080303797T patent/DE3065190D1/de not_active Expired
- 1980-10-29 ZA ZA00806641A patent/ZA806641B/xx unknown
- 1980-11-03 GR GR63267A patent/GR72121B/el unknown
- 1980-11-04 NO NO803304A patent/NO163867C/no unknown
- 1980-11-04 DK DK468880A patent/DK158994C/da not_active IP Right Cessation
- 1980-11-04 AR AR283122A patent/AR224786A1/es active
- 1980-11-04 IL IL61408A patent/IL61408A/xx not_active IP Right Cessation
- 1980-11-04 IE IE2277/80A patent/IE50174B1/en not_active IP Right Cessation
- 1980-11-04 CA CA000363957A patent/CA1174621A/en not_active Expired
- 1980-11-05 JP JP15573380A patent/JPS5678590A/ja active Granted
- 1980-11-05 HU HU802661A patent/HU185223B/hu not_active IP Right Cessation
- 1980-11-05 ES ES496586A patent/ES8204467A1/es not_active Expired
- 1980-11-05 NZ NZ195469A patent/NZ195469A/en unknown
-
1986
- 1986-08-29 US US06/902,429 patent/US4808405A/en not_active Expired - Lifetime
- 1986-09-04 HK HK658/86A patent/HK65886A/xx not_active IP Right Cessation
-
1991
- 1991-12-19 CS CS913919A patent/CS391991A3/cs unknown
- 1991-12-19 CS CS913911A patent/CS391191A3/cs unknown
-
1993
- 1993-04-22 NL NL930029C patent/NL930029I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
CS391991A3 (en) | 1992-06-17 |
NZ195469A (en) | 1984-05-31 |
AU534017B2 (en) | 1983-12-22 |
IL61408A0 (en) | 1980-12-31 |
IE50174B1 (en) | 1986-02-19 |
CS391191A3 (en) | 1992-08-12 |
NL930029I2 (nl) | 1993-12-01 |
IE802277L (en) | 1981-05-05 |
EP0028489A1 (en) | 1981-05-13 |
HK65886A (en) | 1986-09-12 |
GR72121B (hu) | 1983-09-16 |
US4808405A (en) | 1989-02-28 |
JPH0316114B2 (hu) | 1991-03-04 |
NO163867C (no) | 1990-08-01 |
JPS5678590A (en) | 1981-06-27 |
NO803304L (no) | 1981-05-06 |
DE3065190D1 (en) | 1983-11-10 |
NO163867B (no) | 1990-04-23 |
DK158994B (da) | 1990-08-13 |
NL930029I1 (nl) | 1993-06-01 |
EP0028489B1 (en) | 1983-10-05 |
ES496586A0 (es) | 1982-05-01 |
AR224786A1 (es) | 1982-01-15 |
ES8204467A1 (es) | 1982-05-01 |
CA1174621A (en) | 1984-09-18 |
AU6401180A (en) | 1981-05-14 |
HU185223B (en) | 1984-12-28 |
ZA806641B (en) | 1981-10-28 |
DK468880A (da) | 1981-05-06 |
DK158994C (da) | 1991-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RH | Patent void |