IL58475A - Carbaprostacyclin derivatives,process for their preparation and pharmaceutical compositions containing them - Google Patents
Carbaprostacyclin derivatives,process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL58475A IL58475A IL58475A IL5847579A IL58475A IL 58475 A IL58475 A IL 58475A IL 58475 A IL58475 A IL 58475A IL 5847579 A IL5847579 A IL 5847579A IL 58475 A IL58475 A IL 58475A
- Authority
- IL
- Israel
- Prior art keywords
- substituted
- aryl
- alkyl
- fluoromethyl
- chloromethyl
- Prior art date
Links
- XZFRIPGNUQRGPI-WBQKLGIQSA-N Carbaprostacyclin Chemical class C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WBQKLGIQSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- -1 carboxy, hydroxy Chemical group 0.000 abstract 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000006546 (C4-C10) cycloalkyl group Chemical group 0.000 abstract 4
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 abstract 4
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006413 ring segment Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000003705 antithrombocytic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782845770 DE2845770A1 (de) | 1978-10-19 | 1978-10-19 | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL58475A0 IL58475A0 (en) | 1980-01-31 |
| IL58475A true IL58475A (en) | 1989-09-10 |
Family
ID=6052699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL58475A IL58475A (en) | 1978-10-19 | 1979-10-17 | Carbaprostacyclin derivatives,process for their preparation and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4692464A (ru) |
| EP (1) | EP0011591B1 (ru) |
| JP (1) | JPS5557559A (ru) |
| AT (1) | ATE1283T1 (ru) |
| AU (1) | AU534090B2 (ru) |
| CA (1) | CA1181747A (ru) |
| CS (1) | CS219260B2 (ru) |
| DD (1) | DD146594B3 (ru) |
| DE (2) | DE2845770A1 (ru) |
| DK (1) | DK160246C (ru) |
| ES (1) | ES485199A1 (ru) |
| FI (1) | FI69056C (ru) |
| GR (1) | GR72247B (ru) |
| HU (1) | HU184926B (ru) |
| IE (1) | IE49085B1 (ru) |
| IL (1) | IL58475A (ru) |
| LU (1) | LU88288I2 (ru) |
| MX (1) | MX9203690A (ru) |
| NL (1) | NL930070I2 (ru) |
| NO (2) | NO151318C (ru) |
| NZ (1) | NZ191827A (ru) |
| PH (1) | PH20359A (ru) |
| SU (2) | SU1003754A3 (ru) |
| YU (1) | YU41668B (ru) |
| ZA (1) | ZA795598B (ru) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5495552A (en) * | 1978-01-06 | 1979-07-28 | Sankyo Co Ltd | Prostacyline derivative and its preparation |
| GB2013661B (en) * | 1978-01-26 | 1982-11-10 | Erba Farmitalia | 9-deoxy-9 -methylene isosteres of pgi2 |
| DE3021895A1 (de) * | 1980-06-06 | 1981-12-24 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Neues verfahren zur herstellung von carbacyclin-zwischenprodukten |
| DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3104044A1 (de) * | 1981-02-02 | 1982-08-26 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE3121155A1 (de) * | 1981-05-22 | 1982-12-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3204443A1 (de) * | 1982-02-08 | 1983-08-18 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4533749A (en) * | 1982-02-16 | 1985-08-06 | The Upjohn Company | 9-Substituted carbacyclin analogs |
| DE3306125A1 (de) * | 1983-02-18 | 1984-08-23 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4486598A (en) * | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
| DE3225287A1 (de) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB2129427B (en) * | 1982-10-01 | 1986-01-08 | Erba Farmitalia | 15-cycloaliphatic derivatives of 13,14-didehydrocarboprostacyclins and process for their preparation |
| HU191110B (en) * | 1982-10-01 | 1987-01-28 | Farmitala Carlo Erba Spa,It | Process for the production of the 15-cycloaliphatic derivatives 13,14-didehydro-carbaprostacyclines |
| EP0136779B1 (en) * | 1983-07-26 | 1988-09-14 | Sankyo Company Limited | New carbacyclin derivatives, processes for their preparation and compositions containing them |
| DE3408699A1 (de) * | 1984-03-08 | 1985-09-12 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB2156343B (en) * | 1984-03-26 | 1988-01-13 | Erbo Spa Farmitalia Carlo | 13,14,19,19,20,20-hexadehydro derivatives of carboprostacyclins and process for their preparation |
| GB2156341B (en) * | 1984-03-26 | 1987-10-21 | Erba Farmitalia | Furyl and imidazolyl derivatives of carboprostacyclins and process for their preparation |
| DE3448257C2 (en) * | 1984-07-25 | 1988-08-18 | Schering Ag, 1000 Berlin Und 4709 Bergkamen, De | Cytoprotective action of prostacyclin derivatives on the kidney |
| DE3448256C2 (en) * | 1984-07-25 | 1988-08-18 | Schering Ag, 1000 Berlin Und 4709 Bergkamen, De | Cytoprotective action of prostacyclin derivatives on the pancreas |
| DE3428266A1 (de) * | 1984-07-27 | 1986-01-30 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| AU5473786A (en) * | 1985-03-18 | 1986-09-25 | G.D. Searle & Co. | Allenic prostacyclins |
| JPS6216A (ja) * | 1985-03-19 | 1987-01-06 | Sankyo Co Ltd | カルバサイクリン類及びこれを有効成分とする抗潰瘍剤 |
| DE3608088C2 (de) * | 1986-03-07 | 1995-11-16 | Schering Ag | Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten |
| DE3631169A1 (de) * | 1986-09-11 | 1988-03-24 | Schering Ag | Prostacyclinderivate enthaltende mittel fuer die topische anwendung |
| US5663203A (en) * | 1986-09-11 | 1997-09-02 | Schering Aktiengesellschaft | Agents containing prostacyclin derivatives for topical application |
| US5221763A (en) * | 1987-04-30 | 1993-06-22 | R-Tech Ueno, Ltd. | Prostaglandins of the F series |
| HU206084B (en) | 1987-07-17 | 1992-08-28 | Schering Ag | Process for producing 9-halogen-/z/-prostaglandin derivatives and pharmaceutical compositions comprising such active ingredient |
| US5891910A (en) * | 1987-07-17 | 1999-04-06 | Schering Aktiengesellschaft | 9-halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents |
| DE3839155A1 (de) * | 1988-11-17 | 1990-05-23 | Schering Ag | Verfahren zur herstellung von carbacyclin-derivaten durch stereoselektive einfuehrung der 5,6-doppelbindung |
| DE4010355A1 (de) * | 1990-03-28 | 1991-10-02 | Schering Ag | Bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
| DE4104606C1 (ru) * | 1991-02-12 | 1992-10-15 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
| DE4104607A1 (de) * | 1991-02-12 | 1992-08-13 | Schering Ag | Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen |
| DE4135193C1 (ru) * | 1991-10-22 | 1993-03-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
| DK0686036T3 (da) * | 1992-08-07 | 1997-10-13 | Schering Ag | Anvendelse af prostan-derivater til fremstilling af et lægemiddel til behandling af kronisk polyarthritis. |
| US5534589A (en) * | 1994-05-04 | 1996-07-09 | Minnesota Mining And Manufacturing Company | Repulpable plastic films |
| JP3783873B2 (ja) * | 1994-06-07 | 2006-06-07 | 中外製薬株式会社 | 肺における類線維素形成又は血栓形成に起因する疾患の予防及び治療薬並びに該疾患のモデル動物 |
| DE19530884C2 (de) * | 1995-08-11 | 1997-07-31 | Schering Ag | Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis |
| DE19828881A1 (de) * | 1998-06-22 | 1999-12-23 | Schering Ag | Oxidationsinhibitor bei Prostan-Derivaten |
| WO2000002450A1 (en) * | 1998-07-08 | 2000-01-20 | Fibrogen, Inc. | Method for treatment of fibrosis related diseases by the administration of prostacyclin derivatives |
| ES2362998T3 (es) | 2002-08-19 | 2011-07-18 | Pfizer Inc. | Terapia de combinación para enfermedades hiperproliferativas. |
| JPWO2004032964A1 (ja) * | 2002-10-10 | 2006-02-09 | 国立大学法人京都大学 | アレルギー性疾患治療剤 |
| US20050043391A1 (en) * | 2003-07-17 | 2005-02-24 | Fong Benson M. | Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome |
| EP2422814A1 (en) | 2003-07-25 | 2012-02-29 | Ono Pharmaceutical Co., Ltd. | Remedy for cartilage-related diseases |
| US20090124697A1 (en) | 2003-12-16 | 2009-05-14 | United Therapeutics Corporation | Inhalation formulations of treprostinil |
| CN1917866B (zh) * | 2003-12-16 | 2010-12-15 | 联合治疗公司 | 曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途 |
| US20060147520A1 (en) * | 2004-07-26 | 2006-07-06 | Curtis Ruegg | Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| ATE551059T1 (de) | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| US20080200449A1 (en) * | 2006-05-15 | 2008-08-21 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| WO2008058766A1 (en) | 2006-11-16 | 2008-05-22 | Bayer Schering Pharma Aktiengesellschaft | Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection |
| JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
| EP2065054A1 (en) | 2007-11-29 | 2009-06-03 | Bayer Schering Pharma Aktiengesellschaft | Combinations comprising a prostaglandin and uses thereof |
| MX350011B (es) | 2008-08-13 | 2017-08-22 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas que contienen macitentan. |
| EP2488168A1 (en) | 2009-10-14 | 2012-08-22 | Gemmus Pharma Inc. | Combination therapy treatment for viral infections |
| ES2525748T3 (es) | 2009-11-13 | 2014-12-29 | Toray Industries, Inc. | Agente terapéutico o profiláctico para la diabetes |
| EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| KR20160042039A (ko) | 2013-08-09 | 2016-04-18 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| CR20210441A (es) | 2019-01-18 | 2022-03-11 | Astrazeneca Ab | Inhibidores de la pcsk9 y métodos de uso de los mismos |
| US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
| US11826327B2 (en) | 2020-04-17 | 2023-11-28 | United Therapeutics Corporation | Treatment for interstitial lung disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4097489A (en) * | 1977-06-17 | 1978-06-27 | The Upjohn Company | 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds |
| JPS5495552A (en) * | 1978-01-06 | 1979-07-28 | Sankyo Co Ltd | Prostacyline derivative and its preparation |
| GB2013661B (en) * | 1978-01-26 | 1982-11-10 | Erba Farmitalia | 9-deoxy-9 -methylene isosteres of pgi2 |
| US4238414A (en) * | 1978-02-13 | 1980-12-09 | The Upjohn Company | 2-Decarboxy-2-aminomethyl-6a-carba-PGI2 compounds |
| JPS54119441A (en) * | 1978-03-09 | 1979-09-17 | Sumitomo Chem Co Ltd | Novel bicyclooctane derivative |
| JPS54130543A (en) * | 1978-03-31 | 1979-10-09 | Ono Pharmaceut Co Ltd | Prostagladin i2 analog, and its preparation |
| JPS5528945A (en) * | 1978-08-22 | 1980-02-29 | Sankyo Co Ltd | Prostacycline-family compound and its preparation |
-
1978
- 1978-10-19 DE DE19782845770 patent/DE2845770A1/de not_active Withdrawn
-
1979
- 1979-10-07 GR GR60293A patent/GR72247B/el unknown
- 1979-10-16 DD DD79216259A patent/DD146594B3/de not_active IP Right Cessation
- 1979-10-17 IL IL58475A patent/IL58475A/xx unknown
- 1979-10-18 AT AT79710099T patent/ATE1283T1/de active
- 1979-10-18 NO NO793353A patent/NO151318C/no unknown
- 1979-10-18 EP EP79710099A patent/EP0011591B1/de not_active Expired
- 1979-10-18 PH PH23193A patent/PH20359A/en unknown
- 1979-10-18 SU SU792837202A patent/SU1003754A3/ru active
- 1979-10-18 DE DE7979710099T patent/DE2963260D1/de not_active Expired
- 1979-10-18 HU HU79SCHE698A patent/HU184926B/hu unknown
- 1979-10-18 YU YU2530/79A patent/YU41668B/xx unknown
- 1979-10-19 FI FI793263A patent/FI69056C/fi not_active IP Right Cessation
- 1979-10-19 CA CA000338081A patent/CA1181747A/en not_active Expired
- 1979-10-19 AU AU51987/79A patent/AU534090B2/en not_active Expired
- 1979-10-19 ZA ZA00795598A patent/ZA795598B/xx unknown
- 1979-10-19 ES ES485199A patent/ES485199A1/es not_active Expired
- 1979-10-19 NZ NZ191827A patent/NZ191827A/xx unknown
- 1979-10-19 IE IE1993/79A patent/IE49085B1/en not_active IP Right Cessation
- 1979-10-19 CS CS797108A patent/CS219260B2/cs unknown
- 1979-10-19 DK DK441479A patent/DK160246C/da not_active IP Right Cessation
- 1979-10-19 JP JP13503779A patent/JPS5557559A/ja active Granted
-
1981
- 1981-02-12 SU SU813242701A patent/SU1310390A1/ru active
-
1982
- 1982-02-26 US US06/352,411 patent/US4692464A/en not_active Expired - Lifetime
-
1992
- 1992-06-29 MX MX9203690A patent/MX9203690A/es unknown
-
1993
- 1993-06-09 LU LU88288C patent/LU88288I2/fr unknown
- 1993-06-14 NL NL930070C patent/NL930070I2/nl unknown
-
1995
- 1995-12-19 NO NO1995010C patent/NO1995010I1/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed |