IL55154A - Process for the preparation of liposomes in aqueous solution - Google Patents

Process for the preparation of liposomes in aqueous solution

Info

Publication number
IL55154A
IL55154A IL55154A IL5515478A IL55154A IL 55154 A IL55154 A IL 55154A IL 55154 A IL55154 A IL 55154A IL 5515478 A IL5515478 A IL 5515478A IL 55154 A IL55154 A IL 55154A
Authority
IL
Israel
Prior art keywords
liposomes
preparation
aqueous solution
aqueous
solution
Prior art date
Application number
IL55154A
Other languages
English (en)
Other versions
IL55154A0 (en
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Publication of IL55154A0 publication Critical patent/IL55154A0/xx
Publication of IL55154A publication Critical patent/IL55154A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/929—Specified combination of agitation steps, e.g. mixing to make subcombination composition followed by homogenization

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
IL55154A 1977-08-05 1978-07-17 Process for the preparation of liposomes in aqueous solution IL55154A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH961677A CH624011A5 (fr) 1977-08-05 1977-08-05

Publications (2)

Publication Number Publication Date
IL55154A0 IL55154A0 (en) 1978-09-29
IL55154A true IL55154A (en) 1981-09-13

Family

ID=4353843

Family Applications (1)

Application Number Title Priority Date Filing Date
IL55154A IL55154A (en) 1977-08-05 1978-07-17 Process for the preparation of liposomes in aqueous solution

Country Status (20)

Country Link
US (1) US4224179A (fr)
JP (1) JPS5441279A (fr)
AU (1) AU520916B2 (fr)
BE (1) BE869490A (fr)
CA (1) CA1098410A (fr)
CH (1) CH624011A5 (fr)
DE (1) DE2834307A1 (fr)
DK (1) DK155036C (fr)
ES (1) ES472326A1 (fr)
FR (1) FR2399242A1 (fr)
GB (1) GB2001929B (fr)
HU (1) HU179672B (fr)
IE (1) IE47067B1 (fr)
IL (1) IL55154A (fr)
IT (1) IT1097928B (fr)
LU (1) LU80071A1 (fr)
NL (1) NL7808167A (fr)
SE (1) SE433169B (fr)
SU (1) SU1158031A3 (fr)
ZA (1) ZA784407B (fr)

Families Citing this family (293)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356167A (en) * 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
IT1111367B (it) * 1978-11-17 1986-01-13 Serono Ist Farm Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti
ATE8584T1 (de) 1980-01-16 1984-08-15 Hans Georg Prof. Dr. Weder Verfahren und dialysiereinrichtung zur herstellung von bilayer-vesikeln und verwendung der bilayer-vesikel.
US4302459A (en) * 1980-03-19 1981-11-24 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives
DE3161962D1 (en) * 1980-07-01 1984-02-23 Oreal Process for obtaining stable dispersions in an aqueous phase of at least a water immiscible liquid phase, and corresponding dispersions
DE3173713D1 (en) * 1980-09-05 1986-03-20 Frappier Armand Inst Formation of an immunosome exclusively made of viral antigens reconstituted on an artificial membrane
GR77320B (fr) * 1980-12-22 1984-09-11 Procter & Gamble
US4394372A (en) * 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
DE3269389D1 (en) * 1981-08-10 1986-04-03 Wellcome Found Pharmaceutical formulations containing antimony
NL193099C (nl) * 1981-10-30 1998-11-03 Novo Industri As Gestabiliseerde insuline-oplossing.
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4416872A (en) * 1982-03-17 1983-11-22 The United States Of America As Represented By The Secretary Of The Army Treatment of malaria with liposomes containing 8-aminoquinoline derivatives and glycoconjugates
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
AU564876B2 (en) * 1982-03-29 1987-08-27 Liposome Company, Inc., The Stable plurilamellar vesicles
US5435989A (en) 1982-03-30 1995-07-25 Vestar, Inc. Method of targeting a specific location in a body
US5441745A (en) * 1982-03-30 1995-08-15 Vestar, Inc. Method of delivering micellular particles encapsulating chemotherapeutic agents to tumors in a body
US4612370A (en) * 1982-04-02 1986-09-16 The Regents Of The University Of California Lipid-saccharide reaction products
US4425334A (en) 1982-04-02 1984-01-10 The Regents Of The University Of California Functional oxygen transport system
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
EP0100964A3 (fr) * 1982-07-31 1984-06-13 Reifenrath, Rainer, Dr. Produit pharmaceutique pour le traitement et la prophylaxie d'infections, de la toux et d'affections obstructives des voies respiratoires, ainsi que son procédé de préparation
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4501728A (en) * 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
FR2540381B1 (fr) * 1983-02-08 1986-05-30 Dior Sa Parfums Christian Procede pour stimuler la croissance des cellules; composition cosmetique, pharmaceutique et composition complementaire pour milieu de culture cellulaire appliquant ce procede
US5387410A (en) * 1983-03-18 1995-02-07 Mallinckrodt, Inc. Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US5186941A (en) * 1983-05-06 1993-02-16 Vestar, Inc. Vesicle formulation for the controlled release of therapeutic agents
FR2561101B1 (fr) * 1984-03-13 1986-10-31 Paris Sud Universite Procede de preparation de liposomes et liposomes ainsi obtenus
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US5231112A (en) * 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4707453A (en) * 1985-04-05 1987-11-17 Becton Dickinson And Company Vesicle including a metal marker for use in an assay
US4698263A (en) * 1985-05-23 1987-10-06 Becton Dickinson And Company Sac having a marker linked thereto
US5409704A (en) * 1985-06-26 1995-04-25 The Liposome Company, Inc. Liposomes comprising aminoglycoside phosphates and methods of production and use
US5041278A (en) * 1985-10-15 1991-08-20 The Liposome Company, Inc. Alpha tocopherol-based vesicles
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
FR2591105B1 (fr) 1985-12-11 1989-03-24 Moet Hennessy Rech Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide.
JPH0751496B2 (ja) * 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
FR2597345B1 (fr) * 1986-04-22 1990-08-03 Oreal Composition cosmetique ou pharmaceutique a base d'une dispersion aqueuse de spherules lipidiques.
US6759057B1 (en) 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
JP2760355B2 (ja) * 1986-06-16 1998-05-28 ザ リポソーム カンパニー，インコーポレイテッド 不均整誘導リポソーム
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
EP0293465B1 (fr) * 1986-11-28 1992-03-18 The Liposome Company, Inc. Composition a base de phospholipides
US4783220A (en) * 1986-12-18 1988-11-08 Xerox Corporation Vesicle ink compositions
EP0498471B1 (fr) * 1986-12-23 1996-08-14 The Liposome Company, Inc. Liposomes contenant un guanidino-aminoglycoside
GB8704171D0 (en) * 1987-02-23 1987-04-01 Clayton Found Res Multivesicular liposomes
US5723147A (en) * 1987-02-23 1998-03-03 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5925375A (en) * 1987-05-22 1999-07-20 The Liposome Company, Inc. Therapeutic use of multilamellar liposomal prostaglandin formulations
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
US4873035A (en) * 1987-11-25 1989-10-10 Abbott Laboratories Preparation of sized populations of liposomes
US5017501A (en) * 1987-11-25 1991-05-21 Abbott Laboratories Preparation of uniformly sized liposomes encapsulating an aqueous liquid
KR900000848B1 (ko) * 1987-12-30 1990-02-17 태평양화학 주식회사 리포좀을 함유한 화장료의 제조방법
US5807572A (en) * 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
CA1339034C (fr) * 1988-08-22 1997-04-01 Paul A. Tremblay Complexes de platine d'isomeres uniques d'acides neoalkyliques
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5043165A (en) * 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
DK0456724T3 (da) 1989-01-27 1995-10-02 Immunolytics Inc Præparat og fremgangsmåde til behandling af benign prostatisk hypertrofi
US5116615A (en) * 1989-01-27 1992-05-26 Immunolytics, Inc. Method for treating benign prostatic hypertrophy
US5078986A (en) * 1989-02-15 1992-01-07 Mallinckrodt Medical, Inc. Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
US5100662A (en) * 1989-08-23 1992-03-31 The Liposome Company, Inc. Steroidal liposomes exhibiting enhanced stability
US5221535A (en) * 1989-11-13 1993-06-22 Nova Pharmaceutical Corporation Sustained release formulations of insect repellent
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
IE904098A1 (en) * 1989-11-13 1991-05-22 Nova Pharm Corp Lipospheres for controlled delivery of substances
US5227165A (en) * 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6088613A (en) * 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US6001335A (en) * 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
ZA911974B (en) * 1990-03-21 1994-08-22 Res Dev Foundation Heterovesicular liposomes
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (fr) * 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
EP0555229B1 (fr) * 1990-07-31 1996-06-05 The Liposome Company, Inc. Accumulation d'acides amines et de peptides dans des liposomes
AU8443591A (en) * 1990-09-06 1992-03-30 S.C. Johnson & Son, Inc. Stabilized liposome process and compositions containing them
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5567432A (en) * 1991-08-02 1996-10-22 Lau; John R. Masking of liposomes from RES recognition
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5455044A (en) * 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
EP1118326A3 (fr) * 1993-05-21 2002-07-31 The Liposome Company, Inc. Réduction de réactions physiologiques indésirables induites par des liposomes
RO116341B1 (ro) * 1993-11-16 2001-01-30 Depotech Corp La Jolia Lipozom multivezicular si procedeu de obtinere a acestuia
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
ATE234638T1 (de) * 1993-12-15 2003-04-15 Bracco Research Sa Gas-mischungen verwendbar als ultraschallkontrastmittel
EP0748215B1 (fr) * 1994-02-17 2003-05-28 New York Blood Center, Inc. Compositions biologiques bioadhesives contenant une colle de fibrine et des liposomes, leur preparation et leur utilisation
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US7091008B1 (en) * 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
US6951743B2 (en) 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US5993850A (en) * 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5800833A (en) * 1995-02-27 1998-09-01 University Of British Columbia Method for loading lipid vesicles
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
EP0839053A2 (fr) * 1995-07-14 1998-05-06 GlycoTech Corp. Composes et methodes de traitement de cancers lies au recepteur egf et purification du recepteur egf
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
US6022500A (en) * 1995-09-27 2000-02-08 The United States Of America As Represented By The Secretary Of The Army Polymer encapsulation and polymer microsphere composites
US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
US6143287A (en) * 1996-02-27 2000-11-07 New York Blood Center, Inc. Method and composition for hair removal
ATE345682T1 (de) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
CA2263568C (fr) * 1996-09-11 2008-12-02 Imarx Pharmaceutical Corp. Methodes d'imagerie diagnostique faisant appel a un milieu de contraste et a un vasodilatateur renal
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US5997899A (en) 1996-10-01 1999-12-07 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
US5891467A (en) 1997-01-31 1999-04-06 Depotech Corporation Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
EP2113247A3 (fr) 1997-05-14 2010-05-05 The University Of British Columbia Encapsulation hautement éfficace d'acides nucléiques dans des vésicules lipidiques
EP1027033B1 (fr) * 1997-05-14 2009-07-22 The University Of British Columbia Encapsulation hautement éfficace d'acides nucléiques dans des vésicules lipidiques
US6123956A (en) * 1997-07-10 2000-09-26 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6306432B1 (en) 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
CA2304096C (fr) 1997-09-18 2003-09-09 Skyepharma Inc. Compositions anesthesiques de liposomes a liberation prolongee
CN101113436B (zh) * 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
CA2307842C (fr) * 1997-10-31 2010-10-19 The Board Of Regents Of The University Of Oklahoma Gene de la synthase de l'hyaluronan et utilisation de ce gene
NZ504188A (en) * 1997-11-14 2001-10-26 Skyepharma Inc Emulsification process for preparing multivesicular liposomes
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6727079B1 (en) * 1998-02-25 2004-04-27 The United States Of America As Represented By The Department Of Health And Human Services cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US6987023B2 (en) * 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7169410B1 (en) * 1998-05-19 2007-01-30 Sdg, Inc. Targeted liposomal drug delivery system
US7094581B2 (en) * 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
ES2275675T3 (es) * 2000-03-23 2007-06-16 Elan Pharmaceuticals, Inc. Compuestos y metodos para tratar la enfermedad de alzheimer.
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US20050287638A1 (en) * 2000-04-25 2005-12-29 Weigel Paul H Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US7034182B2 (en) * 2000-06-30 2006-04-25 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
JP4524071B2 (ja) * 2000-11-09 2010-08-11 ネオファーム、インコーポレイティッド Ｓｎ−３８脂質複合体及び使用方法
US20110301569A1 (en) 2001-01-20 2011-12-08 Gordon Wayne Dyer Methods and apparatus for the CVCS
AU2002258603A1 (en) * 2001-03-23 2002-10-15 University Of Michigan Method of inhibiting cancerous cell proliferation using ras mutants of gdp-bound conformation
WO2003030864A1 (fr) * 2001-05-29 2003-04-17 Neopharm, Inc. Formulation liposomale d'irinotecan
US6982264B2 (en) * 2001-06-27 2006-01-03 Elan Pharmaceuticals, Inc. Substituted alcohols useful in treatment of Alzheimer's disease
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
BRPI0105509B8 (pt) * 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
JP2005516897A (ja) * 2001-11-07 2005-06-09 イネックス ファーマシューティカルズ コーポレイション 改善された粘膜のワクチン及びその使用方法
US7476400B2 (en) * 2001-11-13 2009-01-13 Ferndale Ip, Inc. High-concentration lidocaine compositions and methods for their preparation
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
US20090191259A1 (en) * 2002-01-09 2009-07-30 Transave, Inc. Efficient liposomal encapsulation
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
US20040013649A1 (en) * 2002-05-10 2004-01-22 Inex Pharmaceuticals Corporation Cancer vaccines and methods of using the same
US20040009943A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Pathogen vaccines and methods for using the same
AU2003296897A1 (en) * 2002-08-20 2004-05-04 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
HUE025491T2 (en) 2002-10-29 2016-04-28 Insmed Inc Delayed release of anti-infective agents
CN100367932C (zh) * 2002-11-26 2008-02-13 吉里德科学公司 借助梯度的脂质体中药物装填的方法
US6866856B2 (en) * 2002-12-31 2005-03-15 Avon Products, Inc. Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
US20070248541A1 (en) * 2003-12-01 2007-10-25 Mitsubishi Pharma Corporation Liposome
US7504385B2 (en) * 2003-12-17 2009-03-17 Avon Products, Inc. si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
ES2388064T3 (es) 2004-04-22 2012-10-08 Celator Pharmaceuticals, Inc. Formulaciones liposomales de agentes de antraciclina y análogos de citidina
JP2008506780A (ja) 2004-07-19 2008-03-06 セレーター ファーマスーティカルズ、インク． 活性剤放出のための粒子状構築物
AU2005304914B2 (en) 2004-11-05 2012-02-16 Tekmira Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal camptothecin formulations
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
US9944713B2 (en) 2004-11-24 2018-04-17 Medicinal Bioconvergence Research Center Antibody specific to the AIMP2-DX2
US7459529B2 (en) 2004-11-24 2008-12-02 Seoul National University Industry Foundation AIMP2-DX2 and its uses
MX2007007373A (es) 2004-12-20 2007-08-14 Australian Nuclear Science Tec Liberacion controlada de entidades biologicas.
AU2005318928B2 (en) * 2004-12-20 2010-06-03 Australian Nuclear Science & Technology Organisation Controlled release of biological entities
AU2006257726B2 (en) * 2005-06-17 2010-09-09 Australian Nuclear Science And Technology Organisation Particles having hydrophobic material therein
WO2006133519A1 (fr) 2005-06-17 2006-12-21 Australian Nuclear Science And Technology Organisation Particules contenant un dopant liberable
AU2006257727B2 (en) * 2005-06-17 2010-09-09 Encap Hive Pty Ltd Particles comprising a releasable dopant therein
MX2007016021A (es) * 2005-06-17 2008-04-16 Australian Nuclear Science Tec Particulas que tienen material hidrofobico en estas.
JPWO2007032225A1 (ja) * 2005-09-15 2009-03-19 国立大学法人京都大学 リポソーム、リポソームの製造方法及び微小反応空間内での反応制御方法
US8101741B2 (en) 2005-11-02 2012-01-24 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
WO2007070705A2 (fr) * 2005-12-15 2007-06-21 The Trustees Of The University Of Pennsylvania Nouveaux procedes et modeles d'administration rapide et large de materiel genetique au systeme nerveux central a l'aide de vecteurs non viraux medies par lipides cationiques
US20080094573A1 (en) * 2006-04-04 2008-04-24 Vermette Patrick Surface-modified materials, such as contact lenses, methods and kits for their preparation, and uses thereof
ATE531727T1 (de) 2006-09-18 2011-11-15 Compugen Ltd Bioaktive peptide und verfahren zu ihrer verwendung
WO2008130373A2 (fr) 2006-10-03 2008-10-30 The Board Of Regents Of The University Of Oklahoma Polymères de glycosaminoglycane ciblés obtenus par greffage polymère et leurs procédés de fabrication et d'utilisation
WO2008130641A1 (fr) * 2007-04-20 2008-10-30 Biocure, Inc. Véhicule pour l'administration de médicaments contenant des vésicules dans une base hydrogel
AU2008273813B2 (en) 2007-07-12 2013-06-13 Compugen Ltd. Bioactive peptides and method of using same
ITRM20070394A1 (it) * 2007-07-16 2009-01-17 Uni Cattolica Del Sacro Cuo Re Liposomi asimmetrici e loro usi in campo medico.
WO2009097011A1 (fr) 2007-08-17 2009-08-06 Celator Pharmaceuticals, Inc. Préparations améliorées de médicaments au platine
EP4223299A3 (fr) 2007-12-04 2023-08-30 Alnylam Pharmaceuticals, Inc. Conjugués glucidiques utilisés comme agents d'administration pour des oligonucléotides
EP2231190B1 (fr) * 2007-12-06 2012-09-26 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Vecteurs de médicaments particulaires en tant qu'agents de désensibilisation
EP2229583B1 (fr) 2007-12-06 2019-04-10 Genalyte Inc. Système et procédé de surveillance de synthèse d'acide nucléique sans marqueurs
JP5697988B2 (ja) 2007-12-27 2015-04-08 プロチバ バイオセラピューティクス インコーポレイティッド 干渉ｒｎａを使用したポロ様キナーゼ発現のサイレンシング方法
EP2224912B1 (fr) 2008-01-02 2016-05-11 TEKMIRA Pharmaceuticals Corporation Compositions et procédés améliorés pour la délivrance d'acides nucléiques
US8058069B2 (en) 2008-04-15 2011-11-15 Protiva Biotherapeutics, Inc. Lipid formulations for nucleic acid delivery
CA2721380A1 (fr) 2008-04-15 2009-10-22 Protiva Biotherapeutics, Inc. Reduction au silence de l'expression du gene csn5 au moyen d'arn interferant
AU2009290396B2 (en) * 2008-09-11 2014-11-06 I.B.R. Israeli Biotechnology Research Ltd. Leucojum bulb extracts and use thereof
ES2475065T3 (es) 2008-10-09 2014-07-10 Tekmira Pharmaceuticals Corporation Aminol�pidos mejorados y métodos para la administración de ácidos nucleicos
JP5656853B2 (ja) 2008-10-27 2015-01-21 ジェナリーテ， インコーポレイテッド 光学的な探査及び検知に基づくバイオセンサ
KR102264822B1 (ko) 2008-11-10 2021-06-14 알닐람 파마슈티칼스 인코포레이티드 치료제 운반용 신규 지질 및 조성물
AU2010208035B2 (en) 2009-01-29 2016-06-23 Arbutus Biopharma Corporation Improved lipid formulation for the delivery of nucleic acids
CN102316852A (zh) 2009-02-11 2012-01-11 丽卡实验有限公司 脂质胞二磷胆碱注射液
CN102421900B (zh) 2009-03-12 2015-07-22 阿尔尼拉姆医药品有限公司 用于抑制Eg5和VEGF基因表达的脂质配制的组合物以及方法
JP5487666B2 (ja) * 2009-03-23 2014-05-07 コニカミノルタ株式会社 内水相を固定化することを特徴とするリポソームの製造方法
EP2416760A4 (fr) 2009-05-05 2014-01-22 Tekmira Pharmaceuticals Corp Compositions lipidiques
EP3698631A3 (fr) 2009-05-05 2020-11-25 Arbutus Biopharma Corporation Procédés d'administration d'oligonucléotides dans des cellules immunes
NZ596958A (en) 2009-06-10 2014-04-30 Tekmira Pharmaceuticals Corp Improved lipid formulation
IL292615B2 (en) 2009-07-01 2023-11-01 Protiva Biotherapeutics Inc Nucleic acid-lipid particles, preparations containing them and their uses
US8716464B2 (en) 2009-07-20 2014-05-06 Thomas W. Geisbert Compositions and methods for silencing Ebola virus gene expression
FR2948035B1 (fr) * 2009-07-20 2015-04-24 Centre Nat Rech Scient Procede de fabrication de capsules, capsules ainsi obtenues et utilisation desdites capsules
AP2015008874A0 (en) 2009-08-14 2015-11-30 Alnylam Pharmaceuticals Inc Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
CA2775092A1 (fr) 2009-09-23 2011-03-31 Protiva Biotherapeutics, Inc. Compositions et procedes pour reduire au silence des genes exprimes dans le cancer
WO2011056682A1 (fr) 2009-10-27 2011-05-12 The University Of British Columbia Lipides à têtes polaires inversées, compositions particulaires lipidiques comprenant les lipides à têtes polaires inversées, et procédés d'administration d'acides nucléiques
CA3044884A1 (fr) 2009-12-07 2011-06-16 Arbutus Biopharma Corporation Compositions utilisees pour l'administration d'acides nucleiques
AU2010330814B2 (en) 2009-12-18 2017-01-12 Acuitas Therapeutics Inc. Methods and compositions for delivery of nucleic acids
US10077232B2 (en) 2010-05-12 2018-09-18 Arbutus Biopharma Corporation Cyclic cationic lipids and methods of use
EP2569276B1 (fr) 2010-05-12 2021-02-24 Arbutus Biopharma Corporation Nouveaux lipides cationiques et procédés d'utilisation de ceux-ci
EP2575764B1 (fr) 2010-06-03 2017-04-19 Alnylam Pharmaceuticals, Inc. Lipides biodégradables pour l'administration de principes actifs
US20130323269A1 (en) 2010-07-30 2013-12-05 Muthiah Manoharan Methods and compositions for delivery of active agents
US20130202652A1 (en) 2010-07-30 2013-08-08 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
US9921165B2 (en) 2010-11-05 2018-03-20 Genalyte, Inc. Optical analyte detection systems and methods of use
JP2014500867A (ja) 2010-11-09 2014-01-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 皮膚浸透性および細胞侵入性（ｓｐａｃｅ）ペプチドとその使用法
EP3202760B1 (fr) 2011-01-11 2019-08-21 Alnylam Pharmaceuticals, Inc. Lipides pégylés et leur utilisation pour l'administration de médicaments
EP2672958A1 (fr) 2011-02-08 2013-12-18 Halozyme, Inc. Composition et formulation lipidique d'une enzyme dégradant le hyaluronane et son utilisation pour le traitement de l'hyperplasie bénigne de la prostate
DK2729127T3 (en) 2011-07-04 2018-08-06 Statens Seruminstitut METHODS FOR LIPOSOMES PREPARATION
AU2012315965A1 (en) 2011-09-27 2014-04-03 Alnylam Pharmaceuticals, Inc. Di-aliphatic substituted PEGylated lipids
EP2780456A1 (fr) 2011-11-17 2014-09-24 The U.S.A. as represented by the Secretary, Department of Health and Human Services Compositions de commutateurs arn thérapeutiques et procédés d'utilisation
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
EP2606897A1 (fr) 2011-12-22 2013-06-26 Laboratorios Del. Dr. Esteve, S.A. Procédés et compositions pour le traitement des maladies causées par les virus enveloppés
KR20220045089A (ko) 2012-02-24 2022-04-12 아뷰터스 바이오파마 코포레이션 트리알킬 양이온성 지질 및 그의 사용 방법
EP3907506A1 (fr) 2012-03-12 2021-11-10 The Board of Trustees of the University of Illinois Systèmes optiques de détection d'analyte avec amplification magnétique et leurs procédés d'utilisation
EP2666456A1 (fr) 2012-05-21 2013-11-27 Natura Bisse International, S.A. Compositions cosmétiques comprenant des magnetosomes et utilisations associées
CN112451486A (zh) 2012-09-04 2021-03-09 埃莱森制药有限责任公司 用顺铂脂质复合物预防癌症的肺部复发
CN105555757A (zh) 2013-07-23 2016-05-04 普洛体维生物治疗公司 用于递送信使rna的组合物和方法
KR101465365B1 (ko) * 2013-10-15 2014-11-25 성균관대학교산학협력단 리포좀 내 고분자 충진된 다중 기능 복합 입자체 및 이의 제조방법
KR101638156B1 (ko) 2013-10-29 2016-07-08 가톨릭대학교 산학협력단 C형 간염 바이러스 감염 질환의 예방 또는 치료용 약학 조성물
PT3186281T (pt) 2014-08-28 2019-07-10 Halozyme Inc Terapia de combinação com uma enzima de degradação de hialuronano e um inibidor de pontos de verificação imunológica
JP2017536092A (ja) 2014-10-02 2017-12-07 プロティバ バイオセラピューティクス インコーポレイテッド Ｂ型肝炎ウイルスの遺伝子発現をサイレンシングするための組成物及び方法
JP2018504380A (ja) 2014-12-18 2018-02-15 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｒｅｖｅｒｓｉｒ（商標）化合物
JP6316182B2 (ja) * 2014-12-19 2018-04-25 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
AU2015374286B2 (en) 2014-12-31 2021-11-18 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
WO2016191547A1 (fr) 2015-05-26 2016-12-01 Comfort Care For Animals Llc Chargement de liposome
WO2016197132A1 (fr) 2015-06-04 2016-12-08 Protiva Biotherapeutics Inc. Traitement d'une infection à virus de l'hépatite b à de l'aide de crispr
CN108350455A (zh) 2015-07-29 2018-07-31 阿布特斯生物制药公司 用于使b型肝炎病毒基因表达沉默的组合物和方法
EP3335028A1 (fr) 2015-08-11 2018-06-20 Scintillon Institute for Biomedical and Bioenergy Research Analyse optique de particules et de vésicules
WO2017027760A1 (fr) 2015-08-12 2017-02-16 North Carolina State University Système d'administration de médicaments recouvert d'une membrane plaquettaire
AU2017206077B2 (en) 2016-01-08 2021-11-18 The Regents Of The University Of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
US10188749B2 (en) 2016-04-14 2019-01-29 Fred Hutchinson Cancer Research Center Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
KR102542533B1 (ko) 2016-04-14 2023-06-13 프레드 허친슨 캔서 센터 표적화 핵산 나노수송체를 이용하여 치료 세포를 프로그램화하기 위한 조성물 및 방법
JP2019515936A (ja) 2016-05-04 2019-06-13 ランセウス メディカル イメージング， インコーポレイテッド 超音波造影剤を調製するための方法およびデバイス
US11191849B2 (en) 2016-06-30 2021-12-07 Arbutus Biopharma Corporation Compositions and methods for delivering messenger RNA
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3558327A4 (fr) 2016-12-21 2020-12-09 Fred Hutchinson Cancer Research Center Échafaudages pour traiter des cellules de tumeurs solides et des variants d'échappement
JP7348063B2 (ja) 2017-01-05 2023-09-20 フレッド ハッチンソン キャンサー センター ワクチン効力を改善するためのシステム及び方法
TW201936201A (zh) 2017-12-14 2019-09-16 美商堅固生物科技公司 基因之非病毒生產及遞送
AU2020295807A1 (en) 2019-06-20 2022-02-17 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis B virus (HBV) vaccines
US20210023023A1 (en) * 2019-07-25 2021-01-28 Vasayo, Llc Liposomal nutraceutical compositions and methods of making the same
WO2022133230A1 (fr) 2020-12-18 2022-06-23 Janssen Pharmaceuticals, Inc. Polythérapie pour le traitement d'une infection par le virus de l'hépatite b
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
WO2022212863A1 (fr) 2021-04-01 2022-10-06 Vestaron Corporation Formulations de liposomes destinées à l'administration de pesticides et leurs procédés de production et d'utilisation
EP4384508A2 (fr) 2021-08-12 2024-06-19 Life Technologies Corporation Lipides pour l'administration d'acides nucléiques
WO2023144798A1 (fr) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Lipides cationiques ionisables pour nanoparticules lipidiques
WO2023144792A1 (fr) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Conjugués poly(alkyloxazoline)-lipide et particules lipidiques les contenant
WO2023233290A1 (fr) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Agents d'arni ciblant pd-l1
NL2035417A (en) 2022-07-19 2024-01-26 Coty Inc Cosmetic composition
WO2024031051A1 (fr) 2022-08-05 2024-02-08 Life Technologies Corporation Lipides pour l'administration d'acides nucléiques

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361680A (en) * 1963-05-13 1968-01-02 Sun Oil Co Use of ultrasonic vibrations to disperse a liquid in another liquid
BE744162A (fr) * 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
DE2249552A1 (de) * 1971-10-12 1973-05-30 Inchema S A Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen
US3932657A (en) * 1973-11-12 1976-01-13 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome encapsulation of chelating agents
GB1502774A (en) * 1974-06-25 1978-03-01 Nat Res Dev Immunological preparations
CH588887A5 (fr) * 1974-07-19 1977-06-15 Battelle Memorial Institute
JPS5126213A (ja) * 1974-08-21 1976-03-04 Tanabe Seiyaku Co Johoseibiryushiseizaino seiho
FR2315991A1 (fr) * 1975-06-30 1977-01-28 Oreal Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes
IL51791A0 (en) * 1976-04-14 1977-05-31 Exxon Research Engineering Co New injectable medicinal compositions
JPS5323872A (en) * 1976-08-17 1978-03-04 Takeda Chem Ind Ltd Preparation of microcapsule
US4107106A (en) * 1976-11-22 1978-08-15 Union Carbide Corporation Phenol-aldehyde-amine resin/glycol curatives for energy absorbing polyurethanes
JP2758985B2 (ja) * 1989-09-05 1998-05-28 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション 親油性薬剤の非侵襲性用量対効果式投与のための方法及び組成物

Also Published As

Publication number Publication date
CA1098410A (fr) 1981-03-31
DK155036C (da) 1989-06-26
IE47067B1 (en) 1983-12-14
GB2001929B (en) 1982-07-28
HU179672B (en) 1982-11-29
NL7808167A (nl) 1979-02-07
DK155036B (da) 1989-01-30
ZA784407B (en) 1979-07-25
JPS6355978B2 (fr) 1988-11-07
GB2001929A (en) 1979-02-14
JPS5441279A (en) 1979-04-02
IT7826441A0 (it) 1978-08-03
FR2399242A1 (fr) 1979-03-02
DK344478A (da) 1979-02-06
SE7808356L (sv) 1979-02-06
DE2834307A1 (de) 1979-02-15
AU3866678A (en) 1980-02-07
BE869490A (fr) 1979-02-05
CH624011A5 (fr) 1981-07-15
ES472326A1 (es) 1979-02-16
AU520916B2 (en) 1982-03-04
LU80071A1 (fr) 1979-05-15
SU1158031A3 (ru) 1985-05-23
IE781574L (en) 1979-02-05
IL55154A0 (en) 1978-09-29
FR2399242B1 (fr) 1983-01-07
US4224179A (en) 1980-09-23
IT1097928B (it) 1985-08-31
SE433169B (sv) 1984-05-14

Similar Documents

Publication Publication Date Title
GB2001929B (en) Process for the preparation of liposomes in aqueous solution
GB2035947B (en) Process for the preparation of liposomes
DE2860230D1 (en) Process for the preparation of polyamides
GB2006212B (en) Process for the preparation of d(-)-a-phenylglycine
IL55819A (en) Process for the preparation of o-methallyloxyphenol
DE3060382D1 (en) Process for the preparation of aqueous solutions of alkali-organosiliconates
NZ189536A (en) Preparation of aqueous solution of rafoxanidepolyvinylpyrrolidone complex
DE2860225D1 (en) Process for the preparation of polyamides
ZA786299B (en) Process for the preparation of 3-iodo-and bromorifamycin s
GR65231B (en) Method for the preparation of aqueous fibres
IL55343A0 (en) Process for the preparation of hydroxyphenylhydantion
PT68946A (en) Process for the preparation of salicylic acid and derivatives thereof
PT68486A (en) Improved process for the preparation of 2-clorosulfinila zeditin-4-onas
GB2006764B (en) Process for the preparation of 4-chloroquinolines
GB2001957B (en) Process for the preparation of 2-alkoxy-tetrahydrofurans
DE2860746D1 (en) Process for the preparation of 3-bromomethyl-3-cephem-sulphoxide derivatives
IL54206A0 (en) Process for the preparation of , -dialkoxycarboxylic acid derivatives
DE3060468D1 (en) Process for the preparation of diazoniumtetrafluoroborates in a diluted aqueous solution
DE2860809D1 (en) Process for the preparation of 3-pyridazinones
GB2001974B (en) Vincinic acid derivatives and process for the preparation thereof
ZA785651B (en) Process for the preparation of(-)-vincamine
PT68882A (en) Process for the preparation of imino-bridged benzocycloheptapyridines
IL54372A (en) Process for the preparation of d thiazolidine-azetidinone
PT71898B (en) Process for the preparation of omega-lactams in particularcaprolactam
DE2860619D1 (en) Process for the preparation of morpholino-dithiothiazoles