IL308949B2 - Modified membrane type 1 serine protease polypeptides (MTSP-1) and methods of use - Google Patents

Modified membrane type 1 serine protease polypeptides (MTSP-1) and methods of use

Info

Publication number
IL308949B2
IL308949B2 IL308949A IL30894923A IL308949B2 IL 308949 B2 IL308949 B2 IL 308949B2 IL 308949 A IL308949 A IL 308949A IL 30894923 A IL30894923 A IL 30894923A IL 308949 B2 IL308949 B2 IL 308949B2
Authority
IL
Israel
Prior art keywords
mtsp
polypeptides
methods
serine protease
membrane type
Prior art date
Application number
IL308949A
Other languages
English (en)
Hebrew (he)
Other versions
IL308949A (en
IL308949B1 (en
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of IL308949A publication Critical patent/IL308949A/en
Publication of IL308949B1 publication Critical patent/IL308949B1/en
Publication of IL308949B2 publication Critical patent/IL308949B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21109—Matriptase (3.4.21.109)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Photolithography (AREA)
  • Beans For Foods Or Fodder (AREA)
IL308949A 2017-06-22 2018-06-21 Modified membrane type 1 serine protease polypeptides (MTSP-1) and methods of use IL308949B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762523735P 2017-06-22 2017-06-22
US201862664051P 2018-04-27 2018-04-27
PCT/US2018/038844 WO2018237201A1 (en) 2017-06-22 2018-06-21 MODIFIED MEMBRANE-LIKE SERINE PROTEASE-1 POLYPEPTIDES (MTSP-1) AND METHODS OF USE

Publications (3)

Publication Number Publication Date
IL308949A IL308949A (en) 2024-01-01
IL308949B1 IL308949B1 (en) 2025-11-01
IL308949B2 true IL308949B2 (en) 2026-03-01

Family

ID=63015005

Family Applications (2)

Application Number Title Priority Date Filing Date
IL308949A IL308949B2 (en) 2017-06-22 2018-06-21 Modified membrane type 1 serine protease polypeptides (MTSP-1) and methods of use
IL271587A IL271587B2 (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL271587A IL271587B2 (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use

Country Status (19)

Country Link
US (5) US10781435B2 (https=)
EP (1) EP3641801A1 (https=)
JP (3) JP7091373B2 (https=)
KR (1) KR102675270B1 (https=)
CN (1) CN111107870A (https=)
AU (2) AU2018290281B2 (https=)
BR (1) BR112019027583A2 (https=)
CA (2) CA3177086A1 (https=)
CL (3) CL2019003813A1 (https=)
CO (1) CO2020000584A2 (https=)
IL (2) IL308949B2 (https=)
JO (1) JOP20190288A1 (https=)
MX (1) MX2019015402A (https=)
MY (1) MY202652A (https=)
PE (1) PE20200697A1 (https=)
PH (1) PH12019502838A1 (https=)
SG (3) SG11201912071QA (https=)
WO (1) WO2018237201A1 (https=)
ZA (1) ZA202000332B (https=)

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US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CA3177086A1 (en) * 2017-06-22 2018-12-27 Catalyst Biosciences, Inc. Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
KR102439221B1 (ko) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
CN114269937B (zh) * 2019-07-03 2026-04-24 帕利昂制药有限公司 重组唾液酸酶及其使用方法
US11396529B2 (en) * 2020-11-12 2022-07-26 National Sun Yat-Sen University Isolated peptide, anti-cancer medicinal composition including the same and method of specifically reducing or inhibiting activities of cancer cells using the same
KR20230142496A (ko) * 2021-01-08 2023-10-11 버텍스 파마슈티칼스 인코포레이티드 인자 b 프로테아제
CN113456527B (zh) * 2021-07-30 2023-04-07 北京清大赛尔生物科技有限公司 一种nadh微胶囊制剂及其制备方法和应用
WO2024205149A1 (ko) * 2023-03-24 2024-10-03 카오티에스 주식회사 신규한 그랜자임 융합단백질 및 이의 용도
CN119570766B (zh) * 2025-02-08 2025-05-16 上海锴泰生物科技有限公司 一种胶原蛋白酶突变体、基因片段、重组质粒、重组表达体系、胶原蛋白肽，及其制备方法和用途
CN121538228B (zh) * 2026-01-21 2026-04-10 山东寿光巨能金玉米开发有限公司 一种NCgl0081基因突变体及其在制备L-赖氨酸中的应用

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