SG11202103886XA - Intein proteins and uses thereof - Google Patents
Intein proteins and uses thereofInfo
- Publication number
- SG11202103886XA SG11202103886XA SG11202103886XA SG11202103886XA SG11202103886XA SG 11202103886X A SG11202103886X A SG 11202103886XA SG 11202103886X A SG11202103886X A SG 11202103886XA SG 11202103886X A SG11202103886X A SG 11202103886XA SG 11202103886X A SG11202103886X A SG 11202103886XA
- Authority
- SG
- Singapore
- Prior art keywords
- intein proteins
- intein
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18200490 | 2018-10-15 | ||
| EP19169116 | 2019-04-12 | ||
| PCT/EP2019/078020 WO2020079034A2 (en) | 2018-10-15 | 2019-10-15 | Intein proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202103886XA true SG11202103886XA (en) | 2021-05-28 |
Family
ID=68234008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202103886XA SG11202103886XA (en) | 2018-10-15 | 2019-10-15 | Intein proteins and uses thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210371878A1 (en) |
| EP (1) | EP3867387A2 (en) |
| JP (1) | JP2022512718A (en) |
| KR (1) | KR20210104661A (en) |
| CN (1) | CN113348249A (en) |
| AU (1) | AU2019360372A1 (en) |
| BR (1) | BR112021007221A2 (en) |
| CA (1) | CA3116606A1 (en) |
| IL (1) | IL282362A (en) |
| MX (1) | MX2021004391A (en) |
| SG (1) | SG11202103886XA (en) |
| WO (1) | WO2020079034A2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2021216410A1 (en) * | 2020-02-07 | 2022-09-01 | The Children's Medical Center Corporation | Large gene vectors and delivery and uses thereof |
| WO2021209574A1 (en) | 2020-04-15 | 2021-10-21 | Fondazione Telethon | Constructs comprising inteins |
| WO2022056440A1 (en) * | 2020-09-14 | 2022-03-17 | President And Fellows Of Harvard College | Dual-aav vector delivery of pcdh15 and uses thereof |
| WO2023004125A2 (en) * | 2021-07-23 | 2023-01-26 | University Of Washington | Generation of large proteins by co-delivery of multiple vectors |
| WO2023070527A1 (en) * | 2021-10-29 | 2023-05-04 | 上海鑫湾生物科技有限公司 | Condition-controlled spliceable chimeric antigen receptor molecule and application thereof |
| CN114854694A (en) * | 2022-04-29 | 2022-08-05 | 四川轻化工大学 | Luciferase complementation system for high-throughput screening of new crown drugs and construction method and application thereof |
| WO2024097763A1 (en) * | 2022-11-01 | 2024-05-10 | Memorial Sloan-Kettering Cancer Center | Intein-based sorting system and modular chimeric polypeptides |
| CN116925239A (en) * | 2023-07-17 | 2023-10-24 | 苏州星奥拓维生物技术有限公司 | Compositions and methods for expression of Otof genes in a dual vector system |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919208A (en) | 1973-10-09 | 1975-11-11 | Yeda Res & Dev | 7-(Cyanomethylaryl)acetamide-cephalosporin derivatives |
| US5166331A (en) | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| US6544786B1 (en) | 1999-10-15 | 2003-04-08 | University Of Pittsburgh Of The Commonwealth Of Higher Education | Method and vector for producing and transferring trans-spliced peptides |
| WO2009132455A1 (en) | 2008-04-30 | 2009-11-05 | Paul Xiang-Qin Liu | Protein splicing using short terminal split inteins |
| US20100098772A1 (en) | 2008-10-21 | 2010-04-22 | Allergan, Inc. | Drug delivery systems and methods for treating neovascularization |
| WO2012125445A2 (en) | 2011-03-11 | 2012-09-20 | President And Fellows Of Harvard College | Small molecule-dependent inteins and uses thereof |
| CA2850411C (en) * | 2011-09-28 | 2023-08-15 | Era Biotech, S.A. | Split inteins and uses thereof |
| US9197705B2 (en) | 2013-04-12 | 2015-11-24 | Samsung Electronics Co., Ltd. | Method and apparatus for supporting driving using wireless communication network and system thereof |
| WO2014170480A1 (en) | 2013-04-18 | 2014-10-23 | Fondazione Telethon | Effective delivery of large genes by dual aav vectors |
| NL2013235B1 (en) | 2014-07-22 | 2016-08-16 | Douwe Egberts Bv | Pad for use in a machine for preparing at least one part of a single beverage serving, system including a machine and method for preparing at least one part of a single beverage serving with such a system. |
| CN107075491B (en) * | 2014-10-28 | 2021-07-06 | 谷万达公司 | Methods and compositions for stabilizing trans-spliced intein-modified proteases |
| BR112017018728A2 (en) * | 2015-03-03 | 2018-04-17 | Fond Telethon | vector system for expressing the coding sequence of a gene of interest in a cell, host cell, pharmaceutical composition, method for treating and / or preventing a condition or disease, using a nucleotide sequence of a degradation signal in a system vector and method for decreasing expression of a protein in truncated form |
| CA3051195A1 (en) * | 2016-01-29 | 2017-08-03 | The Trustees Of Princeton University | Split inteins with exceptional splicing activity |
| CA2968112A1 (en) | 2016-05-26 | 2017-11-26 | Op-Hygiene Ip Gmbh | Dispenser servicing in a multiple washroom facility |
| BR112018075855A2 (en) * | 2016-06-15 | 2019-04-02 | Oxford University Innovation Limited | double-overlapping adeno-associated viral vector system for abc4a expression |
| CN110214180A (en) | 2016-10-14 | 2019-09-06 | 哈佛大学的校长及成员们 | The AAV of nucleobase editing machine is delivered |
-
2019
- 2019-10-15 US US17/285,356 patent/US20210371878A1/en active Pending
- 2019-10-15 KR KR1020217014221A patent/KR20210104661A/en unknown
- 2019-10-15 SG SG11202103886XA patent/SG11202103886XA/en unknown
- 2019-10-15 WO PCT/EP2019/078020 patent/WO2020079034A2/en unknown
- 2019-10-15 AU AU2019360372A patent/AU2019360372A1/en active Pending
- 2019-10-15 JP JP2021521008A patent/JP2022512718A/en active Pending
- 2019-10-15 CA CA3116606A patent/CA3116606A1/en active Pending
- 2019-10-15 BR BR112021007221-7A patent/BR112021007221A2/en unknown
- 2019-10-15 CN CN201980081288.0A patent/CN113348249A/en active Pending
- 2019-10-15 MX MX2021004391A patent/MX2021004391A/en unknown
- 2019-10-15 EP EP19783968.1A patent/EP3867387A2/en active Pending
-
2021
- 2021-04-18 IL IL282362A patent/IL282362A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019360372A1 (en) | 2021-06-03 |
| US20210371878A1 (en) | 2021-12-02 |
| CA3116606A1 (en) | 2020-04-23 |
| KR20210104661A (en) | 2021-08-25 |
| WO2020079034A3 (en) | 2020-06-18 |
| EP3867387A2 (en) | 2021-08-25 |
| IL282362A (en) | 2021-06-30 |
| BR112021007221A2 (en) | 2021-08-10 |
| MX2021004391A (en) | 2021-08-16 |
| JP2022512718A (en) | 2022-02-07 |
| WO2020079034A2 (en) | 2020-04-23 |
| CN113348249A (en) | 2021-09-03 |
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