IL300119B1 - Oligonucleotides for inducing paternal ube3a expression - Google Patents
Oligonucleotides for inducing paternal ube3a expressionInfo
- Publication number
- IL300119B1 IL300119B1 IL300119A IL30011923A IL300119B1 IL 300119 B1 IL300119 B1 IL 300119B1 IL 300119 A IL300119 A IL 300119A IL 30011923 A IL30011923 A IL 30011923A IL 300119 B1 IL300119 B1 IL 300119B1
- Authority
- IL
- Israel
- Prior art keywords
- seq
- gth
- reg
- len
- oligonucleotide
- Prior art date
Links
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15194367 | 2015-11-12 | ||
| EP16189502 | 2016-09-19 | ||
| PCT/EP2016/077383 WO2017081223A1 (en) | 2015-11-12 | 2016-11-11 | Oligonucleotides for inducing paternal ube3a expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL300119A IL300119A (en) | 2023-03-01 |
| IL300119B1 true IL300119B1 (en) | 2026-01-01 |
Family
ID=57345910
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL300119A IL300119B1 (en) | 2015-11-12 | 2016-11-11 | Oligonucleotides for inducing paternal ube3a expression |
| IL281211A IL281211B2 (en) | 2015-11-12 | 2016-11-11 | Oligonucleotides for inducing paternal ube3a expression |
| IL325248A IL325248A (en) | 2015-11-12 | 2016-11-11 | Oligonucleotides for inducing paternal ube3a expression |
| IL258488A IL258488B (en) | 2015-11-12 | 2018-04-03 | Oligonucleotides for inducing paternal ube3a expression |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL281211A IL281211B2 (en) | 2015-11-12 | 2016-11-11 | Oligonucleotides for inducing paternal ube3a expression |
| IL325248A IL325248A (en) | 2015-11-12 | 2016-11-11 | Oligonucleotides for inducing paternal ube3a expression |
| IL258488A IL258488B (en) | 2015-11-12 | 2018-04-03 | Oligonucleotides for inducing paternal ube3a expression |
Country Status (30)
| Country | Link |
|---|---|
| US (10) | US10494633B2 (https=) |
| EP (5) | EP3374499A1 (https=) |
| JP (7) | JP2018533362A (https=) |
| KR (4) | KR102840652B1 (https=) |
| CN (5) | CN108350432A (https=) |
| AU (4) | AU2016352836B2 (https=) |
| CA (1) | CA3004799C (https=) |
| CL (3) | CL2018001189A1 (https=) |
| CO (1) | CO2018004550A2 (https=) |
| CR (3) | CR20200118A (https=) |
| DK (2) | DK3374509T3 (https=) |
| ES (2) | ES2852998T4 (https=) |
| FI (1) | FI4220360T3 (https=) |
| HK (2) | HK1258434A1 (https=) |
| HR (2) | HRP20241138T1 (https=) |
| HU (2) | HUE067905T2 (https=) |
| IL (4) | IL300119B1 (https=) |
| LT (2) | LT3374509T (https=) |
| MA (1) | MA67580B1 (https=) |
| MX (4) | MX2018004978A (https=) |
| PE (2) | PE20210451A1 (https=) |
| PH (1) | PH12018501005A1 (https=) |
| PL (2) | PL3374509T3 (https=) |
| RS (2) | RS61529B9 (https=) |
| RU (1) | RU2742007C2 (https=) |
| SG (1) | SG11201803951QA (https=) |
| SI (2) | SI3374509T1 (https=) |
| UA (1) | UA125963C2 (https=) |
| WO (3) | WO2017081223A1 (https=) |
| ZA (1) | ZA201802494B (https=) |
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| ES2809199T3 (es) | 2012-06-25 | 2021-03-03 | Ionis Pharmaceuticals Inc | Modulación de la expresión de UBE3A-ATS |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | キラル制御 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| WO2016086104A1 (en) | 2014-11-25 | 2016-06-02 | Ionis Pharmaceuticals, Inc. | Modulation of ube3a-ats expression |
| HUE067905T2 (hu) | 2015-11-12 | 2024-11-28 | Hoffmann La Roche | Oligonukleotidok paternális UBE3A expresszió indukálására |
| PT3717646T (pt) | 2017-12-01 | 2025-07-28 | Texas A & M Univ Sys | Tratamento antisense da síndrome de angelman |
| AU2019218987B2 (en) | 2018-02-12 | 2025-04-24 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
| CN108795935B (zh) * | 2018-05-23 | 2022-06-21 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 日本血吸虫SjELAV-like 1基因的siRNA及其应用 |
| CA3113648A1 (en) | 2018-09-21 | 2020-03-26 | University Of Connecticut | Compositions and methods to restore paternal ube3a gene expression in human angelman syndrome |
| JP7241185B2 (ja) * | 2019-01-17 | 2023-03-16 | エフ. ホフマン-ラ ロシュ アーゲー | E3ユビキチンリガーゼ(ube3a)のタンパク質標的 |
| CA3130431A1 (en) * | 2019-02-20 | 2020-08-27 | Roche Innovation Center Copenhagen A/S | Phosphonoacetate gapmer oligonucleotides |
| FI3947684T3 (fi) * | 2019-03-29 | 2025-05-27 | Ionis Pharmaceuticals Inc | Yhdisteitä ja menetelmiä ube3a-ats:n moduloimiseksi |
| WO2020237130A1 (en) * | 2019-05-22 | 2020-11-26 | The University Of North Carolina At Chapel Hill | Ube3a genes and expression cassettes and their use |
| JP7701879B2 (ja) | 2019-05-28 | 2025-07-02 | エフ. ホフマン-ラ ロシュ アーゲー | 単球前駆細胞を生成するための方法 |
| TW202204607A (zh) * | 2020-04-16 | 2022-02-01 | 英商羅斯林科技有限公司 | 誘導性多功能幹細胞(iPSC)之誘導 |
| US20230212572A1 (en) * | 2020-06-09 | 2023-07-06 | Roche Innovation Center Copenhagen A/S | Guanosine Analogues for Use in Therapeutics Polynucleotides |
| JPWO2022158487A1 (https=) | 2021-01-21 | 2022-07-28 | ||
| CN119173632A (zh) | 2022-05-10 | 2024-12-20 | 豪夫迈·罗氏有限公司 | 靶向cfp-elk1基因间区域的反义寡核苷酸 |
| CN121263524A (zh) | 2023-05-04 | 2026-01-02 | 豪夫迈·罗氏有限公司 | 能够上调葡糖脑苷脂酶表达的寡核苷酸 |
| KR20250068540A (ko) * | 2023-11-08 | 2025-05-16 | 한국과학기술원 | Ube3a를 표적으로 하여 발현증강을 유도하는 안티센스 올리고뉴클레오티드 및 이의 용도 |
| WO2025125542A1 (en) | 2023-12-15 | 2025-06-19 | F. Hoffmann-La Roche Ag | Intrathecal dosage method |
| WO2025213123A1 (en) * | 2024-04-05 | 2025-10-09 | Encoded Therapeutics, Inc. | Methods and compositions for increasing expression of ube3a |
| TW202548015A (zh) * | 2024-04-11 | 2025-12-16 | 美商奧崔基尼克斯製藥公司 | 天使症候群反義治療的給藥方案 |
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2016
- 2016-11-11 HU HUE23152543A patent/HUE067905T2/hu unknown
- 2016-11-11 LT LTEP16798440.0T patent/LT3374509T/lt unknown
- 2016-11-11 HR HRP20241138TT patent/HRP20241138T1/hr unknown
- 2016-11-11 CN CN201680066009.XA patent/CN108350432A/zh active Pending
- 2016-11-11 WO PCT/EP2016/077383 patent/WO2017081223A1/en not_active Ceased
- 2016-11-11 DK DK16798440.0T patent/DK3374509T3/da active
- 2016-11-11 CN CN201680065987.2A patent/CN108350431A/zh active Pending
- 2016-11-11 UA UAA201806476A patent/UA125963C2/uk unknown
- 2016-11-11 HK HK19100670.6A patent/HK1258434A1/zh unknown
- 2016-11-11 EP EP16798672.8A patent/EP3374499A1/en not_active Withdrawn
- 2016-11-11 HU HUE16798440A patent/HUE053197T2/hu unknown
- 2016-11-11 IL IL300119A patent/IL300119B1/en unknown
- 2016-11-11 SG SG11201803951QA patent/SG11201803951QA/en unknown
- 2016-11-11 CN CN201680066253.6A patent/CN108291226B/zh active Active
- 2016-11-11 EP EP16797824.6A patent/EP3374498A1/en not_active Withdrawn
- 2016-11-11 LT LTEP23152543.7T patent/LT4220360T/lt unknown
- 2016-11-11 EP EP20204481.4A patent/EP3798307A1/en active Pending
- 2016-11-11 WO PCT/EP2016/077435 patent/WO2017081254A1/en not_active Ceased
- 2016-11-11 CR CR20200118A patent/CR20200118A/es unknown
- 2016-11-11 PE PE2020000810A patent/PE20210451A1/es unknown
- 2016-11-11 HK HK19100676.0A patent/HK1258309A1/zh unknown
- 2016-11-11 PL PL16798440T patent/PL3374509T3/pl unknown
- 2016-11-11 SI SI201631093T patent/SI3374509T1/sl unknown
- 2016-11-11 ES ES16798440T patent/ES2852998T4/es active Active
- 2016-11-11 RS RS20210241A patent/RS61529B9/sr unknown
- 2016-11-11 PL PL23152543.7T patent/PL4220360T3/pl unknown
- 2016-11-11 KR KR1020227045154A patent/KR102840652B1/ko active Active
- 2016-11-11 WO PCT/EP2016/077429 patent/WO2017081250A1/en not_active Ceased
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- 2016-11-11 IL IL281211A patent/IL281211B2/en unknown
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- 2016-11-11 KR KR1020257024980A patent/KR20250121139A/ko active Pending
- 2016-11-11 CR CR20180264A patent/CR20180264A/es unknown
- 2016-11-11 MA MA67580A patent/MA67580B1/fr unknown
- 2016-11-11 HR HRP20210227TT patent/HRP20210227T1/hr unknown
- 2016-11-11 RU RU2018119315A patent/RU2742007C2/ru active
- 2016-11-11 DK DK23152543.7T patent/DK4220360T3/da active
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- 2016-11-11 JP JP2018521350A patent/JP2018533362A/ja active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003000707A2 (en) * | 2001-06-21 | 2003-01-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of superoxide dismutase 1, soluble expression |
| US20050124572A1 (en) * | 2002-06-17 | 2005-06-09 | Freier Susan M. | Compositions and their uses directed to signal tranducers |
| WO2004028458A2 (en) * | 2002-09-25 | 2004-04-08 | Pharmacia Corporation | Antisense modulation of microsomal prostaglandin e2 synthase expression |
| WO2014004572A2 (en) * | 2012-06-25 | 2014-01-03 | Isis Pharmaceuticals, Inc. | Modulation of ube3a-ats expression |
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