IL296875A - Fat-wrapped gas microsphere preparations and related methods - Google Patents

Fat-wrapped gas microsphere preparations and related methods

Info

Publication number
IL296875A
IL296875A IL296875A IL29687522A IL296875A IL 296875 A IL296875 A IL 296875A IL 296875 A IL296875 A IL 296875A IL 29687522 A IL29687522 A IL 29687522A IL 296875 A IL296875 A IL 296875A
Authority
IL
Israel
Prior art keywords
composition
container
lipid
chamber
glycerol
Prior art date
Application number
IL296875A
Other languages
English (en)
Hebrew (he)
Original Assignee
Lantheus Medical Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lantheus Medical Imaging Inc filed Critical Lantheus Medical Imaging Inc
Publication of IL296875A publication Critical patent/IL296875A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
IL296875A 2014-12-31 2015-12-28 Fat-wrapped gas microsphere preparations and related methods IL296875A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462098453P 2014-12-31 2014-12-31
PCT/US2015/067615 WO2016109400A2 (en) 2014-12-31 2015-12-28 Lipid-encapsulated gas microsphere compositions and related methods

Publications (1)

Publication Number Publication Date
IL296875A true IL296875A (en) 2022-12-01

Family

ID=56285147

Family Applications (2)

Application Number Title Priority Date Filing Date
IL296875A IL296875A (en) 2014-12-31 2015-12-28 Fat-wrapped gas microsphere preparations and related methods
IL252705A IL252705B2 (en) 2014-12-31 2015-12-28 Fat-wrapped gas microsphere preparations and related methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL252705A IL252705B2 (en) 2014-12-31 2015-12-28 Fat-wrapped gas microsphere preparations and related methods

Country Status (16)

Country Link
US (5) US10583207B2 (cg-RX-API-DMAC7.html)
EP (2) EP3240579B1 (cg-RX-API-DMAC7.html)
JP (3) JP6728186B2 (cg-RX-API-DMAC7.html)
KR (2) KR102618877B1 (cg-RX-API-DMAC7.html)
CN (2) CN113289034A (cg-RX-API-DMAC7.html)
AU (2) AU2015374286B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017013787A2 (cg-RX-API-DMAC7.html)
CA (1) CA2972423A1 (cg-RX-API-DMAC7.html)
EA (1) EA201791437A1 (cg-RX-API-DMAC7.html)
ES (1) ES2928401T3 (cg-RX-API-DMAC7.html)
IL (2) IL296875A (cg-RX-API-DMAC7.html)
MX (3) MX2017008721A (cg-RX-API-DMAC7.html)
NZ (1) NZ733010A (cg-RX-API-DMAC7.html)
TW (2) TWI821755B (cg-RX-API-DMAC7.html)
WO (1) WO2016109400A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201704426B (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102618877B1 (ko) 2014-12-31 2023-12-28 랜티우스 메디컬 이메징, 인크. 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법
BR112018072342A2 (pt) 2016-05-04 2019-02-19 Lantheus Medical Imaging, Inc. métodos e dispositivos para preparação de agentes de contraste de ultrassom
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

Family Cites Families (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873564A (en) 1971-03-03 1975-03-25 Synvar Ass 2-Imidazolinyl-3-oxide-1-oxypropionic acid
CH588887A5 (cg-RX-API-DMAC7.html) 1974-07-19 1977-06-15 Battelle Memorial Institute
CH624011A5 (cg-RX-API-DMAC7.html) 1977-08-05 1981-07-15 Battelle Memorial Institute
CH621479A5 (cg-RX-API-DMAC7.html) 1977-08-05 1981-02-13 Battelle Memorial Institute
US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
DE3173476D1 (en) 1980-11-17 1986-02-20 Schering Ag Composition generating microbubbles
DE3141641A1 (de) 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4718433A (en) 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
SE463651B (sv) 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
DE3585967D1 (de) 1984-03-08 1992-06-11 Phares Pharma Holland Liposombildende zusammensetzung.
ES2054658T3 (es) 1986-01-24 1994-08-16 Childrens Hosp Medical Center Metodo para la preparacion de una emulsion fisiologicamente aceptable.
JPS6360943A (ja) 1986-09-01 1988-03-17 Green Cross Corp:The 超音波診断造影剤
FR2634375B3 (fr) 1988-06-30 1991-07-05 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles de lipide amphiphiles sous forme de liposomes submicroniques
FR2608942B1 (fr) 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5219538A (en) 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
JPS63277618A (ja) 1987-03-31 1988-11-15 Noebia:Kk リポソ−ムの製造方法
CH672733A5 (cg-RX-API-DMAC7.html) 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
DE3803972A1 (de) 1988-02-05 1989-08-10 Schering Ag Ultraschallkontrastmittel
DE3812816A1 (de) 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
US5171755A (en) 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5045304A (en) 1988-08-31 1991-09-03 Wayne State University Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same
GB8824593D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Liposomes
US5114703A (en) 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
FR2649335B1 (fr) 1989-07-05 1991-09-20 Texinfine Sa Procede et dispositif de production directe de liposomes
US5843473A (en) 1989-10-20 1998-12-01 Sequus Pharmaceuticals, Inc. Method of treatment of infected tissues
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5352435A (en) 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5209720A (en) 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5334381A (en) 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5149319A (en) 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5123414A (en) 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5088499A (en) 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5230882A (en) 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (cg-RX-API-DMAC7.html) 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5368840A (en) 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
US5358702A (en) 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
WO1991015753A1 (en) 1990-04-10 1991-10-17 Unger Evan C Polymers as contrast media for magnetic resonance imaging
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
IS1685B (is) 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
GB9106673D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
EP0660714B1 (en) 1991-06-18 2003-07-02 ImaRx Pharmaceutical Corp. Novel liposomal drug delivery systems
US5409688A (en) 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
CA2119129C (en) 1991-09-17 1999-11-09 Steven C. Quay Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
AU2789192A (en) 1991-10-04 1993-05-03 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
GB9200387D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
SK281535B6 (sk) 1993-01-25 2001-04-09 Sonus Pharmaceuticals, Inc. Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy
US5558855A (en) 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
GB9305349D0 (en) 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents
GB9305351D0 (en) 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents
DE4313402A1 (de) 1993-04-23 1994-10-27 Hexal Pharma Gmbh Transdermale Wirkstoffzubereitung
US5853755A (en) 1993-07-28 1998-12-29 Pharmaderm Laboratories Ltd. Biphasic multilamellar lipid vesicles
AU694135B2 (en) 1993-07-30 1998-07-16 Imcor Pharmaceutical Company Stabilized microbubble compositions for ultrasound
GB9318288D0 (en) 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
DK0717617T3 (da) 1993-09-09 2001-02-05 Schering Ag Mikropartikler indeholdende aktive bestanddele og gas
DE69409361T2 (de) 1993-11-05 1998-11-12 Amgen Inc Herstellung von liposomen und verfahren zur substanzverkapselung
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
PT682530E (pt) 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
NO940711D0 (no) 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
CA2184834A1 (en) 1994-03-11 1995-09-14 Yoshiyuki Mori Liposome preparation
CA2185810A1 (en) 1994-03-28 1995-10-05 Jo Klaveness Liposomes
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US6066331A (en) 1994-07-08 2000-05-23 Barenholz; Yechezkel Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
US5562893A (en) 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
JPH08151335A (ja) 1994-09-27 1996-06-11 Otsuka Pharmaceut Co Ltd 超音波造影剤およびその製造方法
US5540909A (en) 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5558092A (en) 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
EP0831932B1 (en) 1995-06-07 2004-05-06 Imarx Pharmaceutical Corp. Novel targeted compositions for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US5897851A (en) 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US6120794A (en) 1995-09-26 2000-09-19 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells
ATE345682T1 (de) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
US6214375B1 (en) * 1996-07-16 2001-04-10 Generex Pharmaceuticals, Inc. Phospholipid formulations
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE69737915T2 (de) 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
IL129423A (en) 1996-10-21 2003-01-12 Nycomed Imaging As Preparation for use as a contrast agent in ultrasound imaging
WO1998018495A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
WO1998018498A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
CA2269985A1 (en) 1996-10-28 1998-05-07 Aslak Godal Improvements in or relating to diagnostic/therapeutic agents
EP0973552B1 (en) 1996-10-28 2006-03-01 Amersham Health AS Improvements in or relating to diagnostic/therapeutic agents
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
ATE296113T1 (de) 1998-02-09 2005-06-15 Bracco Research Sa Zielgerichtete abgabe von biologische-aktive medien
US6572840B1 (en) * 1999-07-28 2003-06-03 Bristol-Myers Squibb Pharma Company Stable microbubbles comprised of a perfluoropropane encapsulated lipid moiety for use as an ultrasound contrast agent
JP2004522960A (ja) 2001-02-02 2004-07-29 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー バイアルのヘッドスペース中のフッ素化材料をオンラインモニターするための装置及び方法
US20030044354A1 (en) * 2001-08-16 2003-03-06 Carpenter Alan P. Gas microsphere liposome composites for ultrasound imaging and ultrasound stimulated drug release
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
CN100563718C (zh) * 2003-12-22 2009-12-02 伯拉考开发股份有限公司 用于反差成像的充气微囊组件
CN102600485B (zh) 2004-06-04 2014-10-22 阿库斯菲尔公司 超声对比剂剂量配方
WO2006028959A2 (en) * 2004-09-03 2006-03-16 Imarx Therapeutics, Inc. Apparatus and method to prepare a microsphere-forming composition
CN101229382A (zh) * 2008-02-04 2008-07-30 许川山 一种适用于多种成像模式的新型造影剂
US8459462B2 (en) 2008-10-10 2013-06-11 Quest Diagnostics Investments Incorporated System and method for sorting specimen
JP5347714B2 (ja) 2009-05-26 2013-11-20 三菱電機株式会社 映像情報再生方法及び映像情報再生装置
JP2012213475A (ja) 2011-03-31 2012-11-08 Panasonic Corp 超音波造影剤注入装置
US9101895B2 (en) 2011-04-15 2015-08-11 General Electric Company System for mixing and dispersing microbubble pharmaceuticals
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same
US20130123781A1 (en) * 2011-08-24 2013-05-16 California Institute Of Technology Targeting microbubbles
JP2015002752A (ja) 2011-12-09 2015-01-08 パナソニック株式会社 薬剤容器
DK2874736T3 (da) 2012-07-18 2023-05-22 Accroma Labtec Ltd Automatiseret opløsningsdispenser
JP6318177B2 (ja) 2013-02-11 2018-04-25 アンドリュー イー． ブロック 非対称振動をもたらすための装置
EP2968825A4 (en) 2013-03-15 2016-09-07 Childrens Medical Center Gas-filled stabilized particles and methods of use
EP4332978B1 (en) 2013-04-05 2025-08-13 F. Hoffmann-La Roche AG Analysis method for a biological sample
TWI552761B (zh) 2013-05-03 2016-10-11 博信生物科技股份有限公司 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置
TWI504413B (zh) 2013-07-24 2015-10-21 Univ Nat Chiao Tung 奈米級複合高分子顯影劑及藥物載體
GB201405735D0 (en) 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
CA2951922C (en) 2014-06-12 2023-02-28 Evan C. Unger Phospholipid composition and microbubbles and emulsions formed using same
HK1244428A1 (zh) 2014-10-30 2018-08-10 Lantheus Medical Imaging, Inc. 脂质包封气体微球组合物及相关方法
KR102618877B1 (ko) 2014-12-31 2023-12-28 랜티우스 메디컬 이메징, 인크. 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법
BR112018072342A2 (pt) 2016-05-04 2019-02-19 Lantheus Medical Imaging, Inc. métodos e dispositivos para preparação de agentes de contraste de ultrassom
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP4192611A4 (en) 2020-08-04 2024-12-18 Lantheus Medical Imaging, Inc. METHODS AND DEVICES FOR THE PREPARATION OF ULTRASOUND CONTRAST AGENTS
AU2023217725A1 (en) 2022-02-09 2024-08-15 Lantheus Medical Imaging, Inc. Gas nano/micro-bubble compositions and uses thereof

Also Published As

Publication number Publication date
TW202228793A (zh) 2022-08-01
JP2020172507A (ja) 2020-10-22
HK1244677A1 (zh) 2018-08-17
IL252705A0 (en) 2017-08-31
US20170258946A1 (en) 2017-09-14
TW201632173A (zh) 2016-09-16
KR20170098880A (ko) 2017-08-30
US10022460B2 (en) 2018-07-17
CN113289034A (zh) 2021-08-24
AU2022201065A1 (en) 2022-03-10
JP6728186B2 (ja) 2020-07-22
JP2018503629A (ja) 2018-02-08
WO2016109400A3 (en) 2016-10-06
EP3240579A2 (en) 2017-11-08
ZA201704426B (en) 2022-01-26
US12296029B2 (en) 2025-05-13
MX2017008721A (es) 2017-11-17
US20220395590A1 (en) 2022-12-15
TWI745282B (zh) 2021-11-11
TWI821755B (zh) 2023-11-11
AU2015374286A1 (en) 2017-07-13
US20160331851A1 (en) 2016-11-17
CN107206111A (zh) 2017-09-26
BR112017013787A2 (pt) 2018-03-13
IL252705B (en) 2022-11-01
US10583207B2 (en) 2020-03-10
MX2020002793A (es) 2020-07-22
EP3240579B1 (en) 2022-07-27
JP2023089124A (ja) 2023-06-27
HK1246207A1 (en) 2018-09-07
KR20240005184A (ko) 2024-01-11
ES2928401T3 (es) 2022-11-17
EP4154915A1 (en) 2023-03-29
CA2972423A1 (en) 2016-07-07
IL252705B2 (en) 2023-03-01
NZ733010A (en) 2023-01-27
EA201791437A1 (ru) 2017-12-29
AU2015374286B2 (en) 2021-11-18
US11395856B2 (en) 2022-07-26
US20200384132A1 (en) 2020-12-10
CN107206111B (zh) 2021-04-27
WO2016109400A2 (en) 2016-07-07
KR102618877B1 (ko) 2023-12-28
US20250262334A1 (en) 2025-08-21
MX2022010827A (es) 2022-09-29
EP3240579A4 (en) 2018-08-22

Similar Documents

Publication Publication Date Title
US20250262334A1 (en) Lipid-encapsulated gas microsphere compositions and related methods
EP0840570B1 (en) Apparatus and method for making gas-filled vesicles of optimal size
EP3212240B1 (en) Lipid encapsulated gas microsphere compositions and related methods
HK40090959A (en) Lipid-encapsulated gas microsphere compositions and related methods
HK40059740A (en) Lipid-encapsulated gas microsphere compositions and related methods
HK1246207B (en) Lipid-encapsulated gas microsphere compositions and related methods
EA040609B1 (ru) Композиция для диагностических и/или терапевтических целей, композиция, набор и способ для получения микросфер с инкапсулированным в липиде перфторуглеродным газом
HK1244677B (zh) 脂质封装的气体微球组合物及相关方法