IL295230A - Combination therapy with anti-cd73 antibodies - Google Patents
Combination therapy with anti-cd73 antibodiesInfo
- Publication number
- IL295230A IL295230A IL295230A IL29523022A IL295230A IL 295230 A IL295230 A IL 295230A IL 295230 A IL295230 A IL 295230A IL 29523022 A IL29523022 A IL 29523022A IL 295230 A IL295230 A IL 295230A
- Authority
- IL
- Israel
- Prior art keywords
- seq
- nos
- cdr2
- cdr3 sequences
- combination
- Prior art date
Links
- 238000002648 combination therapy Methods 0.000 title 1
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 42
- 229940045207 immuno-oncology agent Drugs 0.000 claims 23
- 239000002584 immunological anticancer agent Substances 0.000 claims 23
- 229940120727 CD73 antagonist Drugs 0.000 claims 17
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 102000045309 human NT5E Human genes 0.000 claims 9
- 102100022464 5'-nucleotidase Human genes 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 230000002255 enzymatic effect Effects 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 238000011284 combination treatment Methods 0.000 claims 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 208000036832 Adenocarcinoma of ovary Diseases 0.000 claims 1
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 101150030213 Lag3 gene Proteins 0.000 claims 1
- 206010061328 Ovarian epithelial cancer Diseases 0.000 claims 1
- 229940124060 PD-1 antagonist Drugs 0.000 claims 1
- 229940123751 PD-L1 antagonist Drugs 0.000 claims 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000033781 Thyroid carcinoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 201000003914 endometrial carcinoma Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 208000013371 ovarian adenocarcinoma Diseases 0.000 claims 1
- 201000006588 ovary adenocarcinoma Diseases 0.000 claims 1
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 238000002424 x-ray crystallography Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303985P | 2016-03-04 | 2016-03-04 | |
| US201662305378P | 2016-03-08 | 2016-03-08 | |
| US201662341220P | 2016-05-25 | 2016-05-25 | |
| US201662363703P | 2016-07-18 | 2016-07-18 | |
| US201662431987P | 2016-12-09 | 2016-12-09 | |
| PCT/US2017/020714 WO2017152085A1 (en) | 2016-03-04 | 2017-03-03 | Combination therapy with anti-cd73 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL295230A true IL295230A (en) | 2022-10-01 |
Family
ID=58361103
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL295230A IL295230A (en) | 2016-03-04 | 2017-03-03 | Combination therapy with anti-cd73 antibodies |
| IL261395A IL261395A (en) | 2016-03-04 | 2018-08-27 | Combined treatment with antibodies against cd73 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL261395A IL261395A (en) | 2016-03-04 | 2018-08-27 | Combined treatment with antibodies against cd73 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190284293A1 (OSRAM) |
| EP (1) | EP3423494A1 (OSRAM) |
| JP (2) | JP2019514844A (OSRAM) |
| KR (3) | KR20180118725A (OSRAM) |
| CN (1) | CN109476740A (OSRAM) |
| AU (1) | AU2017228470A1 (OSRAM) |
| BR (1) | BR112018067368A2 (OSRAM) |
| CA (1) | CA3016187A1 (OSRAM) |
| EA (1) | EA201891983A8 (OSRAM) |
| IL (2) | IL295230A (OSRAM) |
| MX (1) | MX2018010473A (OSRAM) |
| SG (2) | SG11201806861SA (OSRAM) |
| WO (1) | WO2017152085A1 (OSRAM) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1246304A1 (zh) * | 2014-11-11 | 2018-09-07 | Medimmune Limited | 包含抗cd73抗体和a2a受体抑制剂的治疗组合及其用途 |
| DK3221363T3 (da) | 2014-11-21 | 2020-08-10 | Bristol Myers Squibb Co | Antistoffer mod cd73 og anvendelser deraf |
| HRP20201756T8 (hr) | 2014-11-21 | 2021-08-20 | Bristol-Myers Squibb Company | Antitijela koja sadrže modificirane regije teškog lanca |
| CA3037380A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
| IL270596B1 (en) * | 2017-05-25 | 2025-09-01 | Bristol Myers Squibb Co | Antibodies comprising modified heavy constant region for use in treating cancer |
| EP3641812A1 (en) | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
| EP3706752A4 (en) * | 2017-11-06 | 2021-12-15 | Corvus Pharmaceuticals, Inc. | COMBINATORY THERAPY FOR ANTI-CANCER TREATMENT |
| WO2019090347A1 (en) * | 2017-11-06 | 2019-05-09 | Corvus Pharmaceuticals Inc. | Adenosine pathway inhibitors for cancer treatment |
| US11572405B2 (en) * | 2018-01-12 | 2023-02-07 | Bristol-Myers Squibb Company | Combination therapy with anti-IL-8 antibodies and anti-PD-1 antibodies for treating cancer |
| TWI823906B (zh) * | 2018-03-09 | 2023-12-01 | 美商艾吉納斯公司 | 抗-cd73 抗體及其使用方法 |
| EP3761993A4 (en) | 2018-03-09 | 2022-03-09 | Arcus Biosciences, Inc. | PARENTERALLY ADMINISTRATED IMMUNE-ENHANCERING DRUGS |
| KR102804816B1 (ko) | 2018-03-09 | 2025-05-09 | 페인스 테라퓨틱스 인코포레이티드 | 항-cd73 항체 및 이의 용도 |
| AU2019233581B2 (en) * | 2018-03-13 | 2025-08-28 | Cancer Research Technology Limited | Anti-CD25 for tumour specific cell depletion |
| US20210024873A1 (en) | 2018-03-27 | 2021-01-28 | Bristol-Myers Squibb Company | Real-time monitoring of protein concentration using ultraviolet signal |
| AU2019252795A1 (en) * | 2018-04-12 | 2020-10-29 | Bristol-Myers Squibb Company | Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody |
| EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
| MA53097A (fr) | 2018-07-05 | 2021-05-12 | Incyte Corp | Dérivés de pyrazine fusionnés en tant qu'inhibiteurs d'a2a/a2b |
| MX2021005396A (es) | 2018-11-12 | 2021-07-06 | Jiangsu Hengrui Medicine Co | Anticuerpo anti-cd73, fragmento de union a antigeno y aplicacion del mismo. |
| CN111499747B (zh) * | 2019-01-11 | 2022-03-18 | 康诺亚生物医药科技（成都）有限公司 | 一种抗cd73单克隆抗体及其应用 |
| CA3126735A1 (en) | 2019-01-11 | 2020-07-16 | Omeros Corporation | Methods and compositions for treating cancer |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US20220135619A1 (en) | 2019-02-24 | 2022-05-05 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| AU2020239048B2 (en) | 2019-03-12 | 2025-10-16 | Arcus Biosciences, Inc. | Treatment of oncogene-driven cancers |
| KR20210144821A (ko) * | 2019-03-29 | 2021-11-30 | 아르커스 바이오사이언시즈 인코포레이티드 | 규명된 아데노신 지문을 이용한 암의 치료방법 |
| WO2020202038A1 (en) * | 2019-04-02 | 2020-10-08 | Medimmune, Llc | Anti-cd73, anti-pd-l1 antibodies and chemotherapy for treating tumors |
| KR20220012292A (ko) | 2019-05-23 | 2022-02-03 | 브리스톨-마이어스 스큅 컴퍼니 | 세포 배양 배지를 모니터링하는 방법 |
| CN112300279A (zh) * | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | 针对抗cd73抗体和变体的方法和组合物 |
| PH12022551150A1 (en) * | 2019-11-15 | 2023-10-09 | Genzyme Corp | Biparatopic cd73 antibodies |
| TWI873265B (zh) * | 2020-01-03 | 2025-02-21 | 美商英塞特公司 | 抗ｃｄ７３抗體及其用途 |
| MX2022007573A (es) | 2020-01-03 | 2022-09-23 | Incyte Corp | Terapia de combinación de inhibidor de grupo de diferenciación 73 (cd73) e inhibidor del receptor de adenosina a2a/a2b. |
| CN113248611A (zh) * | 2020-02-13 | 2021-08-13 | 湖南华康恒健生物技术有限公司 | 抗bcma抗体、其药物组合物及应用 |
| EP4132975A4 (en) * | 2020-04-09 | 2024-10-23 | Aprilbio Co., Ltd | MONOCLONAL ANTIBODIES AND THEIR ANTIGEN-BINDING FRAGMENTS FOR SUPPRESSING THE CD73 IMMUNE CHECKPOINT AND USES THEREOF |
| MX2022013311A (es) * | 2020-04-22 | 2022-11-14 | Akeso Biopharma Inc | Anticuerpo biespecifico anti-cd73-anti-pd-1 y uso del mismo. |
| US20230159655A1 (en) * | 2020-04-22 | 2023-05-25 | Akeso Biopharma, Inc | Anti-cd73 antibody and use thereof |
| WO2021247188A1 (en) | 2020-06-05 | 2021-12-09 | Bristol-Myers Squibb Company | Cd73 antagonist potency assay and methods of use thereof |
| AU2021297856A1 (en) * | 2020-06-22 | 2023-02-02 | Innovent Biologics (Suzhou) Co., Ltd. | Anti-CD73 antibody and use thereof |
| US20240034792A1 (en) * | 2020-07-16 | 2024-02-01 | Harbour Biomed (Shanghai) Co., Ltd | Pd-1 antigen-binding protein and use thereof |
| CN114075289B (zh) * | 2020-08-17 | 2024-07-02 | 中山康方生物医药有限公司 | 抗cd73的抗体及其用途 |
| CN116209468A (zh) * | 2020-09-23 | 2023-06-02 | 免疫医疗有限责任公司 | 使用抗cd73和抗pd-l1抗体和化疗的治疗方法 |
| CN116406369A (zh) | 2020-10-05 | 2023-07-07 | 百时美施贵宝公司 | 用于浓缩蛋白质的方法 |
| AU2021363350A1 (en) * | 2020-10-23 | 2023-06-22 | Akeso Biopharma, Inc | Anti-cd73 antibody and use thereof |
| CN116529265A (zh) | 2020-12-11 | 2023-08-01 | 上海华奥泰生物药业股份有限公司 | Cd73的抗原结合蛋白及其应用 |
| MX2023007850A (es) * | 2020-12-29 | 2023-09-11 | Incyte Corp | Terapia combinada que comprende inhibidores de adora2a/adora2b (a2a/a2b), inhibidores de muerte programada/ligando 1 de muerte programada (pd-1/pd-l1) y anticuerpos de cumulo de diferenciacion 73 (anti-cd73). |
| JP2024502758A (ja) * | 2021-01-13 | 2024-01-23 | 上海華奥泰生物藥業股▲フン▼有限公司 | Ｃｄ７３結合タンパク質及びその使用 |
| CN118591559A (zh) * | 2022-01-25 | 2024-09-03 | 石药集团巨石生物制药有限公司 | 抗cd73抗体及应用 |
| US12187806B2 (en) | 2022-03-04 | 2025-01-07 | Development Center For Biotechnology | Anti-CD73 antibodies and use thereof |
| WO2023173011A1 (en) | 2022-03-09 | 2023-09-14 | Bristol-Myers Squibb Company | Transient expression of therapeutic proteins |
| WO2023227115A1 (en) * | 2022-05-26 | 2023-11-30 | I-Mab Biopharma Co., Ltd. | A method of treating solid tumor |
| CA3257530A1 (en) * | 2022-05-26 | 2023-11-30 | Shanghai Junshi Biosciences Co Ltd | BIOMARKERS AND METHODS FOR THE TREATMENT OF NSCLC |
| WO2023230605A1 (en) * | 2022-05-26 | 2023-11-30 | I-Mab Biopharma Co., Ltd. | A method of treating solid tumor |
Family Cites Families (200)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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-
2017
- 2017-03-03 KR KR1020187028091A patent/KR20180118725A/ko not_active Ceased
- 2017-03-03 AU AU2017228470A patent/AU2017228470A1/en not_active Abandoned
- 2017-03-03 CN CN201780026552.1A patent/CN109476740A/zh active Pending
- 2017-03-03 IL IL295230A patent/IL295230A/en unknown
- 2017-03-03 MX MX2018010473A patent/MX2018010473A/es unknown
- 2017-03-03 SG SG11201806861SA patent/SG11201806861SA/en unknown
- 2017-03-03 WO PCT/US2017/020714 patent/WO2017152085A1/en not_active Ceased
- 2017-03-03 KR KR1020227006534A patent/KR20220033522A/ko not_active Ceased
- 2017-03-03 US US16/081,115 patent/US20190284293A1/en not_active Abandoned
- 2017-03-03 BR BR112018067368A patent/BR112018067368A2/pt not_active IP Right Cessation
- 2017-03-03 EP EP17712299.1A patent/EP3423494A1/en not_active Withdrawn
- 2017-03-03 JP JP2018546508A patent/JP2019514844A/ja active Pending
- 2017-03-03 EA EA201891983A patent/EA201891983A8/ru unknown
- 2017-03-03 SG SG10201913033UA patent/SG10201913033UA/en unknown
- 2017-03-03 CA CA3016187A patent/CA3016187A1/en active Pending
- 2017-03-03 KR KR1020237007841A patent/KR20230038311A/ko not_active Ceased
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2018
- 2018-08-27 IL IL261395A patent/IL261395A/en unknown
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2022
- 2022-03-30 JP JP2022056810A patent/JP2022104961A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230038311A (ko) | 2023-03-17 |
| AU2017228470A8 (en) | 2020-04-23 |
| WO2017152085A8 (en) | 2020-04-16 |
| JP2019514844A (ja) | 2019-06-06 |
| WO2017152085A1 (en) | 2017-09-08 |
| BR112018067368A2 (pt) | 2019-01-15 |
| CA3016187A1 (en) | 2017-09-08 |
| EA201891983A1 (ru) | 2019-02-28 |
| EA201891983A8 (ru) | 2020-05-28 |
| KR20220033522A (ko) | 2022-03-16 |
| AU2017228470A1 (en) | 2018-08-30 |
| SG10201913033UA (en) | 2020-03-30 |
| SG11201806861SA (en) | 2018-09-27 |
| IL261395A (en) | 2018-10-31 |
| EP3423494A1 (en) | 2019-01-09 |
| CN109476740A (zh) | 2019-03-15 |
| US20190284293A1 (en) | 2019-09-19 |
| KR20180118725A (ko) | 2018-10-31 |
| MX2018010473A (es) | 2018-09-28 |
| JP2022104961A (ja) | 2022-07-12 |
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