IL291665B2 - Inhibitors of receptor interacting protein kinase i for the treatment of disease - Google Patents

Inhibitors of receptor interacting protein kinase i for the treatment of disease

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Publication number
IL291665B2
IL291665B2 IL291665A IL29166522A IL291665B2 IL 291665 B2 IL291665 B2 IL 291665B2 IL 291665 A IL291665 A IL 291665A IL 29166522 A IL29166522 A IL 29166522A IL 291665 B2 IL291665 B2 IL 291665B2
Authority
IL
Israel
Prior art keywords
chosen
disease
onn
recited
optionally
Prior art date
Application number
IL291665A
Other languages
English (en)
Hebrew (he)
Other versions
IL291665B1 (en
IL291665A (en
Inventor
Lewis Richard
Hamilton Matthew
Ray William
Alvarez Fernando
Pfaffinger Dana
Reyna Naphtali
Cross Jason
Kesava Vijayan RAMASWAMY Suyambu
Original Assignee
Univ Texas
Lewis Richard
Hamilton Matthew
Ray William
Alvarez Fernando
Pfaffinger Dana
Reyna Naphtali
Cross Jason
Kesava Vijayan RAMASWAMY Suyambu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Lewis Richard, Hamilton Matthew, Ray William, Alvarez Fernando, Pfaffinger Dana, Reyna Naphtali, Cross Jason, Kesava Vijayan RAMASWAMY Suyambu filed Critical Univ Texas
Publication of IL291665A publication Critical patent/IL291665A/en
Publication of IL291665B1 publication Critical patent/IL291665B1/en
Publication of IL291665B2 publication Critical patent/IL291665B2/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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