IL278423B2 - Pd-1 / pd-l1 inhibitors for the treatment of cancer - Google Patents
Pd-1 / pd-l1 inhibitors for the treatment of cancerInfo
- Publication number
- IL278423B2 IL278423B2 IL278423A IL27842320A IL278423B2 IL 278423 B2 IL278423 B2 IL 278423B2 IL 278423 A IL278423 A IL 278423A IL 27842320 A IL27842320 A IL 27842320A IL 278423 B2 IL278423 B2 IL 278423B2
- Authority
- IL
- Israel
- Prior art keywords
- composition according
- antibody
- receptor
- human
- subject
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562121025P | 2015-02-26 | 2015-02-26 | |
| US201562133721P | 2015-03-16 | 2015-03-16 | |
| US201562160291P | 2015-05-12 | 2015-05-12 | |
| US201562215394P | 2015-09-08 | 2015-09-08 | |
| US201562254424P | 2015-11-12 | 2015-11-12 | |
| PCT/US2016/019120 WO2016137985A1 (en) | 2015-02-26 | 2016-02-23 | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL278423A IL278423A (enExample) | 2020-12-31 |
| IL278423B1 IL278423B1 (en) | 2023-12-01 |
| IL278423B2 true IL278423B2 (en) | 2024-04-01 |
Family
ID=55588542
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL278423A IL278423B2 (en) | 2015-02-26 | 2016-02-23 | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
| IL254131A IL254131B (en) | 2015-02-26 | 2017-08-24 | Fidi-1 / Fidi-AL1 inhibitors for cancer treatment |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL254131A IL254131B (en) | 2015-02-26 | 2017-08-24 | Fidi-1 / Fidi-AL1 inhibitors for cancer treatment |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10800846B2 (enExample) |
| EP (2) | EP3262073A1 (enExample) |
| JP (3) | JP6885869B2 (enExample) |
| KR (1) | KR20170132171A (enExample) |
| CN (2) | CN107405401B (enExample) |
| AU (3) | AU2016222928B2 (enExample) |
| BR (1) | BR112017018234A2 (enExample) |
| CA (1) | CA2977767C (enExample) |
| IL (2) | IL278423B2 (enExample) |
| MX (2) | MX393976B (enExample) |
| NZ (1) | NZ733854A (enExample) |
| RU (1) | RU2714233C2 (enExample) |
| SG (2) | SG11201706918YA (enExample) |
| TW (2) | TWI748942B (enExample) |
| WO (1) | WO2016137985A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101764096B1 (ko) | 2011-11-28 | 2017-08-02 | 메르크 파텐트 게엠베하 | 항-ｐｄ-ｌ1 항체 및 그의 용도 |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| RU2714233C2 (ru) | 2015-02-26 | 2020-02-13 | Мерк Патент Гмбх | Ингибиторы pd-1 / pd-l1 для лечения рака |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| MY193229A (en) | 2015-06-16 | 2022-09-26 | Merck Patent GmbH | Pd-l1 antagonist combination treatments |
| EP4458417A3 (en) | 2015-08-11 | 2025-02-19 | Wuxi Biologics Ireland Limited | Novel anti-pd-1 antibodies |
| AU2016317915B2 (en) | 2015-09-01 | 2021-02-18 | Agenus Inc. | Anti-PD-1 antibodies and methods of use thereof |
| LT3386541T (lt) | 2015-12-07 | 2020-10-26 | Merck Patent Gmbh | Vandeninė farmacinė kompozicija, apimanti anti-pd-1 antikūną avelumabą |
| CA3025391A1 (en) * | 2016-05-26 | 2017-11-30 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for cancer treatment |
| CA3027705A1 (en) | 2016-06-17 | 2017-12-21 | The Trustees Of The University Of Pennsylvania | Compounds, compositions and methods for prevention and/or treatment of cancer |
| PE20191076A1 (es) * | 2016-09-14 | 2019-08-20 | Beijing hanmi pharm co ltd | Anticuerpo que se une especificamente a pd-1 y fragmento funcional del mismo |
| KR20190062515A (ko) | 2016-10-06 | 2019-06-05 | 화이자 인코포레이티드 | 암의 치료를 위한 아벨루맙의 투약 용법 |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| CN110300599B (zh) | 2016-12-07 | 2024-07-02 | 艾吉纳斯公司 | 抗体和其使用方法 |
| KR20230145547A (ko) * | 2017-02-16 | 2023-10-17 | 메디뮨 엘엘씨 | 방광암의 항-pd-l1 항체 치료 |
| EP3372615A1 (en) | 2017-03-06 | 2018-09-12 | Merck Patent GmbH | Composition comprising avelumab |
| BR112019018401A2 (pt) | 2017-03-06 | 2020-04-07 | Merck Patent Gmbh | formulação aquosa de anticorpo anti-pd-l1 |
| RU2765997C2 (ru) * | 2017-03-30 | 2022-02-07 | Мерк Патент Гмбх | Комбинация анти-pd-l1 антитела и ингибитора днк-пк для лечения злокачественного новообразования |
| CN110914302A (zh) | 2017-06-01 | 2020-03-24 | 赛托姆克斯治疗学股份有限公司 | 可活化抗pdl1抗体及其使用方法 |
| CA3078806A1 (en) * | 2017-10-13 | 2019-04-18 | Merck Patent Gmbh | Combination of a parp inhibitor and a pd-1 axis binding antagonist |
| WO2019118855A1 (en) * | 2017-12-14 | 2019-06-20 | The Trustees Of The University Of Pennsylvania | Compounds and compositions for prevention and/or treatment of cancer |
| BR112020016986A2 (pt) | 2018-02-21 | 2021-03-02 | Five Prime Therapeutics, Inc. | formulações de anticorpo contra b7-h4 |
| MX2020009550A (es) * | 2018-03-22 | 2020-11-11 | Keires Ag | Proteinas de union a antigeno antagonistas. |
| JP2021527083A (ja) * | 2018-06-13 | 2021-10-11 | メルク パテント ゲーエムベーハー | ステージｉｉｉ ｎｓｃｌｃの治療及びその治療に伴う病理学的状態の鎮静 |
| KR20210066837A (ko) * | 2018-09-26 | 2021-06-07 | 메르크 파텐트 게엠베하 | 암 치료를 위한 pd-1 안타고니스트, atr 억제제 및 백금화제의 조합 |
| KR20210076025A (ko) * | 2018-10-15 | 2021-06-23 | 파이브 프라임 테라퓨틱스, 인크. | 암 병용 요법 |
| CN112996814B (zh) * | 2018-11-14 | 2025-01-03 | 拜耳公司 | 用于治疗癌症的抗ceacam6和抗pd-1或抗pd-l1抗体的药物组合 |
| US11851490B2 (en) | 2019-08-15 | 2023-12-26 | Northwestern University | Methods and compositions for treating, inhibiting, and/or preventing heterotopic ossification |
| US20210169979A1 (en) * | 2019-12-05 | 2021-06-10 | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges | System and method for sonosensitized cancer immunotherapy with nanoparticles |
| US20230058779A1 (en) * | 2020-01-02 | 2023-02-23 | Merck Sharp & Dohme Llc | Combination cancer treatment using a pd-1 antagonist, an ilt4 antagonist, and lenvatinib or salts thereof |
| AU2020466790B2 (en) * | 2020-09-04 | 2025-07-10 | Pharma Mar, S.A. | Combination of lurbinectedin and immune checkpoint inhibitor |
| WO2023154799A1 (en) | 2022-02-14 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination immunotherapy for treating cancer |
| TW202404634A (zh) * | 2022-04-05 | 2024-02-01 | 美商安進公司 | 胃癌的治療 |
| WO2024137442A1 (en) | 2022-12-21 | 2024-06-27 | Gilead Sciences, Inc. | Combination therapy for treating cancer |
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2016
- 2016-02-23 RU RU2017133273A patent/RU2714233C2/ru active
- 2016-02-23 SG SG11201706918YA patent/SG11201706918YA/en unknown
- 2016-02-23 CN CN201680012312.1A patent/CN107405401B/zh not_active Expired - Fee Related
- 2016-02-23 CA CA2977767A patent/CA2977767C/en active Active
- 2016-02-23 MX MX2017010773A patent/MX393976B/es unknown
- 2016-02-23 AU AU2016222928A patent/AU2016222928B2/en not_active Ceased
- 2016-02-23 EP EP16711389.3A patent/EP3262073A1/en not_active Withdrawn
- 2016-02-23 EP EP23193773.1A patent/EP4279087A3/en not_active Withdrawn
- 2016-02-23 US US15/553,437 patent/US10800846B2/en active Active
- 2016-02-23 IL IL278423A patent/IL278423B2/en unknown
- 2016-02-23 NZ NZ733854A patent/NZ733854A/en not_active IP Right Cessation
- 2016-02-23 KR KR1020177026975A patent/KR20170132171A/ko not_active Ceased
- 2016-02-23 CN CN202011179277.7A patent/CN112263677A/zh active Pending
- 2016-02-23 SG SG10201810615VA patent/SG10201810615VA/en unknown
- 2016-02-23 WO PCT/US2016/019120 patent/WO2016137985A1/en not_active Ceased
- 2016-02-23 JP JP2017545299A patent/JP6885869B2/ja not_active Expired - Fee Related
- 2016-02-23 BR BR112017018234A patent/BR112017018234A2/pt not_active Application Discontinuation
- 2016-02-26 TW TW105106010A patent/TWI748942B/zh not_active IP Right Cessation
- 2016-02-26 TW TW109124450A patent/TWI755791B/zh not_active IP Right Cessation
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- 2020-03-23 JP JP2020050850A patent/JP7116113B2/ja not_active Expired - Fee Related
- 2020-08-05 US US16/985,805 patent/US20200362040A1/en not_active Abandoned
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