IL278423B2 - Pd-1 / pd-l1 inhibitors for the treatment of cancer - Google Patents

Pd-1 / pd-l1 inhibitors for the treatment of cancer

Info

Publication number
IL278423B2
IL278423B2 IL278423A IL27842320A IL278423B2 IL 278423 B2 IL278423 B2 IL 278423B2 IL 278423 A IL278423 A IL 278423A IL 27842320 A IL27842320 A IL 27842320A IL 278423 B2 IL278423 B2 IL 278423B2
Authority
IL
Israel
Prior art keywords
composition according
antibody
receptor
human
subject
Prior art date
Application number
IL278423A
Other languages
English (en)
Hebrew (he)
Other versions
IL278423A (enExample
IL278423B1 (en
Original Assignee
Merck Patent Gmbh
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Pfizer filed Critical Merck Patent Gmbh
Publication of IL278423A publication Critical patent/IL278423A/en
Publication of IL278423B1 publication Critical patent/IL278423B1/en
Publication of IL278423B2 publication Critical patent/IL278423B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL278423A 2015-02-26 2016-02-23 Pd-1 / pd-l1 inhibitors for the treatment of cancer IL278423B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562121025P 2015-02-26 2015-02-26
US201562133721P 2015-03-16 2015-03-16
US201562160291P 2015-05-12 2015-05-12
US201562215394P 2015-09-08 2015-09-08
US201562254424P 2015-11-12 2015-11-12
PCT/US2016/019120 WO2016137985A1 (en) 2015-02-26 2016-02-23 Pd-1 / pd-l1 inhibitors for the treatment of cancer

Publications (3)

Publication Number Publication Date
IL278423A IL278423A (enExample) 2020-12-31
IL278423B1 IL278423B1 (en) 2023-12-01
IL278423B2 true IL278423B2 (en) 2024-04-01

Family

ID=55588542

Family Applications (2)

Application Number Title Priority Date Filing Date
IL278423A IL278423B2 (en) 2015-02-26 2016-02-23 Pd-1 / pd-l1 inhibitors for the treatment of cancer
IL254131A IL254131B (en) 2015-02-26 2017-08-24 Fidi-1 / Fidi-AL1 inhibitors for cancer treatment

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL254131A IL254131B (en) 2015-02-26 2017-08-24 Fidi-1 / Fidi-AL1 inhibitors for cancer treatment

Country Status (15)

Country Link
US (2) US10800846B2 (enExample)
EP (2) EP4279087A3 (enExample)
JP (3) JP6885869B2 (enExample)
KR (1) KR20170132171A (enExample)
CN (2) CN112263677A (enExample)
AU (3) AU2016222928B2 (enExample)
BR (1) BR112017018234A2 (enExample)
CA (1) CA2977767C (enExample)
IL (2) IL278423B2 (enExample)
MX (2) MX393976B (enExample)
NZ (1) NZ733854A (enExample)
RU (1) RU2714233C2 (enExample)
SG (2) SG10201810615VA (enExample)
TW (2) TWI748942B (enExample)
WO (1) WO2016137985A1 (enExample)

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WO2019118855A1 (en) * 2017-12-14 2019-06-20 The Trustees Of The University Of Pennsylvania Compounds and compositions for prevention and/or treatment of cancer
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KR20200135447A (ko) * 2018-03-22 2020-12-02 카이레스 아게 길항성 pd-1, pd-l1 및 lag-3 결합 단백질
MX2020013535A (es) * 2018-06-13 2021-02-26 Merck Patent Gmbh Tratamiento de cáncer pulmonar de células no pequeñas (nsclc) en etapa iii y mitigación de las condiciones patológicas asociadas con el tratamiento.
BR112021004935A2 (pt) * 2018-09-26 2021-06-01 Merck Patent Gmbh combinação de antagonista de pd-1, inibidor de atr e agente de platinação para tratamento de câncer
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AU2019379261B2 (en) * 2018-11-14 2026-03-05 Bayer Aktiengesellschaft Pharmaceutical combination of anti-CEACAM6 and either anti-PD-1 or anti-PD-L1 antibodies for the treatment of cancer
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US20210169979A1 (en) * 2019-12-05 2021-06-10 The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges System and method for sonosensitized cancer immunotherapy with nanoparticles
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